Skip to main content
Springer Nature Link
Log in

Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor

  • Chapter
  • First Online:
Save chapter
View saved research
Neurotoxin Modeling of Brain Disorders—Life-long Outcomes in Behavioral Teratology

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 29))

  • 1608 Accesses

  • 6 Citations

Abstract

This mini review focuses on the importance of the dopamine D2-like receptor family and its importance in psychosis. Past findings from this laboratory along with collaborators have been that neonatal quinpirole (a dopamine D2-like receptor agonist) results in increases in dopamine D2 receptor sensitivity that persists throughout the animal’s lifetime. Findings from this model have been shown to have particular application and validity to schizophrenia, but may have broader implications toward other psychoses, which is reviewed in the present manuscript. In the present review, we also highlight other models of psychoses that have been centered on the subchronic administration of quinpirole to rats in order to model certain psychoses, which has uncovered some interesting and valid behavioral findings. This review highlights the importance of the combination of behavioral findings and neurobiological mechanisms focusing on neural plasticity in discovering underlying pathologies in these disorders that may lead to treatment discoveries, as well as the value of animal models across all psychoses.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+
from €37.37 /Month
  • Starting from 10 chapters or articles per month
  • Access and download chapters and articles from more than 300k books and 2,500 journals
  • Cancel anytime
View plans

Buy Now

Chapter
EUR 29.95
Price includes VAT (Netherlands)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 117.69
Price includes VAT (Netherlands)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
EUR 163.49
Price includes VAT (Netherlands)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles, books and news in related subjects, suggested using machine learning.

References

  • Aase H, Sagvolden T (2006) Infrequent, but not frequent, reinforcers produce more variable responding and deficient sustained attention in young children with attention deficit/hyperactivity disorder (ADHD). J Child Psychol Psychiatry 47:457–471

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (2002) Practice guideline for the treatment of patients with bipolar disorder. American Psychiatric Pub

    Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Publishing, Arlington

    Book  Google Scholar 

  • Andersen SL, Teicher MH (2000) Sex differences in dopamine receptors and their relevance to ADHD. Neurosci Biobehav Rev 24:137–141

    Article  CAS  PubMed  Google Scholar 

  • Andersen SL, Greene-Colozzi EA, Sonntag KC (2010) A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals. Biol Psychiatry 68:741–747

    Article  PubMed  Google Scholar 

  • Andréasson S, Engström A, Allebeck P, Rydberg U (1987) Cannabis and schizophrenia longitudinal study of Swedish conscripts. The Lancet 330:1483–1486

    Article  Google Scholar 

  • Aouizerate B, Guehl D, Cuny E, Rougier A, Burbaud P, Tignol J, Bioulac B (2005) Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder. Neuropsychiatr Dis Treat 1:231–243

    CAS  PubMed  PubMed Central  Google Scholar 

  • Beaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182–217

    Article  CAS  PubMed  Google Scholar 

  • Beaulieu JM, Del’guidice T, Sotnikova TD, Lemasson M, Gainetdinov RR (2011) Beyond camp: the regulation of Akt and GSK3 by dopamine receptors. Front Mol Neurosci. 4:38

    Article  PubMed  PubMed Central  Google Scholar 

  • Berg SA, Chambers RA (2008) Accentuated behavioral sensitization to nicotine in the neonatal ventral hippocampal lesion model of schizophrenia. Neuropharmacology 8:1201–1207

    Article  CAS  Google Scholar 

  • Binder DK, Scharfman HE (2004) Brain-derived neurotrophic factor. Growth Factors 22:123–131

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brown RW, Gass JT, Kostrzewa RM (2002) Ontogenetic quinpirole treatments produce spatial memory deficits and enhance skilled reaching in adult rats. Pharmacol Biochem Behav 72:591–600

    Article  CAS  PubMed  Google Scholar 

  • Brown RW, Perna MK, Maple AM, Wilson TD, Miller BE (2008) Adulthood olanzapine treatment fails to alleviate decreases of ChAT and BDNF RNA expression in rats quinpirole-primed as neonates. Brain Res 20:66–77

    Article  CAS  Google Scholar 

  • Brown RW, Maple AM, Perna MK, Sheppard AB, Cope ZA, Kostrzewa RM (2012) Schizophrenia and substance abuse comorbidity: nicotine addiction and the neonatal quinpirole model. Dev Neurosci 34(2–3):140–151

    Article  CAS  PubMed  Google Scholar 

  • Cardno AG, Holmans PA, Rees MI, Jones LA, McCarthy GM, Hamshere ML, Williams NM, Norton N, Williams HJ, Fenton I, Murphy KC, Sanders RD, Gray MY, O'Donovan MC, McGuffin P, Owen MJ (2001) A genomewide linkage study of age at onset in schizophrenia. Am J Med Genet 105:439–45

    Article  CAS  PubMed  Google Scholar 

  • Celver J, Sharma M, Kovoor A (2010) RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors. J Neurochem 114:739–749

    Article  CAS  PubMed  Google Scholar 

  • Chambers RA, McClintick JN, Sentir AM, Berg SA, Runyan M, Choi KH, Edenberg HJ (2013) Cortical-striatal gene expression in neonatal hippocampal lesion (NVHL)-amplified cocaine sensitization. Genes Brain Behav 12:564–575

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen G, Henter ID, Manji HK (2010) Translational research in bipolar disorder: emerging insights from genetically based models. Mol Psychiatry 15:883–895

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chiu P, Rajakumar G, Chiu S, Kwan CY, Mishra RK (1982) Enhanced [3 H] spiroperidol binding in striatum of spontaneously hypertensive rat (SHR). Eur J Pharmacol 82:243–244

    Article  CAS  PubMed  Google Scholar 

  • Cohen SM, Tsien RW, Goff DC, Halassa MM (2015) The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophr Res 167:98–107

    Article  PubMed  Google Scholar 

  • Conroy SK, Rodd Z, Chambers RA (2007) Ethanol sensitization in a neurodevelopmental lesion model of schizophrenia in rats. Pharmacol Biochem Behav 86:386–394

    Article  CAS  PubMed  Google Scholar 

  • Cope ZA, Huggins KN, Sheppard AB, Noel DM, Roane DS, Brown RW (2010) Neonatal quinpirole treatment enhances locomotor activation and dopamine release in the nucleus accumbens core in response to amphetamine treatment in adulthood. Synapse 64:289–300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cowansage KK, LeDoux JE, Monfils MH (2010) Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr Mol Pharmacol 3:12–29

    Article  CAS  PubMed  Google Scholar 

  • Cuesta MJ, Jalón EG, Campos MS, Peralta V (2009) Cognitive effectiveness of olanzapine and risperidone in first-episode psychosis. Br J Psychiatry 194:439–445

    Article  PubMed  Google Scholar 

  • Denys D (2006) Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders. Psychiatr Clin North Am 29:553–584

    Article  PubMed  Google Scholar 

  • Denys D, de Geus F, van Megen HJ, Westenberg HG (2004a) A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors. J Clin Psychiatry 65:1040–1048

    Article  CAS  PubMed  Google Scholar 

  • Denys D, van der Wee N, Janssen J, De Geus F, Westenberg HG (2004b) Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol Psychiatry 55:1041–1045

    Article  CAS  PubMed  Google Scholar 

  • Dixon L (1999) Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes. Schizophr Res 35(Suppl):S93–S100

    Article  PubMed  Google Scholar 

  • Durany N, Michel T, Zöchling R, Boissl KW, Cruz-Sánchez FF, Riederer P, Thome J (2001) Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res 52:79–86

    Article  CAS  PubMed  Google Scholar 

  • Eilam D, Zor R, Szechtman H, Hermesh H (2006) Rituals, stereotypy and compulsive behavior in animals and humans. Neurosci Biobehav Rev 30:456–471

    Article  PubMed  Google Scholar 

  • Einat H (2007a) Establishment of a battery of simple models for facets of bipolar disorder: a practical approach to achieve increased validity, better screening and possible insights into endophenotypes of disease. Behav Genet 37:244–255

    Article  PubMed  Google Scholar 

  • Einat H (2007b) Different behaviors and different strains: potential new ways to model bipolar disorder. Neurosci Biobehav Rev 31:850–857

    Article  PubMed  Google Scholar 

  • Einat H, Szechtman H (1995) Perseveration without hyperlocomotion in a spontaneous alternation task in rats sensitized to the dopamine agonist quinpirole. Physiol Behav 57:55–59

    Article  CAS  PubMed  Google Scholar 

  • Fineberg NA, Sivakumaran T, Roberts A, Gale T (2005) Adding quetiapine to SRI in treatment-resistant obsessive–compulsive disorder: a randomized controlled treatment study. Int Clin Psychopharmacol 20:223–226

    Article  PubMed  Google Scholar 

  • Ford CP (2014) The role of D2-autoreceptors in regulating dopamine neuron activity and transmission. Neuroscience 282C:13–22

    Article  CAS  Google Scholar 

  • Freedman R, Adams CE, Leonard S (2000) The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia. Chem Neuroanat 2000(20):299–306

    Article  Google Scholar 

  • Frodl T (2010) Comorbidity of ADHD and substance use disorder (SUD): a neuroimaging perspective. J Attention Disord 14(2):109–120

    Article  Google Scholar 

  • Greenbaum L, Pelov I, Teltsh O, Lerer B, Kohn Y (2010) No association between regulator of G-protein signaling 9 (RGS9) and schizophrenia in a Jewish population. Psychiatr Genet 20:47–48

    Article  PubMed  Google Scholar 

  • Haenlein M, Caul WF (1987) Attention deficit disorder with hyperactivity: a specific hypothesis of reward dysfunction. J Am Acad Child Adolesc Psychiatry 26:356–362

    Article  CAS  PubMed  Google Scholar 

  • Hand DJ, Fox AT, Reilly MP (2009) Differential effects of d-amphetamine onimpulsive choice in spontaneously hypertensive and wistar-kyoto rats. Behav Pharmacol 20:549–553

    Article  CAS  PubMed  Google Scholar 

  • Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122:593–624

    Article  PubMed  Google Scholar 

  • Henquet C, Murray R, Linszen D, van Os J (2005) The environment and schizophrenia: the role of cannabis use. Schizophr Bull 31:608–612

    Article  PubMed  Google Scholar 

  • Hesse S, Muller U, Lincke T, Barthel H, Villmann T, Angermeyer MC et al (2005) Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder. Psychiatry Res 140:63–72

    Article  CAS  PubMed  Google Scholar 

  • Hoffman KL, Rueda Morales RI (2012) D1 and D2 dopamine receptor antagonists decrease behavioral bout duration, without altering the bout’s repeated behavioral components, in a naturalistic model of repetitive and compulsive behavior. Behav Brain Res 230:1–10

    Article  CAS  PubMed  Google Scholar 

  • Hollinger S, Hepler JR (2002) Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev 54:527–559

    Article  CAS  PubMed  Google Scholar 

  • Iritani S (2007) Neuropathology of schizophrenia: A mini review. Neuropathology 27:604–608

    Article  PubMed  Google Scholar 

  • Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677–736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Janhunen SK, Svärd H, Talpos J, Kumar G, Steckler T, Plath N, Lerdrup L, Ruby T, Haman M, Wyler R, Ballard TM (2015) The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia. Psychopharmacology

    Google Scholar 

  • Johansen E, Killeen PR, Russell VA, Tripp G, Wickens JR, Tannock R, Sagvolden T (2009) Origins of altered reinforcement effects in ADHD. Behav Brain Functions 5:7–11

    Article  CAS  Google Scholar 

  • Johnston L, Bachman J, O’Malley P, Schulenberg J (2012) Monitoring the future: a continuing study of American youth (12th-Grade Survey), ICPSR34409-v2. Ann Arbor MI Inter-Univ Consort Polit Soc Res Distrib 11–20

    Google Scholar 

  • Jones CA, Zempléni E, Davis B, Reynolds GP (1993) Glutamate stimulates dopamine release from cortical and limbic rat brain in vitro. Eur J Pharmacol 242:183–187

    Article  CAS  PubMed  Google Scholar 

  • Julien RM, Advokat C, Comaty J (2015) A primer of drug action, 12th edn. Worth Publishers, New York

    Google Scholar 

  • Kaiser S, Wonnacott S (2000) Alpha-bungarotoxin-sensitive nicotinic receptors indirectly modulate [(3)H]dopamine release in rat striatal slices via glutamate release. Mol Pharmacol 58:312–318

    Article  CAS  PubMed  Google Scholar 

  • Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96

    Article  CAS  PubMed  Google Scholar 

  • Kim CH, Koo MS, Cheon KA, Ryu YH, Lee JD, Lee HS (2003) Dopamine transporter density of basal ganglia assessed with [123I] IPT SPET in obsessive-compulsive disorder. Eur J Nucl Med Mol Imaging 30(12):1637–1643

    Article  CAS  PubMed  Google Scholar 

  • Kostrzewa RM (1995) Dopamine receptor supersensitivity. Neurosci Biobehav Rev 19:1–17

    Article  CAS  PubMed  Google Scholar 

  • Kostrzewa RM, Brus R (1991) Ontogenic homologous supersensitization of quinpirole-induced yawning in rats. Pharmacol Biochem Behav 39:517–519

    Article  CAS  PubMed  Google Scholar 

  • Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J (2005) D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci 25:2157–2165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Laruelle M, Abi-Dargham A, Gil R, Kegeles L, Innis R (1999) Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol Psychiatry 46:56–72

    Article  CAS  PubMed  Google Scholar 

  • Lipska BK, Weinberger DR (2002) A neurodevelopmental model of schizophrenia: neonatal disconnection of the hippocampus. Neurotox Res 4:469–475

    Article  PubMed  Google Scholar 

  • Lyon L, Saksida LM, Bussey TJ (2012) Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models. Psychopharmacology 220:647–672

    Article  CAS  PubMed  Google Scholar 

  • Magnuson B, Ekim B, Fingar DC (2012) Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 441:1–21

    Article  CAS  PubMed  Google Scholar 

  • Malkesman O, Austin DR, Chen G, Manji HK (2009) Reverse translational strategies for developing animal models of bipolar disorder. Disease Models Mechanisms. 2:238–245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mao D, McGehee DS (2010) Nicotine and behavioral sensitization. J Mol Neurosci 40:154–163

    Article  CAS  PubMed  Google Scholar 

  • Maple AM, Perna MK, Parlaman JP, Stanwood GD, Brown RW (2007) Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex. Eur J Neurosci 26(9):2532–2538

    Article  PubMed  Google Scholar 

  • Maple AM, Smith KJ, Perna MK, Brown RW (2015) Neonatal quinpirole treatment produces prepulse inhibition deficits in adult male and female rats. Pharmacol Biochem Behav 137:93–100

    Article  CAS  PubMed  Google Scholar 

  • McCreadie RG, Kelly C (2000) Patients with schizophrenia who smoke. Private disaster, public resource. Br J Psychiatry 176:109–116

    Article  CAS  PubMed  Google Scholar 

  • Monteiro P, Feng G (2015) Learning from animal models of obsessive-compulsive disorder. Biol Psychiatry

    Google Scholar 

  • Mook DM, Jeffrey J, Neuringer A (1993) Spontaneously hypertensive rats (SHR) readily learn to vary but not repeat instrumental responses. Behav Neural Biol 59:126–135

    Article  CAS  PubMed  Google Scholar 

  • Mueser KT, Gingerich S (2013) Treatment of co-occurring psychotic and substance use disorders. Soc Work Public Health 28:424–439

    Article  PubMed  Google Scholar 

  • Neubig RR (2002) Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets. J Pept Res 60:312–316

    Article  CAS  PubMed  Google Scholar 

  • Neubig RR, Siderovski DP (2002) Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov 1:187–197

    Article  CAS  PubMed  Google Scholar 

  • Nikam SS, Awasthi AK (2008) Evolution of schizophrenia drugs: a focus on dopaminergic systems. Curr Opin Investig Drugs 9:37–46

    CAS  PubMed  Google Scholar 

  • Nikolaus S, Antke C, Beu M, Müller HW (2010) Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders-results from in vivo imaging studies. Rev Neurosci 21:119–139

    Article  CAS  PubMed  Google Scholar 

  • Nutt D, King LA, Saulsbury W, Blakemore C (2007) Development of a rational scale to assess the harm of drugs of potential misuse. The Lancet 369:1047–1053

    Article  Google Scholar 

  • Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H (2011) Association between the regulator of G-protein signaling 9 gene and patients with methamphetamine use disorder and schizophrenia. Curr Neuropharmacol 9:190–194

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Olver JS, O’Keefe G, Jones GR, Burrows GD, Tochon-Danguy HJ, Ackermann U, Norman TR (2009) Dopamine D1 receptor binding in the striatum of patients with obsessive–compulsive disorder. J Affect Disord 114:321–326

    Article  CAS  PubMed  Google Scholar 

  • Perani D, Garibotto V, Gorini A, Moresco RM, Henin M, Panzacchi A, Fazio F (2008) In vivo PET study of 5HT 2A serotonin and D2 dopamine dysfunction in drug naive obsessive-compulsive disorder. Neuroimage 42:306–314

    Article  PubMed  Google Scholar 

  • Picchioni MM, Murray RM (2007) Schizophrenia. BMJ 335:91–95

    Article  PubMed  PubMed Central  Google Scholar 

  • Pinsonneault JK, Han DD, Burdick KE, Kataki M, Bertolino A, Malhotra AK, Gu HH, Sadee W (2011) Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology. 36:1644–1655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rizos EN, Papadopoulou A, Laskos E, Michalopoulou PG, Kastania A, Vasilopoulos D, Katsafouros K, Lykouras L (2010) Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics. World J Biol Psychiatry 11:251–255

    Article  PubMed  Google Scholar 

  • Robinson TE, Becker JB (1986) Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res 396:157–198

    Article  CAS  PubMed  Google Scholar 

  • Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, McClung CA (2007) Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci 104:6406–6411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication. Mol Psychiatry 15:53–63

    Article  CAS  PubMed  Google Scholar 

  • Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J (1995) Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of attention-deficit hyperactivity disorder—the spontaneously hypertensive rat. Brain Res 676:343–351

    Article  CAS  PubMed  Google Scholar 

  • Russell VA, Sagvolden T, Johansen EB (2005) Animal models of attention-deficit hyperactivity disorder. Behav Brain Functions 1(1):9

    Article  CAS  Google Scholar 

  • Sagvolden T (2000) Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD). Neurosci Biobehav Rev 24:31–39

    Article  CAS  PubMed  Google Scholar 

  • Sagvolden T, Asse H, Johansen EB, Russell VA (2005) A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominately hyperactive/impulsive and combined subtypes. Behav Brain Sci 28(397):486

    Google Scholar 

  • Saldana L, Neuringer A (1998) Is instrumental variability abnormally high in children exhibiting ADHD and aggressive behavior? Behav Brain Res 94:51–59

    Article  CAS  PubMed  Google Scholar 

  • Salvadore G, Quiroz JA, Machado-Vieira R, Henter ID, Manji HK, Zarate CA (2010) The neurobiology of the switch process in bipolar disorder: a review. J Clin Psychiatry 71:1488–1501

    Article  PubMed  PubMed Central  Google Scholar 

  • Sams-Dodd F, Lipska BK, Weinberger DR (1997) Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood. Psychopharmacology 132:303–310

    Article  CAS  PubMed  Google Scholar 

  • Saul MC, Gessay GM, Gammie SC (2012) A new mouse model for mania shares genetic correlates with human bipolar disorder. PLoS ONE 7:e38128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schilman EA, Klavir O, Winter C, Sohr R, Joel D (2010) The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system. Neuropsychopharmacology 35:1026–1039

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schmitz Y, Lee CJ, Schmauss C, Gonon F, Sulzer D (2001) Amphetamine distorts stimulation-dependent dopamine overflow: effects on D2 autoreceptors, transporters, and synaptic vesicle stores. J Neurosci 21:5916–5924

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schneider M, Koch M (2003) Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology 28:1760–1769

    Article  CAS  PubMed  Google Scholar 

  • Seeman P, Schwarz J, Chen JF, Szechtman H, Perreault M, McKnight GS, Roder JC, Quirion R, Boksa P, Srivastava LK, Yanai K, Weinshenker D, Sumiyoshi T (2006) Psychosis pathways converge via D2 high dopamine receptors. Synapse 60:319–346

    Article  CAS  PubMed  Google Scholar 

  • Selvaraj S, Arnone D, Cappai A, Howes O (2014) Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies. Neurosci Biobehav Rev 45:233–245

    Article  CAS  PubMed  Google Scholar 

  • Seutin V, Verbanck P, Massotte L, Dresse A (1991) Acute amphetamine-induced subsensitivity of A10 dopamine autoreceptors in vitro. Brain Res 558:141–144

    Article  CAS  PubMed  Google Scholar 

  • Shaldubina A, Einat H, Szechtman H, Shimon H, Belmaker RH (2002) Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. J Neural Transm 109(3):433–440

    Article  CAS  PubMed  Google Scholar 

  • Sharma A, Couture J (2014) A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Ann Pharmacother 48(2):209–225

    Article  PubMed  Google Scholar 

  • Smolders I, Sarre S, Vanhaesendronck C, Ebinger C, Michotte C (1996) Extracellular striatal dopamine and glutamate after decortication and kainate receptor stimulation, as measured by microdialysis. J Neurochem 66:2373–2380

    Article  CAS  PubMed  Google Scholar 

  • Szabo ST, Machado-Vieira R, Yuan P, Wang Y, Wei Y, Falke C, Du J (2009) Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology 56:47–55

    Article  CAS  PubMed  Google Scholar 

  • Thacker SK, Perna MK, Ward JJ, Schaefer TL, Williams MT, Kostrzewa RM, Brown RW (2006) The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpirole. Eur J Neurosci 24:2075–2083

    Article  PubMed  Google Scholar 

  • Thompson JL, Urban N, Slifstein M, Xu X, Kegeles LS, Girgis RR, Beckerman Y, Harkavy-Friedman JM, Gil R, Abi-Dargham A (2013) Striatal dopamine release in schizophrenia comorbid with substance dependence. Mol Psychiatry. 18:909–915

    Article  CAS  PubMed  Google Scholar 

  • Tizabi Y, Copeland RL Jr, Brus R, Kostrzewa RM (1999) Nicotine blocks quinpirole-induced behavior in rats: psychiatric implications. Psychopharmacology 145:433–441

    Article  CAS  PubMed  Google Scholar 

  • Tollefson GD (1996) Update on new atypical antipsychotics. J Clin Psychiatry 57:318–319

    Google Scholar 

  • Tripp G, Wickens JR (2009) Neurobiology of ADHD. Neuropharmacology 57:579–589

    Article  CAS  PubMed  Google Scholar 

  • Tucci MC, Dvorkin-Gheva A, Sharma R, Taji L, Cheon P, Peel J, Kirk A, Szechtman H (2014) Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD). Psychopharmacology 231:3707–3718

    Article  CAS  PubMed  Google Scholar 

  • van der Wee NJ, Stevens H, Hardeman JA, Mandl RC, Denys DA, van Megen HJ, Westenberg HM (2004) Enhanced dopamine transporter density in psychotropic naive patients with obsessive-compulsive disorder shown by [123I] β-CIT SPECT. Am J Psychiatry 161:2201–2206

    Article  PubMed  Google Scholar 

  • Volkow ND, Wang G-J, Kollins SH, Wigal TL, Newcorn JH, Telang F (2009) Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA 302:1084–1091

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wade TR, de Wit H, Richards JB (2000) Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology 150:90–101

    Article  CAS  PubMed  Google Scholar 

  • Wan Y, Ade KK, Caffall Z, Ilcim Ozlu M, Eroglu C, Feng G, Calakos N (2014) Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Biol Psychiatry 75:623–630

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Barbaro MF, Baraban SC (2006) A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett 401:35–39

    Article  CAS  PubMed  Google Scholar 

  • Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD, Feliciano C, Chen M, Adams JP, Luo J, Dudek SM, Weinberg RJ, Calakos N, Wetsel WC, Feng G (2007) Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 448:894–900

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Winstanley CA, Eagle DM, Robbins TW (2006) Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin Psychol Rev 26:379–395

    Article  PubMed  PubMed Central  Google Scholar 

  • Wultz B, Sagvolden T (1992) The hyperactive spontaneously hypertensive rat learns to sit still, but not to stop bursts of responses with short interresponse times. Behav Genet 22:415–433

    Article  CAS  PubMed  Google Scholar 

  • Zeeb FD, Robbins TW, Winstanley CA (2009) Serotonergic and dopaminergicmodulation of gambling behavior as assessed using a novel rat gambling task. Neuropsychopharmacology 34:1–15

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Science, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614-1702, USA

    Russell W. Brown

  2. Department of Psychology, East Tennessee State University, Johnson City, TN, 37614-1702, USA

    Daniel J. Peterson

Authors
  1. Russell W. Brown
    View author publications

    Search author on:PubMed Google Scholar

  2. Daniel J. Peterson
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Russell W. Brown .

Editor information

Editors and Affiliations

  1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, TN, USA

    Richard M. Kostrzewa

  2. Department of Psychology, University of Gothenburg, Gothenburg, Sweden

    Trevor Archer

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Brown, R.W., Peterson, D.J. (2015). Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor. In: Kostrzewa, R.M., Archer, T. (eds) Neurotoxin Modeling of Brain Disorders—Life-long Outcomes in Behavioral Teratology. Current Topics in Behavioral Neurosciences, vol 29. Springer, Cham. https://doi.org/10.1007/7854_2015_394

Download citation

Keywords

Publish with us

Policies and ethics