Steps to reproduce:

1. Open native mouse settings
   
2. Change the windows "Select your primary button" to be "Right"
3. Open Chrome or FireFox
4. Go to a web page with a plain text heading. Here's one I created on CodePen
5. Navigate to the heading
6. Press the 'Space' or 'Enter' key

Actual behavior:

NVDA right clicks on the page and shows a dialog.

Expected behavior:

NVDA should respect the Windows mouse configuration for primary keys. As a result, NVDA should trigger the left click in this scenario.

System configuration

NVDA installed/portable/running from source:

Not sure what to put here.

NVDA version:

NVDA 2020.4

Windows version:

Windows 10 Pro, 20H2

Name and version of other software in use when reproducing the issue:

• Firefox 89.0.2
• Chrome 91.0.4472.124

Other information about your system:

I am using a Kensington mouse with Logitech software, however I have tested this with the native touchpad or a standard mouse.

Other questions

Does the issue still occur after restarting your computer?

Yes.

Have you tried any other versions of NVDA? If so, please report their behaviors.

No.

If add-ons are disabled, is your problem still occurring?

Yes.

Does the issue still occur after you run the COM Registration Fixing Tool in NVDA's tools menu?

Haven't been able to find such an option in NVDA.