Hello,
I'm currently working on a project to secure the passwords of our employees. As long user of KeePass and KeePassXC I'm planning to rollout it company wide. For additional security we bought some Yubikeys 5 NFC and I programmed the Slot 2 with HMAC-SHA1 which works fine in normal use case.
But because of Covid-19 most employees are in HomeOffice. Some have notebooks, so no issue there but some use their personal PC and connect via VPN and RDP to their company PC.
What I did was enabling Smartcard in the Remote Settings:

Which seems to work with the newer Yubikey applications like Authenticator, even the button press is working.
The Yubikey Manager finds the Yubikey and shows a serial, but you can't config everything.
The old Personalization Tool doesn't find the Yubikey at all.
So I guess they changed the API in their new applications

Did I miss something in the configuration / settings or is the keepass implementation like the personalization tool? I don't know anything about the yubikey API.

It would be cool if someone could lead me to a workaround or is there any change planned?