after switching to JNA inchi, there is still a dependency to the old jni inchi in org.openscience.cdk.smiles.SmilesGenerator.#inchiNumbers method which dynamically loads the class org.openscience.cdk.graph.invariant.InChINumbersTools which imports classes from the inchi package. If you don't still have the old jni inchi class on your classpath (which has log4j vulnerabilities) then the code will error out with

java.lang.NoClassDefFoundError: [Lnet/sf/jniinchi/INCHI_OPTION;

	at java.lang.Class.getDeclaredMethods0(Native Method)
	at java.lang.Class.privateGetDeclaredMethods(Class.java:2701)
	at java.lang.Class.getDeclaredMethod(Class.java:2128)
	at org.openscience.cdk.smiles.SmilesGenerator.inchiNumbers(SmilesGenerator.java:715)
	at org.openscience.cdk.smiles.SmilesGenerator.labels(SmilesGenerator.java:681)