Social Behavior

Three-chamber sociability automation, social discrimination protocols, and social self-administration paradigms. ConductMaze controls divider doors, interaction sensors, and stimulus delivery.

Social Interaction (Crawley 3-Chamber)

The Crawley three-chamber sociability test is the most widely used assay for social approach behavior in rodents.

6 parameters

Resident-Intruder

The resident-intruder test is the standard paradigm for quantifying territorial aggression and social investigation in rodents.

6 parameters

Chronic Social Defeat Stress

Chronic social defeat stress (CSDS) is a widely used model for depression and anxiety-like behavior in which a subject mouse is repeatedly exposed to a larger, aggressive resident mouse (typically a retired CD-1 breeder) over 10 consecutive days.

6 parameters

Tube Dominance

The tube dominance test is a simple, robust assay for social hierarchy and dominance behavior in mice.

6 parameters

Three-Chamber Sociability Test

The three-chamber sociability test, developed by Crawley and colleagues, is the most widely used paradigm for quantifying social approach behavior and social novelty preference in rodents.

7 parameters

Social Discrimination Test

The social discrimination test (also called social recognition memory) measures the ability of a rodent to distinguish between familiar and novel conspecifics based on olfactory and multisensory cues.

6 parameters

Social Self-Administration

Social self-administration (social conditioned place preference variant or operant social reward) measures the reinforcing value of social interaction by requiring animals to perform an operant response (lever press or nose poke) to gain access to a conspecific.

7 parameters

Empathy and Emotional Contagion Test

The empathy and emotional contagion paradigm measures vicarious affective responses by exposing an observer animal to a demonstrator experiencing a salient emotional state, typically pain (via dilute formalin injection or mild footshock) or fear (via conditioned freezing).

7 parameters

Three-Chamber Social Novelty Preference

The three-chamber social novelty preference test constitutes Phase 2 of the Crawley sociability paradigm, designed to assess social recognition memory and preference for novelty in a familiar versus unfamiliar social context.

10 parameters

Resident-Intruder Aggression Test

The resident-intruder aggression test is the gold standard paradigm for quantifying offensive aggression in rodents, exploiting the territorial behavior that male mice exhibit when a conspecific is introduced into their established home cage.

9 parameters

Social Dominance Tube Test

The social dominance tube test is a widely used assay for determining hierarchical rank among cage-mate rodents by exploiting competitive behavior in a narrow transparent tube that permits only single-file passage.

8 parameters

Social Approach-Avoidance Test

The social approach-avoidance test quantifies an animal's motivation to seek proximity to a social target versus actively avoiding it, serving as a sensitive readout for social withdrawal following chronic stress, social defeat, or in models of social anxiety.

9 parameters

Zebrafish Social Preference (Shoaling)

The zebrafish social preference test measures shoaling motivation, the innate drive of zebrafish to aggregate with conspecifics, by quantifying the time a focal fish spends near a visible group of conspecifics versus an empty compartment.

9 parameters

Zebrafish Mirror Biting (Aggression)

The zebrafish mirror biting test quantifies aggressive behavior by presenting a mirror on one wall of the test tank, eliciting the full repertoire of agonistic displays directed at the perceived intruder (the fish own reflection).

9 parameters

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