Research Fellow · Singapore
Jiaen Lin, PhD
Bioinformatician · Multi-Omics · AI for Biomedicine
🎓 Duke-NUS Medical School · IBM Programme
I develop analysis pipeline, computational methods and machine learning models to integrate multi-omics data — single-cell RNA-seq, metabolomics, and proteomics — for biomarker discovery and disease mechanism research. My work spans brain development, Autism, and stem cell biology.
Focus Areas
Research Interests
Multi-Omics Integration
Single-Cell RNA-seq
Machine Learning for Biomedicine
High Throughput Experimental Validation
Disease Mechanisms
Clinical Application
Latest
News & Updates
May 2026
🏆 Honoured with the
Duke-NUS Achievement Prize
for Most Outstanding PhD Student — recognising research excellence and academic achievement at Duke-NUS Medical School.
Award
2026
🤖 Developing
RegStatusNet, an AI model for cell regulatory status prediction combining transcriptomics and metabolomics signals.
Nov 2025
🚀 Published Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila in Nature Communications
Oct 2025
🏆 Received the
Duke-NUS NBD Publication Award
from the Neuroscience & Behavioural Disorders Programme at Duke-NUS Medical School.
Award
Aug 2025
🎓 Graduated
from the Duke-NUS IBM programme — completing the Integrative Biomedical PhD journey.
Milestone
Aug 2025
🚀 Selected Oral presentation, Decoding Microproteins Across Evolution and Disease, Gordan Research Conference, Spain 2025.
Research Output
Selected Publications
2025-2026
Manuscript in preparation
Cell Type Classification Pipeline for Neural Stem Cell Identification in Human Brain Single-Cell RNA-seq atlas
Coming Soon
Manuscript under review
BMP Signaling Modulates Human Cortical Expansion and Maturation
Nature Communications
Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila
2020-2024
Nature Communications
SUMOylation of Warts kinase promotes neural stem cell reactivation.
Science Advances
Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling.
Full publication list → Google Scholar
Career
Experience
2025 – Present
Research Fellow
Duke-NUS Medical School · Singapore
Multi-omics integration, CRISPR gRNA library screening, machine learning models for disease marker discovery. PI: Prof. Hongyan Wang.
2020 – 2025
PhD Student
Duke-NUS IBM Programme · Singapore
Single-cell and bulk RNA-seq pipelines, and Microprotein research in brain development and neural stem cell biology.
Academic
Education
2020 – Aug 2025
PhD, Integrated Biology and Medicine
Duke-NUS Medical School
Graduated August 2025. Research on neural stem cell biology and multi-omics.
Before 2020
Bachelor Degree
Huazhong University of Science and Technology
Bachelor's degree in Neuroscience.
Technical
Skills & Tools
Languages
PythonRBash
Single cell transcriptomics
scRNA-seq analysis
Spatial Omics
data integration
Multi-omics
Proteomics
ChIP-seq analysis
Metabolomics
Bulk RNA-seq
Machine Learning
MLPCNN
GNN
Transformer
HPC computing
GitLinux/HPCSnakemake
Molecular biology
Fly Genetics
Confocal imaging
Western Blot
Cell Culture
Global
Research Network
🇸🇬
Singapore
Duke-NUS Medical School
Research Fellow · Current
🇨🇳
China
Huazhong University of Science & Technology
Home country
🇦🇺
Cairns, Australia
Conference
🇪🇸
Barcelona, Spain
Conference
Globe powered by cobe (MIT) · Shu Ding
Get In Touch
Contact
I'm open to collaborations in multi-omics data integration, AI/ML for biomedical research, and translational studies. Feel free to reach out for research discussions or potential positions.
📍 Singapore
Scan to visit my site
jiaenlin.github.io