There is this new feature called generated columns in SQLite 3.31.0. See here for details. We should add support for this in the future. As far as I can tell these parts of DB4S need to be changed:

• Parser and SQL object representation classes
• Disable writing to these columns in the Browse Data tab
• Automatically refresh contents of generated columns when other columns are changed in the Browse Data tab
• Add support for this in the Edit Table dialog

The first item is the most important one since it is required for even opening these databases.