PHARMO Institute

Your Global Partner for Coordinating Multi-Country Real-World Database Studies

Advancing Health Through Evidence

PHARMO Institute, part of Lumanity, delivers high-quality, real-world research to help the healthcare industry understand how medicines perform beyond the clinical trial setting. Since 1999, we have been analyzing healthcare data to identify side effects earlier, improve patient safety and outcomes, and guide better treatment decisions.

With direct access to unique Dutch healthcare databases and strong global partnerships, PHARMO offers a combination of local expertise and international reach that produces fast, reliable, and actionable evidence.

Expertise You Can Rely On

Our team of specialists in epidemiology, statistics, and data science, deliver tailor-made observational studies that answer complex research questions about safety, effectiveness, and the value of medicines.

We provide:

Post-authorization safety and efficacy studies (PASS, PAES)
Drug utilization studies (DUS)
Incidence, prevalence, treatment patterns, and patient pathways
Comparative effectiveness studies, including synthetic control arms
Healthcare resource use and cost of illness research
AI-driven patient finding, classification, and disease progression analysis

All projects follow internationally recognized standards, including the ENCePP Guide on Methodological Standards, the ENCePP Code of Conduct, and Good Pharmacovigilance Practice guidelines. PHARMO is an certified research organization.

Rich, Linked Data for Powerful Insights

PHARMO has direct access to anonymized patient-level data from multiple healthcare settings in the Netherlands, linked through validated algorithms.

Our data sources include:

General practitioners
Hospitals (admissions, ambulatory visits, high-cost medicines)
Clinical laboratories
Community and hospital pharmacies
Specialized registries (pathology, cancer, perinatal care)

At a glance

This integrated dataset supports research into slow-progressing illnesses, rare diseases, and conditions requiring multi-setting care—areas often unaddressable by other secondary databases.

250

Million person-years of data

Million patients

1,400

Practices, hospitals, pharmacies, and labs

Global Reach, Local Insight

PHARMO collaborates with leading and researchers worldwide to deliver multi-country studies that meet the highest standards of quality and transparency.

We are a founding member of the SIGMA Consortium, an alliance of European ENCePP research centers providing:

Single-point coordination for multi-country pharmacoepidemiologic and real-world evidence studies
Common study protocols and programming
Quality-assured delivery
Access to 10 of the top 15 secondary databases used in European PASS studies

Additionally, PHARMO is part of ENCePP, SIGMA, VAC4EU, and EU PPV.

Why Work With PHARMO?

Medicines can affect people differently depending on biology, lifestyle, and healthcare context. We help uncover the reasons and patterns behind these differences, providing the clarity needed for better health decisions.

Scientific rigor

Academically trained researchers applying the right methodologies for each challenge

Global collaboration

Coordinated multi-country studies with consistent quality

Proven track record

Decades of delivering trusted evidence for regulators, payers, and healthcare providers

Our Perspectives View all perspectives

View Mar 10, 2026

The IO Landscape Is Shifting — Here’s What Leadership Teams Need to Know

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Navigating the Most Favored Nation Terminology Maze

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View Mar 6, 2026

Closing the Gap: Advancing Equity in Cardiovascular Care for Women

Resource

Real-World Evidence Expertise in Dravet Syndrome

View Feb 27, 2026

Rare Disease Day 2026: Moving Forward with FDA Innovation and Patient-Centered Progress

View Feb 27, 2026

The Expected, Unexpected: Q&A with Jason Madison, Hunter Syndrome Patient Advocate

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View Feb 26, 2026

Voices of Rare Disease: Perspectives Across the Community

On-Demand Webinar Feb 26, 2026

Navigating Value Creation in Cell & Gene Therapy: Strategy, Access, and Adoption

Explore our publications

Browse PHARMO’s publications to see the impact of our work across therapeutic areas.

2024

Ruigomez, A. S., T, Annemarie, V. Herings, M.C. Ron, Smits, E, Swart-Polinder, Balabonva, Y. Brobert, G. . (2024). Safety profile of rivaroxaban in first-time users treated for venous thromboembolism in four European countries. PLoS One. doi: https://doi.org/10.1371/journal.pone.0298596

Kiss, P. A. J., Uijl, A., de Boer, A. R., Duk, T. C. X., Grobbee, D. E., Hollander, M., . . . Peters, S. A. E. (2024). Sex differences in the intensity of statin prescriptions at initiation in a primary care setting. Heart, 110(15), 981-987. doi: https://doi.org/10.1136/heartjnl-2023-323722

2023

Hendriksen, L. C., van der Linden, P. D., Herings, R. M. C., Stricker, B. H., & Visser, L. E. (2023). Women on diuretics have a higher risk of hospital admission because of hyponatremia than men. Pharmacoepidemiol Drug Saf. doi: https://doi.org/10.1002/pds.5592

Vervloet, M. G., de Jong, H. J., Pander, J., & Overbeek, J. A. (2023). Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications. BMC Nephrol, 24(1), 337. doi: https://doi.org/10.1186/s12882-023-03384-y

Heintjes, E. M., Anastassopoulou, A., Kuiper, J., Bilitou, A., Penning-van Beest, F. J. A., Herings, R. M. C., . . . Jukema, J. W. (2023). Treatment and low-density lipoprotein cholesterol levels in patients with hypercholesterolaemia or mixed dyslipidaemia at high or very high cardiovascular risk: a population-based cross-sectional study in the Netherlands. Curr Med Res Opin, 39(1), 1-11. doi: https://doi.org/10.1080/03007995.2022.2129228

van Trier, T. J., Snaterse, M., Herings, R. M. C., Overbeek, J. A., Peters, R. J. G., & Jorstad, H. T. (2023, Oct 23). Impact of implementing Dutch versus European guideline risk factor targets in older patients with ischaemic heart disease. Neth Heart J. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/37870710

Voss, A., Smits, E., Swart, K. M. A., Balabanova, Y., Brobert, G., Suzart-Woischnik, K., . . . Haug, U. (2023). Time Trends in Patient Characteristics of New Rivaroxaban Users with Atrial Fibrillation in Germany and the Netherlands. Drugs Real World Outcomes, 10(2), 215-224. doi: https://doi.org/10.1007/s40801-022-00350-2

Swart, K. M. A., Baak, B. N., Lemmens, L., Penning-van Beest, F. J. A., Bengtsson, C., Lobier, M., . . . Simons, S. O. (2023). Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands. Respir Res, 24(1), 293. doi: https://doi.org/10.1186/s12931-023-02601-4

2022

Komen, J., Pottegard, A., Hjemdahl, P., Mantel-Teeuwisse, A. K., Wettermark, B., Hellfritzsch, M., . . . Klungel, O. (2022). Non-vitamin K antagonist oral anticoagulants, proton pump inhibitors and gastrointestinal bleeds. Heart. doi: https://doi.org/10.1136/heartjnl-2021-319332

Kruik-Kolloffel, W. J., Vallejo-Yague, E., Movig, K. L. L., Linssen, G. C. M., Heintjes, E. M., & van der Palen, J. (2022). Non-cardiovascular medication and readmission for heart failure: an observational cohort study. Int J Clin Pharm, 44(3), 762-768. doi: https://doi.org/10.1007/s11096-022-01418-3

Smits, E., Andreotti, F., Houben, E., Crijns, H., Haas, S., Spentzouris, G., . . . Herings, R. (2022). Adherence and Persistence with Once-Daily vs Twice-Daily Direct Oral Anticoagulants Among Patients with Atrial Fibrillation: Real-World Analyses from the Netherlands, Italy and Germany. Drugs Real World Outcomes. doi: https://doi.org/10.1007/s40801-021-00289-w

Kuiper, J. G., van Herk-Sukel, M. P. P., Lemmens, V., Kuiper, M. J., Kuipers, E. J., & Herings, R. M. C. (2022). Risk of heart failure among colon and rectal cancer survivors: a population-based case-control study. ESC Heart Fail, 9(4), 2139-2146. doi: https://doi.org/10.1002/ehf2.13923

Ouahoud, S., Jacobs, R. J., Kodach, L. L., Voorneveld, P. W., Hawinkels, L., Weil, N. L., . . . Hardwick, J. C. H. (2022). Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4. Br J Cancer. doi: https://doi.org/10.1038/s41416-021-01604-6

Holthuis, E., Smits, E., Spentzouris, G., Beier, D., Enders, D., Gini, R., . . . Herings, R. (2022). Increased Risk of Stroke Due to Non-adherence and Non-persistence with Direct Oral Anticoagulants (DOACs): Real-World Analyses Using a Nested Case-Control Study from The Netherlands, Italy and Germany. Drugs Real World Outcomes, 9(4), 597-607. doi: https://doi.org/10.1007/s40801-022-00317-3

2021

Brand, A. R., Houben, E., Bezemer, I. D., Visseren, F. L. J., Bots, M. L., Herings, R. M., & de Borst, G. J. (2021). Platelet aggregation inhibitor prescription for newly diagnosed peripheral arterial disease in the Netherlands: a cohort study. BMJ Open, 11(1), e041715. doi: https://doi.org/10.1136/bmjopen-2020-041715

Hempenius, M. M., Groenwold, R., Souverein, P. C. P., de Boer, A. A., Klungel, O. H. O., & Gardarsdottir, H. H. (2021). Impact Of Anticoagulant Exposure Misclassification On The Bleeding Risk Of DOACs. Br J Clin Pharmacol, 3508-3517. doi: https://doi.org/10.1111/bcp.14764

Morales, D. R., Macfarlane, T., MacDonald, T. M., Hallas, J., Ernst, M. T., Herings, R. M. C., . . . Flynn, R. W. F. (2021). Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: an interrupted time series regression analysis. Pharmacoepidemiol Drug Saf, p1897, 482-491. doi: https://doi.org/10.1002/pds.5191

Morales, D. R., Morant, S. V., MacDonald, T. M., Hallas, J., Ernst, M. T., Pottegard, A., . . . Flynn, R. W. V. (2021). Impact of EU regulatory label changes for diclofenac in people with cardiovascular disease in four countries: interrupted time series regression analysis. Br J Clin Pharmacol, 1129-1140. doi: https://doi.org/10.1111/bcp.14478

van Dongen, L. H., Harms, P. P., Hoogendoorn, M., Zimmerman, D. S., Lodder, E. M., t Hart, L. M., . . . Tan, H. L. (2021). Discovery of predictors of sudden cardiac arrest in diabetes: rationale and outline of the RESCUED (REcognition of Sudden Cardiac arrest vUlnErability in Diabetes) project. Open Heart, 8(1). doi: https://doi.org/10.1136/openhrt-2020-001554

George, G., Garmo, H., Scailteux, L. M., Balusson, F., De Coster, G., De Schutter, H., . . . Van Hemelrijck, M. (2021). Risk of cardiovascular disease following gonadotropin-releasing hormone agonists vs antagonists in prostate cancer: Real-world evidence from five databases. Int J Cancer, 2203–2211. doi: https://doi.org/10.1002/ijc.33397

2020

Eroglu, T. E., Mohr, G. H., Blom, M. T., Verkerk, A. O., Souverein, P. C., Torp-Pedersen, C., . . . Tan, H. L. (2020). Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries. Eur Heart J Cardiovasc Pharmacother, 347-355. doi: https://doi.org/10.1093/ehjcvp/pvz038

Kruik-Kolloffel, W. J., van der Palen, J., Doggen, C. J. M., van Maaren, M. C., Kruik, H. J., Heintjes, E. M., . . . Linssen, G. C. M. (2020). Heart failure medication after a first hospital admission and risk of heart failure readmission, focus on beta-blockers and renin-angiotensin-aldosterone system medication: A retrospective cohort study in linked databases. PLoS One, 15(12), e0244231. doi: https://doi.org/10.1371/journal.pone.0244231

Wollersheim, B. M., Boekhout, A. H., van der Poel, H. G., van de Poll-Franse, L. V., & Schoormans, D. (2020). The risk of developing cardiovascular disease is increased for prostate cancer patients who are pharmaceutically treated for depression. BJU Int, 125, 433-441. doi: https://doi.org/10.1111/bju.14961

Birkeland, K. I., Bodegard, J., Eriksson, J. W., Norhammar, A., Haller, H., Linssen, G. C. M., . . . Kadowaki, T. (2020). Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: a large multinational cohort study. Diabetes Obes Metab, 22, 1607-1618. doi: https://doi.org/10.1111/dom.14074

2019

Bakhriansyah, M., Souverein, P. C., de Boer, A., & Klungel, O. H. (2019). Risk of myocardial infarction associated with non-steroidal anti-inflammatory drugs: Impact of additional confounding control for variables collected from self-reported data. J Clin Pharm Ther, 44(4), 623-631. doi: https://doi.org/10.1111/jcpt.12836

Bakhriansyah, M., Souverein, P. C., Klungel, O. H., de Boer, A., Blom, M. T., & Tan, H. L. (2019). Non-steroidal anti-inflammatory drugs and the risk of out-of-hospital cardiac arrest: a case-control study. Europace, 21(1), 99-105. doi: https://doi.org/10.1093/europace/euy180

Hempenius, M., Groenwold, R. H. H., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2019). Amiodarone use and the risk of acute pancreatitis: Influence of different exposure definitions. Pharmacoepidemiol Drug Saf, 28(12), 1563-1571. doi: https://doi.org/10.1002/pds.4851

Houben, E., Smits, E., Overbeek, J. A., Penning-van Beest, F. J. A., Herings, R. M. C., van Herk-Sukel, M. P. P., . . . de Smet, P. (2019). Nierfunctie en ernstige bloedingen bij patiënten behandeld met cumarines. Pharmaceutisch Weekblad, 154(11), 19-28.

Kruik-Kolloffel, W. J., Linssen, G. C. M., Kruik, H. J., Movig, K. L. L., Heintjes, E. M., & van der Palen, J. (2019). Effects of European Society of Cardiology guidelines on medication profiles after hospitalization for heart failure in 22,476 Dutch patients: from 2001 until 2015. Heart Fail Rev, 24(4), 499-510. doi: https://doi.org/10.1007/s10741-019-09777-2

Heintjes, E. M., Houben, E., Beekman-Hendriks, W. L., Lighaam, E., Cremers, S. M., Penning-van Beest, F. J. A., . . . Herings, R. M. C. (2019). Trends in mortality, cardiovascular complications, and risk factors in type 2 diabetes. Neth J Med, 77(9), 317-329. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/31814586

George, G., Scailteux, L. M., Garmo, H., Balusson, F., Cardwell, C., De Coster, G., . . . Van Hemelrijck, M. (2019). Real-world insights into risk of developing cardiovascular disease following GnRH agonists versus antagonists for prostate cancer: a methodological protocol to a study using five European databases. Fundam Clin Pharmacol, 33, 479-499. doi: https://doi.org/10.1111/fcp.12454

2018

Houben, E., Smits, E., Overbeek, J. A., Penning-van Beest, F. J. A., Herings, R. M. C., van Herk-Sukel, M. P. P., . . . de Smet, P. (2018). No Evidence for an Association Between Renal Function and Serious Bleeding Events in Patients Treated With Coumarins: A Population-Based Study. Ann Pharmacother, 52(3), 221 – 234. doi: https://doi.org/10.1177/1060028017735340

Masclee, G. M. C., Straatman, H., Arfe, A., Castellsague, J., Garbe, E., Herings, R., . . . Sturkenboom, M. (2018). Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project. PLoS One, 13(11), e0204746. doi: https://doi.org/10.1371/journal.pone.0204746

2017

Kruik-Kolloffel, W. J., van der Palen, J., van Herk-Sukel, M. P. P., Kruik, H. J., & Movig, K. L. L. (2017). Decrease in Switches to ‘Unsafe’ Proton Pump Inhibitors After Communications About Interactions with Clopidogrel. Clin Drug Investig, 37(8), 787-794. doi: https://doi.org/10.1007/s40261-017-0536-x

Kuiper, J. G., Sanchez, R. J., Houben, E., Heintjes, E. M., Penning-van Beest, F. J., Khan, I., . . . Herings, R. M. (2017). Use of Lipid-Modifying Therapy and LDL-C Goal Attainment in a High-Cardiovascular-Risk Population in the Netherlands. Clin Ther, 819 – 827. doi: https://doi.org/10.1016/j.clinthera.2017.03.001

Poluzzi, E., Diemberger, I., De Ridder, M., Koci, A., Clo, M., Oteri, A., . . . Trifiro, G. (2017). Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project. Eur J Clin Pharmacol, 1499 – 1510. doi: https://doi.org/10.1007/s00228-017-2317-0

Trifiro, G., de Ridder, M., Sultana, J., Oteri, A., Rijnbeek, P., Pecchioli, S., . . . Sturkenboom, M. (2017). Use of azithromycin and risk of ventricular arrhythmia. CMAJ, 189(15), E560-E568. doi: https://doi.org/10.1503/cmaj.160355

Yasmina, A., de Boer, A., Deneer, V. H., Souverein, P. C., & Klungel, O. H. (2017). Patterns of antiplatelet drug use after a first myocardial infarction during a 10-year period. Br J Clin Pharmacol, 83(3), 632-641. doi: https://doi.org/10.1111/bcp.13139

Heintjes, E., Kuiper, J., Lucius, B., Penning-van Beest, F., Kutikova, L., Liem, A., & Herings, R. (2017). Characterization and cholesterol management in patients with cardiovascular events and/or type 2 diabetes in the Netherlands. Curr Med Res Opin, 33(1), 91-100. doi: https://doi.org/10.1080/03007995.2016.1239190

van Wijngaarden, R. P. T., Overbeek, J. A., Heintjes, E. M., Schubert, A., Diels, J., Straatman, H., . . . Herings, R. M. C. (2017). Relation Between Different Measures of Glycemic Exposure and Microvascular and Macrovascular Complications in Patients with Type 2 Diabetes Mellitus: An Observational Cohort Study. Diabetes Ther, 1097-1109. doi: https://doi.org/10.1007/s13300-017-0301-4

Voorneveld, P. W., Reimers, M. S., Bastiaannet, E., Jacobs, R. J., van Eijk, R., Zanders, M. M. J., . . . Liefers, G. J. (2017). Statin Use After Diagnosis of Colon Cancer and Patient Survival. Gastroenterology, 153(2), 470-479 e474. doi: https://doi.org/10.1053/j.gastro.2017.05.011

Weberpals, J., Jansen, L., Haefeli, W. E., Hoffmeister, M., Wolkewitz, M., Herk-Sukel, M., . . . Brenner, H. (2017). Pre- and post-diagnostic beta-blocker use and lung cancer survival: A population-based cohort study. Sci Rep, 7(1), 2911. doi: https://doi.org/10.1038/s41598-017-02913-8

Schoormans, D., van de Poll-Franse, L., Vissers, P., van Herk-Sukel, M. P. P., Pedersen, S. S., Rottmann, N., . . . Denollet, J. (2017). Pharmaceutically treated anxiety but not depression prior to cancer diagnosis predicts the onset of cardiovascular disease among breast cancer survivors. Breast Cancer Res Treat, 259-266. doi: https://doi.org/10.1007/s10549-017-4387-1

2016

Arfe, A., Scotti, L., Varas-Lorenzo, C., Nicotra, F., Zambon, A., Kollhorst, B., . . . Safety of Non-steroidal Anti-inflammatory Drugs Project, C. (2016). Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study. BMJ, 354, i4857. doi: https://doi.org/10.1136/bmj.i4857

Bezemer, I. D., van den Berg, E. J., Herings, R. M. C., Bamber, L., Penning-van Beest, F. J. A., Folkerts, K., & Coppens, M. (2016). Anticoagulant Treatment after VTE in the Netherlands: A Retrospective Cohort Study. J J Hemato, 2(2), 030. Retrieved from http://hematology.jacobspublishers.com/images/Hematology/J_J_Hemato_2_2_030.pdf

Koopman, C., Vaartjes, I., van Dis, I., Verschuren, W. M., Engelfriet, P., Heintjes, E. M., . . . Capewell, S. (2016). Explaining the Decline in Coronary Heart Disease Mortality in the Netherlands between 1997 and 2007. PLoS One, 11(12), e0166139. doi: https://doi.org/10.1371/journal.pone.0166139

Kruik-Kollöffel, W. J., van der Palen, J., Kruik, H. J., van Herk-Sukel, M. P. P., & Movig, K. L. L. (2016). Prescription behavior for gastroprotective drugs in new users as a result of communications regarding clopidogrel – proton pump inhibitor interaction. Pharmacology Research & Perspectives, 4(4), e00242. doi: https://doi.org/10.1002/prp2.242

Sneeboer, M. M., Hutten, B. A., Majoor, C. J., Bel, E. H., & Kamphuisen, P. W. (2016). Oral and inhaled corticosteroid use and risk of recurrent pulmonary embolism. Thromb Res, 140, 46-50. doi: https://doi.org/10.1016/j.thromres.2016.02.010

Ahmadizar, F., Fazeli Farsani, S., Souverein, P. C., van der Vorst, M. M., de Boer, A., & Maitland-van der Zee, A. H. (2016). Cardiovascular medication use and cardiovascular disease in children and adolescents with type 1 diabetes: a population-based cohort study. Pediatr Diabetes, 17(6), 433-440. doi: https://doi.org/10.1111/pedi.12302

Coloma, P. M., de Ridder, M., Bezemer, I., Herings, R. M., Gini, R., Pecchioli, S., . . . Consortium, E.-A. (2016). Risk of cardiac valvulopathy with use of bisphosphonates: a population-based, multi-country case-control study. Osteoporos Int, 27(5), 1857-1867. doi: https://doi.org/10.1007/s00198-015-3441-2

Cardwell, C. R., Pottegard, A., Vaes, E., Garmo, H., Murray, L. J., Brown, C., . . . Bennett, K. (2016). Propranolol and survival from breast cancer: a pooled analysis of European breast cancer cohorts. Breast Cancer Res, 18(1), 119. doi: https://doi.org/10.1186/s13058-016-0782-5

2015

Stoekenbroek, R. M., Rensing, K. L., Bernelot Moens, S. J., Nieuwdorp, M., DeVries, J. H., Zwinderman, A. H., . . . Hutten, B. A. (2015). High daily insulin exposure in patients with type 2 diabetes is associated with increased risk of cardiovascular events. Atherosclerosis, 240(2), 318-323. doi: https://doi.org/10.1016/j.atherosclerosis.2015.03.040

Zanders, M. M., van Herk-Sukel, M. P., Vissers, P. A., Herings, R. M., Haak, H. R., & van de Poll-Franse, L. V. (2015). Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another? Br J Cancer, 113(3), 403-410. doi: https://doi.org/10.1038/bjc.2015.259

2014

Livingstone, E., Hollestein, L. M., van Herk-Sukel, M. P., van de Poll-Franse, L., Joosse, A., Schilling, B., . . . de Vries, E. (2014). Statin use and its effect on all-cause mortality of melanoma patients: a population-based Dutch cohort study. Cancer Med, 3(5), 1284-1293. doi: https://doi.org/10.1002/cam4.285

2013

Bezemer, I. D., Roemer, W. H., Penning-van Beest, F. J., van Eekelen, E., & Kramer, M. H. (2013). INR control calculation: comparison of Dutch and international methods. Neth J Med, 71(4), 194-198. doi:projectnumber study/report: p-1121

projectnumber manuscript: p-1121

Biere-Rafi, S., Hutten, B. A., Squizzato, A., Ageno, W., Souverein, P. C., de Boer, A., . . . Kamphuisen, P. W. (2013). Statin treatment and the risk of recurrent pulmonary embolism. Eur Heart J, 34(24), 1800-1806. doi: https://doi.org/10.1093/eurheartj/eht046

Coloma, P. M., Schuemie, M. J., Trifiro, G., Furlong, L., van Mulligen, E., Bauer-Mehren, A., . . . consortium, E.-A. (2013). Drug-induced acute myocardial infarction: identifying ‘prime suspects’ from electronic healthcare records-based surveillance system. PLoS One, 8(8), e72148. doi: https://doi.org/10.1371/journal.pone.0072148

Koopman, C., Vaartjes, I., Heintjes, E. M., Spiering, W., van Dis, I., Herings, R. M., & Bots, M. L. (2013). Persisting gender differences and attenuating age differences in cardiovascular drug use for prevention and treatment of coronary heart disease, 1998-2010. Eur Heart J, 34(41), 3198-3205. doi: https://doi.org/10.1093/eurheartj/eht368

Stuijver, D. J., Majoor, C. J., van Zaane, B., Souverein, P. C., de Boer, A., Dekkers, O. M., . . . Gerdes, V. E. (2013). Use of oral glucocorticoids and the risk of pulmonary embolism: a population-based case-control study. Chest, 143(5), 1337-1342. doi: https://doi.org/10.1378/chest.12-1446

Klop, C., De Vries, F., Lalmohamed, A., Leufkens, H. G. M., Bijlsma, J. W. J., & Welsing, P. M. J. (2013). Risk of myocardial infarction in Dutch patients following discharge for total hip/knee replacement and matched controls: a population-based cohort study. OA Epidemiology, 1(1), 6. Retrieved from http://www.oapublishinglondon.com/images/article/pdf/1370374645.pdf

Livingstone, E., Hollestein, L. M., van Herk-Sukel, M. P., van de Poll-Franse, L., Nijsten, T., Schadendorf, D., & de Vries, E. (2013). beta-Blocker use and all-cause mortality of melanoma patients: results from a population-based Dutch cohort study. Eur J Cancer, 49(18), 3863-3871. doi: https://doi.org/10.1016/j.ejca.2013.07.141

van Herk-Sukel, M. P., Shantakumar, S., Penning-van Beest, F. J., Kamphuisen, P. W., Majoor, C. J., Overbeek, L. I., & Herings, R. M. (2013). Pulmonary embolism, myocardial infarction, and ischemic stroke in lung cancer patients: results from a longitudinal study. Lung, 191(5), 501-509. doi: https://doi.org/10.1007/s00408-013-9485-1

Warnier, M. J., Blom, M. T., Bardai, A., Berdowksi, J., Souverein, P. C., Hoes, A. W., . . . Tan, H. L. (2013). Increased risk of sudden cardiac arrest in obstructive pulmonary disease: a case-control study. PLoS One, 8(6), e65638. doi: https://doi.org/10.1371/journal.pone.0065638

2012

Czernichow, S., Knol, M. J., Fezeu, L., & Grobbee, D. E. (2012). Impact of orlistat initiation on cardiovascular treatment use: a 6-year population-based cohort study. Eur J Prev Cardiol, 19(3), 484-489. doi: https://doi.org/10.1177/1741826711406058

Heintjes, E. M., Penning-van Beest, F. J., Plat, A. W., Meerding, W. J., Webb, K., Sturkenboom, M. C., & Herings, R. M. (2012). Cholesterol Level Goal Attainment with Statins: Clinical Management Guideline Recommendations versus Management in Actual Clinical Practice. Pharmacotherapy, 32(7), 631-641. doi: https://doi.org/10.1002/j.1875-9114.2011.01086.x

Arbouw, M. E., Movig, K. L., Guchelaar, H. J., Neef, C., & Egberts, T. C. (2012). Dopamine agonists and ischemic complications in Parkinson’s disease: a nested case-control study. Eur J Clin Pharmacol, 68(1), 83-88. doi: https://doi.org/10.1007/s00228-011-1084-6

Kroger, E., Berkers, M., Carmichael, P. H., Souverein, P., van Marum, R., & Egberts, T. (2012). Use of rivastigmine or galantamine and risk of adverse cardiac events: a database study from the Netherlands. Am J Geriatr Pharmacother, 10(6), 373-380. doi: https://doi.org/10.1016/j.amjopharm.2012.11.002

Mokhles, M. M., Trifiro, G., Dieleman, J. P., Haag, M. D., van Soest, E. M., Verhamme, K. M., . . . Sturkenboom, M. C. (2012). The risk of new onset heart failure associated with dopamine agonist use in Parkinson’s disease. Pharmacol Res, 65(3), 358-364. doi: https://doi.org/10.1016/j.phrs.2011.11.009

Overbeek, J. A., Zhao, Z., van Herk-Sukel, M. P., Barber, B. L., & Herings, R. (2012). Cardiovascular comorbidities among patients with metastatic colorectal cancer. Journal of Cancer Therapeutics & Research.

2011

Biere-Rafi, S., Di Nisio, M., Gerdes, V., Porreca, E., Souverein, P., Boer, A., . . . Kamphuisen, P. (2011). Non-steroidal anti-inflammatory drugs and risk of pulmonary embolism. Pharmacoepidemiol Drug Saf, 20(6), 635-642. doi: https://doi.org/10.1002/pds.2130

de Peuter, O. R., Lip, G. Y., Souverein, P. C., Klungel, O. H., de Boer, A., Buller, H. R., & Kamphuisen, P. W. (2011). Time-trends in treatment and cardiovascular events in patients with heart failure: a pharmacosurveillance study. Eur J Heart Fail, 13(5), 489-495. doi: https://doi.org/10.1093/eurjhf/hfq228

de Peuter, O. R., Souverein, P. C., Klungel, O. H., Buller, H. R., de Boer, A., & Kamphuisen, P. W. (2011). Non-selective vs. selective beta-blocker treatment and the risk of thrombo-embolic events in patients with heart failure. Eur J Heart Fail, 13(2), 220-226. doi: https://doi.org/10.1093/eurjhf/hfq176

Geers, H. C., Bouvy, M. L., & Heerdink, E. R. (2011). Estimates of statin discontinuation rates are influenced by exposure and outcome definitions. Ann Pharmacother, 45(5), 576-581. doi: https://doi.org/10.1345/aph.1P607

Peters, B. J., Pett, H., Klungel, O. H., Stricker, B. H., Psaty, B. M., Glazer, N. L., . . . Maitland-van der Zee, A. H. (2011). Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI. Atherosclerosis, 217(2), 458-464. doi: https://doi.org/10.1016/j.atherosclerosis.2011.06.023

Risselada, R., Straatman, H., van Kooten, F., Dippel, D. W., van der Lugt, A., Niessen, W. J., . . . Sturkenboom, M. C. (2011). Platelet aggregation inhibitors, vitamin K antagonists and risk of subarachnoid hemorrhage. J Thromb Haemost, 9(3), 517-523. doi: https://doi.org/10.1111/j.1538-7836.2010.04170.x

Valkhoff, V. E., t Jong, G. W., Van Soest, E. M., Kuipers, E. J., & Sturkenboom, M. C. (2011). Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors. Aliment Pharmacol Ther, 33(1), 77-88. doi: https://doi.org/10.1111/j.1365-2036.2010.04485.x

Penning-van Beest, F. J., Overbeek, J. A., Meijer, W. M., Woodruff, K., Jackson, J., van der Vis, H., . . . Herings, R. M. (2011). Venous thromboembolism prophylaxis after total knee or hip replacement: treatment pattern and outcomes. Pharmacoepidemiol Drug Saf, 20(9), 972-978. doi: https://doi.org/10.1002/pds.2187

van Herk-Sukel, M. P., Shantakumar, S., Kamphuisen, P. W., Penning-van Beest, F. J., & Herings, R. M. (2011). Myocardial infarction, ischaemic stroke and pulmonary embolism before and after breast cancer hospitalisation. A population-based study. Thromb Haemost, 106(1), 149-155. doi: https://doi.org/10.1160/TH10-12-0778

2010

Garcia Rodriguez, L. A., Herings, R., & Johansson, S. (2010). Use of multiple international healthcare databases for the detection of rare drug-associated outcomes: a pharmacoepidemiological programme comparing rosuvastatin with other marketed statins. Pharmacoepidemiol Drug Saf, 19(12), 1218-1224. doi: https://doi.org/10.1002/pds.2032

McAfee, A. T., Rodriguez, L. A., Goettsch, W. G., Gonzalez-Perez, A., Johansson, S., Ming, E. E., . . . Herings, R. M. (2010). Characteristics and drug utilization patterns of new users of rosuvastatin and other statins in four countries. Minerva Cardioangiol, 58(6), 611-622. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21135803

Peters, B. J., Rodin, A. S., Klungel, O. H., Stricker, B. H., de Boer, A., & Maitland-van der Zee, A. H. (2010). Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction. Pharmacogenet Genomics, 20(12), 766-774. doi: https://doi.org/10.1097/FPC.0b013e328340aded

Wakkee, M., Herings, R. M., & Nijsten, T. (2010). Psoriasis may not be an independent risk factor for acute ischemic heart disease hospitalizations: results of a large population-based Dutch cohort. J Invest Dermatol, 130(4), 962-967. doi: https://doi.org/10.1038/jid.2009.321

Kleijer, B. C., Heerdink, E. R., Egberts, T. C., Jansen, P. A., & van Marum, R. J. (2010). Antipsychotic drug use and the risk of venous thromboembolism in elderly patients. J Clin Psychopharmacol, 30(5), 526-530. doi: https://doi.org/10.1097/JCP.0b013e3181f0e87d

van den Haak, P., Heintjes, E., Plat, A. W., Jan Meerding, W., Webb, K., Sturkenboom, M. C., & Herings, R. M. (2010). Determination of non-treatment with statins of high risk patients in The Netherlands. Curr Med Res Opin, 26(2), 271-278. doi: https://doi.org/10.1185/03007990903435184

Pouwels, S., Lalmohamed, A., van Staa, T., Cooper, C., Souverein, P., Leufkens, H. G., . . . de Vries, F. (2010). Use of organic nitrates and the risk of hip fracture: a population-based case-control study. J Clin Endocrinol Metab, 95(4), 1924-1931. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20130070

2009

Heintjes, E. M., Penning-van Beest, F. J., Johansson, S., Stalenhoef, A. F., & Herings, R. M. (2009). Comparison of incidences of cardiovascular events among new users of different statins: a retrospective observational cohort study. Curr Med Res Opin, 25(11), 2621-2629. doi: https://doi.org/projectnumber study/report: p-407, p-513

projectnumber manuscript: p-617

Risselada, R., Straatman, H., van Kooten, F., Dippel, D. W., van der Lugt, A., Niessen, W. J., . . . Sturkenboom, M. C. (2009). Withdrawal of statins and risk of subarachnoid hemorrhage. Stroke, 40(8), 2887-2892. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19520985

van der Linden, M. W., van der Bij, S., Welsing, P., Kuipers, E. J., & Herings, R. M. (2009). The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis, 68(5), 668-673. doi:projectnumber study/report: p-198

projectnumber manuscript: p-476

projectnumber manuscript: p-749

van Wieren-de Wijer, D. B., Maitland-van der Zee, A. H., de Boer, A., Kroon, A. A., de Leeuw, P. W., Schiffers, P., . . . Klungel, O. H. (2009). Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction. J Hypertens, 27(1), 61-68. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19145769

van Wieren-de Wijer, D. B., Maitland-van der Zee, A. H., de Boer, A., Stricker, B. H., Kroon, A. A., de Leeuw, P. W., . . . Klungel, O. H. (2009). Recruitment of participants through community pharmacies for a pharmacogenetic study of antihypertensive drug treatment. Pharm World Sci, 31(2), 158-164. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19043802

Wakkee, M., Meijer, W., Neumann, H. A., Herings, R. M., & Nijsten, T. (2009). Psoriasis may not be an independent predictor for the use of cardiovascular and anti-diabetic drugs: a 5-year prevalence study. Acta Derm Venereol, 89(5), 476-483. doi: projectnumber study/report: p-550

Pouwels, S., Lalmohamed, A., Leufkens, B., de Boer, A., Cooper, C., van Staa, T., & de Vries, F. (2009). Risk of hip/femur fracture after stroke: a population-based case-control study. Stroke, 40(10), 3281-3285. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19661475

Koomen, E. R., Herings, R. M., Guchelaar, H. J., & Nijsten, T. (2009). Melanoma incidence and exposure to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Cancer Epidemiol, 33(5), 391-395. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19896919

2008

Breekveldt-Postma, N. S., Penning-van Beest, F. J., Siiskonen, S. J., Falvey, H., Vincze, G., Klungel, O. H., & Herings, R. M. (2008). The effect of discontinuation of antihypertensives on the risk of acute myocardial infarction and stroke. Curr Med Res Opin, 24(1), 121-127. doi:projectnumber study/report: p-332 (p-275)

projectnumber manuscript: p-458

Breekveldt-Postma, N. S., Penning-van Beest, F. J., Siiskonen, S. J., Koerselman, J., Klungel, O. H., Falvey, H., . . . Herings, R. M. (2008). Effect of persistent use of antihypertensives on blood pressure goal attainment. Curr Med Res Opin, 24(4), 1025-1031. doi:projectnumber study/report: p-313 (p-229)

projectnumber manuscript: p-528

de Vries, F., Pouwels, S., Bracke, M., Lammers, J. W., Klungel, O., Leufkens, H., & van Staa, T. (2008). Use of beta2 agonists and risk of acute myocardial infarction in patients with hypertension. Br J Clin Pharmacol, 65(4), 580-586. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18279472

Heintjes, E. M., Hirsch, M. W., Van der Linden, M. W., O’Donnell, J. C., Stalenhoef, A. F., & Herings, R. M. C. (2008). LDL-C reductions and goal attainment among naive statin users in the Netherlands: real life results. Curr Med Res Opin, 24(8), 2241-2250 doi:projectnumber study/report: p-230 (p-314)

projectnumber manuscript: p-432

Penning-van Beest, F. J., Koerselman, J., & Herings, R. M. (2008). Risk of major bleeding during concomitant use of antibiotic drugs and coumarin anticoagulants. J Thromb Haemost, 6(2), 284-290. doi:projectnumber study/report: p-246 (p-321)

projectnumber manuscript: p-246 (p-321)

Peters, B. J., Maitland-van der Zee, A. H., Stricker, B. H., van Wieren-de Wijer, D. B., de Boer, A., Kroon, A. A., . . . Klungel, O. H. (2008). Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant. Pharmacogenet Genomics, 18(7), 631-636. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18551043

van Wijk, B. L., Shrank, W. H., Klungel, O. H., Schneeweiss, S., Brookhart, M. A., & Avorn, J. (2008). A cross-national study of the persistence of antihypertensive medication use in the elderly. J Hypertens, 26(1), 145-153. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18090552

Sukel, M. P., Breekveldt-Postma, N. S., Erkens, J. A., van der Linden, P. D., Beiderbeck, A. B., Coebergh, J. W., & Herings, R. M. (2008). Incidence of cardiovascular events in breast cancer patients receiving chemotherapy in clinical practice. Pharmacoepidemiol Drug Saf, 17(2), 125-134. doi:projectnumber study/report: p-306 (p-202)

projectnumber manuscript: p-368

de Vries, F., Pouwels, S., Bracke, M., Lammers, J. W., Leufkens, H., Klungel, O., & van Staa, T. (2008). Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction. J Hypertens, 26(1), 124-129. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18090549

2007

Penning-van Beest, F. J., Koerselman, J., & Herings, R. M. (2007). Quantity and quality of potential drug interactions with coumarin anticoagulants in the Netherlands. Pharm World Sci, 29(6), 671-675. doi:projectnumber study/report: p-190

projectnumber manuscript: p-320 (p-245)

Penning-van Beest, F. J., Termorshuizen, F., Goettsch, W. G., Klungel, O. H., Kastelein, J. J., & Herings, R. M. (2007). Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study. Eur Heart J, 28(2), 154-159. doi:projectnumber study/report: p-327 (p-224)

projectnumber manuscript: p-327 (p-224)

Siiskonen, S. J., Breekveldt-Postma, N. S., Vincze, G., Khan, Z. M., Erkens, J. A., & Herings, R. M. (2007). Higher persistence with valsartan compared with enalapril in daily practice. Vasc Health Risk Manag, 3(6), 1039-1044. doi:projectnumber study/report: p-229

projectnumber manuscript: p-313 (p-229)

van der Elst, M. E., Bouvy, M. L., de Blaey, C. J., & de Boer, A. (2007). Effect of drug combinations on admission for recurrent myocardial infarction. Heart, 93(10), 1226-1230. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17502329

van Wijk, B. L., Avorn, J., Solomon, D. H., Klungel, O. H., Heerdink, E. R., de Boer, A., & Brookhart, A. M. (2007). Rates and determinants of reinitiating antihypertensive therapy after prolonged stoppage: a population-based study. J Hypertens, 25(3), 689-697. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17278986

de Vries, F., Souverein, P. C., Cooper, C., Leufkens, H. G., & van Staa, T. P. (2007). Use of beta-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands. Calcif Tissue Int, 80(2), 69-75. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17308987

Koomen, E. R., Joosse, A., Herings, R. M., Casparie, M. K., Bergman, W., Nijsten, T., & Guchelaar, H. J. (2007). Is statin use associated with a reduced incidence, a reduced Breslow thickness or delayed metastasis of melanoma of the skin? Eur J Cancer, 43(17), 2580-2589. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17950596

2006

Goettsch, W. G., Heintjes, E. M., Kastelein, J. J., Rabelink, T. J., Johansson, S., & Herings, R. M. (2006). Results from a rosuvastatin historical cohort study in more than 45,000 Dutch statin users, a PHARMO study. Pharmacoepidemiol Drug Saf, 15(7), 435-443. doi:projectnumber study/report: p-338 (p-277)

projectnumber manuscript: p-338 (p-277)

Johansson, S., E.E., M., M.A., W., L.A., R., Herings, R. M., Goettsch, W., . . . A.M., W. (2006). Rosuvastatin safety: a comprehensive, international pharmacoepidemiology programme. Pharmacoepidemiol Drug Saf, 15(7), 454-461. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16733834

van der Elst, M. E., Bouvy, M. L., de Blaey, C. J., & de Boer, A. (2006). Improving pharmacotherapy after myocardial infarction by group academic detailing using feedback data on a patient level. Pharmacotherapy, 26(2), 254-259. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16466330

Van Wijk, B. L., Klungel, O. H., Heerdink, E. R., & de Boer, A. (2006). Generic substitution of antihypertensive drugs: does it affect adherence? Ann Pharmacother, 40(1), 15-20. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16303985

Van Wijk, B. L., Klungel, O. H., Heerdink, E. R., & de Boer, A. (2006). Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy. Pharmacoepidemiol Drug Saf, 15(8), 587-593. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16586465

Van Wijk, B. L., Klungel, O. H., Heerdink, E. R., & de Boer, A. (2006). Refill persistence with chronic medication assessed from a pharmacy database was influenced by method of calculation. J Clin Epidemiol, 59(1), 11-17. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16360556

Houben, M. P., Coebergh, J. W., Herings, R. M., Casparie, M. K., Tijssen, C. C., van Duijn, C. M., & Stricker, B. H. (2006). The association between antihypertensive drugs and glioma. Br J Cancer, 94(5), 752-756. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16495922

van de Garde, E. M., Souverein, P. C., van den Bosch, J. M., Deneer, V. H., & Leufkens, H. G. (2006). Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population. Eur Respir J, 27(6), 1217-1222. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16455828

2025

Reimes, N., Bailey, S. E., Post, J. B., Kuiper, J. G., van Nieuwenhuizen, B. P., Overbeek, J. A., . . . Takes, R. P. (2025). The patient journey of head neck cancer from primary care to diagnosis – A retrospective cohort study in the Netherlands. Cancer Epidemiol, 97, 102865. doi: https://doi.org/10.1016/j.canep.2025.102865

2024

Holthuis, E. I., Heins, M. J., van Houdt, W. J., Haas, R. L., Overbeek, J. A., Olde Hartman, T. C., . . . Husson, O. (2024). Improving Diagnosis and Care for Patients With Sarcoma: Do Real-World General Practitioners Data and Prospective Data Collections Have a Place Next to Clinical Trials? JCO Clin Cancer Inform, 8, e2400054. doi: https://doi.org/10.1200/cci.24.00054

2023

van den Biggelaar, Y., Kuiper, J. G., van der Sangen, M. J. C., Luiten, E. J. T., Siesling, S., van Herk-Sukel, M., . . . Mesters, I. (2023). 5-year adherence to adjuvant endocrine treatment in Dutch women with early stage breast cancer: A population-based database study (2006-2016). Breast Dis, 42(1), 331-339. doi: https://doi.org/10.3233/BD-230024

2022

Arena, P. J., Huang, K., Lofling, L., Bahmanyar, S., Mo, J., Schachterle, S. E., . . . Ehrenstein, V. (2022). Validation of safety outcomes in routinely collected data: Lessons learned from a multinational postapproval safety study. Pharmacoepidemiol Drug Saf. doi: https://doi.org/10.1002/pds.5582

Ham, L., Geijteman, E. C. T., Aarts, M. J., Kuiper, J. G., Kunst, P. W. A., Raijmakers, N. J. H., . . . Fransen, H. P. (2022). Use of potentially inappropriate medication in older patients with lung cancer at the end of life. J Geriatr Oncol. doi: https://doi.org/10.1016/j.jgo.2021.07.009

Kuiper, J. G., van Herk-Sukel, M. P. P., Lemmens, V., Kuipers, E. J., & Herings, R. M. C. (2022). A population-based linked cohort of cancer and primary care data: A new source to study the management of cancer in primary care. Eur J Cancer Care (Engl), e13529. doi: https://doi.org/10.1111/ecc.13529

Kuiper, J. G., Overbeek, J. A., Foch, C., Boutmy, E., & Sabido, M. (2022). Incidence of malignancies in patients with multiple sclerosis versus a healthy matched cohort: A population-based cohort study in the Netherlands using the PHARMO Database Network. J Clin Neurosci, 103, 49-55. doi: https://doi.org/10.1016/j.jocn.2022.06.025

Holthuis, E. I., Vondeling, G. T., Kuiper, J. G., Dezentje, V., Rosenlund, M., Overbeek, J. A., & van Deurzen, C. H. M. (2022). Real-world data of HER2-low metastatic breast cancer: A population based cohort study. Breast, 66, 278-284. doi: https://doi.org/10.1016/j.breast.2022.11.003

Kuiper, J. G., Fenneman, A. C., van der Spek, A. H., Rampanelli, E., Nieuwdorp, M., van Herk-Sukel, M. P. P., . . . Fliers, E. (2022). Levothyroxine use and the risk of colorectal cancer: a large population-based case-control study. Endocr Connect. doi: https://doi.org/10.1530/EC-21-0463

2021

Crezee, T., Tesselaar, M. H., Nagarajah, J., Corver, W. E., Morreau, J., Pritchard, C., . . . Plantinga, T. S. (2021). Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non-medullary thyroid cancer. Cell Oncol (Dordr), 611-625. doi: https://doi.org/10.1007/s13402-021-00588-y

Ehrenstein, V., Huang, K., Kahlert, J., Bahmanyar, S., Karlsson, P., Lofling, L., . . . Sorensen, H. T. (2021). Outcomes in patients with lung cancer treated with crizotinib and erlotinib in routine clinical practice: A post-authorization safety cohort study conducted in Europe and in the United States. Pharmacoepidemiol Drug Saf, 30, 758-769. doi: https://doi.org/10.1002/pds.5193

Kuiper, J. G., van Herk-Sukel, M. P. P., Lemmens, V., Kuipers, E. J., & Herings, R. M. C. (2021). A steep increase in healthcare seeking behaviour in the last months before colorectal cancer diagnosis. BMC Fam Pract, 22(1), 121. doi: https://doi.org/10.1186/s12875-021-01482-0

Oppelt, K. A., Kuiper, J. G., Ingrasciotta, Y., Ientile, V., Herings, R. M. C., Tari, M., . . . Haug, U. (2021). Characteristics and Absolute Survival of Metastatic Colorectal Cancer Patients Treated With Biologics: A Real-World Data Analysis From Three European Countries. Front Oncol, 11, 630456. doi: https://doi.org/10.3389/fonc.2021.630456

2020

2019

Overbeek, J. A., Kuiper, J. G., van der Heijden, A., Labots, M., Haug, U., Herings, R. M. C., & Nijpels, G. (2019). Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes. Int J Colorectal Dis, 34(2), 269-276. doi: https://doi.org/10.1007/s00384-018-3191-7

Overbeek, J. A., van Herk-Sukel, M. P. P., Vissers, P. A. J., van der Heijden, A., Bronsveld, H. K., Herings, R. M. C., . . . Nijpels, G. (2019). Type 2 Diabetes, but Not Insulin (Analog) Treatment, Is Associated With More Advanced Stages of Breast Cancer: A National Linkage of Cancer and Pharmacy Registries. Diabetes Care, 42(3), 434-442. doi: https://doi.org/10.2337/dc18-2146

2018

Overbeek, J. A., Bakker, M., van der Heijden, A., van Herk-Sukel, M. P. P., Herings, R. M. C., & Nijpels, G. (2018). Risk of dipeptidyl-peptidase-4 (DPP-4) inhibitors on site-specific cancer: a systematic review and meta-analysis. Diabetes Metab Res Rev, 34(5), e3004. doi: https://doi.org/10.1002/dmrr.3004

Zanders, M. M. J., Haak, H. R., van Herk-Sukel, M. P. P., Herings, R. M. C., van de Poll-Franse, L. V., & Johnson, J. A. (2018). Changes in glucose-lowering drug use before and after cancer diagnosis in patients with diabetes. Diabetes Metab, 44(1), 22 – 29. doi: https://doi.org/10.1016/j.diabet.2017.08.004

Castellsague, J., Kuiper, J. G., Pottegard, A., Anveden Berglind, I., Dedman, D., Gutierrez, L., . . . Perez-Gutthann, S. (2018). A cohort study on the risk of lymphoma and skin cancer in users of topical tacrolimus, pimecrolimus, and corticosteroids (Joint European Longitudinal Lymphoma and Skin Cancer Evaluation – JOELLE study). Clin Epidemiol, 10, 299-310. doi: https://doi.org/10.2147/CLEP.S146442

2017

de Jong, R. G., Burden, A. M., de Kort, S., van Herk-Sukel, M., Vissers, P. A., Janssen, P. K., . . . Janssen-Heijnen, M. L. (2017). No decreased risk of gastrointestinal cancers in users of metformin in The Netherlands; a time-varying analysis of metformin exposure. Cancer Prev Res (Phila), 290-297. doi: https://doi.org/10.1158/1940-6207.CAPR-16-0277

de Jong, R. G. P. J., Burden, A. M., de Kort, S., van Herk-Sukel, M. P. P., Vissers, P. A. J., Janssen, P. K. C., . . . Janssen-Heijnen, M. L. G. (2017). Impact of detection bias on the risk of gastrointestinal cancer and its subsites in type 2 diabetes mellitus. Eur J Cancer, 79, 61-71. doi: https://doi.org/10.1016/j.ejca.2017.03.039

de Kort, S., Masclee, A. A. M., Sanduleanu, S., Weijenberg, M. P., van Herk-Sukel, M. P. P., Oldenhof, N. J. J., . . . Janssen-Heijnen, M. L. (2017). Higher risk of colorectal cancer in patients with newly diagnosed diabetes mellitus before the age of colorectal cancer screening initiation. Sci Rep, 7, 46527. doi: https://doi.org/10.1038/srep46527

Frouws, M. A., Mulder, B. G., Bastiaannet, E., Zanders, M. M., van Herk-Sukel, M. P., de Leede, E. M., . . . Liefers, G. J. (2017). No association between metformin use and survival in patients with pancreatic cancer: An observational cohort study. Medicine (Baltimore), 96(10), e6229. doi: https://doi.org/10.1097/MD.0000000000006229

Frouws, M. A., Bastiaannet, E., Langley, R. E., Chia, W. K., van Herk-Sukel, M. P., Lemmens, V. E., . . . Liefers, G. J. (2017). Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study. Br J Cancer, 116(3), 405-413. doi: https://doi.org/10.1038/bjc.2016.425

Frouws, M. A., Rademaker, E., Bastiaannet, E., van Herk-Sukel, M. P., Lemmens, V. E., Van de Velde, C. J., . . . Liefers, G. J. (2017). The difference in association between aspirin use and other thrombocyte aggregation inhibitors and survival in patients with colorectal cancer. Eur J Cancer, 77, 24-30. doi: https://doi.org/10.1016/j.ejca.2017.02.025

Frouws, M. A., Reimers, M. S., Swets, M., Bastiaannet, E., Prinse, B., van Eijk, R., . . . Liefers, G. J. (2017). The Influence of BRAF and KRAS Mutation Status on the Association between Aspirin Use and Survival after Colon Cancer Diagnosis. PLoS One, 12(1), e0170775. doi: https://doi.org/10.1371/journal.pone.0170775

Jansen, L., Weberpals, J., Kuiper, J. G., Vissers, P. A., Wolkewitz, M., Hoffmeister, M., & Brenner, H. (2017). Pre- and post-diagnostic beta-blocker use and prognosis after colorectal cancer: Results from a population-based study. Int J Cancer, 62-71. doi: https://doi.org/10.1002/ijc.30717

Kuiper, J., Musingarimi, P., Tapprich, C., Penning-van Beest, F., & Gaudig, M. (2017). Chemotherapy Exposure and outcomes of Chronic Lymphoid Leukemia Patients. J Clin Intensive Care Med, 2, 025-033.

Weberpals, J., Jansen, L., van Herk-Sukel, M. P. P., Kuiper, J. G., Aarts, M. J., Vissers, P. A. J., & Brenner, H. (2017). Immortal time bias in pharmacoepidemiological studies on cancer patient survival: empirical illustration for beta-blocker use in four cancers with different prognosis. Eur J Epidemiol, 1019 – 1031. doi: https://doi.org/10.1007/s10654-017-0304-5

Houben, E., van Haalen, H. G., Sparreboom, W., Overbeek, J. A., Ezendam, N. P., Pijnenborg, J. M., . . . van Herk-Sukel, M. P. (2017). Chemotherapy for ovarian cancer in the Netherlands: a population-based study on treatment patterns and outcomes. Med Oncol, 34(4), 50. doi: https://doi.org/10.1007/s12032-017-0901-x

2016

Korhonen, P., Heintjes, E. M., Williams, R., Hoti, F., Christopher, S., Majak, M., . . . Bahmanyar, S. (2016). Pioglitazone use and risk of bladder cancer in patients with type 2 diabetes: retrospective cohort study using datasets from four European countries. BMJ, 354, i3903. doi: https://doi.org/10.1136/bmj.i3903

van Erning, F. N., Zanders, M. M., Kuiper, J. G., van Herk-Sukel, M. P., Maas, H. A., Vingerhoets, R. W., . . . Lemmens, V. E. (2016). Drug dispensings among elderly in the year before colon cancer diagnosis versus matched cancer-free controls. J Clin Pharm Ther, 41(5), 538-545. doi: https://doi.org/10.1111/jcpt.12434

van Staalduinen, J., Frouws, M., Reimers, M., Bastiaannet, E., van Herk-Sukel, M. P., Lemmens, V., . . . Liefers, G. J. (2016). The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patients. Br J Cancer, 114(9), 1053-1059. doi: https://doi.org/10.1038/bjc.2016.65

2015

Zanders, M. M., Haak, H. R., van Herk-Sukel, M. P., van de Poll-Franse, L. V., & Johnson, J. A. (2015). Impact of cancer on adherence to glucose-lowering drug treatment in individuals with diabetes. Diabetologia, 58(5), 951-960. doi: https://doi.org/10.1007/s00125-015-3497-8

Issa, D. E., Gelderblom, H., Lugtenburg, P. J., van Herk-Sukel, M. P., Houweling, L. M., De La Orden, M., . . . de Jong, F. A. (2015). Healthcare utilisation in patients with breast cancer or non-Hodgkin lymphoma who experienced febrile neutropenia in the Netherlands: a retrospective matched control study using the PHARMO database. Eur J Cancer Care (Engl), 24(2), 232-241. doi: https://doi.org/10.1111/ecc.12189

2014

Hollestein, L. M., van Herk-Sukel, M. P., Ruiter, R., de Vries, E., Mathijssen, R. H., Wiemer, E. A., . . . Nijsten, T. (2014). Incident cancer risk after the start of aspirin use: results from a Dutch population-based cohort study of low dose aspirin users. Int J Cancer, 135(1), 157-165. doi: https://doi.org/10.1002/ijc.28634

Reimers, M. S., Bastiaannet, E., Langley, R. E., van Eijk, R., van Vlierberghe, R. L., Lemmens, V. E., . . . Liefers, G. J. (2014). Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon Cancer. JAMA Intern Med, 174(5), 732-739. doi: https://doi.org/10.1001/jamainternmed.2014.511

van Gestel, Y. R., de Hingh, I. H., van Herk-Sukel, M. P., van Erning, F. N., Beerepoot, L. V., Wijsman, J. H., . . . Lemmens, V. E. (2014). Patterns of metachronous metastases after curative treatment of colorectal cancer. Cancer Epidemiol, 38(4), 448-454. doi: https://doi.org/10.1016/j.canep.2014.04.004

2013

Siiskonen, S. J., Koomen, E. R., Visser, L. E., Herings, R. M., Guchelaar, H. J., Stricker, B. H., & Nijsten, T. E. (2013). Exposure to phototoxic NSAIDs and quinolones is associated with an increased risk of melanoma. Eur J Clin Pharmacol, 69(7), 1437-1444. doi: https://doi.org/10.1007/s00228-013-1476-x

Binkhorst, L., Mathijssen, R. H., van Herk-Sukel, M. P., Bannink, M., Jager, A., Wiemer, E. A., & van Gelder, T. (2013). Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen. Breast Cancer Res Treat, 139(3), 923-929. doi: https://doi.org/10.1007/s10549-013-2585-z

van Herk-Sukel, M. P., van de Poll-Franse, L. V., Creemers, G. J., Lemmens, V. E., van der Linden, P. D., Herings, R. M., . . . Voogd, A. C. (2013). Major changes in chemotherapy regimens administered to breast cancer patients during 2000-2008 in the Netherlands. Breast J, 19(4), 394-401. doi: https://doi.org/10.1111/tbj.12125

2012

Ruiter, R., Visser, L. E., van Herk-Sukel, M. P., Coebergh, J. W., Haak, H. R., Geelhoed-Duijvestijn, P. H., . . . Stricker, B. H. (2012). Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study. Diabetes Care, 35(1), 119-124. doi: https://doi.org/10.2337/dc11-0857

Ruiter, R., Visser, L. E., van Herk-Sukel, M. P., Coebergh, J. W., Haak, H. R., Geelhoed-Duijvestijn, P. H., . . . Stricker, B. H. (2012). Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study. Diabetologia, 55(1), 51-62. doi: https://doi.org/10.1007/s00125-011-2312-4

Bastiaannet, E., Sampieri, K., Dekkers, O. M., de Craen, A. J., van Herk-Sukel, M. P., Lemmens, V., . . . Liefers, G. J. (2012). Use of Aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer, 106(9), 1564-1570. doi: https://doi.org/10.1038/bjc.2012.101

Landis, S. H., El-Hariry, I. A., van Herk-Sukel, M. P., van den Haak, P., Janssen-Heijnen, M. L., Penning-van Beest, F. J., & Herings, R. M. (2012). Prevalence and incidence of acute and chronic comorbidity in patients with squamous cell carcinoma of the head and neck. Head Neck, 34(2), 238-244. doi: https://doi.org/10.1002/hed.21720

Reimers, M. S., Bastiaannet, E., van Herk-Sukel, M. P., Lemmens, V. E., van den Broek, C. B., van de Velde, C. J., . . . Liefers, G. J. (2012). Aspirin use after diagnosis improves survival in older adults with colon cancer: a retrospective cohort study. J Am Geriatr Soc, 60(12), 2232-2236. doi: https://doi.org/10.1111/jgs.12033

Timmers, L., Beckeringh, J. J., van Herk-Sukel, M. P., Boven, E., & Hugtenburg, J. G. (2012). Use and costs of oral anticancer agents in the Netherlands in the period 2000-2008. Pharmacoepidemiol Drug Saf, 21(10), 1036-1044. doi: https://doi.org/10.1002/pds.2225

van Herk-Sukel, M. P., Lemmens, V. E., Poll-Franse, L. V., Herings, R. M., & Coebergh, J. W. (2012). Record linkage for pharmacoepidemiological studies in cancer patients. Pharmacoepidemiol Drug Saf, 21(1), 94-103. doi: https://doi.org/10.1002/pds.2205

van Herk-Sukel, M. P., Shantakumar, S., Overbeek, L. I., van Boven, H., Penning-van Beest, F. J., & Herings, R. M. (2012). Occurrence of Comorbidities before and after Soft Tissue Sarcoma Diagnosis. Sarcoma, 2012, 402109. doi: https://doi.org/10.1155/2012/402109

2011

Overbeek, J. A., Zhao, Z., van Herk-Sukel, M. P., Barber, B. L., Gao, S., & Herings, R. M. (2011). Costs of hospital events in patients with metastatic colorectal cancer. J Med Econ, 14(5), 656-661. doi: https://doi.org/10.3111/13696998.2011.610394

2010

van Herk-Sukel, M. P., van de Poll-Franse, L. V., Lemmens, V. E., Vreugdenhil, G., Pruijt, J. F., Coebergh, J. W., & Herings, R. M. (2010). New opportunities for drug outcomes research in cancer patients: the linkage of the Eindhoven Cancer Registry and the PHARMO Record Linkage System. Eur J Cancer, 46(2), 395-404. doi: https://doi.org/10.1016/j.ejca.2009.09.010

Dekkers, O. M., Romijn, J. A., de Boer, A., & Vandenbroucke, J. P. (2010). The risk for breast cancer is not evidently increased in women with hyperprolactinemia. Pituitary, 13(3), 195-198. doi: https://doi.org/10.1007/s11102-009-0214-y

Dezentje, V. O., van Blijderveen, N. J., Gelderblom, H., Putter, H., van Herk-Sukel, M. P., Casparie, M. K., . . . Guchelaar, H. J. (2010). Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer. J Clin Oncol, 28(14), 2423-2429. doi: https://doi.org/10.1200/JCO.2009.25.0894

van Herk-Sukel, M. P., van de Poll-Franse, L. V., Voogd, A. C., Nieuwenhuijzen, G. A., Coebergh, J. W., & Herings, R. M. (2010). Half of breast cancer patients discontinue tamoxifen and any endocrine treatment before the end of the recommended treatment period of 5 years: a population-based analysis. Breast Cancer Res Treat, 122(3), 843-851. doi: https://doi.org/10.1007/s10549-009-0724-3

2009

Joosse, A., Koomen, E. R., Casparie, M. K., Herings, R. M., Guchelaar, H. J., & Nijsten, T. (2009). Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study. J Invest Dermatol, 129(11), 2620-2627. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19587697

Koomen, E. R., Joosse, A., Herings, R. M., Casparie, M. K., Guchelaar, H. J., & Nijsten, T. (2009). Does use of estrogens decrease the Breslow thickness of melanoma of the skin? Oral contraceptives and hormonal replacement therapy. Melanoma Res, 19(5), 327-332. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19593232

Koomen, E. R., Joosse, A., Herings, R. M., Casparie, M. K., Guchelaar, H. J., & Nijsten, T. (2009). Estrogens, oral contraceptives and hormonal replacement therapy increase the incidence of cutaneous melanoma: a population-based case-control study. Ann Oncol, 20(2), 358-364. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18725391

2008

projectnumber manuscript: p-368

Sukel, M. P., van de Poll-Franse, L. V., Nieuwenhuijzen, G. A., Vreugdenhil, G., Herings, R. M., Coebergh, J. W., & Voogd, A. C. (2008). Substantial increase in the use of adjuvant systemic treatment for early stage breast cancer reflects changes in guidelines in the period 1990-2006 in the southeastern Netherlands. Eur J Cancer, 1846-1854. doi:projectnumber manuscript: p-347

2007

Engels, F. K., de Jong, F. A., Mathijssen, R. H., Erkens, J. A., Herings, R. M., & Verweij, J. (2007). Medicinal cannabis in oncology. Eur J Cancer, 43(18), 2638-2644. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17976975

2006

2024

Overbeek, J. A., Nijpels, G., Swart, K. M. A., Blom, M. T., Elders, P. J. M., & Herings, R. M. C. (2024). Type 2 Diabetes, the Epidemic: Trends in Prevalence and Incidence, 2004-2020. Diabetes Metab Syndr Obes, 17, 1503-1509. doi: https://doi.org/10.2147/dmso.S445288

2023

Serne, E. H., Overbeek, J. A., Palmen, J., de Jong, H. J. I., & Stehouwer, C. D. A. (2023, Sep 19). [Prevalence and drug treatment of people with type 2 diabetes mellitus and a very high risk of cardiovascular disease]. Ned Tijdschr Geneeskd, 167. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/37742128

2022

Overbeek, J. A., Swart, K. M. A., van der Pal, E. Y. M., Blom, M. T., Beulens, J. W. J., Nijpels, G., . . . Herings, R. M. C. (2022). The DIAbetes MANagement and Treatment (DIAMANT) Cohort. Clin Epidemiol, 14, 1453-1462. doi: https://doi.org/10.2147/CLEP.S381728

van den Berg, J. M., Remmelzwaal, S., Blom, M. T., van Hoek, B., Swart, K. M. A., Overbeek, J. A., . . . Elders, P. J. M. (2022). Effectiveness of COVID-19 Vaccines in Adults with Diabetes Mellitus: A Systematic Review. Vaccines (Basel), 11(1). doi: https://doi.org/10.3390/vaccines11010024

2021

2020

2019

2018

Birkeland, K., Bodegard, J., Norhammar, A., Kuiper, J., Georgiado, E., Beekman-Hendriks, W., . . . Kooy, A. (2018). How Representative are the Patients Included in the CV outcome Trials with SGLT2 Inhibitors of a General Type 2 Diabetes Population? A Large European Observational study. Diabetes Obes Metab, 21(4), 968-974.

Overbeek, J. A., Heintjes, E. M., Huisman, E. L., Tikkanen, C. K., van Diermen, A. W., Penning-van Beest, F. J. A., & Herings, R. M. C. (2018). Clinical effectiveness of liraglutide vs basal insulin in a real-world setting: Evidence of improved glycaemic and weight control in obese people with type 2 diabetes. Diabetes Obes Metab, 20(9), 2093-2102. doi: https://doi.org/10.1111/dom.13335

Strongman, H., Christopher, S., Majak, M., Williams, R., Bahmanyar, S., Linder, M., . . . Hoti, F. (2018). Pioglitazone and cause-specific risk of mortality in patients with type 2 diabetes: extended analysis from a European multidatabase cohort study. BMJ Open Diabetes Res Care, 6(1), e000481. doi: https://doi.org/10.1136/bmjdrc-2017-000481

2017

Fazeli Farsani, S., Abdullah-Koolmees, H., Souverein, P. C., de Boer, A., & Mantel-Teeuwisse, A. K. (2017). Psychiatric medication use before and after the onset of type 1 diabetes in children and adolescents: A population-based cohort study. Pediatr Diabetes, 121 – 128 doi: https://doi.org/10.1111/pedi.12529

Heintjes, E. M., Overbeek, J. A., Hall, G. C., Prieto-Alhambra, D., Lapi, F., Hammar, N., & Bezemer, I. D. (2017). Factors Associated with Type 2 Diabetes Mellitus Treatment Choice Across Four European Countries. Clin Ther, 39(11), 2296-2310. doi: https://doi.org/10.1016/j.clinthera.2017.09.016

Kuiper, J. G., Heintjes, E. M., Penning-van Beest, F. J. A., & Herings, R. M. C. (2017, 02 March 2017). Glykemische controle met basale insuline in vergelijking met DPP-4-remmers. Nederlands Tijdschrift voor Diabetologie, 15(1), 5-10. Retrieved from http://link.springer.com/article/10.1007/s12467-017-0002-7

Overbeek, J. A., Heintjes, E. M., Prieto-Alhambra, D., Blin, P., Lassalle, R., Hall, G. C., . . . Herings, R. M. (2017). Type 2 Diabetes Mellitus Treatment Patterns Across Europe: A Population-Based Multi-Database Study. Clin Ther, 39(4), 759-770. doi: https://doi.org/10.1016/j.clinthera.2017.02.008

Overbeek, J. A., van der Heijden, A. W., Herings, R. M., & Nijpels, G. (2017). Prevalence of diabetes mellitus in the Netherlands more than doubled in the period 1999-2014. Ned Tijdschr Geneeskd, 161, D673. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/28098041

Strongman, H., Korhonen, P., Williams, R., Bahmanyar, S., Hoti, F., Christopher, S., . . . Heintjes, E. M. (2017). Pioglitazone and risk of mortality in patients with type 2 diabetes: results from a European multidatabase cohort study. BMJ Open Diabetes Res Care, 5(1), e000364. doi: https://doi.org/10.1136/bmjdrc-2016-000364

2016

Ahmadizar, F., Souverein, P. C., Arets, H. G., de Boer, A., & Maitland-van der Zee, A. H. (2016). Asthma related medication use and exacerbations in children and adolescents with type 1 diabetes. Pediatr Pulmonol, 51(11), 1113-1121. doi: https://doi.org/10.1002/ppul.23428

Fazeli Farsani, S., Souverein, P. C., van der Vorst, M. M., Knibbe, C. A., Herings, R. M., de Boer, A., & Mantel-Teeuwisse, A. K. (2016). Increasing trends in the incidence and prevalence rates of type 1 diabetes among children and adolescents in the Netherlands. Pediatr Diabetes, 17(1), 44-52. doi: https://doi.org/10.1111/pedi.12232

Roberto, G., Leal, I., Sattar, N., Loomis, A. K., Avillach, P., Egger, P., . . . Gini, R. (2016). Identifying Cases of Type 2 Diabetes in Heterogeneous Data Sources: Strategy from the EMIF Project. PLoS One, 11(8), e0160648. doi: https://doi.org/10.1371/journal.pone.0160648

2015

Fazeli Farsani, S., Souverein, P. C., Overbeek, J. A., van der Vorst, M. M., Knibbe, C. A., Herings, R. M., . . . Mantel-Teeuwisse, A. K. (2015). Long term trends in oral antidiabetic drug use among children and adolescents in the Netherlands. Br J Clin Pharmacol, 80(2), 294-303. doi: https://doi.org/10.1111/bcp.12608

Fazeli Farsani, S., Souverein, P. C., van der Vorst, M. M., Knibbe, C. A., de Boer, A., & Mantel-Teeuwisse, A. K. (2015). Chronic comorbidities in children with type 1 diabetes: a population-based cohort study. Arch Dis Child, 100(8), 763-768. doi: https://doi.org/10.1136/archdischild-2014-307654

doi: https://doi.org/10.1016/j.atherosclerosis.2015.03.040

2014

Fazeli Farsani, S., Souverein, P. C., van der Vorst, M. M., Knibbe, C. A., de Boer, A., & Mantel-Teeuwisse, A. K. (2014). Population-based cohort study of anti-infective medication use before and after the onset of type 1 diabetes in children and adolescents. Antimicrob Agents Chemother, 58(8), 4666-4674. doi: https://doi.org/10.1128/AAC.03080-14

Fazeli Farsani, S., Souverein, P. C., van der Vorst, M. M., Mantel-Teeuwisse, A. K., Knibbe, C. A., & de Boer, A. (2014). Disease history and medication use as risk factors for the clinical manifestation of type 1 diabetes in children and young adults: an explorative case control study. PLoS One, 9(2), e87408.

doi: https://doi.org/10.1371/journal.pone.0087408

2013

Bazelier, M. T., de Vries, F., Vestergaard, P., Herings, R. M., Gallagher, A. M., Leufkens, H. G., & van Staa, T. P. (2013). Risk of fracture with thiazolidinediones: an individual patient data meta-analysis. Front Endocrinol (Lausanne), 4, 11. doi: https://doi.org/10.3389/fendo.2013.00011

2012

Bazelier, M. T., Gallagher, A. M., van Staa, T. P., Cooper, C., Leufkens, H. G., Vestergaard, P., & de Vries, F. (2012). Use of thiazolidinediones and risk of osteoporotic fracture: disease or drugs? Pharmacoepidemiol Drug Saf, 21(5), 507-514. doi: https://doi.org/10.1002/pds.3234

Ruiter, R., Visser, L. E., van Herk-Sukel, M. P., Geelhoed-Duijvestijn, P. H., de Bie, S., Straus, S. M., . . . Stricker, B. H. (2012). Prescribing of rosiglitazone and pioglitazone following safety signals: analysis of trends in dispensing patterns in the Netherlands from 1998 to 2008. Drug Saf, 35(6), 471-480.

doi: https://doi.org/10.2165/11596950-000000000-00000

Schneeberger, C., Stolk, R. P., de Vries, J. H., Herings, R. M. C., & Geerlings, S. E. (2012). Recurrence of urinary tract infections in postmenopausal diabetic women using different antibiotics. Journal of Diabetes Mellitus, 2(2), 261-263. doi: https://doi.org/10.4236/jdm.2012.22042

2011

Eland, I. A., Heintjes, E. M., Houweling, L., de Grooth, R., Veneman, T. F., & Bouter, K. P. (2011). Insulin Glargine versus Insulin Detemir: Glycemic Control and Insulin Dose in Type 2 Diabetes Mellitus Patients Using a Medical Record Linkage System in the Netherlands. J Diabetes Metab, 2(9), 165. doi: https://doi.org/10.4172/2155-6156.1000165

2010

Heintjes, E. M., Thomsen, T. L., Penning-van Beest, F. J., Christensen, T. E., & Herings, R. M. (2010). Glycemic control and long-acting insulin analog utilization in patients with type 2 diabetes. Adv Ther, 27(4), 211-222. doi:projectnumer study/report: p-897

projectnumber manuscript: p-988, p-1041

2009

Plat, A., Penning-van Beest, F., Kessabi, S., Groot, M., & Herings, R. (2009). Change of initial oral antidiabetic therapy in type 2 diabetic patients. Pharm World Sci, 31(6), 622-626. doi:projectnumber study/report: p-489

projectnumber manuscript: p-696

van der Linden, M. W., Penning-van Beest, F. J., Nijsten, T., & Herings, R. M. (2009). Topical corticosteroids and the risk of diabetes mellitus: a nested case-control study in the Netherlands. Drug Saf, 32(6), 527-537. doi:projectnumber study/report: p-191

projectnumber manuscript: p-514

van der Linden, M. W., Plat, A. W., Erkens, J. A., Emneus, M., & Herings, R. M. (2009). Large Impact of Antidiabetic Drug Treatment and Hospitalizations on Economic Burden of Diabetes Mellitus in The Netherlands during 2000 to 2004. Value Health, 909-914. doi:projectnumber study/report: p-318 (p-240)

projectnumber manuscript: p-408

2008

Derijks, H. J., Heerdink, E. R., De Koning, F. H., Janknegt, R., Klungel, O. H., & Egberts, A. C. (2008). The association between antidepressant use and hypoglycaemia in diabetic patients: a nested case-control study. Pharmacoepidemiol Drug Saf, 17(4), 336-344. Retrieved from

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18302302

Knol, M. J., Derijks, H. J., Geerlings, M. I., Heerdink, E. R., Souverein, P. C., Gorter, K. J., . . . Egberts, A. C. (2008). Influence of antidepressants on glycaemic control in patients with diabetes mellitus. Pharmacoepidemiol Drug Saf, 17(6), 577-586. Retrieved from

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18449949

Penning-van Beest, F. J. A., van der Bij, S., Erkens, J. A., Kessabi, S., Groot, M., & Herings, R. M. (2008). Effect on non-persistent use of oral glucose-lowering drugs on HbA1c goal attainment. Curr Med Res Opin, 24(9), 2523-2529. doi:projectnumber study/report: p-489

projectnumber manuscript: p-697

Penning-van Beest, F. J., Wolffenbuttel, B. H., & Herings, R. M. (2008). Haemoglobin A(1)(c) Goal Attainment in Relation to Dose in Patients with Diabetes Mellitus Taking Metformin : A Nested, Case-Control Study. Clin Drug Investig, 28(8), 487-493. doi:projectnumber study/report: p-327

projectnumber manuscript: p-224

Schneeberger, C., Stolk, R. P., Devries, J. H., Schneeberger, P. M., Herings, R. M., & Geerlings, S. E. (2008). Differences in the pattern of antibiotic prescription profile and recurrence rate for possible urinary tract infections in women with and without diabetes. Diabetes Care, 31(7), 1380-1385. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18362200

2007

Knol, M. J., Geerlings, M. I., Egberts, A. C., Gorter, K. J., Grobbee, D. E., & Heerdink, E. R. (2007). No increased incidence of diabetes in antidepressant users. Int Clin Psychopharmacol, 22(6), 382-386. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17917558

2006

Storimans, M. J., Klungel, O. H., Talsma, H., & de Blaey, C. J. (2006). Regional Influences on the Dispensing of Glucose Test Strips in Dutch Community Pharmacies. Pharm World Sci, 28(1), 26-32. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16703268

epub

Harms, P. P., van Dongen, L. H., Bennis, F., Swart, K. M. A., Hoogendoorn, M., Beulens, J. W. J., . . . Blom, M. T. (epub). Associations of Clinical Characteristics With Sudden Cardiac Arrest in People With Type 2 Diabetes With and Without Cardiovascular Disease: A Longitudinal Case-Control Study Using Routine Primary Care Data. Diabetes Care, 48(1), 125-135. doi: https://doi.org/10.2337/dc24-0715

Johannes, C. B., Ziemiecki, R., Pladevall-Vila, M., Ebert, N., Kovesdy, C. P., Thomsen, R. W., . . . Oberprieler, N. G. (epub). Clinical Profile and Treatment Adherence in Patients with Type 2 Diabetes and Chronic Kidney Disease Who Initiate an SGLT2 Inhibitor: A Multi-cohort Study. Diabetes Ther, 16(2), 205-226. doi: https://doi.org/10.1007/s13300-024-01671-x

2024

Sadreghaemy, M., Gamba, M. A., Bloem, L. T., & Egberts, T. C. G. (2024). Leftover of Amoxicillin Suspension After Use by Children in the Netherlands. Pharmacoepidemiol Drug Saf, 33(8), e5868. doi: https://doi.org/10.1002/pds.5868

Jajou, R., Lieber, T., van Puijenbroek, E. P., Mulder, E., Overbeek, J., Hek, K., . . . Kant, A. (2024). GP consultations for menstrual disorders after COVID-19 vaccination – A self-controlled cohort study based on routine healthcare data from the Netherlands. Vaccine, 42(25), 126130. doi: https://doi.org/10.1016/j.vaccine.2024.07.031

2023

Houben, E., Swart, K. M., Steegers, E. A., Elders, P. J., & Herings, R. M. (2023). GPs’ awareness of pregnancy: trends and association with hazardous medication use. Br J Gen Pract, 73(732), e493-e501. doi: https://doi.org/10.3399/BJGP.2022.0193

Abtahi, S., Pajouheshnia, R., Duran, C. E., Riera-Arnau, J., Gamba, M., Alsina, E., . . . Klungel, O. (2023). Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study. Drug Saf, 46(7), 689-702. doi: https://doi.org/10.1007/s40264-023-01314-3

2022

Tran, Y. H., Huynh, H. K., Faas, M. M., de Vos, S., & Groen, H. (2022). Antidepressant use during pregnancy and development of preeclampsia: A focus on classes of action and specific transporters/receptors targeted by antidepressants. J Psychiatr Res, 146, 92-101. doi: https://doi.org/10.1016/j.jpsychires.2021.12.038

Thurin, N. H., Pajouheshnia, R., Roberto, G., Dodd, C., Hyeraci, G., Bartolini, C., . . . Gini, R. (2022). From Inception to ConcePTION: Genesis of a Network to Support Better Monitoring and Communication of Medication Safety During Pregnancy and Breastfeeding. Clin Pharmacol Ther, 111(1), 321-331. doi: https://doi.org/10.1002/cpt.2476

Houben, E., Benson, R. J., Steegers, E. A. P., & Herings, R. M. C. (2022). Twenty-year trends in the use of anti-seizure medication among pregnant women in the Netherlands. Epilepsy Behav, 127, 108549. doi: https://doi.org/10.1016/j.yebeh.2021.108549

2021

Houben, E., Siffel, C., Overbeek, J., Penning-van Beest, F., Niklas, V., & Sarda, S. P. (2021). Respiratory morbidity, healthcare resource use, and cost burden associated with extremely preterm birth in The Netherlands. J Med Econ, 24(1), 1290-1298. doi: https://doi.org/10.1080/13696998.2021.1999664

2020

Houben, E., Broeders, L., Steegers, E. A. P., & Herings, R. M. C. (2020). Cohort profile: the PHARMO Perinatal Research Network (PPRN) in the Netherlands: a population-based mother-child linked cohort. BMJ Open, 10(9), e037837. doi: https://doi.org/10.1136/bmjopen-2020-037837

Penning-van Beest, F. J. A., Bezemer, I. D., Smits, E., Garcia Rodriguez, L. A., Cea Soriano, L., Lapi, F., . . . Herings, R. M. C. (2020). Reduction in use of cyproterone/ethinylestradiol (Diane-35 and generics) after risk minimization measures in the Netherlands, UK and Italy. Contraception, 102, 243-245. doi: https://doi.org/10.1016/j.contraception.2020.05.010

Houben, E., Te Winkel, B., Steegers, E. A. P., & Herings, R. M. C. (2020). Dutch trends in the use of potentially harmful medication during pregnancy. Br J Clin Pharmacol, 2377-2392. doi: https://doi.org/10.1111/bcp.14341

Kaguelidou, F., Holstiege, J., Schink, T., Bezemer, I., Poluzzi, E., Mazzaglia, G., . . . Trifiro, G. (2020). Use of antipsychotics in children and adolescents: a picture from the ARITMO population-based European cohort study. Epidemiol Psychiatr Sci, 29, e117. doi: https://doi.org/10.1017/S2045796020000293

2018

Houben, E., Smits, E., Pimenta, J. M., Black, L. K., Bezemer, I. D., & Penning-van Beest, F. J. (2018). Increased risk of morbidities and health-care utilisation in children born following preterm labour compared with full-term labour: A population-based study. J Paediatr Child Health, 55(4), 446-453. doi: https://doi.org/10.1111/jpc.14225

Kuiper, J. G., van Herk-Sukel, M. P. P., Castellsague, J., Pottegard, A., Berglind, I. A., Dedman, D., . . . Perez-Gutthann, S. (2018). Use of Topical Tacrolimus and Topical Pimecrolimus in Four European Countries: A Multicentre Database Cohort Study. Drugs Real World Outcomes, 5(2), 109-116. doi: https://doi.org/10.1007/s40801-018-0133-1

Engelkes, M., van Blijderveen, J. C., Overbeek, J. A., Kuiper, J., Herings, R. C. M., Sturkenboom, M., . . . Janssens, H. M. (2018). Brand and generic use of inhalation medication and frequency of switching in children and adults: A population-based cohort study. J Asthma, 55(10), 1086-1094. doi: https://doi.org/10.1080/02770903.2017.1396468

2017

Bezemer, I. D., Smits, E., Penning-van Beest, F. J. A., Asiimwe, A., & Herings, R. M. C. (2017). Thrombotic risk minimization for Diane-35 and generics. Pharmacoepidemiol Drug Saf, 26, 1411-1417. doi: https://doi.org/10.1002/pds.4319

Houben, E., Johansson, S., Nagy, P., Penning-van Beest, F. J. A., Kuipers, E. J., & Herings, R. M. C. (2017). Observational cohort study: safety outcomes in children using proton pump inhibitors or histamine-2 receptor antagonists. Curr Med Res Opin, 34(4), 577-583. doi: https://doi.org/10.1080/03007995.2017.1407302

Ruigomez, A., Kool-Houweling, L. M. A., Garcia Rodriguez, L. A., Penning-van Beest, F. J. A., & Herings, R. M. C. (2017). Characteristics of children and adolescents first prescribed proton pump inhibitors or histamine-2-receptor antagonists: an observational cohort study. Curr Med Res Opin, 33(12), 2251-2259. doi: https://doi.org/10.1080/03007995.2017.1336083

2016

Bezemer, I. D., Verhamme, K. M., Gini, R., Mosseveld, M., Rijnbeek, P. R., Trifiro, G., . . . Herings, R. M. (2016). Use of oral contraceptives in three European countries: a population-based multi-database study. Eur J Contracept Reprod Health Care, 21(1), 81-87. doi: https://doi.org/10.3109/13625187.2015.1102220

Vasbinder, E. C., Belitser, S. V., Souverein, P. C., van Dijk, L., Vulto, A. G., & van den Bemt, P. M. (2016). Non-adherence to inhaled corticosteroids and the risk of asthma exacerbations in children. Patient Prefer Adherence, 10, 531-538. doi: https://doi.org/10.2147/PPA.S92824

2015

de Bie, S., Coloma, P. M., Ferrajolo, C., Verhamme, K. M., Trifiro, G., Schuemie, M. J., . . . consortium, E.-A. (2015). The role of electronic healthcare record databases in paediatric drug safety surveillance: a retrospective cohort study. Br J Clin Pharmacol, 80(2), 304-314. doi: https://doi.org/10.1111/bcp.12610

Holstiege, J., Enders, D., Schink, T., Innocenti, F., Oteri, A., Bezemer, I., . . . Garbe, E. (2015). Trends in paediatric macrolide use in five European countries-a population-based study. Eur J Clin Pharmacol, 71(8), 991-999. doi: https://doi.org/10.1007/s00228-015-1870-7

Zomerdijk, I. M., Ruiter, R., Houweling, L. M., Herings, R. M., Straus, S. M., & Stricker, B. H. (2015). Dispensing of potentially teratogenic drugs before conception and during pregnancy: a population-based study. BJOG, 122(8), 1119-1129. doi: https://doi.org/10.1111/1471-0528.13128

Kool-Houweling, L. M., Penning-van Beest, F. J., Bezemer, I. D., van Lingen, R. A., & Herings, R. M. (2015). Infants born before 32 weeks of gestation or with respiratory disease are most likely to receive palivizumab in the Netherlands. Acta Paediatr, 104(9), 927-932. doi:projectnumber study/report: p-852

projectnumber manuscript: p-1046

2014

Ferrajolo, C., Coloma, P. M., Verhamme, K. M., Schuemie, M. J., de Bie, S., Gini, R., . . . consortium, E.-A. (2014). Signal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database network. Drug Saf, 37(2), 99-108. doi: https://doi.org/10.1007/s40264-013-0132-9

Holstiege, J., Schink, T., Molokhia, M., Mazzaglia, G., Innocenti, F., Oteri, A., . . . Garbe, E. (2014). Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study. BMC Pediatr, 14, 174. doi: https://doi.org/10.1186/1471-2431-14-174

Zomerdijk, I. M., Ruiter, R., Houweling, L. M., Herings, R. M., Sturkenboom, M. C., Straus, S. M., & Stricker, B. H. (2014). Isotretinoin exposure during pregnancy: a population-based study in The Netherlands. BMJ Open, 4(11), e005602. doi: https://doi.org/10.1136/bmjopen-2014-005602

Bottelier, M. A., Schouw, M. L., Klomp, A., Tamminga, H. G., Schrantee, A. G., Bouziane, C., . . . Reneman, L. (2014). The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design. BMC Psychiatry, 14, 48. doi: https://doi.org/10.1186/1471-244X-14-48

van den Ban, E., Souverein, P., Meijer, W., van Engeland, H., Swaab, H., Egberts, T., & Heerdink, E. (2014). Association between ADHD drug use and injuries among children and adolescents. Eur Child Adolesc Psychiatry, 23(2), 95-102. doi: https://doi.org/10.1007/s00787-013-0432-8

2013

Houweling, L. M., Bezemer, I. D., Penning-van Beest, F. J., Meijer, W. M., van Lingen, R. A., & Herings, R. M. (2013). First year of life medication use and hospital admission rates: premature compared with term infants. J Pediatr, 163(1), 61-66 e61. doi: https://doi.org/10.1016/j.jpeds.2012.12.014

Valkhoff, V. E., Schade, R., t Jong, G. W., Romio, S., Schuemie, M. J., Arfe, A., . . . investigators of The Safety of Non-steroidal Anti-inflammatory Drugs, p. (2013). Population-based analysis of non-steroidal anti-inflammatory drug use among children in four European countries in the SOS project: what size of data platforms and which study designs do we need to assess safety issues? BMC Pediatr, 13, 192. doi: https://doi.org/10.1186/1471-2431-13-192

2011

Hodgkins, P., Sasane, R., & Meijer, W. M. (2011). Pharmacologic treatment of attention-deficit/hyperactivity disorder in children: incidence, prevalence, and treatment patterns in the Netherlands. Clin Ther, 33(2), 188-203. doi: https://doi.org/10.1016/j.clinthera.2011.03.001

2010

van Herk-Sukel, M. P., van de Poll-Franse, L. V., Voogd, A. C., Nieuwenhuijzen, G. A., Coebergh, J. W., &

Herings, R. M. (2010). Half of breast cancer patients discontinue tamoxifen and any endocrine treatment before the end of the recommended treatment period of 5 years: a population-based analysis. Breast Cancer Res Treat, 122(3), 843-851. doi: https://doi.org/10.1007/s10549-009-0724-3

Sasane, R., Hodgkins, P., & Meijer, W. (2010). Treatment stabilization in children and adolescents with attention-deficit/hyperactivity disorder: data from the Netherlands. Curr Med Res Opin, 26(11), 2565-2574. doi:projectnumber study/report: p-768

projectnumber manuscript: manuscript written by customer

2009

2008

projectnumber manuscript: p-368

2007

Gibbons, R. D., Brown, C. H., Hur, K., Marcus, S. M., Bhaumik, D. K., Erkens, J. A., . . . Mann, J. J. (2007). Early Evidence on the Effects of Regulators’ Suicidality Warnings on SSRI Prescriptions and Suicide in Children and Adolescents. Am J Psychiatry, 164(9), 1356-1363. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17728420

2024

Leung, M. W. Y., Bazelier, M. T., Uitdehaag, B. M. J., De Jong, H. J. I., Klungel, O. H., & van de Garde, E. M. W. (2024). Antibiotic Utilization Among People With Multiple Sclerosis in the Netherlands, 2018-2020. Pharmacoepidemiol Drug Saf, 33(12), e70070. doi: https://doi.org/10.1002/pds.70070

2023

Tsai, D. H., Bell, J. S., Abtahi, S., Baak, B. N., Bazelier, M. T., Brauer, R., . . . Lai, E. C. (2023). Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders. Clin Epidemiol, 15, 1241-1252. doi: https://doi.org/10.2147/CLEP.S426485

2022

Kuiper, J. G., Overbeek, J. A., Foch, C., Boutmy, E., & Sabido, M. (2022). Incidence of malignancies in patients with multiple sclerosis versus a healthy matched cohort: A population-based cohort study in the Netherlands using the PHARMO Database Network. J Clin Neurosci, 103, 49-55. doi: https://doi.org/10.1016/j.jocn.2022.06.025

2020

2019

Nederlof, M., Egberts, T. C. G., van Londen, L., de Rotte, M., Souverein, P. C., Herings, R. C. M., & Heerdink, E. R. (2019). Compliance with the guidelines for laboratory monitoring of patients treated with lithium: a retrospective follow-up study among ambulatory patients in the Netherlands. Bipolar Disord, 21, 419-427. doi: https://doi.org/10.1111/bdi.12730

de Bruin, I. J. A., Klop, C., Wyers, C. E., Overbeek, J. A., Geusens, P., van den Bergh, J. P. W., . . . de Vries, F. (2019). All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture. Osteoporos Int, 30(3), 573-581. doi: https://doi.org/10.1007/s00198-019-04851-9

2018

van de Ven, L. I., Klop, C., Overbeek, J. A., de Vries, F., Burden, A. M., & Janssen, P. K. (2018). Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands. Osteoporos Int, 29(11), 2477-2485. doi: https://doi.org/10.1007/s00198-018-4632-4

2017

van Strien, A. M., Souverein, P. C., Keijsers, C. K., Heerdink, E. R., Derijks, H. J., & van Marum, R. J. (2017). Antipsychotic drug use associated with urinary tract infections in older women. Maturitas, 98, 46-50. doi: https://doi.org/10.1016/j.maturitas.2017.01.009

2016

Heintjes, E. M., Overbeek, J. A., Penning-van Beest, F. J., Brobert, G., & Herings, R. M. (2016). Post authorization safety study comparing quetiapine to risperidone and olanzapine. Hum Psychopharmacol, 31(4), 304-312. doi: https://doi.org/10.1002/hup.2539

Oteri, A., Mazzaglia, G., Pecchioli, S., Molokhia, M., Ulrichsen, S. P., Pedersen, L., . . . Trifiro, G. (2016). Prescribing pattern of antipsychotic drugs during the years 1996-2010: a population-based database study in Europe with a focus on torsadogenic drugs. Br J Clin Pharmacol, 82(2), 487-497. doi: https://doi.org/10.1111/bcp.12955

2015

Kroger, E., Van Marum, R., Souverein, P., Carmichael, P. H., & Egberts, T. (2015). Treatment with rivastigmine or galantamine and risk of urinary incontinence: results from a Dutch database study. Pharmacoepidemiol Drug Saf, 24(3), 276-285. doi: https://doi.org/10.1002/pds.3741

2014

2013

2012

Bazelier, M. T., van Staa, T. P., Uitdehaag, B. M., Cooper, C., Leufkens, H. G., Vestergaard, P., . . . de Vries, F. (2012). Risk of fractures in patients with multiple sclerosis: a population-based cohort study. Neurology, 78(24), 1967-1973. doi: https://doi.org/10.1212/WNL.0b013e318259e0ff

van Melick, E. J., Wilting, I., Souverein, P. C., & Egberts, T. C. (2012). Differences in lithium use patterns in the Netherlands: comparing middle-aged and older patients in a database study. Am J Geriatr Pharmacother, 10(3), 193-200. doi: https://doi.org/10.1016/j.amjopharm.2012.02.001

2011

Verdel, B. M., Souverein, P. C., Meenks, S. D., Heerdink, E. R., Leufkens, H. G., & Egberts, T. C. (2011). Use of serotonergic drugs and the risk of bleeding. Clin Pharmacol Ther, 89(1), 89-96. doi: https://doi.org/10.1038/clpt.2010.240

Arbouw, M. E., Movig, K. L., van Staa, T. P., Egberts, A. C., Souverein, P. C., & de Vries, F. (2011). Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control study. Osteoporos Int, 22(7), 2197-2204. doi: https://doi.org/10.1007/s00198-010-1455-3

2010

Kroger, E., van Marum, R., Souverein, P., & Egberts, T. (2010). Discontinuation of cholinesterase inhibitor treatment and determinants thereof in the Netherlands: A retrospective cohort study. Drugs Aging, 27(8), 663-675. doi: https://doi.org/10.2165/11538230-000000000-00000

Stolk, P., Souverein, P. C., Wilting, I., Leufkens, H. G., Klein, D. F., Rapoport, S. I., & Heerdink, E. R. (2010). Is aspirin useful in patients on lithium? A pharmacoepidemiological study related to bipolar disorder. Prostaglandins Leukot Essent Fatty Acids, 82(1), 9-14. doi: https://doi.org/10.1016/j.plefa.2009.10.007

Verdel, B. M., Souverein, P. C., Egberts, T. C., van Staa, T. P., Leufkens, H. G., & de Vries, F. (2010). Use of antidepressant drugs and risk of osteoporotic and non-osteoporotic fractures. Bone, 47(3), 604-609. doi: https://doi.org/10.1016/j.bone.2010.06.006

projectnumber manuscript: manuscript written by customer

2009

Gardarsdottir, H., van Geffen, E. C., Stolker, J. J., Egberts, T. C., & Heerdink, E. R. (2009). Does the length of the first antidepressant treatment episode influence risk and time to a second episode? J Clin Psychopharmacol, 29(1), 69-72. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19142111

Pouwels, S., van Staa, T. P., Egberts, A. C., Leufkens, H. G., Cooper, C., & de Vries, F. (2009). Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study. Osteoporos Int, 20(9), 1499-1506. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19156348

van den Brand, M. W., Samson, M. M., Pouwels, S., van Staa, T. P., Thio, B., Cooper, C., . . . de Vries, F. (2009). Use of anti-depressants and the risk of fracture of the hip or femur. Osteoporos Int, 20(10), 1705-1713. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19238308

2008

Knol, W., van Marum, R. J., Jansen, P. A., Souverein, P. C., Schobben, A. F., & Egberts, A. C. (2008). Antipsychotic drug use and risk of pneumonia in elderly people. J Am Geriatr Soc, 56(4), 661-666. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18266664

2007

Arbouw, M. E., Movig, K. L., Neef, C., Guchelaar, H. J., & Egberts, T. C. (2007). Influence of initial use of serotonergic antidepressants on antiparkinsonian drug use in levodopa-using patients. Eur J Clin Pharmacol, 63(2), 181-187. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17200834

Handoko, K. B., Zwart-van Rijkom, J. E., Hermens, W. A., Souverein, P. C., & Egberts, T. C. (2007). Changes in medication associated with epilepsy-related hospitalisation: a case-crossover study. Pharmacoepidemiol Drug Saf, 16(2), 189-196. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17036373

Klein, D., Strom, B. L., Wang, P., Cunningham, F., Herings, R. M. C., & O’Brien, C. P. (2007). The future of postmarketing surveillance of psychotropic medications. In CNS Spectr (Vol. 12, pp. 1-20). (Reprinted from: Funding: none.).

2006

Gardarsdottir, H., Heerdink, E. R., & Egberts, A. C. (2006). Potential bias in pharmacoepidemiological studies due to the length of the drug free period: a study on antidepressant drug use in adults in the Netherlands. Pharmacoepidemiol Drug Saf, 15(5), 338-343. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16496430

Wammes-van der Heijden, E. A., Rahimtoola, H., Leufkens, H. G., Tijssen, C. C., & Egberts, A. C. (2006). Risk of ischemic complications related to the intensity of triptan and ergotamine use. Neurology, 67(7), 1128-1134. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17030745

2024

Rodrigues, G., Antão, J., Deng, Q., Baak, B. N., Marques, A., Franssen, F. M. E., & Spruit, M. A. (2024). Trends in initial pharmacological COPD treatment in primary care (2010-2021): a population-based study using the PHARMO Data Network. Respir Res, 25(1), 447. doi: https://doi.org/10.1186/s12931-024-03073-w

2023

2021

Schildkraut, J. A., Zweijpfenning, S. M. H., Nap, M., He, K., Dacheva, E., Overbeek, J., . . . van Ingen, J. (2021). The epidemiology of nontuberculous mycobacterial pulmonary disease in the Netherlands. ERJ Open Res, 7(3). doi: https://doi.org/10.1183/23120541.00207-2021

2020

Rebordosa, C., Houben, E., Laugesen, K., Bothner, U., Montonen, J., Aguado, J., . . . Gilsenan, A. W. (2020). No Evidence of Off-label Use of Olodaterol and Indacaterol in Denmark, France, and the Netherlands: A Drug Utilization Study. Sci Rep, 10(1), 586. doi: https://doi.org/10.1038/s41598-019-57397-5

2018

2017

Burden, A., Roche, N., Miglio, C., Hillyer, E. V., Postma, D. S., Herings, R. M., . . . Price, D. B. (2017). An evaluation of exact matching and propensity score methods as applied in a comparative effectiveness study of inhaled corticosteroids in asthma. Pragmat Obs Res, 8, 15-30. doi: https://doi.org/10.2147/POR.S122563

Postma, D. S., Dekhuijzen, R., van der Molen, T., Martin, R. J., van Aalderen, W., Roche, N., . . . Price, D. B. (2017). Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids. Allergy Asthma Immunol Res, 9(2), 116-125. doi: https://doi.org/10.4168/aair.2017.9.2.116

2016

van der Molen, T., Postma, D. S., Martin, R. J., Herings, R. M., Overbeek, J. A., Thomas, V., . . . Price, D. B. (2016). Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands. BMC Pulm Med, 16(1), 80. doi: https://doi.org/10.1186/s12890-016-0234-0

2015

Overbeek, J. A., Penning-van Beest, F. J., Balp, M. M., Dekhuijzen, P. N., & Herings, R. M. (2015). Burden of Exacerbations in Patients with Moderate to Very Severe COPD in the Netherlands: A Real-life Study. COPD, 12(2), 132-143. doi: https://doi.org/10.3109/15412555.2014.898053

van de Garde, E. M., Natsch, S., Prins, J. M., & van der Linden, P. D. (2015). Antibiotic prescribing on admission to patients with pneumonia and prior outpatient antibiotic treatment: a cohort study on clinical outcome. BMJ Open, 5(2), e006892. doi: https://doi.org/10.1136/bmjopen-2014-006892

projectnumber manuscript: p-1046

2013

2012

Hoogendoorn, M., Kappelhoff, B. S., Overbeek, J. A., Wouters, E. F., & Rutten-van Molken, M. P. (2012). Which long-acting bronchodilator is most cost-effective for the treatment of COPD? Neth J Med, 70(8), 357-364. doi:projectnumber study/report: p-1260

projectnumber manuscript: p-1260

2011

Penning-van Beest, F., van Herk-Sukel, M., Gale, R., Lammers, J. W., & Herings, R. (2011). Three-year dispensing patterns with long-acting inhaled drugs in COPD: a database analysis. Respir Med, 105(2), 259-265. doi: https://doi.org/10.1016/j.rmed.2010.07.007

Penning-van Beest, F. J., Overbeek, J. A., Smulders, M., van Spiegel, P. I., Meerding, W. J., & Herings, R. M. (2011). Evaluation of smoking cessation drug use and outcomes in the Netherlands. J Med Econ, 14(1), 124-129. doi: https://doi.org/10.3111/13696998.2010.551165

2010

Velthove, K. J., Leufkens, H. G., Schweizer, R. C., van Solinge, W. W., & Souverein, P. C. (2010). Medication changes prior to hospitalization for obstructive lung disease: a case-crossover study. Ann Pharmacother, 44(2), 267-273. doi: https://doi.org/10.1345/aph.1M513

Velthove, K. J., Souverein, P. C., van Solinge, W. W., Leufkens, H. G., & Lammers, J. W. (2010). Effects of corticosteroid use on readmission in obstructive lung disease. Respir Med, 104(2), 211-218. doi: https://doi.org/10.1016/j.rmed.2009.08.014

Velthove, K. J., Souverein, P. C., van Solinge, W. W., Leufkens, H. G., & Lammers, J. W. (2010). Measuring exacerbations in obstructive lung disease. Pharmacoepidemiol Drug Saf, 19(4), 367-374. doi: https://doi.org/10.1002/pds.1892

2008

Breekveldt-Postma, N. S., Erkens, J. A., Aalbers, R., van de Ven, M. J., Lammers, J. W., & Herings, R. M. (2008). Extent of uncontrolled disease and associated medical costs in severe asthma–a PHARMO study. Curr Med Res Opin, 24(4), 975-983. doi:projectnumber study/report: p-325 (p-263)

projectnumber manuscript: p-402

Breekveldt-Postma, N. S., Koerselman, J., Erkens, J. A., van der Molen, T., Lammers, J. W., & Herings, R. M. (2008). Treatment with inhaled corticosteroids in asthma is too often discontinued. Pharmacoepidemiol Drug Saf, 17(4), 411-422. doi:projectnumber study/report: p-234

projectnumber manuscript: p-404

Roede, B. M., Bresser, P., Bindels, P. J., Kok, A., Prins, M., ter Riet, G., . . . Prins, J. M. (2008). Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study. Thorax, 63(11), 968-973. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18682520

2007

Breekveldt-Postma, N. S., Koerselman, J., Erkens, J. A., Lammers, J. W., & Herings, R. M. (2007). Enhanced persistence with tiotropium compared with other respiratory drugs in COPD. Respir Med, 101(7), 1398-1405. doi:projectnumber study/report: p-169 (p-301)

projectnumber study/report: p-324 (p-262)

projectnumber manuscript: p-369

Menckeberg, T. T., Belitser, S. V., Bouvy, M. L., Bracke, M., Lammers, J. W., Raaijmakers, J. A., & Leufkens, H. G. (2007). Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence. BMC Health Serv Res, 7, 106. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17620145

de Vries, F., Pouwels, S., Bracke, M., Leufkens, H. G., Cooper, C., Lammers, J. W., & van Staa, T. P. (2007). Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study. Pharmacoepidemiol Drug Saf, 16(6), 612-619. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16998945

2006

2023

Pellekooren, S., Ben, A. J., van Dongen, J. M., Pool-Goudzwaard, A. L., van Tulder, M. W., van den Berg, J. M., & Ostelo, R. (2023). Predicting direct healthcare costs of general practitioner-guided care in patients with musculoskeletal complaints. Pain. doi: https://doi.org/10.1097/j.pain.0000000000003028

2019

2018

2017

Karlsson, L., Mesterton, J., Tepie, M. F., Intorcia, M., Overbeek, J., & Strom, O. (2017). Exploring methods for comparing the real-world effectiveness of treatments for osteoporosis: adjusted direct comparisons versus using patients as their own control. Arch Osteoporos, 12(1), 81. doi: https://doi.org/10.1007/s11657-017-0375-7

2016

Bezemer, I. D., Kool-Houweling, L. M. A., Alemao, E., Penning-van Beest, F. J. A., & Herings, R. M. C. (2016). Musculoskeletal Hospital Admission and Surgical Procedure Rates among Patients Treated for Rheumatoid Arthritis in the Netherlands 1999-2012. J Orthopedics Rheumatol, 3(1), 6. Retrieved from http://www.avensonline.org/wp-content/uploads/JOR-2334-2846-03-0021.pdf

2015

Klop, C., Welsing, P. M., Elders, P. J., Overbeek, J. A., Souverein, P. C., Burden, A. M., . . . de Vries, F. (2015). Long-term persistence with anti-osteoporosis drugs after fracture. Osteoporos Int, 26(6), 1831-1840. doi:projectnumber study: p-1265

projectnumber manuscript: p-1265

Klop, C., Welsing, P. M., Leufkens, H. G., Elders, P. J., Overbeek, J. A., van den Bergh, J. P., . . . de Vries, F. (2015). The Epidemiology of Hip and Major Osteoporotic Fractures in a Dutch Population of Community-Dwelling Elderly: Implications for the Dutch FRAX(R) Algorithm. PLoS One, 10(12), e0143800. doi: https://doi.org/10.1371/journal.pone.0143800

2013

2012

Klop, C., de Vries, F., Lalmohamed, A., Mastbergen, S. C., Leufkens, H. G., Noort-van der Laan, W. H., . . . Welsing, P. M. (2012). COX-2-selective NSAIDs and risk of hip or knee replacements: a population-based case-control study. Calcif Tissue Int, 91(6), 387-394. doi: https://doi.org/10.1007/s00223-012-9646-x

Lalmohamed, A., Opdam, F., Arden, N. K., Prieto-Alhambra, D., van Staa, T., Leufkens, H. G., & de Vries, F. (2012). Knee arthroplasty and risk of hip fracture: a population-based, case-control study. Calcif Tissue Int, 90(2), 144-150. doi: https://doi.org/10.1007/s00223-011-9558-1

2011

Overbeek, J. A., Penning-van Beest, F. J., Heintjes, E. M., Gerber, R. A., Cappelleri, J. C., Hovius, S. E., & Herings, R. M. (2011). Dupuytren’s contracture: a retrospective database analysis to determine hospitalizations in the Netherlands. BMC Res Notes, 4, 402. doi: https://doi.org/10.1186/1756-0500-4-402

Pouwels, S., Lalmohamed, A., Souverein, P., Cooper, C., Veldt, B. J., Leufkens, H. G., . . . de Vries, F. (2011). Use of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control study. Osteoporos Int, 22(3), 903-910. doi: https://doi.org/10.1007/s00198-010-1337-8

2010

2009

2008

Meijer, W. M., Penning-van Beest, F. J. A., Olson, M., & Herings, R. M. (2008). Relationship between duration of compliant bisphosphonate use and the risk of osteoporotic fractures. Curr Med Res Opin, 24(11), 3217-3222. doi:projectnumber study/report: p-225 (p-312)

projectnumber manuscript: p-416

Penning-van Beest, F. J., Erkens, J. A., Olson, M., & Herings, R. M. (2008). Determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. Curr Med Res Opin, 24(5), 1337-1344. doi:projectnumber study/report: p-225 (p-312)

projectnumber manuscript: p-276 (p-333)

Penning-van Beest, F. J., Erkens, J. A., Olson, M., & Herings, R. M. (2008). Loss of treatment benefit due to low compliance with bisphosphonate therapy. Osteoporos Int, 19(4), 511-517. doi:projectnumber study/report: p-312 (p-225)

projectnumber manuscript: p-333 (p-276)

2007

de Vries, F., Pouwels, S., Lammers, J. W., Leufkens, H. G., Bracke, M., Cooper, C., & van Staa, T. P. (2007). Use of inhaled and oral glucocorticoids, severity of inflammatory disease and risk of hip/femur fracture: a population-based case-control study. J Intern Med, 261(2), 170-177. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17241182

Goettsch, W. G., de Jong, R. B., Kramarz, P., & Herings, R. M. (2007). Developments of the incidence of osteoporosis in The Netherlands: a PHARMO study. Pharmacoepidemiol Drug Saf, 16(2), 166-172. doi:projectnumber study/report: p-167

projectnumber manuscript: p-167

2006

Penning-van Beest, F. J., Goettsch, W. G., Erkens, J. A., & Herings, R. M. (2006). Determinants of persistence with bisphosphonates: a study in women with postmenopausal osteoporosis. Clin Ther, 28(2), 236-242. doi:projectnumber study/report: p-166

projectnumber manuscript: p-166

van den Boogaard, C. H. A., Breekveldt-Postma, N. S., Borggreve, S. E., Goettsch, W. G., & Herings, R. M. C. (2006). Persistent biphosphonate use and the risk of osteoporotic fractures in clinical practice: a database analysis study. Curr Med Res Opin, 22(9), 1757-1764. doi:projectnumber study/report: p-315 (p-236)

projectnumber manuscript: p-315 (p-236)

2020

Flinterman, L. E., Kuiper, J. G., Korevaar, J. C., van Dijk, L., Hek, K., Houben, E., . . . Fliers, E. (2020). Impact of a Forced Dose-Equivalent Levothyroxine Brand Switch on Plasma Thyrotropin: A Cohort Study. Thyroid, 30(6), 821-828. doi: https://doi.org/10.1089/thy.2019.0414

2017

Margulis, A. V., Houben, E., Hallas, J., Overbeek, J. A., Pottegard, A., Torp-Pedersen, T., . . . Arana, A. (2017). Ophthalmic nepafenac use in the Netherlands and Denmark. Acta Ophthalmol, 95(5), 509-517. doi: https://doi.org/10.1111/aos.13468

2020

van Gaalen, R. D., Altorf-van der Kuil, W., Wegdam-Blans, M. C. A., Aguilar Diaz, J. M., Beauchamp, M. E., Chaname Pinedo, L. E., . . . Wallinga, J. (2020). Determination of the time-dependent association between ciprofloxacin consumption and ciprofloxacin resistance using a weighted cumulative exposure model compared with standard models. J Antimicrob Chemother, 75, 2326-2333. doi: https://doi.org/10.1093/jac/dkaa141

PHARMO Institute

Advancing Health Through Evidence

At a glance

Cardiovascular

Oncology

Diabetes

Women's Health & Pediatrics

Central Nervous System

Respiratory

Musculoskeletal

Metabolic

Ophthalmology

Infectious disease