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Awesome Workflow Optimization for LLM Agents

Paper

A curated list of papers on workflow optimization for LLM agents.

This repository accompanies the survey paper: From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents (https://arxiv.org/abs/2603.22386).

Overview

This list focuses on papers whose main contribution is workflow optimization. To keep the repository concise and method-centric, it does not aim to cover general survey papers, benchmarks, datasets, or framework/tooling papers.

The list is organized by when workflow structure is determined: static optimization and dynamic optimization.

Table of Contents

Static Optimization

Offline template search over constrained design spaces

Title Year Paper
AFlow: Automating Agentic Workflow Generation 2025 Link
Automated Design of Agentic Systems 2025 Link
A²Flow: Automating Agentic Workflow Generation via Self-Adaptive Abstraction Operators 2026 Link
SEW: Self-Evolving Agentic Workflows for Automated Code Generation 2025 Link
Evolutionary Generation of Multi-Agent Systems 2026 Link

Node-level optimization inside fixed scaffolds

Title Year Paper
DSPy: Compiling Declarative Language Model Calls into State-of-the-Art Pipelines 2024 Link
Large Language Models as Optimizers 2024 Link
Connecting Large Language Models with Evolutionary Algorithms Yields Powerful Prompt Optimizers 2024 Link
CAPO: Cost-Aware Prompt Optimization 2025 Link
GEPA: Reflective Prompt Evolution Can Outperform Reinforcement Learning 2026 Link
Optima: Optimizing Effectiveness and Efficiency for LLM-Based Multi-Agent System 2025 Link

Joint optimization of structure and local configuration

Title Year Paper
Multi-Agent Design: Optimizing Agents with Better Prompts and Topologies 2026 Link
Learning Multi-Agent Communication from Graph Modeling Perspective 2024 Link
Maestro: Joint Graph & Config Optimization for Reliable AI Agents 2025 Link

Verifiability in static workflow optimization

Title Year Paper
MermaidFlow: Redefining Agentic Workflow Generation via Safety-Constrained Evolutionary Programming 2025 Link
VFlow: Discovering Optimal Agentic Workflows for Verilog Generation 2026 Link

Dynamic Optimization and Runtime Adaptation

Selection and pruning as the lightest form of runtime adaptation

Title Year Paper
Cut the Crap: An Economical Communication Pipeline for LLM-Based Multi-Agent Systems 2025 Link
Adaptive Graph Pruning for Multi-Agent Communication 2025 Link
DAGP: Difficulty-Aware Graph Pruning for LLM-Based Multi-Agent Systems 2025 Link
AgentDropout: Dynamic Agent Elimination for Token-Efficient and High-Performance LLM-Based Multi-Agent Collaboration 2025 Link
A Dynamic LLM-Powered Agent Network for Task-Oriented Agent Collaboration 2024 Link
MasRouter: Learning to Route LLMs for Multi-Agent Systems 2025 Link
SkillOrchestra: Learning to Route Agents via Skill Transfer 2026 Link

Construct-then-execute: pre-execution workflow generation

Title Year Paper
Difficulty-Aware Agentic Orchestration for Query-Specific Multi-Agent Workflows 2026 Link
Assemble Your Crew: Automatic Multi-Agent Communication Topology Design via Autoregressive Graph Generation 2026 Link
G-Designer: Architecting Multi-Agent Communication Topologies via Graph Neural Networks 2025 Link
Dynamic Generation of Multi-LLM Agents Communication Topologies with Graph Diffusion Models 2025 Link
Multi-Agent Architecture Search via Agentic Supernet 2025 Link
ScoreFlow: Mastering LLM Agent Workflows via Score-Based Preference Optimization 2025 Link
FlowReasoner: Reinforcing Query-Level Meta-Agents 2025 Link
Workflow-R1: Group Sub-sequence Policy Optimization for Multi-Turn Workflow Construction 2026 Link
AutoFlow: Automated Workflow Generation for Large Language Model Agents 2024 Link
WorkflowLLM: Enhancing Workflow Orchestration Capability of Large Language Models 2025 Link
RobustFlow: Towards Robust Agentic Workflow Generation 2025 Link
ComfyUI-R1: Exploring Reasoning Models for Workflow Generation 2025 Link
AutoAgents: A Framework for Automatic Agent Generation 2024 Link

In-execution editing: interleaving execution with structural change

Title Year Paper
DyFlow: Dynamic Workflow Framework for Agentic Reasoning 2025 Link
AgentConductor: Topology Evolution for Multi-Agent Competition-Level Code Generation 2026 Link
Aime: Towards Fully-Autonomous Multi-Agent Framework 2025 Link
AOrchestra: Automating Sub-Agent Creation for Agentic Orchestration 2026 Link
MetaGen: Self-Evolving Roles and Topologies for Multi-Agent LLM Reasoning 2026 Link
ProAgent: From Robotic Process Automation to Agentic Process Automation 2023 Link
Flow: Modularized Agentic Workflow Automation 2025 Link
EvoFlow: Evolving Diverse Agentic Workflows on the Fly 2025 Link
DebFlow: Automating Agent Creation via Agent Debate 2025 Link
QualityFlow: An Agentic Workflow for Program Synthesis Controlled by LLM Quality Checks 2025 Link

Contributing

Contributions are welcome! To suggest a new paper, please open an issue with the following information:

  1. Paper title, year, and a link to the official paper page.
  2. The subsection you think it belongs to.
  3. A brief reason why its main contribution is workflow optimization.

We will review and update the list accordingly. Please note:

  • Only papers whose main contribution is workflow optimization will be included.
  • Each paper is placed in exactly one subsection that best matches its main contribution.
  • We prefer official paper pages (e.g., conference proceedings, arXiv).

Citation

If you find this repository or the accompanying survey helpful, please cite:

@article{yue2026survey,
  title={From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents},
  author={Yue, Ling and Bhandari, Kushal Raj and Ko, Ching-Yun and Patel, Dhaval and Lin, Shuxin and Zhou, Nianjun and Gao, Jianxi and Chen, Pin-Yu and Pan, Shaowu},
  journal={arXiv preprint arXiv:2603.22386},
  year={2026}
}

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