Prashant Soni
AI Engineer Founding Engineer · OrphaNova NYC/SF Searching for a crazy team

Prashant Soni

Engineering -1 to 1 AI systems that move this ❤️ world forward and add value to people's lives.

Recent Ships:

SpaceGuard: Kalshi for space events 🚀. A predictive intelligence platform providing satellite collision risk assessment via real-time market signals.

Homecastr: FaceTime for real estate 🏠. A conversational video AI that transforms static property listings into interactive, agent-led experiences.

OrphaNova: The OS for orphan drug R&D 🧬. An AI-native research engine architected to accelerate therapeutic discovery for rare diseases.

Experience

Founding Engineer & Lead Developer · OrphaNova Nov 2025 – Present

Building OrphaNova, an AI research system for rare disease discovery. Designed a 7-stage pipeline that retrieves biomedical literature, extracts disease-gene relationships, predicts protein structures (AlphaFold2), screens drug candidates (RDKit), performs molecular docking (Chai-1), and generates publication-ready research reports.

Research Assistant · Yeshiva University Nov 2024 – Dec 2025

Developed deep learning models for cardiomegaly detection from veterinary X-rays, achieving 85.75% accuracy on 2,000+ images. Built OrphanAtlas, a rare disease research platform combining GPT-based retrieval pipelines with biomedical datasets, now used by 500+ researchers.

Received Outstanding R&D Award at the Yeshiva University Research Symposium.

Projects

Featured builds, shipped and live

Other Projects

Kalshi Continual Learning Trading Bot

Sep 2025 - Present

Event-driven trading agent for Kalshi prediction markets. Learns from new market data in real-time, generates trading signals, and executes trades with built-in risk controls and backtesting framework.

Kalshi · Reinforcement Learning · Backtesting · Risk Management

Agents4Science

Sep 2025 - Present

Agent-based generative AI workflows for drug repurposing research. Mines biomedical literature, extracts evidence, and generates hypotheses. Built with LLM + RAG pipelines and domain-constrained prompting to reduce hallucinations in sparse data.

LLMs · RAG · Biomedical NLP · Drug Repurposing

Multimodal Stock Price Predictor

Jun 2025

Deep learning pipeline combining LSTM time-series analysis with FinBERT sentiment from news/social media. Achieved 15% higher accuracy than single-modality models. Includes backtesting and financial metrics (Sharpe ratio, MSE, RMSE) for risk-adjusted insights.

TensorFlow · LSTM · FinBERT · Financial ML

Kaggle ConnectX RL Agent

May 2025

Built reinforcement learning agents using Q-learning, Deep Q-Networks, and Monte Carlo Tree Search. Implemented epsilon-greedy exploration and policy gradients. Secured 7th place globally (top 0.5%) through hyperparameter tuning and reward shaping.

Reinforcement Learning · DQN · MCTS · Python

GitHub Highlights

Latest repositories from GitHub.

Education

Yeshiva University

M.S. in Artificial Intelligence

Katz School of Science and Health

New York, NY · Dec 2025 · GPA 3.8/4.0

IIIT Bangalore

PG Diploma in Data Science

Indian Institute of Information Technology (IIIT) Bangalore

India · Jun 2024 · GPA 3.8/4.0

Research & Publications

Top publications from ResearchGate.

Visit ResearchGate Profile

Technical Skills

Programming & ML

Python, Pandas, NumPy, SciPy, Matplotlib, TensorFlow, PyTorch, Keras, Scikit-learn, OpenCV, Git

Deep Learning & Research

Reinforcement Learning, Computer Vision, NLP, Generative AI, RAG, Responsible AI, CUDA, Multimodal Fusion, W&B, API Development, Hugging Face, LLM Fine-tuning

Data & Cloud

MySQL, MongoDB, Hadoop, Apache Spark, GCP (Vertex AI, TPU), AWS (EC2/S3), Azure ML, Docker

Schedule a Call

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Contact

Email

prashantsonibps@gmail.com psoni@mail.yu.edu

Phone

+1 551 362 9944

Location

NYC / San Francisco