Package rpact updated to version 4.4.0 with previous version 4.3.0 dated 2025-12-16

Wed, 04 Mar 2026 11:02:00 CDT

Title: Confirmatory Adaptive Clinical Trial Design and Analysis
Description: Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2025) <doi:10.1007/978-3-031-89669-9>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.
Author: Gernot Wassmer [aut] , Friedrich Pahlke [aut, cre] , Till Jensen [ctb], Daniel Sabanes Bove [ctb] , Stephen Schueuerhuis [ctb] , Tobias Muetze [ctb] , RPACT GmbH [cph, fnd]
Maintainer: Friedrich Pahlke <friedrich.pahlke@rpact.com>

Diff between rpact versions 4.3.0 dated 2025-12-16 and 4.4.0 dated 2026-03-04

 DESCRIPTION                             |   24
 MD5                                     |  161 +++---
 NAMESPACE                               |    8
 NEWS.md                                 |   39 +
 R/RcppExports.R                         |  632 ++++++++++++++++++++++++++
 R/class_analysis_dataset.R              |  253 +++++-----
 R/class_analysis_results.R              |  207 ++++----
 R/class_analysis_stage_results.R        |  141 ++---
 R/class_core_parameter_set.R            |  478 ++++++++++---------
 R/class_core_plot_settings.R            |   27 -
 R/class_design.R                        |   73 +--
 R/class_design_plan.R                   |  100 +---
 R/class_design_power_and_asn.R          |   19
 R/class_design_set.R                    |  215 ++++----
 R/class_dictionary.R                    |   14
 R/class_event_probabilities.R           |   88 +--
 R/class_simulation_results.R            |   64 +-
 R/class_summary.R                       |   71 +-
 R/class_time.R                          |  331 +++++++------
 R/f_analysis_base.R                     |  101 +---
 R/f_analysis_base_means.R               |   91 +--
 R/f_analysis_base_rates.R               |  131 +----
 R/f_analysis_base_survival.R            |   77 +--
 R/f_analysis_boundary_recalculation.R   |   30 -
 R/f_analysis_enrichment.R               |   52 +-
 R/f_analysis_enrichment_means.R         |  365 +++++++--------
 R/f_analysis_enrichment_rates.R         |  443 ++++++++++--------
 R/f_analysis_enrichment_survival.R      |  384 ++++++++-------
 R/f_analysis_multiarm.R                 |   16
 R/f_analysis_multiarm_means.R           |  294 ++++++------
 R/f_analysis_multiarm_rates.R           |   55 +-
 R/f_analysis_multiarm_survival.R        |   25 -
 R/f_analysis_utilities.R                |   78 +--
 R/f_as251.R                             |    4
 R/f_core_assertions.R                   |  459 +++++++++++--------
 R/f_core_constants.R                    |   14
 R/f_core_output_formats.R               |  118 ++--
 R/f_core_plot.R                         |  299 ++++++------
 R/f_core_utilities.R                    |  111 +---
 R/f_design_fisher_combination_test.R    |  109 ++--
 R/f_design_futility_bounds.R            |    4
 R/f_design_general_utilities.R          |  144 +++++
 R/f_design_group_sequential.R           |  200 ++++----
 R/f_design_plan_counts.R                |  104 ++--
 R/f_design_plan_means.R                 |   35 -
 R/f_design_plan_plot.R                  |  258 +++++-----
 R/f_design_plan_rates.R                 |   74 +--
 R/f_design_plan_survival.R              |  227 +++++----
 R/f_design_plan_utilities.R             |    6
 R/f_io_utilities.R                      |only
 R/f_logger.R                            |    4
 R/f_object_r_code.R                     |   36 -
 R/f_parameter_set_utilities.R           |   17
 R/f_quality_assurance.R                 |  409 +++++++++++-----
 R/f_simulation_base_counts.R            |   22
 R/f_simulation_base_means.R             |   39 -
 R/f_simulation_base_rates.R             |   54 +-
 R/f_simulation_base_survival.R          |   64 +-
 R/f_simulation_calc_subjects_function.R |   16
 R/f_simulation_enrichment.R             |  157 +++---
 R/f_simulation_enrichment_means.R       |  151 +++---
 R/f_simulation_enrichment_rates.R       |  150 +++---
 R/f_simulation_enrichment_survival.R    |  135 ++---
 R/f_simulation_multiarm.R               |  190 ++++---
 R/f_simulation_multiarm_means.R         |   11
 R/f_simulation_multiarm_rates.R         |   25 -
 R/f_simulation_multiarm_survival.R      |   26 -
 R/f_simulation_performance_score.R      |    9
 R/f_simulation_plot.R                   |  100 ++--
 R/f_simulation_utilities.R              |   96 ++-
 R/parameter_descriptions.R              |   38 -
 R/pkgname.R                             |   29 -
 inst/CITATION                           |   63 +-
 inst/WORDLIST                           |  174 ++++---
 inst/doc/rpact_getting_started.html     |    4
 inst/tests/META                         |    2
 man/fetch.ParameterSet.Rd               |    2
 man/readKeyValueFile.Rd                 |only
 man/rpact.Rd                            |    2
 man/testPackage.Rd                      |   15
 man/utilitiesForSurvivalTrials.Rd       |   27 -
 man/writeKeyValueFile.Rd                |only
 src/f_design_group_sequential.cpp       |  770 ++++++++++++++++++++++++++++----
 83 files changed, 6042 insertions(+), 4048 deletions(-)

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