HandyCrypto

This folder encryption software allows you to hide folders and encrypt files with on-the-fly AES encryption.

Just create one or more encrypted, secure folders from your local folders, and then move your sensitive files into the specified encrypted folder. They'll then be encrypted/decrypted in real-time.
From then on, just enter your password and use all your files just as you always have: HandyCrypto handles all the encryption functions instantly and transparently behind the scenes for you. You can work with the encrypted files as usual, and when you're done, lock the secure folder to store the files securely and hide the entire folder from view.