import numpy as np
from PySide6 import QtCore, QtWidgets

class Item(QtWidgets.QTableWidgetItem):
    def __init__(self, value):
        super().__init__(str(value))
        self.value = value

    def __lt__(self, other):
        return self.value < other.value

data = np.arange(10).reshape((5, 2))
nrows, ncols = data.shape

app = QtWidgets.QApplication([])
wgt = QtWidgets.QTableWidget(nrows, ncols)

for row in range(nrows):
    for col in range(ncols):
        wgt.setItem(row, col, Item(data[row, col]))

wgt.sortByColumn(0, QtCore.Qt.SortOrder.DescendingOrder)

wgt.show()
app.exec()