A First-of-its-Kind Female Arousal Cream
If you're tired of uncertain quality and unproven options, you're not alone.
We have a different approach. Now introducing a fast-acting, non-hormonal topical female arousal cream backed by science: DARE to PLAY™ Sildenafil Cream.
DARE to PLAY Sildenafil Cream
DARE to PLAY Sildenafil Cream is a fast-acting, non-hormonal topical formulation designed to increase genital blood flow and enhance natural arousal sensations—like warmth, tingling, swelling, and lubrication. It has been shown to increase blood flow within about 10 minutes after application.
What it Does
Increases genital blood flow to improve physical arousal and heighten sensation (learn more)
Suitable for
Women aged 18+ experiencing issues with sexual arousal
Format
Pricing
About $10 per sexual experience—less than your favorite coffee run, way more satisfying. Each tube will contain ~10 uses and will cost $99 at full price.
Our pre-fulfillment prescription period has begun. Learn more about limited-time discounts and benefits.
OUR PRE-FULFILLMENT PRESCRIPTION PERIOD HAS BEGUN.
You can now get a prescription for DARE to PLAY in all 50 states!
or talking to your healthcare provider
A 10-minute, secure questionnaire is all it takes!
Though you cannot place an order quite yet...
By getting your DARE to PLAY prescription now during the pre-fulfillment prescription period you are eligible for limited-time perks.
25% off
your initial order and all refills under your first DARE to PLAY prescription
Priority Access
DARE to PLAY prescriptions written during this period will be prioritized for fulfillment once pharmacy dispensing begins in your state**
*Roughly a $30 value. Complimentary during the pre-fulfillment prescription period only. State restrictions may apply.
**Initial pharmacy dispensing will be available in the following states: AZ, CO, CT, DC, FL, ID, IL, IN, MD, ME, MO, MT, NH, NJ, NM, OR, PA, RI, TN, TX, UT, VT, and WY. Pharmacy dispensing in additional states will become available on a rolling basis as state licensing is completed.
About the pre-fulfillment prescription period.
What is the pre-fulfillment prescription period?
During this period, you can get a prescription for DARE to PLAY — even though you cannot place an order yet. You will be notified in the coming months when ordering becomes available in your state. Ordering and payment will only occur once the product is available for pharmacy dispensing.
Why is ordering not available yet?
Interest in DARE to PLAY has been strong. This period allows the manufacturer to complete planning and state licensing activities based on interest to ensure that once prescriptions can be filled, patients can receive DARE to PLAY reliably without interruption.
Interested, but not quite ready?
THE BIG “O” (OVERVIEW)
How it Helps You Do It
DARE to PLAY Sildenafil Cream is a topical vaginal cream that works to do all of the following:
- Increases genital blood flow for enhanced sensitivity and responsiveness
- Improves natural lubrication, not just surface moisture
- Enhances sexual arousal, sensation, and pleasure
- Faster onset of arousal during intimacy
HOW TO GET YOUR PRESCRIPTION
DARE to PLAY Sildenafil Cream is a prescription-only medication. Here’s what the process looks like:
Option 01: Complete a Complimentary Virtual Telehealth Questionnaire* ($30 value)
What to expect:
*Complimentary during the pre-fulfillment prescription period only. State restrictions may apply.
Option 02: Consult Your Healthcare Provider
Licensed healthcare providers can now write prescriptions for DARE to PLAY in all 50 states. Talk with your provider to see if DARE to PLAY is right for you. Bring this prescribing guide to your visit:
Right now, you can get a prescription for DARE to PLAY — even though you cannot place an order yet. Learn more.
The Sexy Science Behind Dare to Play
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What is FSAD?
How DARE to PLAY Sildenafil Cream Works
Sildenafil (the active ingredient in Viagra®) has been proven for decades to increase blood flow. DARE to PLAY Sildenafil Cream uses the same trusted ingredient in a targeted topical formula designed for the unique anatomy of the female genitals.
It works by helping blood vessels in the clitoris and vulva relax and open, allowing increased blood flow – resulting in:
- Warmth, swelling, tingling/throbbing, and sensitivity in the genital area
- Increased natural lubrication
- Enhanced readiness for intimacy
It has been shown to increase blood flow within 10-15 minutes after application.
We also got busy with a full clinical study of 200 women experiencing symptoms of FSAD.
Why Topical Application Hits the Spot
Unlike oral drugs which go through the entire body, this cream is applied directly where it’s needed, minimizing systemic side effects, and delivering faster, targeted results.
Where the Magic Happens
Getting powerful ingredients like sildenafil through the skin isn’t easy – most drugs carry an electrical charge, and the skin’s outer layer (called the stratum corneum) is built to keep them out.
That’s where DermaFlux™, a cutting-edge topical drug delivery system, comes in. This advanced cream technology helps deliver sildenafil deep into the tissues that matter for sexual arousal.
The cream uses special salts—tri-sodium
citrate and potassium chloride—to help
push the active ingredient through the
skin’s toughest layer.
Normally, drugs can stick to the skin’s
surface due to hydrogen bonding. The
high salt content in this cream helps
prevent that stickiness, allowing
sildenafil to penetrate deeper into the
tissue.
The cream’s design includes both
water-loving (hydrophilic) and oil-loving
(hydrophobic) regions. This unique
structure helps the cream interact with
different skin layers, ensuring the drug
gets where it needs to go.
Daré’s Proprietary DermaFlux Absorption Technology
Other Sildenafil Creams
Penetrates the Skin’s
Protective Barrier
The cream uses special salts—
tri-sodium citrate and potassium
chloride—to help push the active
ingredient through the skin’s
toughest layer.
Prevents Surface Stickiness
That Limits Absorption
Normally, drugs can stick to the
skin’s surface due to hydrogen
bonding. The high salt content in
this cream helps prevent that
stickiness, allowing sildenafil to
penetrate deeper into the tissue.
Dual-Action Formula Targets
Multiple Skin Layers
The cream’s design includes both
water-loving (hydrophilic) and oil-
loving (hydrophobic) regions. This
unique structure helps the cream
interact with different skin layers,
ensuring the drug gets where it
needs to go.
May not penetrate into
the epithelial tissue
Ready to see why DARE to PLAY could be the best you've ever had?
Let's do it.
Not all creams are created equal. DARE to PLAY Sildenafil Cream is manufactured in a 503B outsourcing facility under pharmaceutical Good Manufacturing Practices (GMP).
This means:
When it comes to your body and your health, consistency and safety aren’t optional – they are essential. You deserve a product that has been clinically studied, carefully formulated, and made to the highest safety and quality standards. With DARE to PLAY Sildenafil Cream, you can feel confident in what you’re using – every single time.
We got busy with a full clinical study.
We’ll never forget our first.
This is the first clinical study of its kind to demonstrate that this specific topical formulation of sildenafil, DARE to PLAY Sildenafil Cream, can support genital blood flow and arousal in women. Offering a non-hormonal option with a faster onset (10–15 minutes) and fewer side effects than oral medications, it represents a significant breakthrough for female sexual health.
Science that Goes All the Way.
Daré’s proprietary formulation of Sildenafil Cream was evaluated in the RESPOND Study, the first-ever randomized, double-blind, placebo-controlled clinical trial for a topical treatment targeting Female Sexual Arousal Disorder (FSAD) submitted to the FDA.
This Phase 2b trial included 200 premenopausal women experiencing symptoms of FSAD, such as reduced genital sensation and frustration during intimacy.
What the Study Showed
Safety Profile: The side effect profile of DARE to PLAY Sildenafil Cream was similar to placebo (cream without sildenafil added), with no serious safety concerns reported.
Study Results:
Women using DARE to PLAY Sildenafil Cream experienced the following improvements, as measured by clinically validated and FDA-reviewed endpoints:
- Increased genital arousal sensations
- Improved sexual desire and orgasm
- Reduced feelings of sexual distress and interpersonal difficulties resulting from the sexual difficulties
Key Findings:
In the Phase 2b trial, after 12 weeks, women who used DARE to PLAY Sildenafil Cream reported statistically significant and clinically meaningful improvements in genital arousal sensation (warmth and tingling) compared to those who used placebo cream. On average, Arousal Sensation scores (measured by a patient-reported questionnaire) increased by over 2 points with DARE to PLAY Sildenafil Cream, compared to almost no change with placebo cream. That’s a real, measurable difference.
Women who used DARE to PLAY Sildenafil Cream also showed improvement across other key areas of sexual function, including desire and orgasm.
Results shown are from a subset of 65 women in a 12-week clinical trial: 33 women who received Sildenafil Cream and 32 who received Placebo Cream.
Publications
The results were published in the Green Journal (Obstetrics & Gynecology), the official journal of the American College of Obstetricians and Gynecologists (ACOG) and highlighted on ACOG’s podcast The Green Room. Clinical trial results were also featured in The Journal of Sexual Medicine, the official journal of the International Society for the Study of Women’s Sexual Health. See all references.
FAQs
What makes DARE to PLAY™ Sildenafil Cream different from other sildenafil creams?
DARE to PLAY is the only sildenafil cream for women supported by published, peer-reviewed clinical data. It was studied in clinical trials that used clinically validated and FDA-reviewed endpoints to measure results.
The cream is designed with a proprietary drug delivery system that helps sildenafil get into the vaginal and vulvar tissue, where it can act locally to increase blood flow.
Other sildenafil creams on the market haven’t been proven to work–they have not been studied, shown to absorb properly or published in peer-reviewed research, and are often compounded without consistent quality standards. DARE to PLAY stands apart because it’s rigorously developed, science-backed, and held to the highest standards of quality and clinical evidence.
Is DARE to PLAY Sildenafil Cream safe?
Sildenafil (the active ingredient in Viagra®) has a long-established safety profile in men. The topical formulation used in DARE to PLAY is designed to work locally (in the tissues that matter for sexual arousal) while minimizing how much of the drug enters the bloodstream. DARE to PLAY has been evaluated in clinical studies and was well tolerated, with no significant safety concerns reported. The safety findings from the Phase 2b clinical study have been published and are available on the DARE to PLAY website.
How do I know if DARE to PLAY Sildenafil Cream is right for me?
If you experience difficulty with sexual arousal, including a lack of physical response or reduced genital sensitivity during sexual activity, you may benefit from DARE to PLAY. A conversation with a licensed healthcare provider can help determine whether it is appropriate for you.
Is this like taking Viagra® for women?
DARE to PLAY contains the same active ingredient as Viagra®, but it’s formulated specifically for women and applied directly where it’s needed. Unlike an oral pill, DARE to PLAY is a topical cream designed to work locally rather than systemically.
How do I use DARE to PLAY Sildenafil Cream?
Apply the cream with your finger 10 to 15 minutes before sexual activity up to once per day. Slowly squeeze out a length of cream about 2 ½ inches long for one 2-gram dose. Lying on your back, apply half the cream on and around the clitoris and the area around the vaginal opening, avoiding areas with hair. Apply the rest of the cream just inside the vagina, rubbing the cream with a curved finger on the front wall of the vagina. Wash your hands after application. Once applied, do not wipe off any of the cream until after sexual activity.
Can DARE to PLAY Sildenafil Cream be used with other sexual wellness products or lubricants?
Yes. In the Phase 2b clinical study, women did not use lubricants because the study was specifically designed to evaluate the impact of DARE to PLAY on the genital arousal response. However, there are no concerns about the compatibility of lubricants with the DARE to PLAY formulation.
Can DARE to PLAY Sildenafil Cream be used by postmenopausal women?
Yes. DARE to PLAY has been studied in both pre-and postmenopausal women to evaluate safety, tolerability, and how the drug is absorbed in the body (pharmacokinetics). In these studies, the cream was well tolerated.
The Phase 2b clinical study enrolled healthy pre-and perimenopausal women aged 18 to 45 who had a diagnosis of Female Sexual Arousal Disorder (FSAD). Similar to FDA-approved products for Hypoactive Sexual Desire Disorder (HSDD), FSAD trials conducted for FDA review typically focus on either pre-or postmenopausal populations.
Selective serotonin reuptake inhibitors (SSRIs) are known to impact sexual function. Can DARE to PLAY Sildenafil Cream help if I’m taking an SSRI?
In the Phase 2b clinical study, approximately one-third of the participants were taking an SSRI. An informal analysis compared women on SSRIs with those who were not and found that both groups showed positive trends in improved arousal sensations.
Is DARE to PLAY Sildenafil Cream compatible with condoms?
Many vaginal products contain ingredients that can weaken condoms, increasing the risk of breakage. DARE to PLAY was tested using ASTM D7661-10, a standardized method that ensures a product is safe to use with condoms. Based on these tests, DARE to PLAY is compatible with all male condoms except those made of polyurethane.
Can DARE to PLAY Sildenafil Cream be used during oral sex?
Yes. In the Phase 2b clinical study, women were allowed to use DARE to PLAY during oral sex, and it was well tolerated with no significant safety concerns. Prior to the Phase 2b clinical study, DARE to PLAY was also tested in a preclinical study to assess its effects on the oral mucosa. These tests showed that daily exposure for 28 days did not cause irritation inside the mouth.
The DARE to PLAY formulation does contain a proprietary combination of salts that support the absorption of sildenafil into the tissue. As a result, you may notice a mildly salty taste.
Can DARE to PLAY Sildenafil Cream be used alone or with a partner?
DARE to PLAY can be used in both situations! In the Phase 2b clinical study, about 20% of sexual events were solo, and women reported that these experiences were often more satisfying than partnered events. Partnered events sometimes occurred under less-than-ideal conditions, like limited time or distractions, which can affect pleasure.
Is DARE to PLAY Sildenafil Cream meant to replace behavioral or psychological therapy for sexual dysfunction?
No. DARE to PLAY is designed to complement, not replace, other approaches. It is a pharmacologic option focused on improving genital blood flow and physical responsiveness. Women often benefit most from a multimodal approach.
Will DARE to PLAY Sildenafil Cream help if I have low desire?
DARE to PLAY is designed to improve physical arousal by increasing genital blood flow. Many women find that enhancing physical responsiveness can also help restore desire and confidence. In the Phase 2b clinical study, women with low desire due to diminished physical arousal sensations experienced improved desire following use of DARE to PLAY.
If low desire is influenced by emotional or relationship factors, combining DARE to PLAY with other approaches—like counseling or therapy—may provide the best results.
Do I need a prescription for DARE to PLAY Sildenafil Cream?
Yes, please see these instructions for how to get a prescription.
Who can prescribe DARE to PLAY Sildenafil Cream?
Anyone who is licensed to write prescriptions can prescribe it—including your primary care provider (PCP), family medicine doctor, OB/GYN, nurse practitioner, physician assistant, or another qualified specialist.
What is the DARE Health Hub?
The DARE Health Hub (powered by Medvantx) is a nationwide pharmacy and telehealth service. Whether you use the DARE Health Hub telehealth offering to get your prescription or get a prescription from your provider, this is where you will order/fill your prescription.
This service offers contact-free ordering and discreet delivery directly to your doorstep.
Here’s what you can expect depending on your preferred method of obtaining a prescription:
Option 01: Telehealth Prescription
- Register for an account at the DARE Health Hub.
- After registering, you will be asked, “Have you seen a provider already?” Select “No” to initiate a telehealth consultation.
- You’ll then be asked to:
- Provide your address information
- Sign the telehealth consent agreement
- Fill out the telehealth questionnaire
- Verify your identification (by uploading a photo ID)
- Within approximately 24 hours, your telehealth questionnaire responses will be reviewed by a licensed healthcare provider, and if medically appropriate, you will receive a prescription for DARE to PLAY. You can check the status of your prescription under “My Prescriptions” in the DARE Health Hub.
- You will be notified in the coming months, via email and text message, when ordering becomes available in your state.
- Ordering details will be added once available! Stay tuned.
Option 02: Healthcare Provider Prescription
- Talk to your healthcare provider about DARE to PLAY. Bring the prescribing guide with you to your appointment.
- If your provider feels DARE to PLAY is medically appropriate for you, they will submit your prescription directly to the DARE Health Hub.
- You will then receive a phone call from the DARE Health Hub confirming receipt of your prescription and inviting you to register for an account.
- After registering, you’ll receive timely updates and a notification as soon as your prescription is ready to be ordered through the DARE Health Hub in the coming months.
- Ordering details will be added once available! Stay tuned.
What is the pre-fulfillment prescription period?
During this period, you can get a prescription for DARE to PLAY — even though you cannot place an order yet. You will be notified in the coming months when ordering becomes available in your state. Ordering and payment will only occur once the product is available for pharmacy dispensing.
Why is ordering not available yet?
Interest in DARE to PLAY has been strong. This period allows the manufacturer to complete planning and state licensing activities based on interest to ensure that once prescriptions can be filled, patients can receive DARE to PLAY reliably without interruption.
Will my insurance cover DARE to PLAY Sildenafil Cream?
Compounded medications like DARE to PLAY are typically not covered by insurance. However, many people are able to use FSA or HSA funds to pay for it.
How much does it cost?
DARE to PLAY Sildenafil Cream will cost about $10 per sexual experience — less than your favorite coffee run, and way more satisfying. Each tube will contain ~10 uses and will cost $99 at full price.
Do you plan to offer a subscribe-and-save option?
No–for a few key reasons. One, we’re not a telehealth company trying to make more money by pushing products on women that they don’t need. We develop real, differentiated solutions for women who want and need them. Two, we don’t want to assume that you will use DARE to PLAY a certain number of times per month. We will offer an option to auto-refill your prescription at a cadence that’s right for you, but we want to support and honor your choices and what feels right in your body, so whether one tube of DARE to PLAY lasts 10 days or one year–we think that’s perfect!
Get on the List
Sign up to receive updates about DARE to PLAY and to be notified when it launches in your state.
1 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Text rev. American Psychiatric Association; 1994.
2 Parish SJ, Cottler-Casanova S, Clayton AH, McCabe MP, Coleman E, Reed GM. The evolution of the female sexual disorder/dysfunction definitions, nomenclature, and classifications: a review of DSM, ICSM, ISSWSH, and ICD. Sex Med Rev 2021;9:36–56. doi: 10.1016/j.sxmr.2020.05.001
3 16% of women in the U.S. ages 21-60 are distressed from experiencing no or low sexual arousal, according to market research, and are actively seeking treatment. Ad Hoc Market Research: FSAD Prevalence Report (Oct 2015) conducted for SST LLC and based on US Census projections for 2016.
4 Thurman AR, Johnson I, Cornell KA, Hatheway J, Kim NN, Parish SJ, Dart C, Friend DR, Goldstein A. Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder. J Sex Med. 2024;21(9):793-799. doi:10.1093/jsxmed/qdae089
5 Goldstein S, Kukkonen T, Monsef A, Goldstein I. A double-blind, placebo-controlled, 2-way crossover study using thermography to assess the pharmacodynamics of sildenafil cream, 3.6% in healthy women. J Sex Med. 2020;17(Suppl 1):S69. doi:10.1016/j.jsxm.2019.11.194
6 Johnson I, Thurman AR, Cornell KA, Hatheway J, Dart C, Brainard CP, Friend DR, Goldstein A. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder: A randomized, placebo‑controlled, Phase 2b trial. Obstet Gynecol. 2024;144(2):144–152. doi:10.1097/AOG.0000000000005648
7 Johnson I, Thurman AR, Cornell KA, et al. Impact of age, race, and medication use on efficacy endpoints in a randomized controlled trial of topical sildenafil cream for the treatment of female sexual arousal disorder. Sex Med. 2024;12(5):qfae079. doi:10.1093/sexmed/qfae079
8 Johnson I, Thurman AR, Cornell KA, et al. Comparisons and correlations of 1‑month recall vs 24‑hour recall in patient‑reported outcomes of an exploratory, phase 2b, randomized, double‑blind, placebo‑controlled clinical trial of sildenafil cream, 3.6% for the treatment of female sexual arousal disorder. J Sex Med. 2024;21(9):787‑792. doi:10.1093/jsxmed/qdae086
9 Symonds T, Kingsberg SA, Simon JA, et al. Symptoms and associated impact in pre‑ and postmenopausal women with sexual arousal disorder: a concept elicitation study. J Sex Med. 2023;20(3):277–286. doi:10.1093/jsxmed/qdac043
10 Strategic Science & Technologies LLC. A New Topical Drug Delivery Platform: The Examples of Sildenafil and Ibuprofen. White paper; June 6, 2019.
11 American College of Obstetricians and Gynecologists. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder [podcast episode]. The Green Room: A Podcast from Obstetrics & Gynecology. Obstet Gynecol (Green Journal). Published August 2024. Accessed July 28, 2025.
This is a compounded drug. It is not FDA approved. This product has not been reviewed by FDA for safety or efficacy. DARE to PLAY Sildenafil Cream is manufactured in a 503B outsourcing facility under pharmaceutical Good Manufacturing Practices (GMP).