Promoting in silico neuroscience with a resource of pretrained encoding models of the brain.
Explore BERGThe functioning of the brain in health and disease is still largely a mystery, partly because the process of collecting in vivo neural data is slow and expensive thus providing a bottleneck for brain experimentation and discovery. In silico neuroscience is an emerging research paradigm that addresses this limitation through experimentation on large amounts of in silico neural responses generated by encoding models in a fast and economical fashion. Compared to in vivo experiments on real brains, the unprecedented amount of in-silico-generated neural responses allows researchers to test more scientific hypotheses and to upscale exploratory research. Crucially, novel findings from large-scale in silico experimentation are eventually validated in vivo, but with targeted small-scale data collection, therefore optimizing research resources and allowing for faster neuroscientific discovery.
To empower this emerging research paradigm, we introduce the Brain Encoding Response Generator (BERG), a resource consisting of diverse pre-trained encoding models of the brain and a Python package to easily generate in silico neural responses to arbitrary stimuli with just a few lines of code. BERG enables researchers to efficiently address a wide range of research questions through in silico neuroscience by providing a growing, well documented library of encoding models trained on different neural recording modalities, species, datasets, subjects, and brain areas.
Beyond BERG's native models, BERG is also integrated with BrainScore, giving you access to hundreds of vision and language encoding models of the brain.
We envision that BERG will empower in silico neuroscience, ultimately accelerating scientific discovery. We warmly welcome models, ideas, and collaboration from the vision science community.
Would you like to make the encoding models from your projects easily accessible and usable with minimal, intuitive, and scalable code? Or would you like to contribute to BERG with new toolbox features or ideas? Then get in touch!
We would be grateful if you could take a few minutes to share your feedback on BERG, to contribute to improving BERG's usefulness and reliability: https://forms.gle/pybrqcaqdso2LJK88
We added to BERG encoding models trained on (Tuckute et al., 2024).
We added to BERG encoding models trained on MOSAIC (Lahner et al., 2025), and mice foundation models (Wang et al., 2025).
We added to BERG encoding models trained on THINGS fMRI1 and THINGS MEG1 (Hebart et al., 2023), and on the THINGS ventral stream spiking dataset (TVSD; Papale et al., 2025).
We presented a poster on BERG at the Cognitive Computational Neuroscience (CCN) conference in Amsterdam.
We added to BERG the fMRI encoding model trained on NSD (Allen et al., 2025) by Huze, the winner of the Algonauts Project 2023 challenge.
The paper "In silico discovery of representational relationships across visual cortex", which used BERG, has been published in Nature Human Behavior (Gifford et al., 2025).
We added to BERG EEG encoding models trained on THINGS EEG2 (Gifford et al., 2022).
For inquiries, contact us at brain.berg.info@gmail.com