Amyloidosis is a clinical disorder caused by extracellular and/or intracellular deposition of insoluble abnormal amyloid fibrils that alter the normal function of tissues. Various types of amyloidosis can be caused by the deposition of about 23 different types of precursor proteins. Insoluble monoclonal immunoglobulin light (L) chains (or L-chain fragments) cause primary systemic amyloidosis, whereas precursor protein amyloid causes a secondary inflammation-associated systemic subtype called amyloid A (AA) amyloidosis (or inflammatory amyloidosis). These disease processes might take place in various tissues, including blood vessel walls, connective tissues, striated and smooth muscles, and peripheral nerves and are likely to involve the liver, kidney, or spleen. As a result, various conditions are associated with systemic amyloidosis, and the most effective therapies are focused on targeting underlying protein accumulation and inflammatory conditions.
Are you up-to-date on the presentation, diagnosis, comorbidities, and treatment associated with the various types of systemic amyloidosis? Find out with this short quiz.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Presentation and Treatment of Systemic Amyloidosis - Medscape - May 12, 2024.
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