@yannickwurm: "Some major work is required for modules which require binaries. Currently using samtools (etc) involves download & compiling... this is extremely prone to fail & a big maintenance effort. Instead, rely on local docker install (so each module relies on a single docker file. (thus each module would include a dockerfile)."

So, either we:

• Rely on Docker like Yannick says (issue: Docker becomes a dependency);
• Don't provide at all the binaries (just the wrapper) and push the responsibility of installing to the user (sucks and hard to control versioning);
• Try to provide pre-compiled binaries (but then, we're doing package management...). @maxogden might have some ideas;
• Turn some of those tools into native addons (hard to do and maintain in sync with upstream).