BioWorld - Thursday, January 15, 2026
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  • Multiple sclerosis-damaged myelin

    New insights bring clarity to multiple sclerosis’ EBV connection

    For decades, scientists have searched for a mechanistic link between viral infection and multiple sclerosis (MS). Insights from three studies recently published in Cell bring that connection into sharper focus. By tracing how the immune system responds to Epstein-Barr virus (EBV) – and how those responses can misfire against the brain – researchers are beginning to uncover a compelling biological explanation for MS.

  • New insights bring clarity to multiple sclerosis’ EBV connection

    For decades, scientists have searched for a mechanistic link between viral infection and multiple sclerosis (MS). Insights from three studies recently published in Cell bring that connection into sharper focus. By tracing how the immune system responds to Epstein-Barr virus (EBV) – and how those responses can misfire against the brain – researchers are beginning to uncover a compelling biological explanation for MS.

  • ‘Therapeutic minigenomes’ turn Ebola against itself

    Ebola virus (EBOV) causes severe febrile illness that frequently leads to death within 10 days of infection due to multiorgan failure. Different therapeutic strategies have been developed against EBOV infection, including small-molecule drugs, monoclonal antibodies and viral vaccine vectors. Despite their promise, all these strategies have significant limitations that limit their clinical application. Researchers from Mayo Clinic recently presented a novel molecular therapy, which they called “therapeutic minigenome,” using EBOV’s own proteins to combat itself.

  • Engrail’s ENX-205 shows promise for PTSD therapy

    Post-traumatic stress disorder (PTSD) is a condition with limited effective therapeutic options to date, where 5-HT2A receptor agonists show promise for enhancing cortical plasticity in the brain and aiming in the processing of trauma. Engrail Therapeutics Inc. has presented data for their 5-HT2A agonist and dopamine D2/D3 receptor antagonist neuroplastogen ENX-205 for the potential treatment of PTSD.

  • Henlius in-licenses anti-IL-1RAP antibody from U-mab Biopharma

    Shanghai Henlius Biotech Inc. has entered into an exclusive global license agreement with U-mab Biopharma (Lianyungang) Co. Ltd., securing rights to a monoclonal antibody (mAb) targeting interleukin-1 receptor accessory protein (IL-1RAP) for inflammatory and autoimmune diseases.

  • Transneural’s TN-001 has antidepressant activity in mice

    Neuroplastogens are an emerging class of compounds that promote neuroplasticity in the brain without inducing hallucinogenic effects. Transneural Therapeutics Inc. has presented data regarding their new neuroplastogen TN-001 for treating major depressive disorder; TN-001 was assayed in vitro and in vivo.

  • Neurocrine Biosciences describes new GLP-1R/GIPR/GCGR agonists

    Neurocrine Biosciences Inc. has disclosed chemically modified polypeptides acting as gastric inhibitory polypeptide receptor (GIPR) and/or glucagon receptor (GCGR) and/or glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of obesity.

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Conferences

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Today's news in brief

Patents

Cancer

  • Liver tumor treatment conceptual illustration

    Chi-NPB40 exerts antitumoral activity in HCC

    Immuno-oncology
    CD276, also known as B7-H3, is an antigen highly expressed in several cancer types, including hepatocellular carcinoma (HCC, 79%-94% expression) and closely tied to aggressiveness and poor survival, but shows very low expression in normal tissues. Increasing evidence exists indicating B7-H3 has...
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Infection

  • Coumarin derivative exhibits potent antibiofilm activity

    The treatment of Pseudomonas aeruginosa infections is significantly challenged by the pathogen’s diverse resistance mechanisms, with biofilm formation being a key driver of antibiotic tolerance. Furthermore, P. aeruginosa pathogenicity is amplified by virulence factors that both evade host defenses...

  • Humanized N-hRSV mAbs show protective preclinical efficacy

    Respiratory
    Human respiratory syncytial virus (hRSV) represents a major global health burden and is a leading cause of severe respiratory disease, particularly among preterm infants. Despite extensive efforts to prevent hRSV infection, currently approved monoclonal antibody (mAb) therapies have been...
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Neurology/psychiatric

  • Antisense targeting of ATN1 reduces DRPLA pathology

    Genetic/congenital
    Dentatorubral-pallidoluysian atrophy (DRPLA) is a lethal neurodegenerative disorder caused by pathogenic expansion of CAG repeats within the atrophin-1 (ATN1) gene. As DRPLA belongs to the broader class of repeat expansion disorders (RED) that are driven by toxic gain-of-function effects, reduction...
  • Illustration of magnifying glass inspecting brain

    Neurotrimin unveiled as marker in intellectual disability

    Biomarkers
    Neurotrimin (NTM) is a member of the IgLON family, the disruption of which has been tied to emotional learning deficits and anxiety-like behavior in animal models. A mutation in the NTM gene was found to disrupt NTM protein heterodimerization with other IgLON family members, suggesting a potential...
More in Neurology/psychiatric

Immune

Endocrine/metabolic

  • Concept art for adeno-associated viral-based gene therapy.

    Généthon and Askbio enter Pompe licensing agreement

    Deals and M&A
    Généthon, a nonprofit laboratory created by the AFM-Téléthon, has reported its exclusive, worldwide licensing agreement with Askbio Inc., a subsidiary of Bayer AG, for the use of a patented component of AB-1009, under development by Askbio, for the treatment of Pompe disease.
More in Endocrine/metabolic

Biomarkers

  • LINC01116 has prognostic value in lung cancer, study shows

    Cancer
    Long noncoding RNAs (lncRNAs) have emerged as potential markers of disease, since they associate with proteins that regulate gene expression, translation or stability, among others, and where hypoxia might play a role in this scenario. In recently published work, researchers analyzed clinical data...
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Gastrointestinal

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