Google Chrome is starting to deprecate the U2F API and is asking developers to use WebAuthn instead.

U2F devices are still supported through WebAuthn and existing U2F device credentials can be challenged through the WebAuthn API.

Also note that

Edge is (very) supportive of this deprecation/removal.

Details:
https://groups.google.com/a/chromium.org/g/blink-dev/c/xHC3AtU_65A?pli=1
https://www.yubico.com/blog/google-chrome-u2f-api-decommission-what-the-change-means-for-your-users-and-how-to-prepare/