one thing that might be useful is to ignore the font attribute setting for numbers, (or create a new one for subscript/superscript) so that NVDA will read numbers like 10^44 as 10 superscript 44, rather than 1044. it's annoying to have to turn all font attributes on for a webpage, just so that I can hear 10 superscript 44.
This might require a redesign of the font settings of the document formatting dialog, maybe a configure font settings button in this dialog, so users can have more fine grained control over the font.