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Comment
. 2024 Oct 17;84(20):3863-3865.
doi: 10.1016/j.molcel.2024.09.029.

Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain

Adam Kosti  1 , Gary J Bassell  2
Affiliations
Comment

Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain

Adam Kosti et al. Mol Cell. .

Abstract

In this issue of Molecular Cell, Lee et al.1 report that alternative translation initiation can generate new proteoforms with distinct localization patterns in a neuronal activity-dependent manner.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Alternative Translation Initiation Overview (A) Schematic illustration of Lee et al findings demonstrating that RNA secondary structure influences ATI to generate distinct proteoforms from a single ORF. (B) Schematic highlighting major gaps in the field of ATI, including the role of AUG near-cognates in initiating translation, the role of RBPs in regulating ATI, and the identification of different peptides arising from the various ATI start sites.
See this image and copyright information in PMC

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References

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