I use different virtual machines to test and some are recreated from zero every day. In the initialization process (vagrant) of the VM firefox is also installed and configured with a cloud profile, this will automatically install also ublock origin but the "Enable cloud storage support" option is never enabled, because it is not synced with the plugin settings with the firefox cloud profile, I couldn't find in the "about:config" anything about syncing this option, or in general syncing any option. Moreover once the checkbox is ticked, you also to switch tab to the "3rd-party filters" and click the "download" button.
Maybe I like automation, but I'm expecting that by syncing my firefox cloud profile and by installing a plugin also the plugin configuration is taken over, and not that I have to reconfigure the plugin every time.