{"id":18091,"date":"2022-03-08T00:00:00","date_gmt":"2022-03-08T00:00:00","guid":{"rendered":"https:\/\/hdbuzzwp.codev.codev\/?p=18091"},"modified":"2022-05-12T00:00:00","modified_gmt":"2022-05-12T00:00:00","slug":"322-2","status":"publish","type":"post","link":"https:\/\/ko.hdbuzz.net\/322-2\/","title":{"rendered":"\ud5cc\ud305\ud134\ubcd1 \uce58\ub8cc \ucee8\ud37c\ub7f0\uc2a4 2022 – Day 3"},"content":{"rendered":"\n

\uc88b\uc740 \uc544\uce68! \uc624\ub298\uc740 \ud31c\uc2a4\ud504\ub9c1\uc2a4\uc5d0\uc11c \uc5f4\ub9b0 #CHDI HD Therapeutics Conference\uc758 \uc138 \ubc88\uc9f8\uc774\uc790 \ub9c8\uc9c0\ub9c9 \ub0a0\uc785\ub2c8\ub2e4. \uc2e4\uc2dc\uac04 \uc5c5\ub370\uc774\ud2b8\ub97c \ubc1b\uc73c\ub824\uba74 \uc624\ub298 \ud53c\ub4dc\ub97c \ud314\ub85c\uc6b0\ud558\uc138\uc694!<\/p>\n\n\n\n\n

\ubc14\uc774\uc624\ub9c8\ucee4 \ubc0f \uc784\uc0c1 \ub3c4\uad6c<\/h2>\n\n\n\n\n

\uc5f0\uad6c \ud68c\ub2f4\uc758 \ub124 \ubc88\uc9f8 \uc138\uc158\uc5d0\uc11c\ub294 HD \uc9c4\ub2e8, \ucd94\uc801 \ubc0f \uce58\ub8cc\ub97c \uc704\ud55c \ubc14\uc774\uc624\ub9c8\ucee4 \ubc0f \uc784\uc0c1 \ub3c4\uad6c\ub97c \ub2e4\ub8f0 \uac83\uc785\ub2c8\ub2e4. CHDI\uc758 Edith Monteagudo \ubc15\uc0ac\uc640 \ucf54\ud39c\ud558\uac90 \ub300\ud559\uad50\uc758 Niels Skotte \ubc15\uc0ac\uac00 \uc18c\uac1c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n\n

\"PET
PET \ub9ac\uac04\ub4dc\ub294 \ud53c\uc9c8\uacfc \uc120\uc870\uccb4\ub97c \ubc1d\ud788\ub294 \ub370 \uc720\uc6a9\ud569\ub2c8\ub2e4.\n\n<\/figcaption><\/figure>\n\n\n\n\n

\ubc14\uc774\uc624\ub9c8\ucee4 \ud0dc\uc2a4\ud06c\ud3ec\uc2a4!<\/h2>\n\n\n\n\n

\uccab \ubc88\uc9f8 \uac15\uc5f0\uc740 CHDI\uc758 Dr. Cristina Sampaio\uc640 Dr. Robert E Pacifici\uc785\ub2c8\ub2e4. \uadf8\ub4e4\uc740 HD\uc6a9 \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \ubc1c\uc804\uc2dc\ud0a4\uae30 \uc704\ud55c \uc804\ub7b5 \uac1c\ubc1c\uc5d0 \uc911\uc810\uc744 \ub454 CHDI\uc758 \ubc14\uc774\uc624\ub9c8\ucee4 \ud0dc\uc2a4\ud06c \ud3ec\uc2a4\uc5d0 \ub300\ud574 \ub17c\uc758\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ubc14\uc774\uc624\ub9c8\ucee4\ub294 \uc57d\ubb3c \uac1c\ubc1c\uc5d0 \ub9e4\uc6b0 \u200b\u200b\uc911\uc694\ud569\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc5f0\uad6c\uc790\ub294 \uc9c8\ubcd1\uc774 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \ud658\uc790\uac00 \uc5b4\ub5bb\uac8c \uc9c4\ud589\ub418\uace0 \uc788\ub294\uc9c0 \ucd94\uc801\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc5f0\uad6c\uc790\uac00 \ud658\uc790\uac00 \uc88b\uc544\uc9c0\uace0 \uc788\ub294\uc9c0 \ud655\uc778\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \uce58\ub8cc \ubd84\uc57c\uac00 \ubc1c\uc804\ud568\uc5d0 \ub530\ub77c \uc911\uc694\ud560 \uac83\uc785\ub2c8\ub2e4. CHDI \ubc0f \uae30\ud0c0 \uc870\uc9c1\uc740 \uac1c\ubcc4 \ud68c\uc0ac\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc804\uccb4 HD \uc5f0\uad6c \ubc0f \uac00\uc871 \ucee4\ubba4\ub2c8\ud2f0\uc5d0 \ud61c\ud0dd\uc744 \uc904 \uc218 \uc788\ub294 \ubc29\uc2dd\uc73c\ub85c \ubc14\uc774\uc624\ub9c8\ucee4 \ub370\uc774\ud130(\ubc0f \uae30\ud0c0 \uc5ec\ub7ec \uc720\ud615\uc758 \ub370\uc774\ud130)\ub97c \uc81c\uacf5\ud558\uae30 \uc704\ud574 \ub178\ub825\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. CHDI\ub294 \uc601\uc0c1(MRI \uc2a4\uce94 \ub4f1), \ud608\uc561 \ubc0f \ucc99\uc218\uc561\uacfc \uad00\ub828\ub41c \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \ubc1c\uc804\uc2dc\ud0a4\ub294 \ub370 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ud608\uc561\uc5d0\uc11c \ud6cc\ub96d\ud55c \ubc14\uc774\uc624\ub9c8\ucee4\ub85c \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc740 \ud55c \ubd84\uc790\ub294 \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4\uc785\ub2c8\ub2e4. HD\ub97c \uc720\ubc1c\ud558\ub294 \uac83\uacfc \uc9c1\uc811\uc801\uc778 \uad00\ub828\uc774 \uc788\uc9c0\ub9cc \uc9c8\ubcd1 \uc9c4\ud589\uc744 \uc798 \ucd94\uc801\ud558\uc9c0 \ubabb\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ubbf8\uc9d5\uc740 \ubc14\uc774\uc624\ub9c8\ucee4 \ubd84\uc57c\uc5d0\uc11c \uac15\ub825\ud55c \ub0b4\uae30\uc778 \uac83 \uac19\uc2b5\ub2c8\ub2e4. \uc774\ubbf8\uc9d5\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud3c9\uac00\ud560 \uc218 \uc788\ub294 \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \uc2dd\ubcc4\ud558\uba74 \uc5f0\uad6c\uc790\uc5d0\uac8c \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c HD \ud658\uc790\ub97c \uc9c0\uc18d\uc801\uc73c\ub85c \ucd94\uc801\ud560 \uc218 \uc788\ub294 \ube44\uce68\uc2b5\uc801 \ubc29\ubc95\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \uc815\uc758\ud558\ub294 \ub610 \ub2e4\ub978 \ud575\uc2ec \uc694\uc18c\ub294 HD \uc9c4\ud589 \ucd08\uae30\uc5d0 \ubcc0\ud654\ud558\ub294 \uac83\ub4e4\uc744 \ucc3e\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uae30 \uc804, \uc989 \uc77c\ubd80 \uc0ac\ub78c\ub4e4\uc740 \uce58\ub8cc\ub97c \uc2dc\uc791\ud574\uc57c \ud55c\ub2e4\uace0 \uc0dd\uac01\ud558\ub294 \uac00\uc7a5 \ucd08\uae30 \ub2e8\uacc4\uc5d0\uc11c \uc9c8\ubcd1 \ubaa8\ub2c8\ud130\ub9c1\uc744 \uc2dc\uc791\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uccb4\uc138\ud3ec \ubc18\ubcf5 \ud655\uc7a5\uc73c\ub85c \uc54c\ub824\uc9c4 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \uc77c\ubd80 \uc138\ud3ec\uc5d0\uc11c CAG \ubc18\ubcf5\uc758 \uae38\uc774\uac00 \ub298\uc5b4\ub098\ub294 \uac83\uc740 \uc9c8\ubcd1 \ubc1c\ubcd1 \uc5f0\ub839\uc774 \ubbf8\uce58\ub294 \uc601\ud5a5 \ub54c\ubb38\uc5d0 \uad00\uc2ec\uc744 \uc5bb\uace0 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ubc14\uc774\uc624\ub9c8\ucee4\ub85c\ub3c4 \uc720\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc774 \uc2e4\uc2dc\uac04\uc73c\ub85c \ub9ce\uc740 \ub370\uc774\ud130\ub97c \uc218\uc9d1\ud558\uae30 \uc704\ud574 \ucc29\uc6a9\ud560 \uc218 \uc788\ub294 \uc2dc\uacc4\uc640 \uac19\uc740 \ub514\uc9c0\ud138 \uc7a5\uce58\uc778 “\uc6e8\uc5b4\ub7ec\ube14"\uc744 \ud65c\uc6a9\ud558\ub294 \ubc29\ubc95\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc7a5\uce58\ub294 \uc6c0\uc9c1\uc784, \uc218\uba74 \uc2b5\uad00 \ubc0f \uae30\ud0c0 \uce21\uc815\ud56d\ubaa9\uc744 \ucd94\uc801\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. CHDI\ub294 \uc774\ub7ec\ud55c \uc911\uc694\ud55c \ubc14\uc774\uc624\ub9c8\ucee4 \uc911 \uc77c\ubd80\ub97c \uc815\uc758\ud558\uae30 \uc704\ud55c 2\ub144 \ubaa9\ud45c\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \uc774 \uc911\uc694\ud55c \ud504\ub85c\uc81d\ud2b8\ub97c \uc704\ud574 \uc804\uccb4 HD \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0\uc640 \ud611\ub825\ud558\uae30\ub97c \uc5f4\ub9dd\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ubc14\uc774\uc624\ub9c8\ucee4 \ubc1c\uacac – \ubbf8\ub798\ub294 \ubc1d\ub2e4!<\/h2>\n\n\n\n\n

\ub2e4\uc74c \uc5f0\uc0ac\ub294 CHDI\uc758 Jim Rosinski \ubc15\uc0ac\uc785\ub2c8\ub2e4. \uadf8\ub294 \ubc14\uc774\uc624\ub9c8\ucee4 \ubc1c\uacac\uc744 \uc704\ud574 HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc744 \ud504\ub85c\ud30c\uc77c\ub9c1\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \ub300\uaddc\ubaa8 \ub370\uc774\ud130 \uc138\ud2b8\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc790\uc2e0\uc758 \uc791\uc5c5\uc744 \uacf5\uc720\ud560 \uac83\uc785\ub2c8\ub2e4. \uadf8\ub294 "\ubbf8\ub798\uac00 \ubc1d\ub2e4!"\ub77c\uace0 \ub290\ub08d\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc6b0\ub9ac\ub294 \uacfc\ud559\uc790\ub4e4\uc774 \ub9ce\uc740 \uac1c\uc778\uc5d0\uc11c \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \uc720\uc804 \uba54\uc2dc\uc9c0\uc640 \ub2e8\ubc31\uc9c8\uc758 \uc218\ucc9c \uac00\uc9c0 \ubcc0\ud654\ub97c \uce21\uc815\ud560 \uc218 \uc788\ub294 \ub370\uc774\ud130\uc758 \uc0c8\ub85c\uc6b4 \uc2dc\ub300\uc5d0 \uc0b4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac15\ub825\ud55c \ubd84\uc11d \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc774 \ub370\uc774\ud130\ub97c \ubd84\ub958\ud558\uba74 \uc57d\ubb3c \uac1c\ubc1c\uc5d0 \ub9e4\uc6b0 \u200b\u200b\uc720\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub97c \uc704\ud574\uc11c\ub294 HD\ub97c \uac00\uc9c4 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\ub85c\ubd80\ud130 \ud608\uc561 \ubc0f \ucc99\uc218\uc561 \uc0d8\ud50c\uc744 \uc218\uc9d1\ud560 \uc218 \uc788\ub294 \uac83\ubd80\ud130 \ub370\uc774\ud130\ub97c \uc774\ud574\ud558\uae30 \uc704\ud55c \uae30\uc220 \ubc0f \uc18c\ud504\ud2b8\uc6e8\uc5b4 \uac1c\ubc1c\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \uac15\ub825\ud55c "\ud30c\uc774\ud504\ub77c\uc778"\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\uc11c Enroll-HD \ubc0f HDClarity\uc640 \uac19\uc740 \uad00\ucc30 \uc5f0\uad6c\uac00 \uc791\ub3d9\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud558\ub294 HD \uac00\uc871\uc774 \uae30\uc99d\ud55c \uc0d8\ud50c\uc740 \uc720\uc804\uc790\uac00 \uc5b4\ub5bb\uac8c \ucf1c\uc9c0\uace0 \uaebc\uc9c0\ub294\uc9c0 \uc0b4\ud3b4\ubcf4\uace0 \ub2e4\uc591\ud55c \ud615\ud0dc\uc758 RNA \ubc0f \ub2e8\ubc31\uc9c8 \uc218\uc900 \ubcc0\ud654\ub97c \uc870\uc0ac\ud568\uc73c\ub85c\uc368 \uc218\ud589\ud560 \uc218 \uc788\ub294 \ub2e4\uc591\ud55c \uc720\ud615\uc758 \ubd84\uc11d\uc5d0 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \ub1cc \uc601\uc5ed, \uc720\uae30\uccb4 \ub610\ub294 \uc9c8\ubcd1\uc5d0 \uac78\ub9b0 \uc0ac\ub78c\ub4e4\uc758 \uadf8\ub8f9 \uc804\ubc18\uc5d0 \uac78\uce5c \ub2e8\ubc31\uc9c8 \uc218\uc900\uc758 \ubcc0\ud654\ub97c \uad00\ucc30\ud558\ub294 \uac83\uc744 \ub2e8\ubc31\uc9c8\uccb4\ud559\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. HDClarity \uc5f0\uad6c\ub97c \ud1b5\ud574 \uae30\uc99d\ub41c \ucc99\uc218\uc561 \uc0d8\ud50c\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5f0\uad6c\uc790\ub4e4\uc740 Enroll HD\uc758 \uc784\uc0c1 \ub370\uc774\ud130\ub97c \ub2e8\ubc31\uc9c8 \ubcc0\ud654\uc640 \uc5f0\uacb0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\nRosinski \ubc15\uc0ac\ub294 HDClarity \ucc38\uac00\uc790\uc758 \ub300\uaddc\ubaa8 \uadf8\ub8f9\uc5d0\uc11c \ub9ce\uc740 \ub2e8\ubc31\uc9c8\uc744 \ucd94\uc801\ud558\ub294 \ud765\ubbf8\ub85c\uc6b4 \uc608\ube44 \ub370\uc774\ud130\ub97c \uacf5\uc720\ud588\uc2b5\ub2c8\ub2e4. \uc784\uc0c1 \ub370\uc774\ud130\uc640 \ud568\uaed8 \uac01 \uac1c\ubcc4 \ub2e8\ubc31\uc9c8\uc744 \uc0b4\ud3b4\ubcf4\uba74 \uc9c8\ubcd1 \uc9c4\ud589\uc5d0 \ub300\ud55c \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \uc815\uc758\ud558\uace0 \uc57d\ubb3c \uc124\uacc4\ub97c \uc704\ud55c \uacbd\ub85c\ub97c \uc2dd\ubcc4\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n\n

HD\uc5d0\uc11c \uc815\uc758\ub41c \ud55c \uac00\uc9c0 \ubc14\uc774\uc624\ub9c8\ucee4\ub294 \uc2e0\uacbd\uc12c\uc720 \ube5b(NfL)\uc785\ub2c8\ub2e4. \uadf8\uac83\uc740 \uc815\ub9d0 \ud6cc\ub96d\ud55c \ubc14\uc774\uc624\ub9c8\ucee4\ub77c\ub294 \uac83\uc774 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4! Rosinski \ubc15\uc0ac\ub294 \uc774 \ub2e8\ubc31\uc9c8 \ud558\ub098\ub9cc \ubcf4\uace0 HD \uc0c1\ud0dc\ub97c \uc608\uce21\ud560 \uc218 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4! \uc6b0\uc640! \uadf8\ub4e4\uc740 \ub610\ud55c \uc0ac\ub78c\uc774 HD \uc99d\uc0c1\uc5d0 \uc788\uc744 \uc218 \uc788\ub294 \uc704\uce58\ub97c \uc608\uce21\ud558\ub294 \uba87 \uac00\uc9c0 \ub2e4\ub978 \ub2e8\ubc31\uc9c8\uc744 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4. \uad81\uadf9\uc801\uc73c\ub85c \uc774\ub7ec\ud55c \ubc1c\uacac\uc744 \uacb0\ud569\ud558\uba74 HD\uc5d0\uc11c \ubcf4\ub2e4 \uac1c\ubcc4\ud654\ub41c \uad00\ub9ac\uc640 \uce58\ub8cc\ub97c \uac15\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ubbf8\ub798\ub294 \ubc1d\ub2e4! \uacfc\ud559\uc790\ub4e4\uc774 \uc6b0\ub9ac\uac00 HD\uc5d0 \ub300\ud55c \uce58\ub8cc\ub97c \ubc1b\uac8c \ub420 \uac83\uc778\uc9c0\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud558\ub294 \ub300\uc2e0, \uadf8\ub4e4\uc740 \uc6b0\ub9ac\uac00 \uce58\ub8cc\ub97c \ubc1b\ub294 \uc2dc\uc810\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \ud658\uc790\uc758 \uc0c1\ud0dc\ub97c \ucd94\uc801\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \ubc14\uc774\uc624\ub9c8\ucee4\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uba3c \uae38\uc744 \uc654\uc2b5\ub2c8\ub2e4!<\/p>\n\n\n\n\n

\ub2e4\uc74c\uc740 KU Leuven\uc758 Aline Delva \ubc15\uc0ac\uc785\ub2c8\ub2e4. Delva \ubc15\uc0ac\ub294 PET\ub77c\uace0 \ud558\ub294 \uc77c\uc885\uc758 \uc774\ubbf8\uc9d5\uc744 \uc0ac\uc6a9\ud558\uc5ec \uadf8\ub140\uc758 \uc791\uc5c5\uc744 \uc124\uba85\ud560 \uac83\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \ucd5c\uadfc\uc5d0 \uc5ec\uae30\uc5d0 \ub300\ud574 \uc37c\uc2b5\ub2c8\ub2e4: https:\/\/en.hdbuzz.net\/319<\/a><\/p>\n\n\n\n\n

PET \ub9ac\uac04\ub4dc\ub97c \uc0ac\uc6a9\ud558\uba74 \uacfc\ud559\uc790\uc640 \uc784\uc0c1\uc758\uac00 \uc2e0\uccb4 \ub610\ub294 \ub1cc \ub0b4\ubd80\uc758 \uc0ac\ubb3c\uc744 \uc2dc\uac01\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ud2b9\uc815 \ub9ac\uac04\ub4dc\ub294 \ud5cc\ud305\ud2f4\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \ub1cc \uc2a4\uce90\ub108\uc5d0\uc11c \ube5b\uc744 \ubc1c\ud558\ub3c4\ub85d \uc124\uacc4\ub418\uc5b4 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \uadf8\ub9ac\uace0 \uacb0\uad6d\uc5d0\ub294 \uce58\ub8cc \uc911\uc5d0 \uc218\uc900\uc744 \ucd94\uc801\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\nDelva \ubc15\uc0ac\ub294 PET \ub9ac\uac04\ub4dc\uac00 \ud2b9\ud788 HD\uc5d0 \uac00\uc7a5 \ucde8\uc57d\ud55c \ub1cc \uc601\uc5ed\uc5d0\uc11c \uc2dc\uac04 \uacbd\uacfc\uc5d0 \ub530\ub978 \uac74\uac15\uc744 \ucd94\uc801\ud558\uae30 \uc704\ud574 \ub1cc \uc138\ud3ec \uc0ac\uc774\uc758 \uc5f0\uacb0 \uc9c0\uc810\uc778 \uc2dc\ub0c5\uc2a4\uc5d0 \ub2ec\ub77c\ubd99\ub294 \uc778\uac04 \uc5f0\uad6c\uc758 \uc0c8\ub85c\uc6b4 \ub370\uc774\ud130\ub97c \uacf5\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774 PET \ub9ac\uac04\ub4dc\ub294 HD \ud658\uc790\uac00 \ub098\ud0c0\ub098\uae30 \uc804\uc5d0\ub3c4 \ubcc0\ud654\ub97c \uac10\uc9c0\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4! \uc774\uac83\uc740 \uc5f0\uad6c\uc790\ub4e4\uc5d0\uac8c HD \uad00\ub828 \ubcc0\ud654\uac00 \ub208\uc5d0 \ub744\uac8c \ub098\ud0c0\ub098\uae30 \uc804\uc5d0 \uce58\ub8cc\uac00 \ud658\uc790\ub97c \uac1c\uc120\ud558\ub294\uc9c0 \uc5ec\ubd80\ub97c \uacb0\uc815\ud560 \uc218 \uc788\ub294 \ub3c4\uad6c\ub97c \uc81c\uacf5\ud558\uae30 \ub54c\ubb38\uc5d0 \uc88b\uc740 \uc18c\uc2dd\uc785\ub2c8\ub2e4.\n\ub2e4\uc74c\uc73c\ub85c \ub378\ubc14 \ubc15\uc0ac\ub294 \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8 \uc790\uccb4\ub97c \uc870\uc0ac\ud55c PET \ub9ac\uac04\ub4dc\ub97c \uc870\uc0ac\ud55c \uadf8\ub140\uc758 \uc5f0\uad6c\uc5d0 \ub300\ud574 \uc124\uba85\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\uc758 \ubaa9\ud45c\ub294 \ud5cc\ud305\ud2f4\uc774 PET \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ucd94\uc801\ud558\ub294 \ub370 \uc0ac\uc6a9\ub420 \uc218 \uc788\ub294\uc9c0 \ud655\uc778\ud558\ub294 \uac83\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc950\uc640 \uc601\uc7a5\ub958 \ubaa8\ub378\uc5d0\uc11c PET \ub9ac\uac04\ub4dc\ub97c \ud14c\uc2a4\ud2b8\ud55c \ud6c4, \uadf8\ub4e4\uc740 \uc778\uac04\uc744 \ub300\uc0c1\uc73c\ub85c \uc18c\uaddc\ubaa8 \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uace0 \uc0ac\uc6a9\ud558\uae30\uc5d0 \uac00\uc7a5 \uc88b\uc740 \uac83\uc744 \uc54c\uc544\ub0bc \uc218 \uc788\uc5c8\uace0 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uc6a9\ub7c9\uc744 \ucc3e\uc744 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc5f0\uad6c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 PET \ub9ac\uac04\ub4dc\ub294 HD\uc5d0\uc11c \ud2b9\ud788 \ucde8\uc57d\ud55c \ub1cc \uc601\uc5ed\uc778 \ud53c\uc9c8\uacfc \uc120\uc870\uccb4\ub97c \ubc1d\ud788\ub294 \ub370 \uc720\uc6a9\ud569\ub2c8\ub2e4. \uc774\uac83\uc740 \uc608\uc0c1\ub418\uc9c0\ub9cc \uc774 \ub3c4\uad6c\uac00 HD \uacf5\ubd80\uc5d0 \uc798 \uc791\ub3d9\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\uae30 \ub54c\ubb38\uc5d0 \ud765\ubbf8\uc9c4\uc9c4\ud569\ub2c8\ub2e4! \uc774\ub7ec\ud55c PET \ub9ac\uac04\ub4dc\uc758 \uc8fc\uc694 \uc774\uc810\uc740 MRI\uc640 \uc720\uc0ac\ud55c \ube44\uce68\uc2b5\uc801\uc774\uace0 \ud1b5\uc99d\uc774 \uc5c6\ub294 \uc601\uc0c1 \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uac80\uc0ac\ud55c\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c HD \ud658\uc790\uc5d0\uac8c \ube44\uad50\uc801 \uc27d\uace0 \uc790\uc8fc \uc218\ud589\ud558\uc5ec \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ucd94\uc801\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubc14\uc774\uc624\ub9c8\ucee4\uc758 \ubaa8\ub4e0 \uc7a5\uc810!<\/p>\n\n\n\n\n

\ub2e4\uc74c \ub2e8\uacc4\ub294 HD \ud658\uc790\uc758 \ub354 \ud070 \uadf8\ub8f9\uc5d0\uc11c PET \ub9ac\uac04\ub4dc\ub97c \ud14c\uc2a4\ud2b8\ud558\uc5ec \uc774\ub7ec\ud55c \uc5f0\uad6c\ub97c \ud655\uc7a5\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub3c4\uad6c\ub294 \ud604\uc7ac \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ubd84\uc57c\uc5d0\uc11c \ub110\ub9ac \uc0ac\uc6a9\ub418\uace0 \uc778\uc815\ub418\uba70, \uc774\ub294 HD\uc5d0\uc11c \uac1c\ubc1c\uc5d0 \ub300\ud55c \uc88b\uc740 \uc120\ub840\ub97c \uc124\uc815\ud569\ub2c8\ub2e4.\n\uc7a0\uc2dc \uc26c\uace0 \uc788\uc9c0\ub9cc \uc7a0\uc2dc \ud6c4 \ucee4\ud53c\ub97c \ub9c8\uc2dc\uba70 \ub3cc\uc544\uc624\uaca0\uc2b5\ub2c8\ub2e4! \uacc4\uc18d \uc9c0\ucf1c\ubd10 \uc8fc\uc138\uc694!<\/p>\n\n\n\n\n

HD\uc758 \ub514\uc9c0\ud138 \ubaa8\ub2c8\ud130\ub9c1<\/h3>\n\n\n\n\n

\ub2e4\uc74c\uc740 Drs.\uc758 \ud765\ubbf8\ub85c\uc6b4 \uc5c5\ub370\uc774\ud2b8\uc785\ub2c8\ub2e4. Roche\uc758 Peter McColgan\uacfc Jonas Dorn\uc774 Tominersen\uc758 GENERATION-HD1 \ud3c9\uac00\ud310 \uc5c5\ub370\uc774\ud2b8\ub97c \uc81c\uacf5\ud558\uae30 \uc704\ud574 \uc654\uc2b5\ub2c8\ub2e4. \uc801\uc808\ud558\uac8c\ub3c4, McColgan \ubc15\uc0ac\ub294 HD \uac00\uc871\uc758 \uc2e4\ub9dd\uc744 \uc778\uc815\ud558\uace0 \uc774\ub7ec\ud55c \uc5f0\uad6c\uc5d0 \ub300\ud55c \ub180\ub77c\uc6b4 \uacf5\ud5cc\uc5d0 \uac10\uc0ac\ub97c \ud45c\ud558\ub294 \uac83\uc73c\ub85c \uc2dc\uc791\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774 \uac15\uc5f0\uc758 \ud2b9\uc815 \uc5c5\ub370\uc774\ud2b8\ub294 \ub514\uc9c0\ud138 \ubaa8\ub2c8\ud130\ub9c1 \ud50c\ub7ab\ud3fc\uc758 \uc77c\ubd80 \uacb0\uacfc\uc5d0 \ub300\ud55c \ub17c\uc758\uc785\ub2c8\ub2e4. Tominersen\uc5d0 \ub300\ud55c Roche\uc758 \ub2e4\uc591\ud55c \uc5f0\uad6c \ucc38\uac00\uc790\uc758 HD \uc9c4\ud589\uc744 \ucd94\uc801\ud558\ub294 \ub370 \uc0ac\uc6a9\ub418\ub294 \ub514\uc9c0\ud138 \ub3c4\uad6c\uc785\ub2c8\ub2e4. \uc2e4\ud5d8 \ucc38\uac00\uc790\ub4e4\uc740 \uc6c0\uc9c1\uc784 \ubc0f \uc778\uc9c0 \ubcc0\ud654\uc640 \uac19\uc740 HD \uad00\ub828 \uc99d\uc0c1\uc758 \uce21\uc815\uc744 \ucd94\uc801\ud558\uae30 \uc704\ud574 \uc2a4\ub9c8\ud2b8\ud3f0\uc744 \uac00\uc9c0\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 \uc758\uc0ac\uac00 \uc9c4\ub8cc\uc18c\uc5d0\uc11c HD\ub97c \ucd94\uc801\ud558\ub294 \ub370 \uc0ac\uc6a9\ud558\ub294 \uc791\uc5c5\uc758 \uc9d1\uc5d0\uc11c \ud560 \uc218 \uc788\ub294 \ubc84\uc804\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub370\uc774\ud130\ub294 784\uba85\uc758 \ud658\uc790\ub85c\ubd80\ud130 \uc218\uc9d1\ub418\uc5c8\uc73c\uba70 350,000\uc77c \uc774\uc0c1\uc758 \ud14c\uc2a4\ud2b8\uac00 \uae30\ub85d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ucc98\ub9ac\ud574\uc57c \ud560 \uc815\ubcf4\uac00 \ub9ce\uc2b5\ub2c8\ub2e4! \uac01 \ucc38\uac00\uc790\ub294 \ud558\ub8e8 \ud3c9\uade0 30-60\ubd84\uc744 \ud734\ub300\uc804\ud654\ub85c \uc791\uc5c5\uc744 \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \ube60\ub978 \ub3c4\uccad \uc791\uc5c5\uc744 \ud3ec\ud568\ud558\uc5ec \ub9ce\uc740 \uc791\uc5c5\uc5d0\uc11c HD \ud658\uc790\uc640 \ub300\uc870\uad70 \uc0ac\uc774\uc758 \uba85\ud655\ud55c \ubcc0\ud654\ub97c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc774\ub97c \uc704\ud574 \ucc38\uac00\uc790\ub294 \ubc84\ud2bc\uc744 \ube60\ub974\uace0 \ubc18\ubcf5\uc801\uc73c\ub85c \ud0ed\ud574\uc57c \ud558\uba70 HD\uac00 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \ub354 \uc5b4\ub824\uc6cc\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc7ac\ud0dd \ud14c\uc2a4\ud2b8\ub294 \uc0c8\ub85c\uc6b4 \uac83\uc774\uae30 \ub54c\ubb38\uc5d0 \ud300\uc740 \uc9d1\uc5d0\uc11c \uc218\ud589\ud55c \ud14c\uc2a4\ud2b8\uc758 \uacb0\uacfc\ub97c \ube44\uad50\ud55c \ub2e4\uc74c \uacf5\uc2dd \uc784\uc0c1 \ud658\uacbd\uc5d0\uc11c \ubc18\ubcf5\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \uc77c\uad00\uc131\uc774 \ub9e4\uc6b0 \ub192\uc544 \uc9d1\uc5d0\uc11c \ub370\uc774\ud130\ub97c \uc218\uc9d1\ud558\ub294 \uac83\uc774 \uac00\ub2a5\ud574 \ubcf4\uc785\ub2c8\ub2e4. \ube60\ub978 \ub3c4\uccad\uc744 \ud3ec\ud568\ud558\uc5ec \ub180\ub77c\uc6b8 \uc815\ub3c4\ub85c \ub2e8\uc21c\ud55c \uc791\uc5c5\uc740 \uc2dc\ud5d8 \uacfc\uc815\uc5d0\uc11c \ub9e4\uc6b0 \ubd84\uba85\ud558\uac8c \uc545\ud654\ub428\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc774\uac83\uc740 \uc774\ub7ec\ud55c \uc870\uce58\uac00 \ud5a5\ud6c4 \uc2dc\ud5d8\uc5d0 \uc720\uc6a9\ud560 \uc218 \uc788\uace0 \uc7a0\uc7ac\uc801\uc73c\ub85c \ucc38\uac00\uc790\uc640 \uac00\uc871\uc774 \ud074\ub9ac\ub2c9\uc5d0\uc11c \ub9ce\uc740 \uc77c\uc744 \ud574\uc57c \ud558\ub294 \uac83\uc744 \uc808\uc57d\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Dorn \ubc15\uc0ac\ub294 \ub514\uc9c0\ud138 \ub370\uc774\ud130\uc5d0 \uc57d\uac04\uc758 \ubcf5\uc7a1\uc131\uc774 \uc788\ub2e4\uace0 \uc124\uba85\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc77c\ubd80 \uc791\uc5c5\uc744 \ub354 \uc798 \uc218\ud589\ud558\uc9c0 \ubabb\ud55c \uc0ac\ub78c\ub4e4\uc740 \uc791\uc5c5 \uc644\ub8cc\ub97c \uc870\uae30\uc5d0 \uc911\ub2e8\ud560 \uac00\ub2a5\uc131\uc774 \ub354 \ub192\uc558\uc2b5\ub2c8\ub2e4. \uc544\ub9c8\ub3c4 \uc99d\uc0c1 \uc9c4\ud589\uc774 \ub354 \uc2ec\ud55c \uc0ac\ub78c\ub4e4\uc774\uae30 \ub54c\ubb38\uc785\ub2c8\uae4c? "\ubaa8\uc591 \uadf8\ub9ac\uae30” \uc791\uc5c5\uc744 \ud3ec\ud568\ud55c \uc77c\ubd80 \uc791\uc5c5\uc758 \uacbd\uc6b0 \uc2e4\ud5d8 \ucc38\uac00\uc790\ub294 \uc791\uc5c5\uc744 \ub354 \ube68\ub9ac \uc218\ud589\ud558\ub294 \ubc29\ubc95\uc744 \ubd84\uba85\ud788 \ubc30\uc6b0\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc744 ‘\uc5f0\uc2b5 \ud6a8\uacfc’\ub77c\uace0 \ud558\uba70, \uc774\ub7ec\ud55c \uc791\uc5c5\uc5d0 \ub300\ud574 \uc7a5\uae30\uac04\uc5d0 \uac78\uccd0 \uc720\uc6a9\ud55c \ub370\uc774\ud130\ub97c \uc0dd\uc131\ud558\uae30\uac00 \uae4c\ub2e4\ub86d\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Roche\uc758 tominersen \uc2dc\ud5d8 \ucc38\uac00\uc790\ub85c\ubd80\ud130 \uc774\ub7ec\ud55c \uac70\ub300\ud55c \ub370\uc774\ud130 \uc138\ud2b8\ub97c \uc18c\ud654\ud558\uae30 \uc704\ud574\uc11c\ub294 \ub9ce\uc740 \uc791\uc5c5\uc774 \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4. Roche\uac00 \uacc4\uc18d\ud574\uc11c \ub370\uc774\ud130\ub97c \uc870\uc0ac\ud568\uc5d0 \ub530\ub77c \ub354 \ub9ce\uc740 \uc18c\uc2dd\uc744 \ub4e4\uc744 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub2e4\uc74c \uac15\uc5f0\uc5d0\uc11c\ub294 Dr. Sarah Tabrizi(UCL)\uc640 Dr. Jeff Long(University of Iowa)\uc774 HD \uc5ec\uc815\uc5d0\uc11c \uc0ac\ub78c\uc758 \uc704\uce58\ub97c \u200b\u200b\ub354 \uc798 \uc815\uc758\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\ub294 \uc2a4\ud14c\uc774\uc9d5 \uc2dc\uc2a4\ud15c\uc758 \uac1c\ubc1c\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud560 \uac83\uc785\ub2c8\ub2e4. \uc774\uac83\uc740 \uc544\uc9c1 \uc99d\uc0c1\uc744 \ub098\ud0c0\ub0b4\uc9c0 \uc54a\uc740 \uc0ac\ub78c\ub4e4\uc744 \ub300\uc0c1\uc73c\ub85c \uc2dc\ud5d8\uc744 \uacc4\ud68d\ud558\ub294 \ub370 \uc911\uc694\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ubcd1\uae30 \uc2dc\uc2a4\ud15c\uc740 \uc720\uc0ac\ud55c \uc9c8\ubcd1 \ud2b9\uc131\uc744 \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc744 \uadf8\ub8f9\ud654\ud558\uc5ec \ud604\uc7ac \uc99d\uc0c1\uc5d0 \ub530\ub77c \uc801\uc808\ud558\uac8c \uce58\ub8cc\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\ub294 \ub370 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc774\uac83\uc740 \uc554 \uce58\ub8cc\uc640 \uac19\uc740 \ubd84\uc57c\uc5d0\uc11c \ub9e4\uc6b0 \ub3c4\uc6c0\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. HD\ub294 \uc5ec\uc804\ud788 \uc8fc\ub85c \ubb34\ub3c4\uc99d\uc744 \uae30\ubc18\uc73c\ub85c \uc9c4\ub2e8\ub418\uae30 \ub54c\ubb38\uc5d0 \uc774\ub7ec\ud55c \uc885\ub958\uc758 \ubcd1\uae30 \uc2dc\uc2a4\ud15c\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc774\ub294 \ub2e4\ub978 \uc0ac\uace0 \ubc0f \uae30\ubd84 \ubcc0\ud654\ubcf4\ub2e4 \ud6e8\uc52c \ub2a6\uac8c \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc758 \uc218\ub9cc \ub370\uc774\ud130 \uc138\ud2b8\ub97c \ubd84\uc11d\ud568\uc73c\ub85c\uc368 \ub300\uaddc\ubaa8 \uc5f0\uad6c\uc6d0 \ucee8\uc18c\uc2dc\uc5c4\uc774 0\ub2e8\uacc4\ubd80\ud130 3\ub2e8\uacc4\uae4c\uc9c0\uc758 \uc2dc\uc2a4\ud15c\uc744 \ub9cc\ub4e4 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 Enroll-HD\uc640 \uac19\uc740 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud558\ub294 \ud798\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ucc99\ub3c4\uc758 \uac00\uc7a5 \uae30\ubcf8\uc801\uc778 \uc218\uc900\uc5d0\uc11c 0\uc740 \uc0ac\ub78c\uc774 \uc720\uc804\uc790\ub97c \uac00\uc9c0\uace0 \uc788\uc9c0\ub9cc \uadf8 \uc678\uc5d0\ub294 \uc544\ubb34 \ubcc0\ud654\uac00 \uc5c6\uc74c\uc744 \uc758\ubbf8\ud558\uace0, 1\uc740 \ubc14\uc774\uc624\ub9c8\ucee4 \ubcc0\ud654\uac00 \uac10\uc9c0\ub420 \uc218 \uc788\uc74c(\uc608: \ud608\uc561 \ub610\ub294 \ub1cc \uc601\uc0c1), 2\ub294 \uc784\uc0c1 \ud14c\uc2a4\ud2b8\uc5d0\uc11c \uce21\uc815\ub41c \ubcc0\ud654, 3\uc740 HD\uc77c \ub54c\ub97c \uc758\ubbf8\ud569\ub2c8\ub2e4. \uc77c\uc0c1\uc801\uc778 \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uae30 \uc2dc\uc791\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc804\uccb4 \uc784\uc0c1 \ubc0f \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0\uc5d0\uc11c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \ucc99\ub3c4\ub97c \ub9cc\ub4dc\ub294 \uac83\uc740 \uce58\ub8cc\uc640 \uc5f0\uad6c\uac00 \uc77c\uad00\ub418\uace0 \ubaa8\ub4e0 \uc2dc\ud5d8\uc5d0\uc11c \ucd5c\ub300\ud55c \ub9ce\uc740 \uac83\uc744 \ubc30\uc6b8 \uc218 \uc788\ub3c4\ub85d \ud558\ub294 \ub370 \uc911\uc694\ud569\ub2c8\ub2e4. \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0\ub294 \ud604\uc7ac \uc774 \uae30\uc874 \uaddc\ubaa8\ub97c \uc911\uc2ec\uc73c\ub85c \uac15\ub825\ud55c \uc0c8 \ub3c4\uad6c\ub97c \uad6c\ucd95\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud55c \uac00\uc9c0 \uc608\ub294 \uac1c\uc778\uc758 CAG \ubc18\ubcf5 \uc218, \uc5f0\ub839, \ub9ce\uc740 \ud14c\uc2a4\ud2b8 \ubc0f \ub1cc \uc774\ubbf8\uc9c0\uc758 \uacb0\uacfc\ub97c \uace0\ub824\ud558\uc5ec \uac1c\uc778\uc774 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \uc801\ud569\ud55c\uc9c0 \uc5ec\ubd80\ub97c \uacb0\uc815\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\ub294 \ud504\ub85c\uadf8\ub7a8\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n\n

\"Roche\ub294
Roche\ub294 HD\uc6a9 \ub514\uc9c0\ud138 \ubaa8\ub2c8\ud130\ub9c1 \ud50c\ub7ab\ud3fc\uc5d0 \ub300\ud574 \ub17c\uc758\ud588\uc2b5\ub2c8\ub2e4.\n\n<\/figcaption><\/figure>\n\n\n\n\n

\ub1cc \uc774\ubbf8\uc9c0, \uc6b4\ub3d9 \ubc0f \uc0ac\uace0 \ud14c\uc2a4\ud2b8, \uac00\uc815 \ubc0f \uc9c1\uc7a5\uc5d0\uc11c\uc758 \ub2a5\ub825 \ubcc0\ud654, \ud608\uc561 \ubc0f \ucc99\uc218\uc561\uc758 \uc7a0\uc7ac\uc801 \ubcc0\ud654 \ub4f1 \ub9ce\uc740 \uce21\uc815\uce58\ub97c \uacb0\ud569\ud558\uace0 \ubd84\uc11d\ud558\ub294 \uac83\uc740 \uc9c4\ud589 \uc0c1\ud669\uc744 \ucd94\uc801\ud558\uace0 \uc57d\ubb3c\uc5d0 \ub300\ud55c \ubc18\uc751\uc744 \uacb0\uc815\ud558\ub294 \ub9e4\uc6b0 \uac15\ub825\ud55c \ubc29\ubc95\uc785\ub2c8\ub2e4.\nHD\uc758 \ub9ce\uc740 \uce21\uba74\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c 4\ub2e8\uacc4 \ub0b4\uc5d0\ub294 \ub9ce\uc740 \ubcc0\ub3d9\uc774 \uc788\uc744 \uc218 \uc788\uc73c\uba70 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc5f0\ub839, \uc720\uc804\ud559, \ud074\ub9ac\ub2c9 \uac80\uc0ac \uacb0\uacfc \ub4f1\uc744 \uae30\ubc18\uc73c\ub85c \uc774\ub97c \ucd94\uac00\ub85c \uc815\uc758\ud558\ub294 \ubc29\ubc95\uc744 \ubaa8\uc0c9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774\uac83\uc740 \uc784\uc0c1 \uc810\uc218\ub97c \uc0ac\uc6a9\ud558\ub294 \ud604\uc7ac \ubc29\ubc95\ubcf4\ub2e4 \uc2dc\ud5d8\uc5d0 \uc801\ud569\ud55c \uc0ac\ub78c\uc744 \ubaa8\uc9d1\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\ub294 \ud6e8\uc52c \ub354 \uc138\ub828\ub41c \ubc29\ubc95\uc785\ub2c8\ub2e4(CAP \ub610\ub294 PIN\uc5d0 \ub300\ud574 \ub4e4\uc5b4\ubcf8 \uc801\uc774 \uc788\uc744 \uc218 \uc788\uc74c). HD \uc5f0\uad6c \ubd84\uc57c\uc758 \ub9ce\uc740 \ucc38\uac00\uc790\ub4e4\uc774 \ucc38\uc11d\ud558\uae30 \ub54c\ubb38\uc5d0 \uc774 \ud68c\uc758\ub294 \uc774\uc640 \uac19\uc740 \uc0c8\ub85c\uc6b4 \ub3c4\uad6c\ub97c \ubc1c\ud45c\ud558\uae30\uc5d0 \uc88b\uc740 \uc7a5\uc18c\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ud587\uc0b4 \uac00\ub4dd\ud55c \uce98\ub9ac\ud3ec\ub2c8\uc544\uc5d0\uc11c \uc810\uc2ec \uc2dc\uac04\uc785\ub2c8\ub2e4. \ub2e4\uc591\ud55c HD \uc784\uc0c1 \uc2dc\ud5d8\uc758 \ud765\ubbf8\ub85c\uc6b4 \uc5c5\ub370\uc774\ud2b8\ub97c \uacf5\uc720\ud558\uae30 \uc704\ud574 \ud734\uc2dd \ud6c4 \ub2e4\uc2dc \ub3cc\uc544\uc624\uaca0\uc2b5\ub2c8\ub2e4. \uace7 \ub2e4\uc2dc \uc870\uc815\ud558\uc2ed\uc2dc\uc624!<\/p>\n\n\n\n\n

\uc784\uc0c1 \ubc0f \uc778\uccb4 \ub370\uc774\ud130<\/h2>\n\n\n\n\n

\ucee8\ud37c\ub7f0\uc2a4\uc758 \ub9c8\uc9c0\ub9c9 \uc138\uc158\uc73c\ub85c \ub3cc\uc544\uc654\uc2b5\ub2c8\ub2e4! \ucd5c\uadfc \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd98 \ud765\ubbf8\ub85c\uc6b4 \uc774\uc57c\uae30\ub97c \ub098\ub204\uaca0\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uba3c\uc800 \uc774 \uc784\uc0c1 \uc138\uc158\uc744 \uc18c\uac1c\ud560 \ud1a0\ub860\ud1a0 \ub300\ud559\uc758 Dr. Jamie Hamilton\uacfc Dr. Mark Guttman\uc785\ub2c8\ub2e4. Guttman \ubc15\uc0ac\ub294 \uc9c0\ub09c \uba87 \ub144 \ub3d9\uc548 HD \ucee4\ubba4\ub2c8\ud2f0\uc758 \ud68c\ubcf5\ub825\uacfc \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uacc4\uc18d \ubc1c\uacac\ub418\uae30\ub97c \ud76c\ub9dd\ud558\uace0 \uc788\uc74c\uc744 \uc778\uc815\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc8fc\ubaa9\ubc1b\ub294 \ud1a0\ubbf8\ub124\ub974\uc13c<\/h3>\n\n\n\n\n

\uc624\ub298 \uc624\ud6c4 \uccab \ubc88\uc9f8 \uac15\uc5f0\uc740 \ub85c\uc288\uc758 Peter McColgan \ubc15\uc0ac\uc640 Lauren Boak \ubc15\uc0ac\uc758 \uac15\uc5f0\uc785\ub2c8\ub2e4. \uadf8\ub4e4\uc740 Phase III GENERATION HD1 \uc5f0\uad6c\uc5d0\uc11c \uc870\uc0ac \uc911\uc778 \ud5cc\ud305\ud2f4 \uc800\ud558 \uc57d\ubb3c\uc778 tominersen\uc5d0 \ub300\ud55c \uc5c5\ub370\uc774\ud2b8\ub97c \uc81c\uacf5\ud560 \uac83\uc785\ub2c8\ub2e4. Lauren\uc774 \uc77c\uc744 \uc2dc\uc791\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ub9c1\ud06c\ub97c \ud1b5\ud574 Roche \ud504\ub808\uc820\ud14c\uc774\uc158\uc758 \uc2ac\ub77c\uc774\ub4dc\ub97c \uacf5\uc720\ud588\uc2b5\ub2c8\ub2e4. \ub530\ub77c\ud558\uac70\ub098 \ub098\uc911\uc5d0 \ubcf4\ub824\uba74 \ub2e4\uc74c \ub9c1\ud06c\ub97c \ucc38\uc870\ud558\uc138\uc694. https:\/\/bit.ly\/3sH1faG<\/a><\/p>\n\n\n\n\n

\ub85c\uc288\uc5d0\ub294 \ud5cc\ud305\ud2f4 \uc218\uce58\ub97c \ub0ae\ucd94\uae30 \uc704\ud55c \uba87 \uac00\uc9c0 \uc811\uadfc \ubc29\uc2dd\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \ud1a0\ubbf8\ub108\uc13c\uc744 \uc0ac\uc6a9\ud558\uc5ec \ucd1d \ud5cc\ud305\ud2f4\uc744 \ub0ae\ucd94\ub294 \uac83\ubfd0\ub9cc \uc544\ub2c8\ub77c \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4 \uce74\ud53c \ubc0f \ud0d0\uc0c9 \uc911\uc778 \uae30\ud0c0 \ub3c4\uad6c\uc758 \uc218\uc900\uc744 \uad6c\uccb4\uc801\uc73c\ub85c \uc904\uc774\ub294 \ud504\ub85c\uadf8\ub7a8\ub3c4 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. Roche\uac00 HD\uc5d0 \uc804\ub150\ud558\uace0 \uc788\ub2e4\ub294 \uc18c\uc2dd\uc740 \uace0\ubb34\uc801\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc624\ub298 Lauren\uc740 tominersen \ud504\ub85c\uadf8\ub7a8\uc73c\ub85c GENERATION-HD1\uc5d0\uc11c \ubc30\uc6b4 \uac83\uc5d0 \uc9d1\uc911\ud560 \uac83\uc785\ub2c8\ub2e4. \uc774 \uc2dc\ud5d8\uc758 \ub370\uc774\ud130\uc5d0 \ub300\ud55c \ucd5c\uc885 \ubd84\uc11d\uc774 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc2e4\uc81c\ub85c Roche\uac00 \ub370\uc774\ud130 \ubd84\uc11d\uc774 \uc544\uc9c1 \uc644\ub8cc\ub418\uc9c0 \uc54a\uc740 3\uac00\uc9c0 \ub2e4\ub978 \uc2dc\ud5d8(\uc790\uc5f0\uc0ac \uc5f0\uad6c, GEN-PEAK \uc5f0\uad6c \ubc0f GENERATION HD1)\uc774 \uc218\ud589\ub418\uace0 \uc788\uc9c0\ub9cc \uc624\ub298\uc740 \uc911\ub2e8\ub41c 3\uc0c1 GENERATION HD1 \uc5f0\uad6c\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd9c \uac83\uc785\ub2c8\ub2e4. Lauren\uc740 \uc774\uc81c \uc2e4\ud5d8\uc5d0 \uc815\ubcf4\ub97c \uc81c\uacf5\ud55c \ub3d9\ubb3c \ubaa8\ub378\uc758 \ub370\uc774\ud130\ub97c \uc694\uc57d\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub4e4\uc740 GENERATION HD1 \uc5f0\uad6c\uc5d0\uc11c \ud1a0\ubbf8\ub108\uc13c\uc758 \uc6a9\ub7c9\uc744 \uacb0\uc815\ud558\ub294 \ub370 \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Roche\ub294 \ud5cc\ud305\ud2f4\uc744 25-45%\uae4c\uc9c0 \ub0ae\ucd9c \uac83\uc774\ub77c\uace0 \uc608\uce21\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774\uc81c Peter\ub294 GENERATION-HD1\uc758 \ub370\uc774\ud130\uc5d0 \ub300\ud574 \uc9c0\uae08\uae4c\uc9c0 \uc218\ud589\ud55c \ubd84\uc11d\uc5d0 \ub300\ud574 \uc54c\ub824\uc904 \uac83\uc785\ub2c8\ub2e4. \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4 \uc218\uce58\ub294 \uc608\uc0c1\ub300\ub85c 8\uc8fc \ubc0f 16\uc8fc \uadf8\ub8f9 \ubaa8\ub450\uc5d0\uc11c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 tominersen\uc774 \ubaa9\ud45c\ubb3c\uacfc \uad50\uc804\ud588\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ucc38\uac00\uc790\uc758 \uc804\ubc18\uc801\uc778 \uc0c1\ud0dc\ub97c \uce21\uc815\ud558\ub294 \ud2b9\uc815 \uc810\uc218\ub97c \ubcf4\uc558\uc744 \ub54c \ud1a0\ubbf8\ub108\uc13c\uc73c\ub85c \uce58\ub8cc\ubc1b\uc740 \uc0ac\ub78c\ub4e4\uc740 \ud2b9\ud788 8\uc8fc\ub9c8\ub2e4 \uce58\ub8cc\ub97c \ubc1b\uc558\uc744 \ub54c \uc704\uc57d\uc73c\ub85c \uce58\ub8cc\ubc1b\uc740 \uc0ac\ub78c\ub4e4\ubcf4\ub2e4 \ub354 \ub098\uc05c \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Peter\ub294 \ub2e4\ub978 \uc57d\ubb3c \uadf8\ub8f9\uc758 \ud658\uc790\uc5d0 \ub300\ud55c \uc804\uccb4 \uc810\uc218\uc640 \ud568\uaed8 \uc6b0\ub9ac\uac00 \ubcf4\ub294 \ucd94\uc138\uc5d0 \ub9de\uac8c \uc57d\ubb3c\uc744 \ub354 \uc790\uc8fc \ubcf5\uc6a9\ud55c \uc0ac\ub78c\ub4e4\uc5d0\uac8c \ub354 \ub9ce\uc740 \uc720\ud574 \uc0ac\ub840(\ubd80\uc791\uc6a9)\uac00 \ub098\ud0c0\ub0ac\uc74c\uc744 \uacf5\uc720\ud569\ub2c8\ub2e4. \uc774\uc804 \uc138\uc158\uc5d0\uc11c\ub294 HD\uc6a9 \ubc14\uc774\uc624\ub9c8\ucee4\uc5d0 \ub300\ud574 \ub9ce\uc740 \uac83\uc744 \ubc30\uc6e0\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\uac00 \uc54c\uac8c \ub41c \ud55c \uac00\uc9c0 \ubc14\uc774\uc624\ub9c8\ucee4\ub294 NfL\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc608\uae30\uce58 \uc54a\uac8c Roche\ub294 NfL \uc218\uce58\uac00 tominersen \ud22c\uc5ec \ud6c4 \uc62c\ub77c\uac14\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \uc774\uac83\uc774 \uc65c \uadf8\ub7f0\uc9c0 \uc544\uc9c1 \ud655\uc2e4\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Tominersen\uc740 \ud5cc\ud305\ud2f4 \uc218\uce58\ub97c \ub0ae\ucdc4\uc9c0\ub9cc \uc784\uc0c1\uc2dc\ud5d8\uc740 \uc885\ub8cc\uc810\uc5d0 \ub3c4\ub2ec\ud558\uc9c0 \ubabb\ud588\uace0 \ud658\uc790\uc758 \uc99d\uc0c1\uc744 \uac1c\uc120\ud558\uc9c0 \ubabb\ud588\uc2b5\ub2c8\ub2e4. \uacfc\ud559\uc790\ub4e4\uc740 \uc774\uc81c \uadf8 \uc774\uc720\ub97c \uc774\ud574\ud558\uae30 \uc704\ud574 \uc5f4\uc2ec\ud788 \ub178\ub825\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub85c\uc288\ub294 \ud1a0\ubbf8\ub108\uc13c \ubcf5\uc6a9\uc744 \uc911\ub2e8\ud55c \ud658\uc790\ub4e4\ub85c\ubd80\ud130 \uc218\uc9d1\ub41c \ub370\uc774\ud130\ub97c \uc870\uc0ac\ud574 \uc654\ub2e4. \ud658\uc790\uc758 84%\ub294 \ud22c\uc5ec\uac00 \uc911\ub2e8\ub41c \ud6c4\uc5d0\ub3c4 \uc2dc\ud5d8\uc5d0 \ub0a8\uc544 \uc788\uc5b4 \ub85c\uc288 \uacfc\ud559\uc790\ub4e4\uc774 \ubb34\uc2a8 \uc77c\uc774 \uc77c\uc5b4\ub0ac\ub294\uc9c0 \uc54c\uc544\ub0b4\ub294\ub370 \ub9e4\uc6b0 \ub3c4\uc6c0\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4.\n\ud22c\uc5ec \uc911\ub2e8 \ud6c4 \uc2dc\ud5d8\uc5d0 \uba38\ubb3c\ub800\ub358 \ud658\uc790\uc758 \uc218\ub294 HD \ud658\uc790\uc5d0 \ub300\ud55c \uc9c4\uc815\ud55c \uc99d\uac70\uc785\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 HD \ucee4\ubba4\ub2c8\ud2f0\uac00 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud558\uace0 \uce58\ub8cc\ubc95\uc744 \ucc3e\ub294 \ub370 \uae30\uc5ec\ud558\ub294 \ub370 \uc5f4\uc815\uc801\uc774\ub77c\ub294 \uac83\uc774 \ubd84\uba85\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub1cc \uad6c\uc870\uc758 \ubcc0\ud654\ub294 \uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud55c \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub418\uc5c8\uc73c\uba70 \uc57d\ubb3c\uc744 \ub354 \uc790\uc8fc \ubcf5\uc6a9\ud55c \ud658\uc790\uc5d0\uac8c\uc11c \ub354 \ud070 \ubcc0\ud654\uac00 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. Peter\ub294 \ud22c\uc5ec\ub97c \uc911\ub2e8\ud55c \ud6c4 \ub1cc \uad6c\uc870\uac00 \uc5b4\ub290 \uc815\ub3c4 \ud68c\ubcf5\ub420 \uc218 \uc788\ub2e4\uace0 \uc81c\uc548\ud588\uc9c0\ub9cc \uc774 \ub370\uc774\ud130\uc5d0 \ub300\ud55c \ubd84\uc11d\uc740 \uacc4\uc18d \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4. Roche \uacfc\ud559\uc790\ub4e4\uc740 HD\uc758 \ub2e4\uc591\ud55c \uc9d5\ud6c4\uc640 \uc99d\uc0c1\uc744 \uad00\ucc30\ud558\ub294 UHDRS\ub77c\ub294 \uc77c\ubc18\uc801\uc778 \uc784\uc0c1 \uce21\uc815\uc744 \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \ud22c\uc5ec\ub97c \uc911\ub2e8\ud55c \ud6c4 \uc774 \uc810\uc218\ub97c \ubcf4\uba74 \uc2dc\ud5d8\uc5d0\uc11c \uc57d\ubb3c\uc744 \ubc1b\uc740 \uc0ac\ub78c\uacfc \ubc1b\uc9c0 \uc54a\uc740 \uc0ac\ub78c \uc0ac\uc774\uc5d0 \uc720\uc758\ubbf8\ud55c \ucc28\uc774\uac00 \ubcf4\uc774\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc9d1\uacfc \uc9c1\uc7a5\uc5d0\uc11c\uc758 \ud65c\ub3d9\uc5d0\uc11c \uc77c\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \uce21\uc815\ud558\ub294 \ucd1d \uae30\ub2a5 \ub2a5\ub825\uc774\ub77c\uace0 \ud558\ub294 \ub2e4\ub978 \uc784\uc0c1 \uce21\uc815\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \ud328\ud134\uc744 \ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud22c\uc5ec \uc911\ub2e8 \ud6c4 \ud658\uc790 \uac04\uc5d0 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud55c \ucc28\uc774\ub294 \uc5c6\uc5c8\ub2e4. Roche\ub294 \uc2e4\ud5d8\uc5d0 \ucc38\uc5ec\ud55c \uc0ac\ub78c\ub4e4\uc744 \uadf8\ub8f9\uc73c\ub85c \ub098\ub204\uc5b4 \uc99d\uc0c1\uc758 \uc911\uc99d\ub3c4\uac00 \uc57d\ubb3c\uc5d0 \ub300\ud55c \ubc18\uc751\uc5d0 \uc601\ud5a5\uc744 \ubbf8\ucce4\ub294\uc9c0 \ud655\uc778\ud558\uace0\uc790 \ud588\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 \uc0ac\ud6c4 \ubd84\uc11d\uc73c\ub85c \uc54c\ub824\uc9c4 \uc2dc\ub3c4\uac00 \uc124\uacc4\ub41c \ud6c4\uc5d0 \uc218\ud589\ub418\uc5c8\uc73c\ubbc0\ub85c \ubaa8\ub4e0 \uacb0\uacfc\ub294 \uc57d\uac04\uc758 \uc18c\uae08\uc73c\ub85c \ucde8\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc6b0\ub9ac\uac00 \uc774\uc804\uc5d0 \uc37c\ub4ef\uc774 Roche\ub294 HD\uc758 \uc99d\uc0c1\uc774 \ub35c \uc9c4\ud589\ub41c \uc80a\uc740 \ucc38\uac00\uc790\uac00 \ub354 \ub098\uc774\uac00 \ub9ce\uc740 \ucc38\uac00\uc790\ubcf4\ub2e4 \uc2dc\ud5d8\uc5d0\uc11c \ub354 \uc798\ud588\uc744 \uc218 \uc788\ub2e4\uace0 \uc0dd\uac01\ud569\ub2c8\ub2e4. https:\/\/en.hdbuzz.net\/316<\/a><\/p>\n\n\n\n\n

\ud558\uc9c0\ub9cc! \uc774\uac83\uc740 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ubbf8\ud55c \ubc1c\uacac\uc774 \uc544\ub2c8\uba70 \ud574\ub2f9 \ubd84\uc57c\uc758 \uacfc\ud559\uc790\ub4e4 \uc0ac\uc774\uc5d0\uc11c \uc5f4\ub764 \ud1a0\ub860\uc758 \uc8fc\uc81c\uc785\ub2c8\ub2e4. Roche\ub294 \uc57d\ubb3c\uc774 \ud558\uc704 \uadf8\ub8f9\uc758 \ud658\uc790\uc5d0\uac8c \uc720\uc775\ud55c\uc9c0 \uc54c\uc544\ubcf4\uae30 \uc704\ud574 \ub2e4\uc591\ud55c \ubc29\ubc95\uc73c\ub85c \ub370\uc774\ud130\ub97c \ucabc\uac1c\uace0 \ucabc\uac1c\uc5c8\uc2b5\ub2c8\ub2e4. \ub610 \ub2e4\ub978 \uc694\uc778\uc740 \ucc99\uc218\uc561\uc5d0\uc11c \uc57d\ubb3c\uc744 \uce21\uc815\ud558\uc5ec \ud658\uc790\uac00 \uc5bc\ub9c8\ub098 \ub9ce\uc740 \uc57d\ubb3c\uc5d0 \ub178\ucd9c\ub418\uc5c8\ub294\uc9c0\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Peter\ub294 \ud604\uc7ac \uc2e4\ud5d8\uc5d0 \ucc38\uc5ec\ud55c \uc0ac\ub78c\ub4e4\uc774 \uc57d\ubb3c\uc5d0 \ub35c \ub178\ucd9c\ub418\uc5c8\uc744 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud558\ub294 \ub370\uc774\ud130\ub97c \uacf5\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. HD\uc5d0 \ub300\ud55c \uc758\uc57d\ud488\uc744 \ub9cc\ub4dc\ub294 \uc77c\uc744 \ud558\ub294 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc740 \uc5b4\ub5a4 \uc720\ud615\uc758 \uc57d\ubb3c, \ud22c\uc57d \ubc0f \uc804\ub2ec\uc774 \uac00\uc7a5 \ud6a8\uacfc\uc801\uc778\uc9c0 \ud3ec\ud568\ud558\uc5ec \ud5a5\ud6c4 \uc784\uc0c1 \uc2dc\ud5d8 \uc124\uacc4\uc5d0 \ub3c4\uc6c0\uc774 \ub418\ub294 \uc774 \uc2dc\ud5d8\uc744 \ud1b5\ud574 \ubc30\uc6b8 \uac83\uc785\ub2c8\ub2e4. \ub370\uc774\ud130\ub294 \ub35c \uc9c4\ud589\ub41c HD \ud658\uc790\uac00 \ud5cc\ud305\ud2f4\uc744 \ub0ae\ucd94\ub294 \ub370 \ub354 \ub098\uc740 \ud6c4\ubcf4\uac00 \ub420 \uc218 \uc788\uc73c\uba70 \ub354 \ub0ae\uc740 \uc57d\ubb3c \uc6a9\ub7c9\uc774 \ub354 \uc720\uc775\ud560 \uc218 \uc788\uc74c\uc744 \ub098\ud0c0\ub0b4\ub294 \uac83 \uac19\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 \ub354 \ub9ce\uc740 \uc778\uad6c\ub97c \ub3c4\uc6b8 \uc218 \uc5c6\ub2e4\ub294 \uac83\uc744 \uc758\ubbf8\ud558\uc9c0\ub294 \uc54a\uc9c0\ub9cc \ub2e4\uc74c \uc2dc\ub3c4\ub97c \uc124\uacc4\ud558\ub294 \ub370 \uc720\uc6a9\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc0c8\ub85c\uc6b4 II\uc0c1 \uc5f0\uad6c\uc5d0\uc11c Roche\ub294 \uc99d\uc0c1\uc774 \ub35c \uc9c4\ud589\ub41c \uc80a\uc740 HD \ud658\uc790\ub97c \ub4f1\ub85d\ud558\uace0 2\uac1c\uc758 \uc0c8\ub85c\uc6b4 \uc6a9\ub7c9\uc744 \uc0ac\uc6a9\ud560 \uacc4\ud68d\uc785\ub2c8\ub2e4. \uc774\ub4e4\uc740 \ud68c\ub2f4\uc5d0\uc11c \uacf5\uac1c\ub418\uc9c0 \uc54a\uc558\uc9c0\ub9cc GENERATION-HD1 \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ub41c \uc6a9\ub7c9\ubcf4\ub2e4 \ub0ae\uc744 \uac83\uc785\ub2c8\ub2e4. Peter\ub294 \uc774\uc81c \uc774 \uc80a\uc740 \uc9d1\ub2e8\uc774 \uc774\uc804\uc5d0 Tabrizi \uad50\uc218\uc758 \uac15\uc5f0\uc5d0\uc11c \uc124\uba85\ud55c \uc0c8\ub85c\uc6b4 HD-ISS \uc2a4\ud14c\uc774\uc9d5\uc5d0 \uc5b4\ub5bb\uac8c \ubd80\ud569\ud558\ub294\uc9c0 \uc124\uba85\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc0c8\ub85c\uc6b4 \uc2dc\uc2a4\ud15c\uc740 \ud1a0\ubbf8\ub124\ub974\uc13c\uacfc \uac19\uc740 \ud5cc\ud305\ud2f4 \uc800\ud558 \uc57d\ubb3c\uc758 \ud61c\ud0dd\uc744 \ubc1b\uc744 \uc218 \uc788\ub294 \uc0ac\ub78c\ub4e4\uc744 \uc815\ud655\ud788 \uc815\uc758\ud558\ub294 \ub370 \uc911\uc694\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Q&A\ub294 \uc0dd\uc0dd\ud558\uace0 \uae30\uc220\uc801\uc785\ub2c8\ub2e4! \uc7a0\uc7ac\uc801\uc778 2\uc0c1 \uc2dc\ud5d8\uc5d0 \ub300\ud55c \uc138\ubd80 \uc0ac\ud56d\uc740 \uc544\uc9c1 \uacf5\uc720\ub418\uc9c0 \uc54a\uc558\uc9c0\ub9cc \ub2e4\uc2dc \ud55c \ubc88 \ubbf8\ub798 \ucc38\uac00\uc790\uc640 \uadf8 \uac00\uc871\uc758 \ud798\uacfc \uc5f4\uc815\uc5d0 \uc758\uc874\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Q&A\ub294 \uc0dd\uc0dd\ud558\uace0 \uae30\uc220\uc801\uc785\ub2c8\ub2e4! \uc7a0\uc7ac\uc801\uc778 2\uc0c1 \uc2dc\ud5d8\uc5d0 \ub300\ud55c \uc138\ubd80 \uc0ac\ud56d\uc740 \uc544\uc9c1 \uacf5\uc720\ub418\uc9c0 \uc54a\uc558\uc9c0\ub9cc \ub2e4\uc2dc \ud55c \ubc88 \ubbf8\ub798 \ucc38\uac00\uc790\uc640 \uadf8 \uac00\uc871\uc758 \ud798\uacfc \uc5f4\uc815\uc5d0 \uc758\uc874\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ucd08\uae30 HD\ub97c \uc704\ud55c \uc720\uc804\uc790 \uce58\ub8cc<\/h3>\n\n\n\n\n

\ub2e4\uc74c\uc740 \ucd08\uae30 \uce58\ub8cc\ub97c \uc704\ud574 \ud14c\uc2a4\ud2b8 \uc911\uc778 AMT-130\uc774\ub77c\ub294 \uc6d0\uc0f7 \uc57d\ubb3c\uc5d0 \ub300\ud55c \uc720\uc804\uc790 \uc694\ubc95 \uc2dc\ud5d8\uc778 HD-GeneTRX-1 \ubc0f HD-GeneTRX-2\uc5d0 \ub300\ud55c \uc5c5\ub370\uc774\ud2b8\ub97c \uc81c\uacf5\ud560 uniQure\uc758 \uc2e0\uacbd\uc678\uacfc \uc758\uc0ac David Cooper \ubc15\uc0ac\uc785\ub2c8\ub2e4. \uc2a4\ud14c\uc774\uc9c0 HD. Cooper \ubc15\uc0ac\ub294 \uc774 \uc57d\ubb3c\uc758 \uad6c\uc870\ub97c \uc124\uba85\ud569\ub2c8\ub2e4. \uc989, \ud5cc\ud2f0\uadf8\ud2f4 \uc720\uc804\uc790\uac00 \uc8fc\uc785\ub418\ub294 \uc601\uc5ed\uc73c\ub85c \uac10\uc18c\ud558\ub294 RNA \uc138\ud2b8\ub97c \ub9cc\ub4dc\ub294 \uc9c0\uce68\uc73c\ub85c \ucc44\uc6cc\uc9c4 \ubb34\ud574\ud55c \ubc14\uc774\ub7ec\uc2a4 \uc785\uc790\uc785\ub2c8\ub2e4. \uc774 \uacbd\uc6b0 \uae4a\uc740 \ub1cc \uad6c\uc870.<\/p>\n\n\n\n\n

UniQure\ub294 \uc811\uc2dc \uc548\uc758 \uc138\ud3ec, \uc6d0\uc22d\uc774 \ubc0f \ub3fc\uc9c0\ub97c \ud3ec\ud568\ud558\uc5ec \ub2e4\uc591\ud55c HD \ubaa8\ub378 \ubc94\uc704\uc5d0\uc11c \uc57d\ubb3c\uc5d0 \ub300\ud55c \ub9ce\uc740 \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub294 HD \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud604\uc7ac \uc9c4\ud589 \uc911\uc778 \uc5f0\uad6c\uc5d0 \uc815\ubcf4\ub97c \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. HD\uc5d0\uc11c \uac00\uc7a5 \ud070 \uc601\ud5a5\uc744 \ubc1b\ub294 \ub1cc\uc758 \uae4a\uc740 \ubd80\ubd84\uc778 “\uc120\uc870\uccb4"\ub294 \ub3c4\ub2ec\ud558\uae30 \uc5b4\ub835\uace0 uniQure\uc758 \ubc14\uc774\ub7ec\uc2a4 \uc785\uc790\ub97c \uc8fc\uc785\ud558\uae30 \uc5b4\ub835\uc2b5\ub2c8\ub2e4. \uc218\uc2ed \ub144\uc5d0 \uac78\uce5c \uc791\uc5c5\uc744 \ud1b5\ud574 \ub1cc \uad6c\uc870\ub97c \uc8fc\uc785\ud558\uc5ec \uc57d\ubb3c\ub85c \uce58\ub8cc\ud560 \uc218 \uc788\ub294 \uc591\uc744 \ucd5c\ub300\ud654\ud558\ub294 \uc808\ucc28\uac00 \ub9cc\ub4e4\uc5b4\uc84c\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

AMT-130\uc740 \ub2e8\ubc31\uc9c8\uc758 \uc815\uc0c1 \ubc0f \ud655\uc7a5\ub41c \ud615\ud0dc\uc778 \ucd1d \ud5cc\ud305\ud2f4\uc744 \ub0ae\ucda5\ub2c8\ub2e4. uniQure\uc758 \ubaa9\ud45c\ub294 \ud5cc\ud305\ud2f4\uc744 100% \uc904\uc774\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \ud55c \ubc88\uc758 \uc8fc\uc0ac\ub85c \ud3c9\uc0dd \ub3d9\uc548 \ud604\uc800\ud788 \ub0ae\uc740 \uc218\uce58\ub97c \uc904\uc774\ub294 \uac83\uc785\ub2c8\ub2e4. \uc720\ub7fd\uacfc \ubbf8\uad6d\uc5d0\uc11c \uac01\uac01 15\uba85\uacfc 26\uba85\uc758 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \ub450 \uac1c\uc758 \uc5f0\uad6c\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc800\uc6a9\ub7c9, \uace0\uc6a9\ub7c9 \ub610\ub294 \uc704\uc57d \ud658\uc790\uac00 \uc788\uc744 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub450 \uc5f0\uad6c\uc758 \uc8fc\uc694 \ubaa9\uc801\uc740 \uce58\ub8cc\uac00 \uc548\uc804\ud558\uace0 \ub0b4\uc57d\uc131\uc774 \uc788\ub294\uc9c0 \ud655\uc778\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \ucd94\uac00 \ubaa9\ud45c\uc5d0\ub294 \ub9c8\uc6b0\uc2a4 \uc791\uc5c5\uc744 \ud1b5\ud574 \uc608\uce21\ud55c \ub300\ub85c \ub2e8\uc77c \uc8fc\uc0ac \ud6c4\uc5d0\ub3c4 \uce58\ub8cc\uac00 \uba87 \ub144 \ub3d9\uc548 \uc9c0\uc18d\ub418\ub294\uc9c0 \uc774\ud574\ud558\ub824\ub294 \uc2dc\ub3c4\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4.\n\ub9ce\uc740 \uc2dc\ud5d8\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud560 \uc218 \uc788\ub294 \uc0ac\ub78c\uc5d0 \uc81c\ud55c\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \ucc38\uac00\uc790\ub294 \ub9c8\ucde8\ub97c \ub2e4\ub8f0 \uc218 \uc788\uc5b4\uc57c \ud569\ub2c8\ub2e4. \uc9c4\ud589\uc911\uc778 \uc804\uc5fc\ubcd1\uc744 \uac10\uc548\ud560 \ub54c \uc774\uac83\uc740 \uc0ac\ub78c\ub4e4\uc774 COVID \uac10\uc5fc\ubcf4\ub2e4 8-12\uc8fc\uac00 \uc9c0\ub098\uc57c \ud55c\ub2e4\ub294 \uac83\uc744 \uc758\ubbf8\ud558\ubbc0\ub85c omicron\uc740 \uc0c1\ud669\uc744 \ub354 \uae4c\ub2e4\ub86d\uac8c \ub9cc\ub4e4\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n\n

\"PTC-518
PTC-518 \ubc0f Branaplam\uc740 \uacbd\uad6c\uc6a9 HTT \uc800\ud558\uc81c\uc785\ub2c8\ub2e4.\n\n
Image credit: Maxx Studio<\/a><\/span><\/figcaption><\/figure>\n\n\n\n\n

\ud604\uc7ac \ubaa9\ud45c\ub294 HD\uc758 \ube44\uad50\uc801 \ucd08\uae30 \ub2e8\uacc4\uc5d0 \uc788\ub294 \uc0ac\ub78c\ub4e4\uacfc \uc57d\ubb3c\uc744 \uc548\uc804\ud558\uac8c \uc8fc\uc0ac\ud560 \uc218 \uc788\uc744 \uc815\ub3c4\ub85c \uae4a\uc740 \ub1cc \uc601\uc5ed\uc774 \ubcf4\uc874\ub41c \uc0ac\ub78c\ub4e4\uc744 \ud3ec\ud568\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\uac83\uc740 HD\uc5d0 \ub300\ud55c \ucd5c\ucd08\uc758 \uc720\uc804\uc790 \uc694\ubc95\uc774\uba70 uniQure\uac00 \uacc4\ud68d\ud55c \ub9cc\ud07c \ub9ce\uc740 \ub1cc \uc8fc\uc0ac\ub97c \ud55c \uc0ac\ub78c\uc740 \ucc98\uc74c\uc785\ub2c8\ub2e4 – 6! \uc774\uac83\uc740 \uadf8\ub4e4\uc5d0\uac8c \ub2e8\uc77c \uc218\uc220 \uc808\ucc28\ub85c \uc804\uccb4 \uc120\uc870\uccb4\ub97c \ub36e\uc744 \uc218 \uc788\ub294 \uac00\uc7a5 \uc88b\uc740 \uae30\ud68c\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uac01 \uc218\uc220\uc740 \uacc4\ud68d\ub41c \uc218\uc220\uc774 \uc548\uc804\ud560 \uac83\uc774\ub77c\ub294 \ub370 \ubaa8\ub450 \ub3d9\uc758\ud574\uc57c \ud558\ub294 \uc2e0\uacbd\uc678\uacfc \ud300\uc5d0 \uc758\ud574 \uac80\ud1a0\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub450 \uac1c\uc758 \ub1cc\ub294 \uc815\ud655\ud788 \ub3d9\uc77c\ud558\uc9c0 \uc54a\uc73c\ubbc0\ub85c \uc218\uc220 \uc804\uc5d0 \uac01 \ud658\uc790\uc758 \ub1cc \uc2a4\uce94\uc744 \uc8fc\uc758 \uae4a\uac8c \ubd84\uc11d\ud574\uc57c \ud569\ub2c8\ub2e4.\nAMT-130\uacfc \ud568\uaed8 \ubb34\ud574\ud55c \uc870\uc601\uc81c\ub97c \uc8fc\uc785\ud558\uc5ec \uc8fc\uc785\ub41c \ubb3c\uc9c8\uc774 \uc5b4\ub514\ub85c \ud37c\uc9c0\ub294\uc9c0 \uc815\ud655\ud788 \uc54c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc678\uacfc\uc758\ub294 \uc804\uccb4 \ud45c\uc801 \uc601\uc5ed\uc5d0 \uc57d\ubb3c\uc758 \uc131\uacf5\uc801\uc778 \uc804\ub2ec\uc744 \ud655\uc778\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uce58\ub8cc\ub97c \ubc1b\uc740 \ucc98\uc74c 4\uba85\uc758 \ud658\uc790\ub294 \ubaa8\ub450 \uc2ec\uac01\ud55c \ud569\ubcd1\uc99d \uc5c6\uc774 \ub2e4\uc74c \ub0a0 \ud1f4\uc6d0\ud588\uc2b5\ub2c8\ub2e4. \uc720\uc0ac\ud558\uac8c, \ud658\uc790\uac00 AMT-130\uc73c\ub85c \uce58\ub8cc\ub97c \ubc1b\uc740 \ud6c4 \uccab \ud574 \ub3d9\uc548 \ub1cc \uc601\uc0c1\uc5d0\uc11c \ub098\uc05c \ubcc0\ud654\uac00 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ub300\uc720\ud589\uc73c\ub85c \uc778\ud55c \uc5b4\ub824\uc6c0\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ubbf8\uad6d \ucf54\ud638\ud2b8\ub294 \uac70\uc758 \uc644\uc804\ud788 \uce58\ub8cc\ub418\uc5c8\uc73c\uba70 \uc720\ub7fd\uc5d0\uc11c \ucc98\uc74c \uba87 \uba85\uc758 \ud658\uc790\uac00 \uce58\ub8cc\ub97c \ubc1b\uc558\uc2b5\ub2c8\ub2e4. UniQure\ub294 \uc774\uc81c AMT-130\uc744 \ub1cc\uc5d0 \uc8fc\uc785\ud558\ub294 \ub370 \ud544\uc694\ud55c \uc218\uc220 \uc808\ucc28\ub97c \ubbf8\uc138 \uc870\uc815\ud558\uc5ec \ub9e4 \uc218\uc220\ub9c8\ub2e4 \uc57d\ubb3c\uc774 \uc62c\ubc14\ub978 \ubd80\uc704\uc5d0 \uc804\ub2ec\ub418\uace0 \uc218\uc220\uc774 \uc218\ud589\ub418\ub294 \ub370 \ub108\ubb34 \uc624\ub798 \uac78\ub9ac\uc9c0 \uc54a\ub3c4\ub85d \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.\n\uadf8\ub4e4\uc774 \uc218\uc220 \uc808\ucc28\uc5d0 \ub300\ud574 \ubc30\uc6b4 \uac83\uc740 \uac00\uae4c\uc6b4 \uc7a5\ub798\uc5d0 \ubbf8\uad6d\uc5d0\uc11c \uacc4\ud68d\ub41c 3\ucc28 \uc2dc\ud5d8 \uadf8\ub8f9(\ucf54\ud638\ud2b8)\uc5d0 \uc815\ubcf4\ub97c \uc81c\uacf5\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ucee8\ud37c\ub7f0\uc2a4\uc758 \ub9c8\uc9c0\ub9c9 \uc774\uc57c\uae30\ub85c \ub4e4\uc5b4\uac00\uae30 \uc804\uc5d0 \uc7a0\uc2dc \ud734\uc2dd\uc744 \ucde8\ud558\uace0 \ud604\uc7ac \uc9c4\ud589 \uc911\uc778 \ub2e4\ub978 \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uc5c5\ub370\uc774\ud2b8\ub97c \ub2e4\ub8f9\ub2c8\ub2e4.<\/p>\n\n\n\n\n

SELECT-HD\ub85c \uc774\uc5b4\uc9c4 \ud601\uc2e0<\/h3>\n\n\n\n\n

\ud734\uc2dd \ud6c4 \uccab \ubc88\uc9f8\ub294 Wave Life Sciences\uc758 Dr. Michael A Panzara\uc785\ub2c8\ub2e4. Panzara \ubc15\uc0ac\ub294 \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4 \ud2b9\uc774\uc801 \uc800\ud558 \uc694\ubc95\uc744 \ud14c\uc2a4\ud2b8\ud558\ub294 SELECT-HD\ub77c\ub294 1b\/2a\uc0c1 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \ub300\ud574 \uc54c\ub824\uc904 \uac83\uc785\ub2c8\ub2e4. Wave\ub294 \uc138\ud3ec\uc5d0\uc11c \ud5cc\ud305\ud2f4 "\uba54\uc2dc\uc9c0” \ubd84\uc790\ub97c \ud45c\uc801\uc73c\ub85c \ud558\uc5ec \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8 \uc218\uc900\uc744 \ub0ae\ucd94\ub294 \uc548\ud2f0\uc13c\uc2a4 \uc62c\ub9ac\uace0\ub274\ud074\ub808\uc624\ud2f0\ub4dc \ub610\ub294 ASO\ub97c \ub9cc\ub4ed\ub2c8\ub2e4. \uc774\uac83\uc740 Roche\uac00 Tominersen\uc5d0 \ub300\ud574 \ucde8\ud55c \uc811\uadfc \ubc29\uc2dd\uacfc \uc720\uc0ac\ud558\uc9c0\ub9cc \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4\ub9cc\uc744 \ub300\uc0c1\uc73c\ub85c \ud558\ub294 \uc57d\ubb3c\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

PRECISION-HD1 \ubc0f PRECISION-HD2\ub294 \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4\uc5d0 \ub300\ud574 2\uac1c\uc758 ASO\ub97c \ud14c\uc2a4\ud2b8\ud558\ub294 \uc2dc\ud5d8\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc57d\ubb3c\uc740 \uc548\uc804\ud588\uc9c0\ub9cc \uc608\uc0c1\ub300\ub85c \ud5cc\ud305\ud2f4\uc744 \ub0ae\ucd94\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub450 \uc2dc\ud5d8 \ubaa8\ub450 \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4 \uc720\uc804\uc790\uc5d0\uc11c\ub9cc \ubc1c\uacac\ub418\ub294 SNP(\uc720\uc804\uc790 \uc0ac\ubcf8 \uac04\uc5d0 \ub2e4\ub978 \uc720\uc804\uc790 \ucf54\ub4dc\uc758 \uc77c\ubd80)\ub77c\ub294 \uc720\uc804 \uc11c\uba85\uc744 \ud45c\uc801\uc73c\ub85c \ud558\uae30 \ub54c\ubb38\uc5d0 \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4\uc5d0 \ud2b9\uc774\uc801\uc778 \uc57d\ubb3c\uc744 \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774\ud6c4 Wave\ub294 \ub2e4\ub978 SNP\ub97c \ud45c\uc801\uc73c\ub85c \ud558\uace0 \ud654\ud559\uc744 \uc5c5\ub370\uc774\ud2b8\ud55c WVE-003\uc774\ub77c\ub294 \ub610 \ub2e4\ub978 ASO \uc57d\ubb3c\uc744 \uac1c\ubc1c\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc57d\ubb3c\uc740 WVE-003\uc774 \ud45c\uc801\uc73c\ub85c \uc0bc\ub294 SNP\ub97c \uac00\uc9c0\uace0 \uc788\uace0 \uc9c0\uae08\uae4c\uc9c0\uc758 \uacb0\uacfc\uac00 \uc720\ub9dd\ud558\uae30 \ub54c\ubb38\uc5d0 \uc77c\ubd80 HD \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \ud14c\uc2a4\ud2b8\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. Wave\ub294 \uc774 \uc0c8\ub85c\uc6b4 \uc811\uadfc \ubc29\uc2dd\uc774 \ub354 \uc801\uc740 \uc591\uc758 ASO\uc5d0\uc11c \ud574\ub85c\uc6b4 \ud5cc\ud305\ud2f4\uc744 \ub354 \ud6a8\uacfc\uc801\uc73c\ub85c \ub0ae\ucd94\uba74\uc11c \uac74\uac15\ud55c \ud615\ud0dc\uc758 \ud5cc\ud305\ud2f4\uc744 \uadf8\ub300\ub85c \uc720\uc9c0\ud558\uae30\ub97c \ud76c\ub9dd\ud569\ub2c8\ub2e4. \ud604\uc7ac SELECT-HD\ub77c\ub294 \uc0c8\ub85c\uc6b4 \uc2dc\ud5d8\uc5d0\uc11c \ud14c\uc2a4\ud2b8 \uc911\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Wave\uac00 HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \uc0c8\ub86d\uace0 \uac1c\uc120\ub41c \uc57d\ubb3c\uc744 \ud14c\uc2a4\ud2b8\ud588\uc744 \ub54c \uc774 \uc57d\ubb3c\uc740 \ud655\uc7a5\ub41c \ud5cc\ud305\ud2f4 \uc218\uce58\ub97c \ucd5c\uc18c 50% \ub0ae\ucd94\uc5c8\uc73c\uba70 \uc774 \ud6a8\uacfc\ub294 \uc57d 3\uac1c\uc6d4 \ub3d9\uc548 \uc9c0\uc18d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Wave\uc758 \uacfc\ud559\uc790\ub4e4\uc740 \ub610\ud55c \ud655\uc7a5\ub418\uc9c0 \uc54a\uc740 \ud5cc\ud305\ud2f4\uc774 \uc774 \uc2e0\uc57d\uc5d0 \uc758\ud574 \uc601\ud5a5\uc744 \ubc1b\ub294\uc9c0 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4. \uc57d\ubb3c\ub85c \ucc98\ub9ac\ub41c HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc740 \ud655\uc7a5\ub418\uc9c0 \uc54a\uc740 \ud5cc\ud305\ud2f4 \uc218\uce58\uc5d0 \ud070 \ubcc0\ud654\uac00 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \uc88b\uc740 \uc18c\uc2dd\uc785\ub2c8\ub2e4! Wave\ub294 \ub610\ud55c \uc6d0\uc22d\uc774\ub97c \ub300\uc0c1\uc73c\ub85c \uc57d\ubb3c\uc774 \ub1cc\uc5d0 \uc5b4\ub5bb\uac8c \ud37c\uc9c0\ub294\uc9c0 \ud14c\uc2a4\ud2b8\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \uc911\uc694\ud55c \ubaa8\ub4e0 \uc9c0\uc5ed\uc774 \ucda9\ubd84\ud55c \uc591\uc758 \uc57d\ubb3c\uc744 \uc12d\ucde8\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\uae30\ub97c \uc6d0\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ub370\uc774\ud130\ub294 \ub610\ud55c \ub9e4\uc6b0 \uace0\ubb34\uc801\uc774\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\uc774 SELECT-HD \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc57d\ubb3c\uc774 \ud45c\uc801\uc73c\ub85c \ud558\ub294 SNP\uac00 \uc788\uc5b4\uc57c \ud558\ubbc0\ub85c \uc6e8\uc774\ube0c\ub294 \uc774\ub97c \ud655\uc778\ud558\uae30 \uc704\ud55c \uc9c4\ub2e8\uac80\uc0ac\ub97c \uac1c\ubc1c\ud588\ub2e4. Wave\ub294 \uc2dc\ud5d8\uc744 “\uc801\uc751\ud615"\uc73c\ub85c \uc124\uacc4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc989, \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \uc2dc\ud5d8\uc774 \uc9c4\ud589\ub418\ub294 \ub3d9\uc548 \uc57d\ubb3c\uc758 \uc6a9\ub7c9\uc774\ub098 \ud22c\uc5ec \ube48\ub3c4\ub97c \ubcc0\uacbd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \ubcc0\uacbd \uc0ac\ud56d\uc740 \ucd08\uae30\uc5d0 \uacc4\ud68d\ub418\uc5b4 \uc788\uae30 \ub54c\ubb38\uc5d0 \uacb0\uacfc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

HD\uc5d0\uc11c \ub1cc\uc2ec\ubd80 \uc790\uadf9<\/h3>\n\n\n\n\n

\ub2e4\uc74c\uc740 \ub4a4\uc140\ub3c4\ub974\ud504\uc758 \ud558\uc778\ub9ac\ud788 \ud558\uc774\ub124 \ub300\ud559\uc758 Jan Vesper \ubc15\uc0ac\uac00 HD-DBS\uc5d0 \ub300\ud574 \ub17c\uc758\ud569\ub2c8\ub2e4. \uc774\uac83\uc740 HD \ud658\uc790\uc758 \uc2ec\ubd80 \ub1cc \uc790\uadf9\uc5d0 \ub300\ud574 \uc81c\uc548\ub41c \ud30c\uc77c\ub7ff \uc2dc\ud5d8\uc785\ub2c8\ub2e4. \uc2ec\ubd80 \ub1cc \uc790\uadf9\uc740 \uc804\uae30 \uc2e0\ud638\ub97c \uc0ac\uc6a9\ud558\uc5ec \ub1cc\ub97c \uc790\uadf9\ud558\ub294 \uc808\ucc28\uc785\ub2c8\ub2e4. \uac70\uc758 10\ub144 \uc804\uc5d0 \ud30c\uc77c\ub7ff \uc2dc\ud5d8\uc774 \uc218\ud589\ub418\uc5c8\ub294\ub370 HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc774 \uc2ec\ubd80 \ub1cc \uc790\uadf9\uc73c\ub85c \uce58\ub8cc\ub97c \ubc1b\uc558\uc744 \ub54c \uc77c\ubd80 HD \uc6b4\ub3d9 \uc99d\uc0c1\uc774 \uac10\uc18c\ud588\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uadf8\ub7f0 \ub2e4\uc74c HD-DBS\ub77c\uace0 \ud558\ub294 \ud6e8\uc52c \ub354 \ud070 \uc2dc\ud5d8\uc774 \uc804 \uc138\uacc4 \uc5ec\ub7ec \uc0ac\uc774\ud2b8\uc5d0\uc11c \uc2e4\ud589\ub418\uc5c8\uc73c\uba70, \uce58\ub8cc \ub610\ub294 \uc704\uc57d\uc744 \ubc1b\uc740 \ucc38\uac00\uc790\uc5d0\uc11c HD\uc758 \ub2e4\uc591\ud55c \uc784\uc0c1 \uc9d5\ud6c4\uc640 \uc99d\uc0c1\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4. \ucc38\uac00\uc790\uc758 \uc548\uc804\uc744 \ud655\ubcf4\ud558\uae30 \uc704\ud574 \ud3ec\ud568 \ubc0f \uc81c\uc678 \uae30\uc900\uc774 \uad11\ubc94\uc704\ud558\uc5ec \uc784\uc0c1 \uc2dc\ud5d8 \ub300\uc0c1\uc790\ub97c \ubaa8\uc9d1\ud558\ub294 \ub370 \uaf64 \uc624\ub79c \uc2dc\uac04\uc774 \uac78\ub838\uc9c0\ub9cc \uacb0\uad6d \ub3c5\uc77c, \uc624\uc2a4\ud2b8\ub9ac\uc544, \ud504\ub791\uc2a4\uc5d0\uc11c 48\uba85\uc758 \ucc38\uac00\uc790\uac00 \ubaa8\uc9d1\ub418\uc5c8\uace0 \uc808\ubc18 \uc815\ub3c4\ub294 \uc704\uc57d \uce58\ub8cc\ub97c \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \ub370\uc774\ud130\ub294 \uc62c\ud574 1\uc6d4\uc5d0 \uc218\uc9d1\ub418\uc5c8\uc73c\uba70 \ubd84\uc11d\uc774 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4. \uc624\ub298 \uc6b0\ub9ac\ub294 \uc608\ube44 \uc870\uc0ac \uacb0\uacfc \uc911 \uc77c\ubd80\ub97c \ub4e3\uac8c \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc2e4\ud5d8\uc5d0 \ucc38\uac00\ud55c \ub450 \uadf8\ub8f9, \uc989 \uc2ec\ubd80 \ub1cc \uc790\uadf9 \uce58\ub8cc\ub97c \ubc1b\uc740 \uadf8\ub8f9\uacfc \uc704\uc57d\uc744 \ubc1b\uc740 \uadf8\ub8f9 \ubaa8\ub450\uc5d0\uc11c \uc77c\ubd80 \uc0ac\ub78c\ub4e4\uc740 \uac1c\uc120\ub418\uc5c8\uc9c0\ub9cc \ub2e4\ub978 \uc0ac\ub78c\ub4e4\uc740 \uc545\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc774 \uce58\ub8cc\ubc95\uc774 HD\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \ud2b9\ud788 \uc720\ub9dd\ud55c \uac83 \uac19\uc9c0\ub294 \uc54a\uc2b5\ub2c8\ub2e4. \uc77c\ubd80 \ud658\uc790\ub294 \uc2dc\ud5d8\uc5d0\uc11c \uac1c\uc120\ub418\uc5c8\uc9c0\ub9cc \uc774\uac83\uc774 \uc65c \uadf8\ub7ac\ub294\uc9c0 \uba85\ud655\ud558\uc9c0 \uc54a\uc73c\uba70 \uce58\ub8cc \ub610\ub294 \uc704\uc57d\uc744 \ubc1b\uc740 \ud658\uc790 \uc0ac\uc774\uc5d0 \uc720\uc758\ubbf8\ud55c \ucc28\uc774\uac00 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e4\ub9dd\uc2a4\ub7ec\uc6b4 \uacb0\uacfc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc5f0\uad6c\uc790\ub4e4\uc740 HD \ubc0f \uae30\ud0c0 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \ud5a5\ud6c4 \uc5f0\uad6c\uc5d0 \uc801\uc6a9\ud560 \uc218 \uc788\ub294 \uc774 \uc2dc\ud5d8\uc5d0\uc11c \uc678\uacfc\uc801 \uae30\uc220\uc744 \uac1c\ubc1c\ud558\uace0 \uac1c\uc120\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774\uc81c \uc6b0\ub9ac\ub294 \uacbd\uad6c \ud5cc\ud305\ud2f4 \uc800\ud558 \uc57d\ubb3c\uc758 \uac1c\ubc1c\uc5d0 \ucc29\uc218\ud588\uc2b5\ub2c8\ub2e4! \ub450 \ud68c\uc0ac\uac00 HD\uc5d0 \ub300\ud55c \uc774\ub7ec\ud55c \uce58\ub8cc\ubc95\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uccab \ubc88\uc9f8 \ubc1c\ud45c\uc790\ub294 PTC Therapeutics\uc758 Brian Beers\uc785\ub2c8\ub2e4. \uadf8\ub294 \uacbd\uad6c\ub85c \ubcf5\uc6a9\ud560 \uc218 \uc788\ub294 \ud5cc\ud305\ud2f4 \uc800\ud558 \uc57d\ubb3c\uc778 PTC518\uc5d0 \ub300\ud574 \uc54c\ub824\uc904 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

PTC518 – \uc5c5\ub370\uc774\ud2b8!<\/h3>\n\n\n\n\n

HD \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c PTC518\uc740 \ucd1d \ud5cc\ud305\ud2f4 \uc218\uce58\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ub0ae\ucd94\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc73c\uba70 \uc804\uc784\uc0c1 \ub370\uc774\ud130\ub294 \ub9e4\uc6b0 \uc720\ub9dd\ud574 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. PTC\ub294 \uac74\uac15\ud55c \uc9c0\uc6d0\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uc57d\ubb3c\uc744 \ud14c\uc2a4\ud2b8\ud588\uc73c\uba70 \uc57d\ubb3c\uc774 RNA \uc2a4\ud50c\ub77c\uc774\uc2f1\uc73c\ub85c \uc54c\ub824\uc9c4 \ud5cc\ud305\ud2f4 \ub808\uc2dc\ud53c\ub97c \uc5c9\ub9dd\uc73c\ub85c \ub9cc\ub4dc\ub294 \uc6d0\ud558\ub294 \uc720\uc804\uc801 \ud6a8\uacfc\ub97c \uac00\uc9c0\uace0 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \ub610\ud55c PTC-518\uc758 \uc548\uc804\ud558\uace0 \ud5c8\uc6a9 \uac00\ub2a5\ud55c \uc6a9\ub7c9\uc744 \uacb0\uc815\ud560 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uacfc\ud559\uc790\ub4e4\uc740 \ub610\ud55c \uc57d\ubb3c \uce58\ub8cc\ub97c \uc911\ub2e8\ud588\uc744 \ub54c \uc5b4\ub5a4 \uc77c\uc774 \uc77c\uc5b4\ub0ac\ub294\uc9c0 \uc0b4\ud3b4\ubcf4\uace0 \uadf8 \ud6a8\uacfc\uac00 \ube60\ub974\uac8c \uc5ed\uc804\ub420 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ub370\uc774\ud130\uac00 \uc5b4\ub5a4 \uc774\uc720\ub85c \ucc38\uac00\uc790\uc758 \ud22c\uc5ec\ub97c \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4\uace0 \uc81c\uc548\ud558\ub294 \uacbd\uc6b0 \uc774\ub294 \uc88b\uc740 \uc18c\uc2dd\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uadf8\ub4e4\uc740 12\uc8fc \ub3d9\uc548 \uc800\uc6a9\ub7c9 \ub610\ub294 \uace0\uc6a9\ub7c9\uc744 \ud22c\uc5ec\ubc1b\ub294 \ub450 \uadf8\ub8f9\uc758 \ucc38\uac00\uc790\ub97c \ud3ec\ud568\ud558\ub294 \uc0c8\ub85c\uc6b4 \uc5f0\uad6c \ub514\uc790\uc778\uc744 \uacf5\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. 162\uba85\uc758 \ud658\uc790\uac00 2022\ub144 1\ubd84\uae30\uc5d0 \uc2dc\uc791\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud558\ub294 \uc774 \uc2dc\ud5d8\uc5d0\uc11c \ubaa8\uc9d1\ub420 \uc608\uc815\uc785\ub2c8\ub2e4. PIVOT-HD\ub294 \uc0c8\ub85c\uc6b4 2\uc0c1 \uc784\uc0c1 \uc2dc\ud5d8\uc774 \ub420 \uac83\uc774\uba70, PTC518\uc774 HD \ud658\uc790\uc758 \ud5cc\ud305\ud2f4 \uc218\uce58\ub97c \ub0ae\ucd94\uace0 \uc57d\ubb3c\uc774 \uc5b4\ub5bb\uac8c \uc791\uc6a9\ud558\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc911\uc694\ud55c \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \ucd94\uc801\ud569\ub2c8\ub2e4. PTC\ub294 \uc57d\ubb3c\uc758 \uc548\uc804\uc131\uacfc \ud5cc\ud305\ud2f4 \ub2e8\ubc31\uc9c8, \ubc14\uc774\uc624\ub9c8\ucee4 NfL \uc218\uce58\uc758 \ubcc0\ud654, HD \uc9d5\ud6c4 \ubc0f \uc99d\uc0c1\uc5d0 \ub300\ud55c \ub2e4\uc591\ud55c \uc784\uc0c1 \uce21\uc815\uce58\ub97c \uac80\ud1a0\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\uc774 \uc7ac\ud310\uc740 \ubbf8\uad6d, \uc601\uad6d, \ud504\ub791\uc2a4, \u200b\u200b\ub3c5\uc77c, \ud638\uc8fc\uc5d0\uc11c \uc2dc\uc791\ub420 \uc608\uc815\uc785\ub2c8\ub2e4. \uace7 PTC\uc758 \uc5c5\ub370\uc774\ud2b8 \uc18c\uc2dd\uc744 \ub4e4\uc744 \uc218 \uc788\uae30\ub97c \ubc14\ub78d\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ube0c\ub77c\ub098\ud50c\ub78c – \uacbd\uad6c\uc6a9 HTT \uc800\ud558 \ubd84\uc790<\/h3>\n\n\n\n\n

\ud68c\uc758\uc758 \ub9c8\uc9c0\ub9c9 \uc5f0\uc124\uc740 Novartis Pharmaceuticals\uc758 Beth Borowsky \ubc15\uc0ac\uac00 \ud560 \uac83\uc785\ub2c8\ub2e4. \ud5cc\ud305\ud2f4 \uc800\ud558\uc81c\uc778 \ube0c\ub77c\ub098\ud50c\ub78c\uc744 \uc870\uc0ac\ud558\ub294 2b\uc0c1 \uc784\uc0c1\uc2dc\ud5d8\uc778 VIBRANT-HD\uc5d0 \ub300\ud55c \uc5c5\ub370\uc774\ud2b8\ub97c \ub4e3\uac8c \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Borowsky \ubc15\uc0ac\ub294 \ucc99\ucd94 \uc8fc\uc0ac\ub098 \ub1cc \uc218\uc220\uacfc \uac19\uc774 \ub354 \ub9ce\uc740 \ubd80\ub2f4\uc744 \uc8fc\ub294 \uacbd\ub85c\ub97c \ud1b5\ud574 \uc81c\uacf5\ub418\ub294 \ub2e4\ub978 \uce58\ub8cc\ubc95\uc5d0 \ube44\ud574 \uacbd\uad6c\ub85c \uc57d\ubb3c\uc744 \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \ud658\uc790\uc5d0\uac8c \uc5bc\ub9c8\ub098 \ub9ce\uc740 \uc774\uc810\uc774 \uc788\ub294\uc9c0 \uc124\uba85\ud569\ub2c8\ub2e4. \uc54c\uc57d\uc740 \ub1cc\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc804\uc2e0\uc5d0\ub3c4 \uc791\uc6a9\ud560 \uc218 \uc788\uc73c\uba70 \uadf8 \ud6a8\uacfc\ub294 \uc5ed\uc804\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4!<\/p>\n\n\n\n\n

Branaplam\uc740 \uc6d0\ub798 SMA\ub77c\ub294 \uce58\uba85\uc801\uc778 \uc544\ub3d9\uae30 \uc7a5\uc560\ub97c \uc704\ud574 \uac1c\ubc1c\ub418\uc5c8\uc9c0\ub9cc \uacfc\ud559\uc758 \ub180\ub77c\uc6b4 \ubc18\uc804\uc73c\ub85c \ud5cc\ud305\ud2f4\ub3c4 \ub0ae\ucd94\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc73c\ubbc0\ub85c Novartis\ub294 HD\ub85c \uadf8\ub4e4\uc758 \ub178\ub825\uc744 \uc7ac\uc870\uc815\ud588\uc2b5\ub2c8\ub2e4. Branaplam\uc740 \uc811\ud569 \uae30\uacc4\ub77c\uace0 \ud558\ub294 \uc720\uc804 \uba54\uc2dc\uc9c0\ub97c \ucc98\ub9ac\ud558\ub294 \uae30\uacc4\ub97c \ud45c\uc801\uc73c\ub85c \ud569\ub2c8\ub2e4. \uba54\uc2dc\uc9c0 \uc5f0\uacb0 \ubc29\ubc95\uc744 \ubcc0\uacbd\ud558\uba74 \uba54\uc2dc\uc9c0\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \ub2e8\ubc31\uc9c8\uc758 \uc591\uc5d0 \uc601\ud5a5\uc744 \uc904 \uc218 \uc788\uc73c\ubbc0\ub85c \uc5f0\uacb0\uc744 \uc218\uc815\ud558\ub294 \uc57d\ubb3c\uc740 \uc138\ud3ec\uc758 \ub2e8\ubc31\uc9c8 \uc218\uc900\uc744 \ubcc0\uacbd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n\n

I\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \uc774 \uc57d\ubb3c\uc740 \uc548\uc804\ud55c \uc591\uacfc \ud22c\uc5ec \ube48\ub3c4\ub97c \ud30c\uc545\ud558\uae30 \uc704\ud574 \uc131\uc778\uc744 \ub300\uc0c1\uc73c\ub85c \ucc98\uc74c\uc73c\ub85c \ud14c\uc2a4\ud2b8\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uac83\uc740 branaplam\uc774 \uc5b4\ub9b0\uc774\uc758 SMA\ub97c \uce58\ub8cc\ud558\uae30 \uc704\ud574 \uac1c\ubc1c\ub418\uc5c8\uae30 \ub54c\ubb38\uc5d0 \uc911\uc694\ud588\uc2b5\ub2c8\ub2e4. VIBRANT-HD\ub294 \ud5cc\ud305\ud2f4\uc744 \ub0ae\ucd94\uae30 \uc704\ud574 \ud22c\uc5ec\ud574\uc57c \ud558\ub294 \uc57d\ubb3c\uc758 \uc6a9\ub7c9\uc744 \ud30c\uc545\ud558\uae30 \uc704\ud574 HD\ub97c \uac00\uc9c4 \uc131\uc778\uc5d0\uc11c \ucc98\uc74c\uc73c\ub85c \ube0c\ub77c\ub098\ud50c\ub78c\uc744 \ud14c\uc2a4\ud2b8\ud558\ub294 IIb\uc0c1 \uc5f0\uad6c\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n\n

Branaplam\uc740 \ud658\uc790\uac00 \uc77c\uc8fc\uc77c\uc5d0 \ud55c \ubc88 \ub9c8\uc2dc\ub294 \uacbd\uad6c \uc561\uccb4\ub85c \uc81c\uacf5\ub429\ub2c8\ub2e4. \ub178\ubc14\ud2f0\uc2a4\ub294 \uc784\uc0c1\uc758 2\ub2e8\uacc4\uc5d0\uc11c \uc5b4\ub5a4 \uc6a9\ub7c9\uc774 \uac00\uc7a5 \ud6a8\uacfc\uc801\uc778\uc9c0 \uacb0\uc815\ud560 \uc218 \uc788\ub3c4\ub85d \ud658\uc790\ub9c8\ub2e4 \ub2e4\ub978 \uc6a9\ub7c9\uc744 \ud22c\uc5ec\ud558\uac8c \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n\n

\ud5cc\ud305\ud2f4 \ubc0f NfL\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \ubc14\uc774\uc624\ub9c8\ucee4\uc758 \uc218\uc900\uc744 \ud3ec\ud568\ud558\uc5ec \uc2dc\ud5d8 \ucc38\uac00\uc790\ub85c\ubd80\ud130 \ub9ce\uc740 \uc784\uc0c1 \uce21\uc815\uac12\uc774 \uc218\uc9d1\ub429\ub2c8\ub2e4. \uc774 \ud3c9\uac00\ud310\uc744 \uc704\ud55c \ubaa8\uc9d1\uc774 \uc9c4\ud589 \uc911\uc774\uba70 \uace7 \ud3c9\uac00\ud310 \uc9c4\ud589 \ubc29\uc2dd\uc5d0 \ub300\ud55c \uc5c5\ub370\uc774\ud2b8\ub97c \ub4e4\uc744 \uc218 \uc788\uae30\ub97c \ubc14\ub78d\ub2c8\ub2e4!<\/p>\n\n\n\n\n

\uadf8\uac8c \ub2e4\uc57c! \ud314\ub85c\uc6b0\ud574\uc8fc\uc154\uc11c \uc815\ub9d0 \uac10\uc0ac\ud569\ub2c8\ub2e4. https:\/\/hdbuzz.net\uc5d0\uc11c<\/a> CHDI \ucee8\ud37c\ub7f0\uc2a4\uc758 \uc77c\uc77c \ubcf4\uace0\uc11c\ub97c \uc77d\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

2022 HD Therapeutics Conference #HDTC2022 3\uc77c \ucc28\uc758 \uc5f0\uad6c \uc5c5\ub370\uc774\ud2b8\ub97c \ud655\uc778\ud558\uc138\uc694.<\/p>\n","protected":false},"author":1,"featured_media":20367,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1065],"class_list":["post-18091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-chdi-conference-2"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/ko.hdbuzz.net\/wp-content\/uploads\/2019\/02\/codev-2019-02-27-4c6ebf9359-AB71A378-9AD8-4E57-966F-A7B9B0DC353B.png?fit=1920%2C1080&quality=80&ssl=1","acf":{"writers":[{"ID":4201,"user_firstname":"Sarah","user_lastname":"Hernandez","nickname":"Dr Sarah Hernandez","user_nicename":"sarahhernandez","display_name":"Dr Sarah Hernandez","user_email":"sjherna2@uci.edu","user_url":"","user_registered":"2025-05-12 17:22:01","user_description":"Dr. Sarah Hernandez is the Director of Research Programs at the Hereditary Disease Foundation (HDF). She carried out her postdoctoral work with Dr. Leslie Thompson at the University of California, Irvine, where she used stem cells and fruit flies to define HD-related changes that exist outside the cell, in the \u201cextracellular matrix\u201d. At the HDF, Sarah oversees the Foundation\u2019s scientific research portfolio by managing the grants program, acting as the scientific liaison, and coordinating scientific programming through webinars, workshops, and conferences. Sarah enthusiastically supports the mission of the HDF, to identify the most promising research and accelerate treatments for Huntington\u2019s disease.","user_avatar":""},{"ID":4130,"user_firstname":"Leora","user_lastname":"Fox","nickname":"Dr Leora Fox","user_nicename":"leorafox","display_name":"Dr Leora Fox","user_email":"leora.fox@gmail.com","user_url":"","user_registered":"2025-05-12 17:21:54","user_description":"Leora Fox trained as a Huntington's Disease scientist, and obtained her PhD in 2016 at Columbia University, where she studied HD mouse models and how brain cells dispose of huntingtin protein. After gaining experience in Medical Communications she worked on research and patient engagement programs at the Huntington's Disease Society of America from 2017-2024. Dr. Fox continues to support the HD research community through her work at Fox Scientific Consulting. She is passionate about communicating science about HD and other brain diseases so that families understand recent progress, can make informed decisions about participating in clinical research, and are supported around research news.","user_avatar":""},{"ID":4202,"user_firstname":"Rachel","user_lastname":"Harding","nickname":"Dr Rachel Harding","user_nicename":"rachelharding","display_name":"Dr Rachel Harding","user_email":"rachel.harding@utoronto.ca","user_url":"","user_registered":"2025-05-12 17:22:01","user_description":"Rachel Harding is an Assistant Professor at the Department of Pharmacology and Toxicology and a Principal Investigator at the Structural Genomics Consortium. Rachel completed her undergraduate and DPhil in structural biology at the University of Oxford, before moving to the University of Toronto for her postdoctoral training. A key focus of Rachel\u2019s research is the huntingtin protein, mutated in people with Huntington\u2019s disease. Huntington\u2019s is a devastating, incurable, genetic, neurodegenerative disease caused by a CAG-tract expansion in the Huntingtin gene. Rachel studies the structure-function of the huntingtin protein in both its wildtype and disease forms, with a view to better understand the mechanisms of disease, as well as trying to find new avenues of therapeutic intervention.","user_avatar":""},{"ID":4198,"user_firstname":"Joel","user_lastname":"Stanton","nickname":"Joel Stanton","user_nicename":"joelstanton","display_name":"Joel Stanton","user_email":"stanton.joel@icloud.com","user_url":"","user_registered":"2025-05-12 17:22:01","user_description":"Joel is a neuroscience nurse who obtained his masters in stroke research from University College London","user_avatar":""}],"editors":[{"ID":4002,"user_firstname":"Ed","user_lastname":"Wild","nickname":"Professor Ed Wild, MRCP, PhD","user_nicename":"edwild","display_name":"Professor Ed Wild, MRCP, PhD","user_email":"ed@hdbuzz.net","user_url":"http:\/\/edwild.com","user_registered":"2025-05-12 17:21:43","user_description":"Ed is a neurologist at the National Hospital for Neurology and Neurosurgery, London, UK, and a Professor of Neurology at University College London where he is Associate Director of the Huntington\u2019s Disease Centre. He has worked in HD research since 2005 focusing on biomarkers and clinical trials. He co-founded HDBuzz with Jeff Carroll in 2010 and was Editor-in-Chief until 2024.","user_avatar":""}],"translators":[4178],"sources":null,"conflicts":"\uc800\uc790\ub294 \ubb38\uc81c\uac00 \ub420 \uc5b4\ub5a0\ud55c \uc774\ud574\uad00\uacc4\ub3c4 \uac00\uc9c0\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. 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