This repo is the aggregate repository featuring all simulation models used within the Blue Brain Project to run in-silico simulations of mouse brains using the NEURON simulator.

The models contained here require a compiler, CMake, MPI, and HDF5 to be installed. On a Ubuntu system,

sudo apt-get install cmake libopenmpi-dev libhdf5-dev

will install the necessary dependencies. The NEURON simulator and Neurodamus simulation framework can be installed via pip:

python -m pip install NEURON-nightly neurodamus

Further, an installation of libsonatareport is required. This can be built with:

git clone https://github.com/BlueBrain/libsonatareport reports/src --recursive --shallow-submodules
cmake \
  -B reports/build \
  -S reports/src \
  -DCMAKE_INSTALL_PREFIX=reports/install \
  -DSONATA_REPORT_ENABLE_SUBMODULES=ON \
  -DSONATA_REPORT_ENABLE_TEST=OFF
cmake --build reports/build
cmake --install reports/build

The mechanisms for a model can be built as follows, using the neocortex model as an example:

git clone https://github.com/BlueBrain/neurodamus-models.git neurodamus-models/src
export CC=$(which mpicc)
export CXX=$(which mpicxx)
# This can be set directly if the installation location of neurodamus is known
DATADIR=$(python -c "import neurodamus; from pathlib import Path; print(Path(neurodamus.__file__).parent / 'data')")
cmake -B neurodamus-models/build -S neurodamus-models/src \
  -DCMAKE_INSTALL_PREFIX=$PWD/neurodamus-models/install \
  -DCMAKE_INSTALL_RPATH_USE_LINK_PATH=ON \
  -DCMAKE_PREFIX_PATH=$PWD/reports/install \
  -DNEURODAMUS_CORE_DIR=${DATADIR} \
  -DNEURODAMUS_MECHANISMS=neocortex
cmake --build neurodamus-models/build
cmake --install neurodamus-models/build

This will also produce a build_neurodamus.sh script that can be used to compile future iterations of the MOD files.

Following the above step, the compiled mechanisms can be accessed from within NEURON, e.g., with:

./neurodamus-models/install/bin/special -python -c "from neuron import h; from neurodamus import Neurodamus; h.quit()"

For an example on how to run a model with compiled mechanisms on a circuit, see the integration test of Neurodamus.

For the cases where a combined set of models is desirable a model_manager.py tool is provided.

The details on how the models can be combined without clashing (i.e. same SUFFIX in MOD files) is to be provided in a configuration file, where the user specifies a number of source models to be combined with an optional "prefix". Let's refer to the included model_config.json for an example:

{
    "ALL": {
        "common": {
            "mods": ["common/mod/*.mod"],
            "hocs": ["common/hoc/*.hoc"]
        },
        "neocortex": {
            "prefix": "NCX",
            "mods": [
                "neocortex/mod/v6/*.mod",
                ["neocortex/mod/v5/DetGABAAB.mod", "new_name_for_DetGABAAB.mod"]
            ],
            "hocs": []
        }
    }
}

Where

• ALL is the name of this combined model. Resulting set will be stored in build/ALL.
• common and neocortex are names of two sources of mod/hoc files.
• For the common, we specified "mods" and "hocs" without prefix which means they are copied verbatim / without any modifications. In our case this is important for existing circuits to keep working with unmodified synapse names.
• neocortex specifies the NCX prefix. This means:
  • File names are prefixed with "NCX", unless otherwise specified
  • All .mod files (density channels, Point Processes and Artificial Cells) get their names prefixed
  • All references to these mechanisms in .hoc files are adjusted accordingly.
• "mods" and "hocs" lists accept a number of entries
  • If the entry is a string then it's the path of the file to be considered (wildcards supported). E.g. neocortex/mod/v6/*.mod
  • If the entry is a list, the second argument is taken as the new name. E.g. new_name_for_DetGABAAB.mod is the new name of DetGABAAB.mod (no prefix)

# It's an executable Python application
$ ./model_manager.py
Usage: ./model_manager.py <config_file> [--only-synapses]

$ ./model_manager.py model_config.json
[INFO] Checking 'ALL'
[INFO] Building 'ALL' (only_synapses=False)
[INFO]  - Processing common
[INFO]  - Processing neocortex
[INFO]    > Path neocortex/mod/v6/*.mod
[INFO]    > Path ['neocortex/mod/v5/DetGABAAB.mod', 'new_name_for_DetGABAAB.mod']
[INFO]    > Path neocortex/hoc/AMPANMDAHelper.hoc
[INFO]    > Path neocortex/hoc/GABAABHelper.hoc
[INFO]    > Path neocortex/hoc/GluSynapseHelper.hoc
...

$ ls build/ALL
hoc mod

Notice an optional --only-synapses argument. It is intended to apply renaming rules only to synapse files, currently ProbAMPANMDA_EMS.mod, ProbGABAAB_EMS.mod and GluSynapse.mod.

This may be useful in case you are working with existing circuits where you do not want to rename machanisms yet, but still you want to rename and bundle the several synapse types together.

The development of this software was supported by funding to the Blue Brain Project, a research center of the École polytechnique fédérale de Lausanne (EPFL), from the Swiss government’s ETH Board of the Swiss Federal Institutes of Technology.

Copyright (c) 2009-2024 Blue Brain Project/EPFL