![\"\ub0a8\uc544\ud504\ub9ac\uce74](\"\/files\/uploads\/2022\/03\/codev-2022-03-02-38634c93cd-FMx9ju4VQAA0nRp.jpeg\")
Paolo Beuzer \ubc15\uc0ac(CHDI)\uc640 Vanessa Wheeler \ubc15\uc0ac(MGH)\ub294 \ud5cc\ud305\ud2f4 DNA \ubc0f RNA\uc5d0\uc11c CAG \ubc18\ubcf5\uc744 \uc5f0\uad6c\ud558\uace0 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc870\uc791\ud558\ub294 \ubc29\ubc95\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd98 \uc5f0\uad6c \ud68c\ub2f4\uc758 \uccab \ubc88\uc9f8 \uc138\uc158\uc744 \uc18c\uac1c\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n
CAG \ubc18\ubcf5 \u2013 \ubcf4\uae30\ubcf4\ub2e4 \ubcf5\uc7a1\ud569\ub2c8\ub2e4.<\/h3>\n\n\n\n\n
\uc624\ub298\uc758 \uccab \ubc88\uc9f8 \uc5f0\uc0ac\ub294 University of Glasgow\uc758 Darren Monckton\uc785\ub2c8\ub2e4. Monckton \uc5f0\uad6c\uc2e4\uc740 \ud5cc\ud305\ud134\ubcd1\uacfc \uac19\uc740 \uc9c8\ubcd1\uc5d0\uc11c DNA \uc11c\uc5f4\uc758 \ubc18\ubcf5\uc744 \uc5f0\uad6c\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n
CAG \ubc18\ubcf5\uc740 \ub108\ubb34 \uc9e7\uc544\uc11c \ub2e8\uc21c\ud574 \ubcf4\uc774\uc9c0\ub9cc \uc2e4\uc81c\ub85c\ub294 \uc0c1\ub2f9\ud788 \ubcf5\uc7a1\ud569\ub2c8\ub2e4. CAG \ubc18\ubcf5\uc758 \ud06c\uae30\ub9cc\uc73c\ub85c\ub294 HD \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a0 \uc5f0\ub839\uc744 \uc124\uba85\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. CAG\ub294 \ub2e8\ubc31\uc9c8 \ube4c\ub529 \ube14\ub85d \uae00\ub8e8\ud0c0\ubbfc\uc5d0 \ub300\ud55c \ucf54\ub4dc\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub2e4\ub978 \ub2e8\ubc31\uc9c8 \ubb38\uc790\ub3c4 \uae00\ub8e8\ud0c0\ubbfc\uc744 \uc554\ud638\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8 \uc911 \ud558\ub098\ub294 HD\uc758 \ud3f4\ub9ac\uae00\ub8e8\ud0c0\ubbfc\uc5d0\ub3c4 \uae30\uc5ec\ud560 \uc218 \uc788\ub294 CAA\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c CAA \uc911\ub2e8\uc740 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\ub294 \uc5f0\ub839\uc5d0\ub3c4 \uc601\ud5a5\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\ub4dc\ubb3c\uac8c CAA \uc911\ub2e8\uc774 \ubc1c\uc0dd\ud558\uba74 \uc21c\uc218\ud55c CAG \ubc18\ubcf5\ub9cc \uc788\ub294 HD \ud658\uc790\uc5d0 \ube44\ud574 \ubc1c\ubcd1 \uc5f0\ub839\uc774 \ub354 \ube68\ub77c\uc9d1\ub2c8\ub2e4.\nCAG \ubc18\ubcf5 \uacbd\ub85c\uc758 “\uc21c\ub3c4” \ubcc0\ud654, \uc989 \uc774\ub7ec\ud55c \uc911\ub2e8\uc774 \uc788\ub294\uc9c0 \uc5ec\ubd80\ub294 \uc6b0\ub9ac\uac00 \uc5ec\uae30\uc5d0 \uc37c\ub358 \uccb4\uc138\ud3ec \ubd88\uc548\uc815\uc131\uc774\ub77c\ub294 \ud504\ub85c\uc138\uc2a4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4. https:\/\/en.hdbuzz.net\/291<\/a><\/p>\n\n\n\n\n \uc774\ub7ec\ud55c \uad00\ucc30\uc774 \uc774\ub8e8\uc5b4\uc9c4 EnrollHD \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub294 \ub9ce\uc740 \uc720\ub7fd \ubc0f \ubd81\ubbf8 \uc0ac\ub78c\ub4e4\uc758 \ub370\uc774\ud130\ub85c \ud3b8\ud5a5\ub418\uc5b4 \uc788\uc9c0\ub9cc \uc138\uacc4 \ub2e4\ub978 \uc9c0\uc5ed\uc758 \ub370\uc774\ud130\ub294 \uc544\ub2d9\ub2c8\ub2e4. Monckton \uc5f0\uad6c\uc18c\ub294 \ub0a8\uc544\ud504\ub9ac\uce74 \uacf5\ud654\uad6d\uc758 \ud55c \uadf8\ub8f9\uacfc \ud611\ub825\ud558\uc5ec \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30\ub85c \uacb0\uc815\ud588\uc2b5\ub2c8\ub2e4.\n\uc774 \ub0a8\uc544\ud504\ub9ac\uce74 \uc778\uad6c\uc5d0\uc11c Monckton \uc5f0\uad6c\uc2e4\uc740 \uc774\ub7ec\ud55c \uc911\ub2e8 \uc5ec\ubd80\uc5d0 \uad00\uacc4\uc5c6\uc774 \ub2e4\uc591\ud55c \uc720\ud615\uc758 CAG \uc18c\ub85c\uc758 \ub9e4\uc6b0 \uc720\uc0ac\ud55c \ubd84\ud3ec\ub97c \ubcf4\uc558\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 HTT \uc720\uc804\uc790\uc758 \ub2e4\ub978 \ubd80\ubd84\uc5d0\ub294 \uc57d\uac04\uc758 \ucc28\uc774\uac00 \uc788\uc5c8\uc2b5\ub2c8\ub2e4…<\/p>\n\n\n\n\n CAG \ub2e4\uc74c\uc5d0 HTT \ub2e8\ubc31\uc9c8\uc5d0\ub294 \ud504\ub864\ub9b0\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8 \ube4c\ub529 \ube14\ub85d\uc744 \uad6c\uc131\ud558\ub294 \ubb38\uc790\uc778 CCG\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4. Monckton \uc5f0\uad6c\uc2e4\uc740 \ub0a8\uc544\ud504\ub9ac\uce74 \uacf5\ud654\uad6d\uc758 HD \ud658\uc790\uac00 \uc5bc\ub9c8\ub098 \ub9ce\uc740 \ud504\ub864\ub9b0\uc744 \uac00\uc9c0\uace0 \uc788\ub294\uc9c0 \uc2dc\ud000\uc2f1\ud558\uc5ec \uc774 \ub2e8\ubc31\uc9c8 \uc601\uc5ed\uc774 \uc720\ub7fd \ud608\ud1b5\uc758 HD \ud658\uc790\uc640 \ub2e4\ub974\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.\n\uadf8\ub4e4\uc740 \uc774 \ub370\uc774\ud130\ub97c \uc0ac\uc6a9\ud558\uc5ec \ud504\ub864\ub9b0 \ubc18\ubcf5\uc758 \uc218\uc640 \uc774\ub7ec\ud55c \ud504\ub864\ub9b0 \ubc18\ubcf5\uc744 \uad6c\uc131\ud558\ub294 \ubb38\uc790\uac00 \ubc1c\ubcd1 \uc5f0\ub839\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4.\n\ucca0\uc790\uac00 \uc57d\uac04 \ub2e4\ub978 \ud504\ub864\ub9b0\uc774 \uc788\ub294 HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc740 HD \uc99d\uc0c1\uc774 10\ub144 \ub354 \uc77c\ucc0d \ubc1c\ubcd1\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub2e8\ubc31\uc9c8 \uad6c\uc131 \uc694\uc18c\uc758 \ucca0\uc790\ub97c \ucd94\uc801\ud558\ub294 \uac83\uc740 \uc9c8\ubcd1 \ubc1c\ubcd1 \uc2dc \uc5f0\ub839\uc758 \uc9c4\ub2e8 \ub610\ub294 \uc608\uce21\uc744 \uac1c\uc120\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\uc804\ubc18\uc801\uc73c\ub85c \uc774\uac83\uc774 \uc758\ubbf8\ud558\ub294 \ubc14\ub294 \ud5cc\ud305\ud2f4 \uc720\uc804\uc790 \uc870\ub9ac\ubc95\uc758 \ub2e4\ub978 \ubcc0\ud654\uac00 \uc9c8\ubcd1\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. HD \uc720\uc804\ud559\uc740 \ucc98\uc74c \ubcf4\uc774\ub294 \uac83\ubcf4\ub2e4 \ud6e8\uc52c \ub354 \uc131\uac00\uc2dc\uace0 \ubcf5\uc7a1\ud55c \uac83\uc73c\ub85c \ud310\uba85\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub354 \uc77c\ucc0d \ub610\ub294 \ub354 \ub2a6\uac8c \uc99d\uc0c1 \ubc1c\ubcd1\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294 \uc774\ub7ec\ud55c \ubcc0\uc774\ub97c \uc774\ud574\ud558\uba74 \uc5f0\uad6c\uc790\ub4e4\uc774 HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc744 \uc704\ud55c \uc758\uc57d\ud488\uc744 \ub9cc\ub4dc\ub294 \uc0c8\ub85c\uc6b4 \ubc29\ubc95\uc744 \ucc3e\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\uac83\uc774 \ud76c\ub9dd\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uc5f0\uad6c\uc790\ub4e4\uc740 \ud5cc\ud305\ud2f4 \uc81c\uc870\ubc95\uc758 \uc774\ub7ec\ud55c \ub2e4\ub978 \ubcc0\ud654\uac00 \uccb4\uc138\ud3ec \ubd88\uc548\uc815\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \ud5cc\ud305\ud2f4 \uc81c\uc870\ubc95\uc774 \uc804\ub2ec\ud558\ub294 \uba54\uc2dc\uc9c0\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc788\ub2e4\uace0 \uacb0\ub860\uc9c0\uc5c8\uc2b5\ub2c8\ub2e4. mRNA \uba54\uc2dc\uc9c0 \ubd84\uc790 \uad6c\uc870\uac00 \ubcc0\uacbd\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud765\ubbf8\ub86d\uac8c\ub3c4, \uc6b0\ub9ac\uac00 \ubc29\uae08 \uc124\uba85\ud55c \uc5b4\ub5a4 \ubcc0\ud654\ub3c4 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8 \uc790\uccb4\ub97c \ubcc0\ud654\uc2dc\ud0a4\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \uc720\uc804\uc790\uc758 \ucca0\uc790 \ub610\ub294 “\ub808\uc2dc\ud53c"\ub9cc \ubcc0\uacbd\ud569\ub2c8\ub2e4. \uc774\uac83\uc740 \uc9c8\ubcd1\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc740 \ub2e8\ubc31\uc9c8\uacfc \uad00\ub828\ub41c \ubcc0\ud654\uac00 \uc544\ub2c8\ub77c RNA \uc218\uc900\uc758 \ubcc0\ud654\uc784\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. RNA\uc758 \ucca0\uc790\ub97c \ubc14\uafb8\uba74 \ubd84\uc790\uac00 \uc811\ud788\ub294 \ubc29\uc2dd\uc774 \ubc14\ub014 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc811\ud788\ub294 \ubcc0\ud654\uac00 \ubb34\uc5c7\uc744 \uc758\ubbf8\ud558\ub294\uc9c0 \uc544\uc9c1 \uc544\ubb34\ub3c4 \ubaa8\ub974\uc9c0\ub9cc \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud558\ub294 \ub370 \ud65c\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n Monckton \ubc15\uc0ac\ub294 \ubaa8\ub4e0 \uac83\uc774 \ub108\ubb34 \ub2e8\uc21c\ud574 \ubcf4\uc774\uc9c0\ub9cc – HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc774 CAG \ubc18\ubcf5 \ud69f\uc218\ub97c \ub298\ub838\ub2e4\ub294 \uc0ac\uc2e4 – \uc0ac\uc2e4\uc740 \ub9e4\uc6b0 \ubcf5\uc7a1\ud558\ub2e4\uace0 \uacb0\ub860\uc9c0\uc5c8\uc2b5\ub2c8\ub2e4! \uadf8\ub7ec\ub098 \uc774\uc640 \uac19\uc740 \uc5f0\uad6c\ub294 \uc6b0\ub9ac\uac00 \uc2e0\uc57d\uc744 \uc124\uacc4\ud558\uae30 \uc704\ud574 \uc774 \ubcf5\uc7a1\uc131\uc744 \uc5b4\ub5bb\uac8c \ud65c\uc6a9\ud560 \uc218 \uc788\ub294\uc9c0\uc5d0 \ub300\ud55c \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub2e4\uc74c\uc740 Harvard Medical School \ubc0f Broad Institute\uc640 \uc81c\ud734\ud55c Steve McCarroll\uc785\ub2c8\ub2e4. \uc2a4\ud2f0\ube0c\ub294 \ub1cc\uc758 \ub2e8\uc77c \uc138\ud3ec \uc218\uc900\uc5d0\uc11c HD\ub97c \uc774\ud574\ud558\ub294 \uc5f0\uad6c\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub1cc\ub294 \ud2b9\uc815 \uae30\ub2a5\uc744 \uc218\ud589\ud558\ub294 \ub2e4\uc591\ud55c \uc138\ud3ec \uc720\ud615\uc73c\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. McCarroll \ubc15\uc0ac\ub294 \uc774\ub807\uac8c \ub2e4\uc591\ud55c \uc720\ud615\uc758 \uc138\ud3ec\uac00 HD\uc758 \uc601\ud5a5\uc744 \ubc1b\ub294 \ubc29\uc2dd\uc744 \uc774\ud574\ud560 \ud544\uc694\uac00 \uc788\uc74c\uc744 \uac15\uc870\ud569\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 \ub2e4\uc591\ud55c \uc720\ud615\uc758 \uc138\ud3ec\ub97c \ubd84\ub9ac\ud558\uace0 \uc720\uc804\ud559\uc744 \uc774\ud574\ud558\uae30 \uc704\ud574 \ud2b9\uc218 \uae30\uc220\uc744 \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \uadf8\ub4e4\uc740 HD \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0 \uc804\uccb4\uc5d0 \ud61c\ud0dd\uc744 \uc8fc\uae30 \uc704\ud574 \ubc29\ubc95\ub860\uc744 \ub110\ub9ac \uacf5\uc720\ud558\uae30 \uc704\ud574 \ucd5c\uc120\uc744 \ub2e4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n McCarroll \ubc15\uc0ac\ub294 \ubd84\uc11d \uc18d\ub3c4\ub97c \ub192\uc774\ub294 \ubc29\ubc95\uc744 \ucc3e\uc558\uc2b5\ub2c8\ub2e4. \uadf8\ub294 HD \ud658\uc790\uc758 \uc778\uac04 \ub1cc \uc0d8\ud50c\uc744 \uacb0\ud569\ud55c \ub2e4\uc74c \ub370\uc774\ud130\ub97c \ubd84\ub9ac\ud569\ub2c8\ub2e4. \ub370\uc774\ud130\ub97c \ub354 \ube68\ub9ac \uc5bb\ub294 \uac83\uc740 \uc5f0\uad6c\uc6d0\uc774 \uac00\ub2a5\ud55c \ud55c \ube68\ub9ac \ub2f5\ubcc0\uc744 \uc5bb\uc744 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \ud070 \uc774\uc810\uc785\ub2c8\ub2e4.\n\uc774\ub7ec\ud55c \uc720\ud615\uc758 \ub300\uaddc\ubaa8 \ubd84\uc11d\uc740 HD \ud658\uc790\uac00 \ud1b5\uacfc\ud55c \ud6c4 \ub1cc \uae30\uc99d\uc744 \ud1b5\ud574 \uac00\ub2a5\ud569\ub2c8\ub2e4. HD \uc5f0\uad6c\uc5d0 \ub300\ud55c \ub1cc \uae30\uc99d\uc740 \uc6b0\ub9ac\uac00 HD \uce58\ub8cc\uc5d0 \uad00\uc2ec\uc744 \uac16\uace0 \uc788\ub294 \uc720\uc77c\ud55c \uc720\uae30\uccb4\uc778 \uc0ac\ub78c\uc5d0\uc11c HD\uc5d0 \ub300\ud55c \ub2f5\uc744 \ud604\uc7a5\uc5d0\uc11c \uc5bb\uc744 \uc218 \uc788\ub294 \uc8fc\uc694 \ubc29\ubc95\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n McCarroll \uc5f0\uad6c\uc2e4\uc740 HD \uc99d\uc0c1\uc774 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \ub1cc\uc5d0 \uc788\ub294 \ub2e4\uc591\ud55c \uc885\ub958\uc758 \uc138\ud3ec \ube44\uc728\uc774 \uc5b4\ub5bb\uac8c \ubcc0\ud558\ub294\uc9c0 \uc774\ud574\ud558\uae30 \uc704\ud574 \uc774\ub7ec\ud55c \uae30\uc220\uc744 \uc801\uc6a9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc9c8\ubcd1\uc774 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \uc774\ub7ec\ud55c \ubcc0\ud654\ub97c \uc815\uc758\ud588\uc73c\uba70, \uc774\ub294 HD \ud658\uc790\uc758 \ub1cc \uc138\ud3ec \uad6c\uc131\uc744 \uc774\ud574\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.\nHD\uac00 \uc788\ub294 \ub300\ubd80\ubd84\uc758 \uc0ac\ub78c\ub4e4\uc5d0\uac8c\ub294 \uc911\uac04 \uac00\uc2dc \ub274\ub7f0\uc774\ub77c\uace0 \ud558\ub294 \uc138\ud3ec\uc758 \uc0c1\ub2f9\ud55c \uc190\uc2e4\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\uac83\uc744 \uc7a0\uc2dc \ub3d9\uc548 \uc54c\uace0 \uc788\uc5c8\uc9c0\ub9cc McCarroll \ubc15\uc0ac\ub294 \ub610\ud55c \ub1cc\uc758 \ub2e4\ub978 \ub9ce\uc740 \uc138\ud3ec \uc720\ud615\uc5d0\uc11c \uc138\ud3ec \ubcc0\ud654\uac00 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.\n\uc138\ud3ec\uc758 \uc190\uc2e4\uc740 \uc720\uc804\uc790\uac00 \ucf1c\uc9c0\uace0 \uaebc\uc9c0\ub294 \ubcc0\ud654\ub97c \ub3d9\ubc18\ud569\ub2c8\ub2e4. McCarroll \ubc15\uc0ac\ub294 \uc9c8\ubcd1\uc774 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \uac01 \uc138\ud3ec \uc720\ud615\uc5d0\uc11c \uc774\ub7ec\ud55c \uc720\uc804\uc790\uc758 \uc774\ub7ec\ud55c \ubcc0\ud654\ub97c \ub9e4\ud551\ud588\uc2b5\ub2c8\ub2e4. \uc640\uc6b0!<\/p>\n\n\n\n\n \uc774\ub7ec\ud55c \uc720\ud615\uc758 \ub370\uc774\ud130\ub294 \uc9c8\ubcd1\uc744 \uc218\uc815\ud558\ub294 \ud2b9\uc815 \uc138\ud3ec \ub0b4\uc758 \ub2e4\ub978 \uc720\uc804\uc790\ub97c \uc2dd\ubcc4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc9c8\ubcd1 \uad00\ub828 \ubcc0\ud615 \uc911 \ud558\ub098\ub294 HD \uc5f0\ub839\uc758 \uc0ac\ub78c\uc73c\ub85c\uc11c CAG \ubc18\ubcf5\uc758 \ud655\uc7a5\uacfc \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n HD\ub97c \uac00\uc9c4 \ud2b9\uc815 \uc0ac\ub78c\ub4e4\uc740 \ud2b9\ud788 \ub1cc\uc5d0\uc11c \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c CAG \ubc18\ubcf5\uc774 \uc99d\uac00\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud655\uc7a5\uc740 HD \ud658\uc790\uc758 \ubc1c\ubcd1 \uc5f0\ub839\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud655\uc7a5\uc758 \uc6d0\uc778\uc744 \uc774\ud574\ud558\uba74 \uc9c8\ubcd1 \ubc1c\ubcd1\uc744 \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \uc758\uc57d\ud488\uc744 \uac1c\ubc1c\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\uc720\uc804\uc790 \ubcc0\ud615\uc790\ub85c \uc54c\ub824\uc9c4 \ub2e4\ub978 \uc720\uc804\uc790\ub294 \uc0ac\ub78c\uc758 CAG \ubc18\ubcf5\uc774 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \ud655\uc7a5\ub418\ub294\uc9c0 \uc5ec\ubd80\uc640 \ud655\uc7a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. McCarroll\uc758 \uc5f0\uad6c\uc2e4\uc740 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc758 \uac1c\ubcc4 \uc138\ud3ec \ub0b4\uc5d0\uc11c \uc774\ub7ec\ud55c \uc218\uc815\uc790\ub97c \ucc3e\uace0 \uc788\uc2b5\ub2c8\ub2e4!<\/p>\n\n\n\n\n \uc774\ub7ec\ud55c \ud504\ub85c\uc138\uc2a4\uac00 \uc791\uc740 \uc218\uc900\uc5d0\uc11c \uc5b4\ub5bb\uac8c \ubcc0\ud558\ub294\uc9c0 \uc54c\uba74 \ub2e4\uc591\ud55c \uc138\ud3ec \uc720\ud615\uc5d0\uc11c CAG \ud655\uc7a5\uc774 \uc5b4\ub5bb\uac8c \ubcc0\ud654\ud558\uace0 \uc788\uc73c\uba70 \uc774\uac83\uc774 \uc9c8\ubcd1 \uc9c4\ud589\uc5d0 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0\uc5d0 \ub300\ud55c \uc218\ub9ce\uc740 \uc815\ubcf4\ub97c \uc81c\uacf5\ud560 \ub9ce\uc740 \ub370\uc774\ud130\ub97c \uc0dd\uc131\ud569\ub2c8\ub2e4. \ud765\ubbf8\ub86d\uac8c\ub3c4 \uadf8\ub294 \uc774\ub7ec\ud55c CAG \ud655\uc7a5\uc774 HD\uc5d0 \uc758\ud574 \uac00\uc7a5 \uc601\ud5a5\uc744 \ubc1b\ub294 \uc138\ud3ec \uc720\ud615 \uc911 \ud558\ub098\uc778 \uc911\uac04 \uac00\uc2dc \ub274\ub7f0\uc5d0\uc11c \ud6e8\uc52c \ub354 \ub9ce\uc774 \ubc1c\uc0dd\ud55c\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 \uc774 \ud2b9\uc815 \uc138\ud3ec \uc720\ud615\uc774 HD\uc5d0\uc11c \ub9e4\uc6b0 \ucde8\uc57d\ud55c \uc774\uc720 \uc911 \ud558\ub098\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\uadf8\ub294 \ub610\ud55c \ub1cc\uc758 \ub2e4\uc591\ud55c \uc138\ud3ec \uc720\ud615\uacfc \ub1cc\uc758 \ub2e4\uc591\ud55c \uc601\uc5ed\uc5d0\uc11c \uc774\ub7ec\ud55c \ubcc0\ud654\ub97c \uc815\uc758\ud588\uc2b5\ub2c8\ub2e4. \ud2b9\uc815 \uc138\ud3ec \uc720\ud615\uc774 \uc788\ub294 \ub1cc\uc758 \uc704\uce58\uc5d0 \ub530\ub77c \ud574\ub2f9 \uc138\ud3ec \uc720\ud615\uc758 CAG \ud655\uc7a5\uc5d0\ub3c4 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc140 ID\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc140 \uc704\uce58\ub3c4 \uc911\uc694\ud569\ub2c8\ub2e4!\n\ub1cc\uc758 \uc138\ud3ec \uc720\ud615\uacfc "\uc774\uc6c3"\uc774 \ubaa8\ub450 CAG \ud655\uc7a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc774\uc720\ub97c \uc774\ud574\ud558\ub294 \uac83\uc740 \uc774\ub97c \ud1f4\uce58\ud558\uae30 \uc704\ud55c \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\uae30 \uc704\ud55c \uc911\uc694\ud55c \ub2e4\uc74c \ub2e8\uacc4\uac00 \ub420 \uac83\uc785\ub2c8\ub2e4.\nMcCarroll \uc5f0\uad6c\uc18c\uc758 \uc774 \ub370\uc774\ud130\ub294 \uc5b8\ub860\uc5d0\uc11c \ub728\uac70\uc6b4 \uad00\uc2ec\uc744 \ubc1b\uace0 \uc788\uc73c\uba70 \uc5f0\uad6c\uc18c \ubc0f \ubd84\uc11d \uae30\uc220\uc758 \ucd5c\uadfc \ud601\uc2e0\uc744 \ubc18\uc601\ud569\ub2c8\ub2e4. \uadf8\ub4e4\uc740 HD\uc758 \ub2e4\uc591\ud55c \ub2e8\uacc4\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc758 \ub354 \ub9ce\uc740 \uc0d8\ud50c\uc5d0 \uc774\ub7ec\ud55c \uae30\uc220\uc744 \uc801\uc6a9\ud560 \uacc4\ud68d\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub2e4\uc74c \uc5f0\uc0ac\ub294 \ub85c\uc2a4\uc564\uc824\ub808\uc2a4 \uce98\ub9ac\ud3ec\ub2c8\uc544 \ub300\ud559\uc758 William Yang \ubc15\uc0ac\uc774\uba70 \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc774 \ucd5c\uadfc \uac1c\ubc1c\ud55c \uadf8\uc758 \uc0c8\ub85c\uc6b4 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud560 \uac83\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \ucd5c\uadfc\uc5d0 \uc774 \uc0c8\ub85c\uc6b4 \ubaa8\ub378\uc5d0 \ub300\ud574 \uc37c\uc2b5\ub2c8\ub2e4: https:\/\/en.hdbuzz.net\/318<\/a><\/p>\n\n\n\n\n HD \uc5f0\uad6c\uc5d0 \uc644\ubcbd\ud55c HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc740 \uc5c6\uc9c0\ub9cc \ub2e4\uc591\ud55c \uc720\ud615\uc774 \uc9c8\ubcd1\uc758 \ub2e4\uc591\ud55c \uce21\uba74\uc744 \ud3ec\ucc29\ud558\uace0 \ub2e4\uc591\ud55c \uc720\ud615\uc758 \uc2e4\ud5d8\uc744 \ud5c8\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc218\ub144 \ub3d9\uc548 Yang \uc5f0\uad6c\uc18c\ub294 HD\uc5d0 \ub300\ud55c \ud2b9\uc815 \uc9c8\ubb38\uc5d0 \ub2f5\ud558\uae30 \uc704\ud55c \ub9c8\uc6b0\uc2a4 \ubaa8\ub378 \uc81c\uc791\uc744 \uc804\ubb38\uc73c\ub85c \ud574\uc654\uc2b5\ub2c8\ub2e4.\n\uc77c\ubd80 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\ub294 \ubcc0\uacbd\ub41c \uc720\uc804\uc790 \ubc1c\ud604 \ub610\ub294 \ub2e8\ubc31\uc9c8 \uc751\uc9d1\uacfc \uac19\uc740 HD\uc758 \ud2b9\uc815 \uae30\ub2a5\ub9cc \uc788\uae30 \ub54c\ubb38\uc5d0 \ud2b9\uc815 \uc2e4\ud5d8\uc5d0 \uc801\ud569\ud55c \ubaa8\ub378\uc744 \uc120\ud0dd\ud558\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4.\n\uc758 \uc8fc\uc694 \ud601\uc2e0<\/p>\n\n\n\n\n Yang lab\uc758 \uc0c8\ub85c\uc6b4 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc740 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \ud2b9\uc815 \uc138\ud3ec\uc5d0\uc11c CAG\uc758 \uc131\uc7a5\uc774 \ubc18\ubcf5\ub418\ub294 \uccb4\uc138\ud3ec \ubd88\uc548\uc815\uc131\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc5f0\uad6c\uc790\ub294 \ud655\uc7a5\uc774 \uc0dd\uc950\uc758 \uac74\uac15\uacfc \ud589\ub3d9\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc774\ud574\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\uc774 \uc950\uc5d0\uc11c CAG \ubc18\ubcf5\uc774 \ub354 \ud655\uc7a5\ub420\uc218\ub85d \ud589\ub3d9\uacfc \ub1cc \uc138\ud3ec \uac74\uac15\uc774 \ub354 \ub9ce\uc774 \uc601\ud5a5\uc744 \ubc1b\uc544 \uc778\uac04\uc758 \ud608\uc561, \ucc99\uc218\uc561 \ubc0f \ub1cc \uae30\uc99d \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \uc6b0\ub9ac\uac00 \uc758\uc2ec\ud588\ub358 \uac83\uc744 \ub3d9\ubb3c\uc5d0\uc11c \ucc98\uc74c\uc73c\ub85c \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4.\n\uc2e4\ud5d8\uc2e4\uc740 \uc774\uc81c \uadf8\ub4e4\uc758 \uc0c8\ub85c\uc6b4 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud558\uc5ec \ubd88\uc548\uc815\ud558\uace0 \ud655\uc7a5\ub418\ub294 CAG \ubc18\ubcf5\uc774 \ud5cc\ud305\ud2f4 \uc81c\uc870\ubc95\uacfc \ub2e8\ubc31\uc9c8\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc138\ud3ec\uc5d0 \ubbf8\uce60 \uc218 \uc788\ub294 \ud53c\ud574\ub97c \ub354 \uc798 \uc774\ud574\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n Yang \ubc15\uc0ac\ub294 \ub610\ud55c HD\uac00 \uc9c4\ud589\ub418\ub294 \ub3d9\uc548 \uc720\uc804\uc790\uac00 \uc5b4\ub5bb\uac8c \ucf1c\uc9c0\uace0 \uaebc\uc9c0\ub294\uc9c0 \uc5f0\uad6c\ud560 \uc218 \uc788\ub294 \ub2e4\ub978 \uc720\ud615\uc758 HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc758 \ub370\uc774\ud130\ub97c \uacf5\uc720\ud588\uc2b5\ub2c8\ub2e4. (McCarroll \uc5f0\uad6c\uc2e4 \ubc0f \uae30\ud0c0 \uc5f0\uad6c\uc2e4\uacfc \ud568\uaed8) \uc774 \uc9c8\ubb38\uc5d0 \uc5ec\ub7ec \uac01\ub3c4\uc5d0\uc11c \uc811\uadfc\ud558\ub294 \uac83\uc744 \ubcf4\ub2c8 \uc815\ub9d0 \uc88b\uc2b5\ub2c8\ub2e4.\n\uc6b0\ub9ac\ub294 \uc9c0\uae08 \uc7a0\uc2dc \ud734\uc2dd\uc744 \ucde8\ud558\uace0 \uc788\uc9c0\ub9cc \uc624\ub298 \uc544\uce68\uc758 \ub098\uba38\uc9c0 \uc5f0\uc0ac\ub4e4\uc758 \uc5c5\ub370\uc774\ud2b8\ub85c \uace7 \ub3cc\uc544\uc62c \uac83\uc785\ub2c8\ub2e4. \uacc4\uc18d \uc9c0\ucf1c\ubd10 \uc8fc\uc138\uc694!<\/p>\n\n\n\n\n \ub2e4\uc74c \uc5f0\uc0ac\ub294 University College London\uc758 Queen Square Institute of Neurology\uc758 Gillian Bates \ubc15\uc0ac\uc785\ub2c8\ub2e4. Bates \ubc15\uc0ac\ub294 \uc5b4\ub5bb\uac8c \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\uac00 \ucc98\ub9ac\ub418\uace0 \uc774 \uc815\ubcf4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud560 \uc218 \uc788\ub294\uc9c0\uc5d0 \ub300\ud574 \uc5c5\ub370\uc774\ud2b8\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\ub294 \ucf54\ub4dc \uc0ac\uc774\uc5d0 \uc788\ub294 \uc720\uc804 \uc815\ubcf4\uc758 \uc791\uc740 \ube44\ud2b8\ub97c \uc81c\uac70\ud558\uae30 \uc704\ud574 "\uc811\ud569"\ub429\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c \uc720\uc804\uc790\ub294 \ub2e8\ubc31\uc9c8\uc774 \ub9cc\ub4e4\uc5b4\uc9c0\uae30 \uc804\uc5d0 \ub2e4\uc2dc \uacb0\ud569\ub429\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ub2e8\uc77c \uc720\uc804\uc790\uc5d0\uc11c \uc0dd\uc131\ud560 \uc218 \uc788\ub294 \uc815\ubcf4\uc758 \ub2e4\uc591\uc131\uc744 \uc138\ud3ec\uc5d0 \uc81c\uacf5\ud558\ub294 \ub370 \uc0ac\uc6a9\ub429\ub2c8\ub2e4.\n\uadf8\ub7ec\ub098 \uc774 \ud504\ub85c\uc138\uc2a4\ub294 HD\uc5d0\uc11c \uc798\ubabb\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. HD\uc5d0\uc11c \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\ub294 "\uc5d1\uc190 1"\uc774\ub77c\uace0 \ud558\ub294 \ub9e4\uc6b0 \uc791\uc740 \ub2e8\ubc31\uc9c8 \ub2e8\ud3b8\uc744 \ub9cc\ub4dc\ub294 \ub370 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc774 \uc5d1\uc190 1\uc740 CAG \ubc18\ubcf5\uc744 \ud3ec\ud568\ud558\uba70 \uc138\ud3ec\uc5d0 \ub9e4\uc6b0 \uc720\ub3c5\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n\n Bates \ubc15\uc0ac\ub294 HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uacfc HD \ud658\uc790\uc758 \ub2e4\uc591\ud55c \ub1cc \uc601\uc5ed\uc5d0\uc11c \uc5d1\uc190 1\uc758 \uc591\uc744 \uc870\uc0ac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 CAG \ubc18\ubcf5\uc774 \uae38\uc218\ub85d exon1 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uc2a4\ud50c\ub77c\uc774\uc2f1 \uacfc\uc815\uc774 \ub354 \uc790\uc8fc \ubc1c\uc0dd\ud55c\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.\nBates \uc5f0\uad6c\uc2e4\uc740 \uc811\ud569\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 \ub2e4\uc591\ud55c \ud615\ud0dc\uc640 \uc870\uac01\uc744 \uac10\uc9c0\ud558\uace0 \uad6c\ubcc4\ud558\ub294 \ubc29\ubc95\uc744 \uc2e4\ud5d8\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \ub2e8\ubc31\uc9c8\uc758 \ub2e4\ub978 \ubd80\ubd84\uc744 \uac10\uc9c0\ud558\ub294 \ubc29\ubc95\uc778 \uc11c\ub85c \ub2e4\ub978 \ud56d\uccb4 \uc870\ud569\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc774\ub97c \uc218\ud589\ud569\ub2c8\ub2e4.\n\uc774 \uc791\uc5c5\uc740 \uc5d1\uc190 1 \ub2e8\ud3b8\uc774 \ub2e8\ubc31\uc9c8 \uc751\uc9d1 \uc0dd\uc131 \ubd80\uc704\uc784\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc774 \uc5b4\ub5bb\uac8c \ubc1c\uc0dd\ud558\ub294\uc9c0 \uc774\ud574\ud558\uba74 \uc774\ub7ec\ud55c \ub2e8\ubc31\uc9c8 \ub369\uc5b4\ub9ac\ub97c \uc904\uc774\ub294 \ubc29\ubc95\uc5d0 \ub300\ud55c \ub9ce\uc740 \ub2e8\uc11c\ub97c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n Bates \uc5f0\uad6c\uc2e4\uc740 \uc0c8\ub85c\uc6b4 \ub9c8\uc6b0\uc2a4\ub97c \ub9cc\ub4e4\uace0 \ub2e4\ub978 \ud654\ud559 \ubb3c\uc9c8\ub85c \uc870\uc9c1\uc744 \ucc98\ub9ac\ud558\ub294 \uac83\uacfc \uac19\uc774 \ud604\ubbf8\uacbd\uc774\ub098 \ubd84\uc11d\uc5d0\uc11c \ub2e4\uc591\ud55c \ud615\ud0dc\uc758 \ub2e8\ubc31\uc9c8\uc744 \uc2dc\ub3c4\ud558\uace0 \ubcfc \uc218 \uc788\ub294 \ud601\uc2e0\uc801\uc778 \ubc29\ubc95\uc744 \uc804\ubb38\uc73c\ub85c \ud569\ub2c8\ub2e4.\n\uadf8\ub4e4\uc740 splicing \ud328\ud134\uc774 \ubcc0\uacbd\ub41c \ud2b9\ubcc4\ud55c \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \ub9cc\ub4e4\uc5c8\uace0 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 exon1 \ub2e8\ud3b8\uc774 \ub354 \uc774\uc0c1 \ub9cc\ub4e4\uc5b4\uc9c0\uc9c0 \uc54a\uc544\uc57c \ud569\ub2c8\ub2e4.\n\uc774 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc2e4\ud5d8\uc2e4\uc740 \uc77c\ubc18 HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uacfc \ube44\uad50\ud558\uc5ec \uc0dd\uc131\ub418\ub294 \ub3c5\uc131 \ub2e8\ubc31\uc9c8 \ub369\uc5b4\ub9ac\uc758 \uc218\uc900\uc744 \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4. \uc0c8\ub85c\uc6b4 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c\ub294 exon1 \ub2e8\ud3b8\uc774 \ub369\uc5b4\ub9ac\ub97c \ub9cc\ub4dc\ub294 \ub370 \uc911\uc694\ud568\uc744 \uc2dc\uc0ac\ud558\ub294 \ub369\uc5b4\ub9ac\uac00 \ud6e8\uc52c \uc801\uc5c8\uc2b5\ub2c8\ub2e4.\n\ub2e4\uc74c \ub2e8\uacc4\ub294 \ud5cc\ud305\ud2f4 \ub369\uc5b4\ub9ac\uc758 \ucc28\uc774\uac00 \uc950\uc758 \ud589\ub3d9\uacfc \ub1cc \uc138\ud3ec \uac04\uc758 \uc758\uc0ac \uc18c\ud1b5 \ud328\ud134\uc744 \uc5b4\ub5bb\uac8c \ubcc0\ud654\uc2dc\ud0ac \uc218 \uc788\ub294\uc9c0 \ud0d0\uad6c\ud558\ub294 \uac83\uc785\ub2c8\ub2e4.\n\ub54c\ub54c\ub85c \ud5cc\ud305\ud2f4 \ub369\uc5b4\ub9ac\ub294 \uc720\uc804 \ubb3c\uc9c8\uc744 \uc218\uc6a9\ud558\ub294 \uc138\ud3ec\uc758 \uc77c\ubd80\uc778 \uc138\ud3ec \ud575 \uadfc\ucc98\uc5d0 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. Bates \uc5f0\uad6c\uc2e4\uc740 \uc5ec\ub7ec \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc774\uac83\uc774 \ub9c8\uc6b0\uc2a4 \ud5cc\ud305\ud2f4\uc774 \uc544\ub2cc \uc778\uac04 \ud5cc\ud305\ud2f4\uc5d0\uc11c\ub9cc \ubc1c\uc0dd\ud55c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.\n\uc774\ub7ec\ud55c \ub370\uc774\ud130\ub294 \uc774\ub7ec\ud55c \ubcd1\uc6d0\uc131 \ub2e8\ubc31\uc9c8 \ub369\uc5b4\ub9ac\ub97c \uc720\ubc1c\ud558\ub294 \uc778\uac04 \ud5cc\ud305\ud2f4\uc5d0 \uace0\uc720\ud55c \ubb34\uc5b8\uac00\uac00 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774\uac83\uc740 \uc778\uac04\uc774 \uc790\uc5f0\uc801\uc73c\ub85c HD\ub97c \uc5bb\uc744 \uc218 \uc788\ub294 \uc720\uc77c\ud55c \uc885\uc778 \uc774\uc720\uc5d0 \ub300\ud55c \ub2e8\uc11c\uac00 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4!<\/p>\n\n\n\n\n \uc5b4\ub5a4 \ud615\ud0dc\uc758 \ud5cc\ud305\ud2f4\uc774 \uac00\uc7a5 \ub3c5\uc131\uc774 \uc788\uace0 \uc65c (\uc778\uac04!) \ub1cc \uc138\ud3ec\uc5d0 \ubbf8\uce58\ub294 \ubd80\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ud1f4\uce58\ud558\uae30 \uc704\ud55c \uc57d\ubb3c\uc744 \uc124\uacc4\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub2e4\uc74c\uc740 \uc2a4\ud0e0\ud3ec\ub4dc \ub300\ud559\uc758 Dr. Judith Frydman\uc785\ub2c8\ub2e4. \uadf8\ub140\ub294 CAG \ubc18\ubcf5 \ud655\uc7a5\uc774 \ub1cc \uc138\ud3ec\uc758 "\uc4f0\ub808\uae30 \ud0dc\uae45 \ubc0f \ucc98\ub9ac” \uc2dc\uc2a4\ud15c\uc5d0 \ubb38\uc81c\ub97c \uc77c\uc73c\ud0ac \uc218 \uc788\ub294 \uc774\uc720\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uc6b0\ub9ac\ub294 HD\uc758 \uc6d0\uc778\uc744 \uc54c\uace0 \uc788\uc9c0\ub9cc \uc5f0\uad6c\uc6d0\ub4e4\uc740 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 “\uc815\uc0c1\uc801\uc778” \uae30\ub2a5\uc744 \uc9c4\uc815\uc73c\ub85c \uc54c\uc9c0 \ubabb\ud569\ub2c8\ub2e4. \uadf8\ub4e4\uc774 \uc544\ub294 \uac83\uc740 \uc138\ud3ec\uc758 \uc2a4\uc704\uc2a4 \uad70\uc6a9 \uce7c\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815\uc5d0 \ucc38\uc5ec\ud55c\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4.\n\uc774 \ub54c\ubb38\uc5d0 \uc5f0\uad6c\uc790\ub4e4\uc740 HD\uac00 \ub2e4\ub978 \uc720\uc804\uc790\uc758 \ud30c\uad34 \ub610\ub294 \ub2e4\ub978 \ub2e8\ubc31\uc9c8\uc758 \ud30c\uad34\ub85c \uc778\ud55c \uc9c8\ubcd1\uc778\uc9c0 \ub17c\uc7c1\uc744 \ubc8c\uc785\ub2c8\ub2e4. Frydman \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 HD\uac00 \uc801\uc5b4\ub3c4 \ubd80\ubd84\uc801\uc73c\ub85c\ub294 \ub2e8\ubc31\uc9c8 \uc218\uc900\uc758 \ubd95\uad34\ub85c \uc778\ud574 \ubc1c\uc0dd\ud55c\ub2e4\uace0 \uc8fc\uc7a5\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n Frydman \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 mRNA\ub77c\uace0 \ud558\ub294 \ud5cc\ud305\ud2f4 \uba54\uc2dc\uc9c0 \ubd84\uc790\uac00 \ubc88\uc5ed\uc774\ub77c\ub294 \uacfc\uc815\uc744 \ud1b5\ud574 \uc5b4\ub5bb\uac8c \ub2e8\ubc31\uc9c8 \ubd84\uc790\ub85c \uc804\ud658\ub418\ub294\uc9c0 \uc774\ud574\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub461\ub2c8\ub2e4.\n\uc138\ud3ec\uc5d0 \ub300\ud55c \uc2a4\ud2b8\ub808\uc2a4(\ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc, \ub2e8\ubc31\uc9c8 \ube4c\ub529 \ube14\ub85d\uc758 \uac00\uc6a9\uc131 \uac10\uc18c, \uc138\ud3ec \uae30\uacc4 \uc791\ub3d9 \ubc29\uc2dd\uc758 \ubcc0\ud654 \ub4f1)\ub294 \ubc88\uc5ed\uc774 \ubc1c\uc0dd\ud558\ub294 \ubc29\uc2dd\uc744 \ubcc0\uacbd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\uc5f0\uad6c\uc790\ub4e4\uc740 HD\uac00 \uc788\ub294 \uc0ac\ub78c\uc774\ub098 \ub3d9\ubb3c \ubaa8\ub378\uc758 \uc138\ud3ec\uac00 \uc138\ud3ec \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc99d\uac00\uc2dc\ud0a8\ub2e4\ub294 \uac83\uc744 \uc54c\uace0 \uc788\uc2b5\ub2c8\ub2e4. Frydman \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc774\ub7ec\ud55c \uc2a4\ud2b8\ub808\uc2a4 \uc870\uac74\uc5d0\uc11c \ub354 \ub9ce\uc740 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc774 \uc0dd\uc131\ub41c\ub2e4\ub294 \ubaa8\ub378\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.\n\uc138\ud3ec\uac00 \ubc88\uc5ed\uc744 \ud1b5\ud574 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4 \ub54c \ub9ac\ubcf4\uc19c\uc774\ub77c\ub294 \uae30\uacc4\ub97c \uc0ac\uc6a9\ud569\ub2c8\ub2e4. Frydman\uacfc \ub3d9\ub8cc\ub4e4\uc740 \uc138\ud3ec\uac00 \ub3cc\uc5f0\ubcc0\uc774 \ud5cc\ud305\ud2f4\uc744 \ub9cc\ub4e4 \ub54c \ub9ac\ubcf4\uc19c\uc774 \ucda9\ub3cc\ud558\uc5ec \ud5cc\ud305\ud2f4 \uba54\uc2dc\uc9c0\uc5d0 \uad50\ud1b5 \uccb4\uc99d\uc744 \uc720\ubc1c\ud55c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.\nFrydman \uc5f0\uad6c\uc2e4\uc740 \uad50\ud1b5 \uccb4\uc99d\uc774 \uc788\uac70\ub098 \uc5c6\ub294 \uba54\uc2dc\uc9c0\uc5d0\uc11c \uc5b4\ub5a4 \uc720\uc804\uc790\uac00 \ubcc0\uacbd\ub418\uc5c8\ub294\uc9c0 \uc0b4\ud3b4\ubcf4\uc558\uc744 \ub54c \uc774\ub7ec\ud55c \uc720\uc804\uc790 \uc911 \ub9ce\uc740 \uc218\uac00 \uc138\ud3ec\uc758 \ub2e8\ubc31\uc9c8 \uc815\ub9ac\uc640 \uad00\ub828\ub418\uc5b4 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n HD \ubaa8\ub378\uc5d0\uc11c\ub294 eIF5A\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uace0\uac08\ub429\ub2c8\ub2e4. eIF5A\ub294 \ub9ac\ubcf4\uc19c\uc774 \uad50\ud1b5 \uccb4\uc99d\uc744 \uc81c\uac70\ud558\ub294 \ub370 \uc911\uc694\ud558\ubbc0\ub85c HD\uc5d0 \uc774 \ub2e8\ubc31\uc9c8\uc774 \uc801\uc73c\uba74 \uc0c8\ub85c\uc6b4 \ub2e8\ubc31\uc9c8 \ubd84\uc790\ub97c \ub9cc\ub4e4\uace0 \uc624\ub798\ub41c \uac83\uc744 \uc81c\uac70\ud558\ub294 \ub370 \ub354 \ub9ce\uc740 \ubb38\uc81c\uac00 \ubc1c\uc0dd\ud569\ub2c8\ub2e4.\n\ud568\uaed8, Dr. Frydman\uc758 \uc5f0\uad6c\ub294 HD\ub85c \uc778\ud55c \ubd84\uc790 \ubd95\uad34\uc758 \uc804\uccb4 \ud638\uc2a4\ud2b8\uac00 RNA \uba54\uc2dc\uc9c0\uc640 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8 \uc218\uc900 \ubaa8\ub450\uc5d0\uc11c \ubc1c\uc0dd\ud558\uba70, \uac01\uac01\uc740 \uc6b0\ub9ac\uac00 \ud658\uc790\uc640 HD \ubaa8\ub378\uc5d0\uc11c \ubcfc \uc218 \uc788\ub294 HD\uc758 \uc9d5\ud6c4\uc640 \uc99d\uc0c1\uc5d0 \uae30\uc5ec\ud55c\ub2e4\uace0 \uc81c\uc548\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub450 \ubc88\uc9f8 \uc138\uc158\uc740 Balajee Somalinga \ubc15\uc0ac(CHDI)\uc640 Ali Brivanlou \ubc15\uc0ac(The Rockefeller University)\uac00 \uc8fc\ucd5c\ud558\uba70 \uc8fc\ub85c \ud5cc\ud305\ud2f4 \uba54\uc2dc\uc9c0\uc640 \ub2e8\ubc31\uc9c8, \uac74\uac15\uacfc \uc9c8\ubcd1\uc5d0\uc11c\uc758 \uc5ed\ud560\uc5d0 \uc911\uc810\uc744 \ub458 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uc774 \uc138\uc158\uc758 \uccab \ubc88\uc9f8 \uc5f0\uc0ac\ub294 INSERM\uc758 Sandrine Humbert\ub85c \ub1cc \ubc1c\ub2ec \uc911 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 \uc5ed\ud560\uc5d0 \ub300\ud55c \uadf8\ub140\uc758 \uc5f0\uad6c\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud560 \uac83\uc785\ub2c8\ub2e4.\n\ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc740 \uc138\ud3ec\uc5d0\uc11c \ub9ce\uc740 \uc5ed\ud560\uc744 \ud558\uba70 \uadf8 \uc911 \ud558\ub098\ub294 \uc138\ud3ec \uc8fc\ubcc0\uc758 \ub2e4\ub978 \ubd84\uc790\ub97c \uc6c0\uc9c1\uc774\ub294 \uac83\uc785\ub2c8\ub2e4. \ud5cc\ud305\ud2f4\uc774 \uc2e0\uacbd \uc138\ud3ec\uc5d0\uc11c \uc218\uc1a1\uc744 \ub3d5\ub294 \ubd84\uc790 \uc911 \ud558\ub098\ub294 \ub1cc \uc138\ud3ec\uc758 \uac74\uac15\uc744 \uc9c0\uc6d0\ud558\ub294 \ub370 \uc911\uc694\ud55c BDNF\uc785\ub2c8\ub2e4.\n\ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 \uc815\uc0c1\uc801\uc778 \ud615\ud0dc\uc640 \ud655\uc7a5\ub41c \ud615\ud0dc\ub294 \ubaa8\ub450 \uc0dd\uba85\uc758 \ucd08\uae30 \ub2e8\uacc4\uc5d0 \uc788\ub294 \uc138\ud3ec\uc5d0 \uc758\ud574 \ub9cc\ub4e4\uc5b4\uc9d1\ub2c8\ub2e4. Humbert \uc5f0\uad6c\uc2e4\uc740 HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc758 \ud655\uc7a5\ub41c \ud615\ud0dc\uc758 \ub2e8\ubc31\uc9c8\ub85c \uc778\ud55c \uc624\ub958\uac00 \ub098\uc911\uc5d0 \uadf8\ub4e4\uc774 \uacaa\ub294 \uc99d\uc0c1\uc758 \uc6d0\uc778\uc774 \ub420 \uc218 \uc788\ub2e4\uace0 \uc0dd\uac01\ud569\ub2c8\ub2e4.\nHumbert \uc5f0\uad6c\uc2e4\uc740 \ud5cc\ud305\ud2f4\uc774 \uc774\ub7ec\ud55c \uc138\ud3ec\uac00 \uc6d0\ub798 \uc5b4\ub5bb\uac8c \ud615\uc131\ub418\uc5c8\ub294\uc9c0, \ucd5c\uc885 \uad6c\uc870, \uad81\uadf9\uc801\uc73c\ub85c \uc5b4\ub5bb\uac8c \uc791\ub3d9\ud558\uace0 \ub2e4\ub978 \uc2e0\uacbd \uc138\ud3ec\uc640 \uc5f0\uacb0\ub418\ub294\uc9c0\ub97c \ud3ec\ud568\ud558\uc5ec \uc2e0\uacbd \uc138\ud3ec \ubc1c\ub2ec\uc758 \ub9ce\uc740 \uae30\ub2a5\uc5d0 \uc911\uc694\ud558\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.\nHumbert \uc5f0\uad6c\uc2e4\uc5d0\uc11c \uc791\uc5c5\ud558\ub294 HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c\ub294 \uc774\ub7ec\ud55c \ubc1c\ub2ec\uc774 \uc81c\ub300\ub85c \uc774\ub8e8\uc5b4\uc9c0\uc9c0 \uc54a\uc544 \ub098\uc911\uc5d0 \uc774 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \uc2e0\uacbd\ubcc0\uc131\uc774 \uc124\uba85\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc774 \uc791\uc5c5\uc5d0 \ub300\ud574 \uc774\uc804\uc5d0 \uc5ec\uae30\uc5d0\uc11c \uc37c\uc2b5\ub2c8\ub2e4: https:\/\/en.hdbuzz.net\/290<\/a>\nDr. Humbert\ub294 HD \ub1cc\uc758 \uc138\ud3ec\uac00 \uc5f0\uacb0\ub418\ub294 \ubc29\uc2dd\uc758 \ubcc0\ud654\uac00 HD \ud658\uc790\uac00 \uc77c\ubc18\uc801\uc73c\ub85c \uc99d\uc0c1\uc744 \ub098\ud0c0\ub0bc \ub54c \uc774\ud6c4\uc5d0 \uadf8\ub4e4\uc744 \ucde8\uc57d\ud558\uac8c \ub9cc\ub4e0\ub2e4\uace0 \uac00\uc815\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uadf8\ub140\uc758 \uc5f0\uad6c\uc2e4\uc758 \ucd5c\uc2e0 \uc5f0\uad6c\ub294 HD\uac00 \uc2e0\uacbd \uc138\ud3ec \uc131\uc7a5, \uad6c\uc870 \ubc0f \uc6b4\ub3d9\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ud3ec\ud568\ud558\uc5ec \uac74\uac15 \ubc0f HD\uc5d0\uc11c \ud5cc\ud305\ud2f4\uc758 \uc5ed\ud560\uc744 \uacc4\uc18d \ud0d0\uad6c\ud569\ub2c8\ub2e4.\n\uac74\ubb3c\uc758 \uc9c0\uc9c0\ub300\uc640 \uc720\uc0ac\ud55c \ub274\ub7f0 \uad6c\uc870 \ub0b4\uc5d0\uc11c \ub354 \ub9ce\uc740 \uc548\uc815\uc131\uc744 \ub9cc\ub4dc\ub294 \uac83\uc740 \ub098\uc911\uc5d0 \uac74\uac15\uc5d0 \uae0d\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uc694\uc57d\ud558\uba74, HD \ubaa8\ub378\uc5d0\uc11c \uc2e0\uacbd \uc138\ud3ec \ubc1c\ub2ec\uc774 \ub2e4\ub974\uc9c0\ub9cc \uc2e0\uacbd \uc138\ud3ec\ub294 \ub9e4\uc6b0 \ud0c4\ub825\uc801\uc774\uba70 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uae30\uae4c\uc9c0 \uc218\uc2ed \ub144\uc774 \uac78\ub9b4 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub2e4\uc74c\uc740 \ubc00\ub77c\ub178 \ub300\ud559\uc758 Raffaele Iennaco \ubc15\uc0ac\uc640 Istituto Nazionale di Genetica Molecolare\uc785\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\ub294 \uc904\uae30 \uc138\ud3ec\ub97c \uc0ac\uc6a9\ud558\uc5ec \ud5cc\ud305\ud2f4 \uc5d1\uc1901 \ub2e8\ud3b8\uc758 \uad6c\uc870\uac00 \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc774\ud574\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n Iennaco \ubc15\uc0ac\ub294 Elena Cattaneo \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc5d0\uc11c “\uc720\ub3c4 \ub9cc\ub2a5 \uc904\uae30 \uc138\ud3ec” \ub610\ub294 iPSC\ub85c \uc54c\ub824\uc9c4 \ud2b9\uc218\ud55c \ud615\ud0dc\uc758 \uc904\uae30 \uc138\ud3ec \uc0ac\uc6a9\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. HD \ud658\uc790\uc5d0\uc11c \ucd94\ucd9c\ud55c \uc774 \uc138\ud3ec\ub97c \ud1b5\ud574 \ud300\uc740 Huntingtin \ub2e8\ubc31\uc9c8\uc758 \uc2dc\uc791 \ubd80\ubd84\uc744 \uc5f0\uad6c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\uc774 \uc791\uc740 \uc870\uac01\uc740 Huntingtin \ub2e8\ubc31\uc9c8\uc758 \uc544\uc8fc \uc791\uc740 \ubd80\ubd84\uc744 \ubc18\uc601\ud569\ub2c8\ub2e4. \uc804\uccb4 \ub2e8\ubc31\uc9c8\uc758 3% \uc815\ub3c4\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774 \uc791\uc740 \uc870\uac01\uc740 \uc138\ud3ec\uc5d0\uc11c \ud5cc\ud305\ud2f4\uc758 \uc791\uc5c5, \ud2b9\ud788 \uc138\ud3ec \uc8fc\uc704\ub97c \uc6c0\uc9c1\uc774\ub294 \ubc29\uc2dd\uc5d0\uc11c \uc5c4\uccad\ub09c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 \uc774 \uc791\uc740 \ubd80\ubd84\uc744 \ub354 \uc798 \uc774\ud574\ud558\uae30 \uc704\ud574 Iennaco \ud300\uc740 209\uac1c\uc758 \ub2e4\ub978 \ub3d9\ubb3c \uc885\uc5d0\uc11c \uc774 \uc601\uc5ed\uc758 \uc815\ud655\ud55c \uc11c\uc5f4\uc744 \uacb0\uc815\ud588\uc2b5\ub2c8\ub2e4! \uc774\uac83\uc740 \uc6b0\ub9ac\uac00 \uc774\ub7f0 \uc885\ub958\uc758 \uc815\ubcf4\ub97c \uac00\uc9c0\uace0 \uc788\ub294 \uc885\uc758 \uc218\ub97c \uadf9\uc801\uc73c\ub85c \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uc885\uc5d0 \ub530\ub77c CAG\uc758 \uc218\ub294 \uc0c1\ub2f9\ud788 \ub2e4\uc591\ud569\ub2c8\ub2e4. \ubb3c\uace0\uae30\uc758 \uacbd\uc6b0 \ud56d\uc0c1 4\uac1c\uc758 CAG\uc778 \uac83\ucc98\ub7fc \ubcf4\uc774\uc9c0\ub9cc \ub3c4\ub9c8\ubc40\uc758 \uacbd\uc6b0 5\uac1c\uc778 \ubc18\uba74 HD\uac00 \uc5c6\ub294 \uc778\uac04\uc758 CAG \ubc18\ubcf5\uc740 17-20\uac1c\uc785\ub2c8\ub2e4. \uc885\ub9c8\ub2e4 \ub2e4\ub978 \uc591\uc758 CAG\uac00 \ud544\uc694\ud55c \uc774\uc720\ub294 Iennaco\uac00 \uc774\ud574\ud558\ub294 \ub370 \uad00\uc2ec\uc774 \uc788\ub294 \ud070 \ubbf8\uc2a4\ud130\ub9ac\uc785\ub2c8\ub2e4.\nIennaco\uc758 \uc5f0\uad6c\uc5d0\uc11c \uc5bb\uc740 \ub2e4\ub978 \uc99d\uac70\uc5d0 \ub530\ub974\uba74 \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\ub294 \ub3cc\uc5f0\ubcc0\uc774\ub97c \ubc1b\uc544\ub4e4\uc77c \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \ud5cc\ud305\ud2f4\uc758 \uc720\uc804 \ucf54\ub4dc\uc5d0\ub294 \uc6b0\uc5f0\ud788 \uc608\uc0c1\ub418\ub294 \uac83\ubcf4\ub2e4 \ud6e8\uc52c \uc801\uc740 \ubcc0\ud654\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\uc758 \uc911\uc694\uc131\uc5d0 \ub300\ud55c \ucd94\uac00 \uc99d\uac70.\n\ub9c8\ubaa8\uc14b\uc5d0\uc11c – \uc544\uc8fc \uadc0\uc5ec\uc6b4 \uc6d0\uc22d\uc774 \uacbd\ud5d8\uc744 \uc704\ud574 Google\ub85c \uc774\ub3d9\ud558\uc2ed\uc2dc\uc624 – \uc2e4\uc81c\ub85c \ub450 \uac1c\uc758 Huntingtin \uc720\uc804\uc790\uac00 \uc788\uc2b5\ub2c8\ub2e4! \uc774\uac83\uc740 \uc5f0\uad6c\ub41c \ub2e4\ub978 \uc885\uc5d0\uc11c\ub294 \ud574\ub2f9\ub418\uc9c0 \uc54a\uc9c0\ub9cc \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\ub97c \ub354 \uc798 \uc774\ud574\ud558\uae30 \uc704\ud574 \ud76c\uadc0 \uc720\uc804\uc801 \uc0ac\uac74\uc758 \uc608\ub97c \ucc3e\uae30 \uc704\ud574 200\uc885 \uc774\uc0c1\uc758 \uc885\uc744 \uc870\uc0ac\ud558\ub294 \ud798\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.\nIennaco \ud300\uc740 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \uc790\ub77c\ub294 \uc904\uae30 \uc138\ud3ec\ub97c \uc0ac\uc6a9\ud558\uc5ec CAG \ubc18\ubcf5 \uc601\uc5ed\uc758 \uae38\uc774\uc640 \uc774\ub7ec\ud55c \uc138\ud3ec\uac00 \ub274\ub7f0\uc774\ub77c\ub294 \ub1cc \uc138\ud3ec\ub85c \ubc1c\ub2ec\ud558\ub294 \ub2a5\ub825 \uc0ac\uc774\uc758 \uc815\ud655\ud55c \uc5f0\uad00\uc131\uc744 \uc5f0\uad6c\ud560 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc2e4\ud5d8\uc740 \uc5fc\uae30\uc11c\uc5f4 \ubd84\uc11d\uc5d0\uc11c \ud655\uc778\ub41c \ubaa8\ub4e0 \uc720\uc804\uc801 \ub2e4\uc591\uc131\uc758 \uc911\uc694\uc131\uc744 \uc774\ud574\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n\n\n \ub2e4\uc74c\uc73c\ub85c Iennaco\uc640 \ud300\uc740 \ub9c8\uc6b0\uc2a4\uc640 \uc778\uac04 \ud5cc\ud305\ud2f4\uc758 \ube44\uad50\uc5d0 \uc9d1\uc911\ud588\uc2b5\ub2c8\ub2e4. \uc774\uc0c1\ud558\uac8c\ub3c4 \uc778\uac04 \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\ub294 \ub9e4\uc6b0 \uc720\uc0ac\ud558\uc9c0\ub9cc \ub9c8\uc6b0\uc2a4 \ubc84\uc804\ubcf4\ub2e4 \ub3c5\uc131\uc774 \ub354 \uac15\ud55c \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc9c0\ub9cc \uadf8 \uc774\uc720\ub294 \ubaa8\ub985\ub2c8\ub2e4.\n\ud300\uc740 \uc811\uc2dc\uc5d0\uc11c \uc790\ub780 \uc904\uae30 \uc138\ud3ec\uac00 \ub1cc \ubc1c\ub2ec\uc758 \uac00\uc7a5 \ucd08\uae30 \ub2e8\uacc4\ub97c \uac70\uce58\ub3c4\ub85d \uc720\ub3c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc791\uc740 \ubcc0\ud654(CAG \uae38\uc774 \ub610\ub294 \uc885 \uc804\uccb4)\uc758 \uc911\uc694\uc131\uc744 \uc5f0\uad6c\ud558\uace0 \ub1cc \ubc1c\ub2ec\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uce21\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\n\ub9e4\uc6b0 \uba4b\uc9c4 \uc790\ub3d9\ud654 \uc2dc\uc2a4\ud15c\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud300\uc740 Huntingtin \uc2dc\ud000\uc2a4\uc758 \uc791\uc740 \ubcc0\ud654\uac00 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ub354 \uc798 \uc774\ud574\ud558\uae30 \uc704\ud574 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \uc57d 5,000\uac1c\uc758 \uc11c\ub85c \ub2e4\ub978 \ubbf8\ub2c8 \ub450\ub1cc\uc758 \uc774\ubbf8\uc9c0\ub97c \ucd2c\uc601\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n \uadf8\ub4e4\uc774 \uce21\uc815\ud55c \uc0c8\ub85c\uc6b4 \ub1cc \uc138\ud3ec \uc131\uc7a5\uc758 \ub9ce\uc740 \uce21\uba74\uc740 \ub9c8\uc6b0\uc2a4 \ud5cc\ud305\ud2f4\ubcf4\ub2e4\ub294 \uc778\uac04 \ud5cc\ud305\ud2f4\uc758 \uc601\ud5a5\uc744 \ub354 \ub9ce\uc774 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 \uc0c8\ub85c \ud0dc\uc5b4\ub09c \ub1cc \uc138\ud3ec\uc5d0 \uc720\ub3c5\ud560 \uc218 \uc788\ub294 \ub2a5\ub825\uc774\ub77c\ub294 \uc810\uc5d0\uc11c \uc778\uac04 \uc5fc\uae30\uc11c\uc5f4\uacfc \uad6c\ubcc4\ub418\ub294 \ubb34\uc5b8\uac00\uac00 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.\n\ud300\uc740 \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\uc758 \ub9e4\uc6b0 \ud2b9\uc815\ud55c \uc601\uc5ed\uc744 \uc881\ud600\uc11c HD \uc720\uc804\uc790\uc758 \uc778\uac04 \ubc84\uc804\uc774 \uc950\uc758 \uac83\ubcf4\ub2e4 \ub3c5\uc131\uc774 \ub354 \uac15\ud55c \uc774\uc720\ub97c \uc124\uba85\ud55c\ub2e4\uace0 \uc0dd\uac01\ud569\ub2c8\ub2e4. \uc774\uac83\uc740 \ub3d9\ubb3c\uc5d0\uc11c \uc774\uc640 \uac19\uc740 \uc720\uc804 \uc5f0\uad6c\uc758 \uc911\uc694\uc131\uc744 \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n \ub2e4\uc74c\uc740 UCLA\uc758 Baljit Khakh \uad50\uc218\uc758 \uac15\uc5f0\uc785\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 HD\uc5d0\uc11c \uc131\uc0c1\uad50\uc138\ud3ec\ub77c\uace0 \ud558\ub294 \ud2b9\uc815 \uc720\ud615\uc758 \uc9c0\uc9c0 \uc138\ud3ec\uc5d0 \uad00\uc2ec\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774\uac83\ub4e4\uc740 HD\uc5d0\uc11c \uac00\uc7a5 \ucde8\uc57d\ud55c \uc138\ud3ec(\ub274\ub7f0)\uac00 \uc544\ub2c8\uc9c0\ub9cc \uc778\uc0dd\uc5d0\uc11c \uc131\uc0c1\uad50\uc138\ud3ec\ub294 \ub274\ub7f0\uc744 \uc9c0\uc6d0\ud558\ub294 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.\n\uc131\uc0c1\uad50\uc138\ud3ec\ub294 HD \ucd08\uae30\uc5d0 \uc8fd\uc9c0 \uc54a\uc9c0\ub9cc HD \uc720\uc804\uc790\ub97c \ud655\uc2e4\ud788 \ubc1c\ud604\ud558\uba70 HD \uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774 \uc0ac\ubcf8\uc744 \ubc1c\ud604\ud560 \ub54c \ubaa8\uc591\uacfc \uae30\ub2a5\uc5d0 \ub9ce\uc740 \ubcc0\ud654\ub97c \ubcf4\uc785\ub2c8\ub2e4. Khakh\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc131\uc0c1\uc138\ud3ec\uc758 \uc774\ub7ec\ud55c \ubcc0\ud654\uac00 HD\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0 \uc5ec\ubd80\ub97c \uc54c\uace0 \uc2f6\uc5b4\ud569\ub2c8\ub2e4.\nKhakh\uc758 \uc5f0\uad6c\uc2e4\uc740 HD \ud658\uc790\uc758 \ub1cc\uc5d0\uc11c \uc0dd\uc131\ub41c \uac70\ub300\ud55c \ub370\uc774\ud130 \uc138\ud2b8\uc640 \uc5b4\ub5a4 \uc720\uc804\uc790\uac00 \ucf1c\uc9c0\uace0 \uaebc\uc9c0\ub294\uc9c0 \ubcf4\uc5ec\uc8fc\ub294 \ub3d9\ubb3c \ubaa8\ub378\uc744 \uc0b4\ud3b4\ubcf4\uace0 \uc131\uc0c1\uc138\ud3ec\uac00 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\uc9c0 \uc54a\uc744 \uc218 \uc788\ub2e4\ub294 \ud78c\ud2b8\ub97c \ucc3e\ub294 \uac83\uc73c\ub85c \uc791\uc5c5\uc744 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7f0 \uacbd\uc6b0\uac00 \uc788\ub294 \uac83 \uac19\uc558\uc2b5\ub2c8\ub2e4.\nHD \ud658\uc790\uc758 \ub1cc\uc5d0\ub294 \uc131\uc0c1\uad50\uc138\ud3ec\uc758 \ubcc0\ud654\uac00 \uc788\uc9c0\ub9cc HD\uc758 \uc9c4\ud589\uc5d0 \uc911\uc694\ud55c\uac00\uc694, \uc544\ub2c8\uba74 \ub2e4\ub978 \uc138\ud3ec \uc720\ud615\uc758 \ubcc0\ud654\ub97c \ubc18\uc601\ud558\ub294 \uac83\uc77c \ubfd0\uc785\ub2c8\uae4c?<\/p>\n\n\n\n\nHD\uac00 \ub1cc\uc758 \uac1c\ubcc4 \uc138\ud3ec\uc5d0 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0 \uc870\uc0ac<\/h3>\n\n\n\n\n
HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378<\/h3>\n\n\n\n\n
\ud5cc\ud305\ud2f4 \uba54\uc2dc\uc9c0 \ucc98\ub9ac<\/h3>\n\n\n\n\n
![\"Sandrine](\"\/files\/uploads\/2022\/03\/codev-2022-03-02-34c877ea7a-FMzF7jvVEAIawBf.jpeg\")
\ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8\uc758 \uc138\ud3ec \ucc98\ub9ac<\/h3>\n\n\n\n\n
\ud5cc\ud305\ud2f4\uc73c\ub85c \uc778\ud55c \uc9c8\ubcd1\uc601\ud5a5<\/h2>\n\n\n\n\n
\ud5cc\ud305\ud2f4\uc73c\ub85c \uc778\ud55c \ucd08\uae30 \ud6a8\uacfc<\/h3>\n\n\n\n\n
\ub2e4\ub978 \uc885\uc758 \ud5cc\ud305\ud2f4<\/h3>\n\n\n\n\n
![\"Dr.Yang\uc740](\"\/files\/uploads\/2022\/03\/codev-2022-03-03-90621eeb12-FMyMGtYVQAE9N_d.jpeg\")
\uc131\uc0c1\uad50\uc138\ud3ec\uc758 \ud5cc\ud305\ud2f4\uc5d0 \uc758\ud55c \uc601\ud5a5<\/h3>\n\n\n\n\n
"},{"ID":4130,"user_firstname":"Leora","user_lastname":"Fox","nickname":"Dr Leora Fox","user_nicename":"leorafox","display_name":"Dr Leora Fox","user_email":"leora.fox@gmail.com","user_url":"","user_registered":"2025-05-12 17:21:54","user_description":"Leora Fox trained as a Huntington's Disease scientist, and obtained her PhD in 2016 at Columbia University, where she studied HD mouse models and how brain cells dispose of huntingtin protein. After gaining experience in Medical Communications she worked on research and patient engagement programs at the Huntington's Disease Society of America from 2017-2024. Dr. Fox continues to support the HD research community through her work at Fox Scientific Consulting. She is passionate about communicating science about HD and other brain diseases so that families understand recent progress, can make informed decisions about participating in clinical research, and are supported around research news.","user_avatar":"
"},{"ID":4201,"user_firstname":"Sarah","user_lastname":"Hernandez","nickname":"Dr Sarah Hernandez","user_nicename":"sarahhernandez","display_name":"Dr Sarah Hernandez","user_email":"sjherna2@uci.edu","user_url":"","user_registered":"2025-05-12 17:22:01","user_description":"Dr. Sarah Hernandez is the Director of Research Programs at the Hereditary Disease Foundation (HDF). She carried out her postdoctoral work with Dr. Leslie Thompson at the University of California, Irvine, where she used stem cells and fruit flies to define HD-related changes that exist outside the cell, in the \u201cextracellular matrix\u201d. At the HDF, Sarah oversees the Foundation\u2019s scientific research portfolio by managing the grants program, acting as the scientific liaison, and coordinating scientific programming through webinars, workshops, and conferences. Sarah enthusiastically supports the mission of the HDF, to identify the most promising research and accelerate treatments for Huntington\u2019s disease.","user_avatar":"
"},{"ID":4198,"user_firstname":"Joel","user_lastname":"Stanton","nickname":"Joel Stanton","user_nicename":"joelstanton","display_name":"Joel Stanton","user_email":"stanton.joel@icloud.com","user_url":"","user_registered":"2025-05-12 17:22:01","user_description":"Joel is a neuroscience nurse who obtained his masters in stroke research from University College London","user_avatar":"
"}],"editors":[{"ID":4201,"user_firstname":"Sarah","user_lastname":"Hernandez","nickname":"Dr Sarah Hernandez","user_nicename":"sarahhernandez","display_name":"Dr Sarah Hernandez","user_email":"sjherna2@uci.edu","user_url":"","user_registered":"2025-05-12 17:22:01","user_description":"Dr. Sarah Hernandez is the Director of Research Programs at the Hereditary Disease Foundation (HDF). She carried out her postdoctoral work with Dr. Leslie Thompson at the University of California, Irvine, where she used stem cells and fruit flies to define HD-related changes that exist outside the cell, in the \u201cextracellular matrix\u201d. At the HDF, Sarah oversees the Foundation\u2019s scientific research portfolio by managing the grants program, acting as the scientific liaison, and coordinating scientific programming through webinars, workshops, and conferences. Sarah enthusiastically supports the mission of the HDF, to identify the most promising research and accelerate treatments for Huntington\u2019s disease.","user_avatar":"