Seems like there some problems in "AnyPlayer" fix patch which will cause auto play pause the game, here is a part of the log:

[INFO] DevConsole: card CASCADE
[INFO] Player 1 playing card CASCADE (no target)
[ERROR] System.TypeLoadException: Could not load type 'MegaCrit.Sts2.Core.Combat.ICombatState' from assembly 'sts2, Version=0.1.0.0, Culture=neutral, PublicKeyToken=null'.
at MonoMod.Core.Interop.CoreCLR.V60.InvokeCompileMethod(IntPtr functionPtr, IntPtr thisPtr, IntPtr corJitInfo, CORINFO_METHOD_INFO* methodInfo, UInt32 flags, Byte** nativeEntry, UInt32* nativeSizeOfCode)
at MonoMod.Core.Platforms.Runtimes.Core60Runtime.JitHookDelegateHolder.CompileMethodHook(IntPtr jit, IntPtr corJitInfo, CORINFO_METHOD_INFO* methodInfo, UInt32 flags, Byte** nativeEntry, UInt32* nativeSizeOfCode)
at BaseLib.Patches.Fixes.CardCmdAutoPlayAnyPlayerPatch.RandomAnyPlayer(CardModel card, Creature& target)

It affects all cards with auto-play function, may need a hot fix