There are some cases where:

1. you cannot hit the column controls because you used negative margins on the below/above sections
2. you have a custom widget that have elements positioned relative/absolute that will be right over the widget controls (edit, delete)

This will fix it:

.elementor-editor-active .elementor.elementor-edit-mode .elementor-editor-widget-settings,
.elementor-editor-active .elementor-column:hover {
	z-index: 9999 !important;
}