Steps to reproduce:

Download and run the installation package of the latest NVDA alpha builds.

Actual behavior:

The sound of the temporary copy of NVDA starting is played, after which it crash

Expected behavior:

The temporary copy of NVDA should start correctly when the launcher starts

System configuration

NVDA installed/portable/running from source:

Occurs when the installation package is started

NVDA version:

alpha-21882,528d5708 and higher

Windows version:

Windows 10 version 1809

Other information about your system:

The problem is reproduced if the Russian language of the interface is selected in the system parameters. If change the language to English and log in again, the problem disappears and NVDA start correctly.
NVDA log is interrupted on the wxPython version, probably the crash occurs when creating an instance of wx.App.

Other questions

Does the issue still occur after restarting your computer?

Yes

Have you tried any other versions of NVDA? If so, please report their behaviors.

Problem appeared in new NVDA builds with Python 3.8 and WXPython 4.1.1

If add-ons are disabled, is your problem still occurring?

Yes
nvda-old.log