Just to add on to this, for me it seems to be related to extensions that show some kind of pop-up window when clicked. For example, Proton Pass (which shows a window with my saved items) and Ublock (which shows the on/off control) when clicked don't work, but extensions that use the toolbar button itself as an on/off toggle still behave as expected.
Also, when browsing with multiple Orion windows open, sometimes it will affect one but not the other, in which case closing/reopening the affected window seems to fix it. But I haven't noticed a consistent pattern with this (sorry...)
Orion 148, macOS 26.5.1