Setup:
Mac OS: Big Sur(11.2) - Apple M1 chip
VSFM:8.9 Preview (8.9 build 1582)
3.1.406(runtime:3.1.12) & 5.0.103(runtime:5.0.3)
.NET 6 arm64: 6.0.100-preview.1.21103.13(runtime 6.0.0-preview.1.21102.12)

Steps to reproduce:
1.Create a project with TFM 5.0 or 3.1 on VSFM or Cli
2.Run this project

Expected result:
This project will run success

Actual result:
Run failed with "Failed to load /usr/local/share/dotnet/shared/Microsoft.NETCore.App/5.0.3/libhostpolicy.dylib, error: dlopen(/usr/local/share/dotnet/shared/Microsoft.NETCore.App/5.0.3/libhostpolicy.dylib, 1): no suitable image found. Did find:
/usr/local/share/dotnet/shared/Microsoft.NETCore.App/5.0.3/libhostpolicy.dylib: mach-o, but wrong architecture
/usr/local/share/dotnet/shared/Microsoft.NETCore.App/5.0.3/libhostpolicy.dylib: mach-o, but wrong architecture
An error occurred while loading required library libhostpolicy.dylib from [/usr/local/share/dotnet/shared/Microsoft.NETCore.App/5.0.3]"

Note:
1.For test project on VSM,project will always keep running

VSFM-info:
=== Visual Studio Enterprise 2019 for Mac (Preview) ===

Version 8.9 Preview (8.9 build 1582)
Installation UUID: d6adba47-7cfd-43b6-b2f0-580b51383850
GTK+ 2.24.23 (Raleigh theme)
Xamarin.Mac 6.18.0.23 (d16-6 / 088c73638)

Package version: 612000113

=== Mono Framework MDK ===

Runtime:
Mono 6.12.0.113 (2020-02/4fdfb5b1fd5) (64-bit)
Package version: 612000113

=== Roslyn (Language Service) ===

3.9.0-4.21104.8+2fc92d84e746c3aab75f0930278ea6675cd5bb5c

=== NuGet ===

Version: 5.8.0.6860

=== .NET Core SDK ===

SDK: /usr/local/share/dotnet/sdk/6.0.100-preview.1.21103.13/Sdks
SDK Versions:
6.0.100-preview.1.21103.13
5.0.103
3.1.406
MSBuild SDKs: /Applications/Visual Studio.app/Contents/Resources/lib/monodevelop/bin/MSBuild/Current/bin/Sdks

=== .NET Core Runtime ===

Runtime: /usr/local/share/dotnet/dotnet
Runtime Versions:
6.0.0-preview.1.21102.12
5.0.3
3.1.12

=== .NET Core 3.1 SDK ===

SDK: 3.1.406

=== Xamarin.Profiler ===

'/Applications/Xamarin Profiler.app' not found

=== Updater ===

Version: 11

=== Apple Developer Tools ===

A valid Xcode installation was not found at the configured location: '/Library/Developer/CommandLineTools'

=== Xamarin.Mac ===

Xamarin.Mac not installed. Can't find /Library/Frameworks/Xamarin.Mac.framework/Versions/Current/Version.

=== Xamarin.iOS ===

Xamarin.iOS not installed.
Can't find mtouch or the Version file at /Library/Frameworks/Xamarin.iOS.framework/Versions/Current.

=== Xamarin Designer ===

Version: 16.9.0.309
Hash: 9a5259fb5
Branch: remotes/origin/9a5259fb55e54a445c145ab5ea29c04a418deed2
Build date: 2021-02-04 09:34:28 UTC

=== Xamarin.Android ===

Not Installed

=== Microsoft OpenJDK for Mobile ===

Java SDK: Not Found

Android Designer EPL code available here:
https://github.com/xamarin/AndroidDesigner.EPL

=== Android SDK Manager ===

Version: 16.9.0.21
Hash: 57e40ba
Branch: remotes/origin/main
Build date: 2021-01-08 01:57:14 UTC

=== Android Device Manager ===

Version: 16.9.0.14
Hash: 0fdccda
Branch: remotes/origin/main
Build date: 2021-01-08 01:57:36 UTC

=== Build Information ===

Release ID: 809001582
Git revision: b0620b767dbf9f79bbacc2053ae155a66f147e04
Build date: 2021-02-04 12:13:43-05
Build branch: release-8.9
Xamarin extensions: b0620b767dbf9f79bbacc2053ae155a66f147e04

=== Operating System ===

Mac OS X 10.16.0
Darwin 20.3.0 Darwin Kernel Version 20.3.0
Thu Jan 21 00:06:51 PST 2021
root:xnu-7195.81.3~1/RELEASE_ARM64_T8101 x86_64