Ryanodine receptor knowledge page
About
Landing page for the ryanodine receptor (Ryr).
Its major function is to create calcium-induced calcium release (CICR): the channel mediates the release of calcium from the sarcoplasmic reticulum into the cytosol, leading to the triggering of muscle contraction following depolarization of T-tubules in the same cell.
Model
The below image shows the bond graph diagram of the channel operating under normal physiological conditions.
Protein knowledge
Visualisation of the Ryr2 protein (PDB)
Subfamilies
The following list contains the known isoforms of Ryr.
| Channel name | Organ | Gene | Structure |
|---|---|---|---|
| RYR1 | Skeletal | Uniprot 1 | PDB 1 |
| RYR2 | Cardiac | Uniprot 2 | PDB 2 |
| RYR3 | Brain | Uniprot 3 | PDB 3 |
Column 'Organ' refers to the site where the isoform primarily exists.
Literature
| Title | Author |
|---|---|
| Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors | Stern et al. |
| Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load | Jafri et al. |
Existing models
| Title | Author |
|---|---|
| BG_Ryr | S Fong |
| Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors* | Stern et al. |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.