I noticed that when i use jamesdsp, i've crackling sound from time to time with pipewire.
I tried to force the quantum even to 512 to no avail and without jamesdsp I can safely go down to 32.

[plasmauser@Gozer ~]$ uname -a
Linux Gozer 5.17.1-arch1-1 #1 SMP PREEMPT Mon, 28 Mar 2022 20:55:33 +0000 x86_64 GNU/Linux
[plasmauser@Gozer ~]$ pacman -Q jamesdsp
jamesdsp-git 2.3.r29.ga11f428-1
[plasmauser@Gozer ~]$ pacman -Q pipewire
pipewire 1:0.3.49-1

I'm not doing anything special, just playing an mp3 and use an equalizer from jamesdsp.
The crackling appears when firefox is loading a page or maybe when i maximize a window.
I even tried to set jamesdsp to realtime priority.