Describe the bug
If we run with watch_job_rules: true we see a memory usage of up to 30GB per handler.
More information including a py-syp trace is here: https://gist.github.com/bgruening/7be19830e254b4bca99a3ae2e3844041
Disabling the watchdog, as done here, usegalaxy-eu/infrastructure-playbook#937 is solving the problem for us.

Feel free to close this issue, if this seems to be a EU-specific thing. We are also using TPV, so ping also @nuwang and @cat-bro.