📊 Public Benchmark Leaderboard | 168/182 passing (92.3%) | Up from 80/140 (57.1%) at original audit | Every failure documented →
📊 Publicly benchmarked · 787 stars · 63 skills · 24 contributors · 1,756 tests

The first bioinformatics-native
AI agent skill library

ClawBio is where biological AI gets its skills: a curated, reproducible, open repository any agent can call.

⭐ View on GitHub 📊 Leaderboard · 168/182 🧬 Submit a Skill 🤖 Try RoboTerri
bioinformaticsgenomicsreproducibilitypopulation-geneticsequityai-agentslocal-firstopenclaw

NutriGx Advisor — community-contributed skill running locally on raw genetic data

The Problem
Reproducing bioinformatics analyses is broken
# Without ClawBio
$ git clone repo && cd repo
# Wrong Python version...
# Reference data link is dead...
# Paths hardcoded to /home/jsmith/data/
# Email first author. Wait 3 weeks.
# Give up.
  • ✗ Dependency hell & broken environments
  • ✗ Dead links to reference data
  • ✗ Hardcoded paths & missing configs
  • ✗ AI hallucinates star alleles & outdated guidelines
  • ✗ No audit trail, no checksums
# With ClawBio
$ python ancestry_pca.py --demo --output fig3

✓ Figure 3 reproduced.
✓ Identical. SHA-256 verified.
✓ 30 seconds.

# Or with natural language:
$ openclaw "Profile my pharmacogenes"

Every skill exports commands.sh, environment.yml, and SHA-256 checksums — anyone can reproduce without the agent.

Why ClawBio
Domain expertise, frozen into code

ChatGPT and Claude are smart generalists. ClawBio skills are domain experts' proven pipelines — executed correctly every time.

🏠
Local-first
Your genomic data never leaves your laptop. No cloud uploads, no data exfiltration. Full privacy by design.
🔁
Reproducible
Every analysis exports a reproducibility bundle — commands, environment, and SHA-256 checksums. Reproduce without the agent.
🧩
Modular
Each skill is a self-contained directory (SKILL.md + Python scripts) that plugs into the orchestrator — or runs standalone.
⚖️
MIT Licensed
Open-source, free, community-driven. Clone it, run it, build a skill, submit a PR.
🌍
Equity-aware
Built-in support for underrepresented populations. HEIM diversity metrics baked into the roadmap.
🎯
Benchmark Validated
Public scientific-correctness leaderboard: 168/182 tests passing (92.3%), 10 skills audited, every failure tagged. AD ground truth (34 genes, 3 evidence tiers), mock API server for offline CI, swappable fine-mapping (ABF vs SuSiE), benchmark scorer with precision/recall/F1. View leaderboard · DOI
🦞
Built on OpenClaw
Powered by OpenClaw, the open agent platform that routes natural language to the right specialist skill. ClawBio is the bioinformatics catalogue any OpenClaw-compatible agent can call.
🔌
Claude Code Plugin
Install with two commands: /plugin marketplace add ClawBio/ClawBio then /plugin install clawbio. All skills instantly available.
Skills Library
63 skills · 1,756 tests · 168 / 182 publicly benchmarked passing

Each skill includes demo data so you can try it immediately without your own files.

💊 PharmGx Reporter
Pharmacogenomic report from 23andMe/AncestryDNA: 12 genes, 31 SNPs, 51 drugs, CPIC guidelines.
MVP
🔍 GWAS Lookup
Federated variant lookup across 9 genomic databases: GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ), GTEx, eQTL Catalogue, and more.
MVP
🔬 scRNA Orchestrator
Local Scanpy pipeline for single-cell RNA-seq: QC, doublet detection, clustering, marker discovery, cell-type annotation.
MVP
📊 GWAS Polygenic Risk
Calculate polygenic risk scores from DTC genetic data using curated PGS Catalog scores across 6 traits.
MVP
⚖️ Equity Scorer
Compute HEIM diversity and equity metrics from VCF or ancestry data: heterozygosity, FST, and population representation scores.
MVP
🦠 Metagenomics Profiler
Shotgun metagenomics profiling: taxonomy, resistome, and functional pathways via Kraken2, RGI, and HUMAnN3.
MVP
🧬 Genome Compare
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture.
MVP
💉 ClinPGx
Query the ClinPGx API for pharmacogenomic gene-drug data, CPIC guidelines, clinical annotations, and FDA drug labels.
MVP
🔭 Galaxy Bridge
Galaxy tool discovery, intelligent recommendation, and execution: 8,000+ bioinformatics tools from usegalaxy.org with multi-signal scoring and workflow suggestions.
MVP
📈 RNA-seq DE
Differential expression for bulk RNA-seq and pseudo-bulk count matrices with QC, PCA, volcano plots, and contrast reporting.
MVP
🏦 UKB Navigator
Semantic search across UK Biobank's 12,000+ data fields and publications: find the right variables for your analysis.
MVP
📷 Drug Photo
Snap a photo of any medication packaging. ClawBio identifies the drug, queries your pharmacogenomic profile, and returns a personalised dosage card.
MVP

+ 51 more skills on GitHub · see which ones are publicly benchmarked →

In Production
ClawBio skills, running in conversation

ClawBio skills aren't just CLI tools — they power live AI agents that talk to real users every day.

RoboTerri avatar
RoboTerri
Telegram AI Agent
A bioinformatics intelligence agent on Telegram — inspired by Professor Teresa K. Attwood, a pioneer of bioinformatics education and research. Run pharmacogenomics reports from your own genetic data. Snap a photo of your medication, get personalised dosage guidance. All local-first, all reproducible.
PharmGx Reporter Drug Photo Lookup NutriGx Advisor Genome Compare Equity Scorer Metagenomics GWAS Lookup scRNA Orchestrator
Community
Wanted: skills from the community

If you work with genomics, proteomics, metabolomics, imaging, or clinical data — wrap your pipeline as a skill.

claw-gwas
PLINK/REGENIE automation — Statistical genetics
claw-acmg
Clinical variant classification — Clinical genomics
claw-pathway
GO/KEGG enrichment — Functional genomics
claw-phylogenetics
IQ-TREE/RAxML automation — Evolutionary biology
claw-spatial
Visium/MERFISH — Spatial transcriptomics
claw-long-reads
ONT/PacBio QC and assembly — Long-read sequencing
+
Your skill here
🎮 Join the Discord 💬 Join the Telegram 📖 Read the contribution guide
Ecosystem
2,100+ skills across 9 repositories

Open-source biology skill repos from Stanford, Imperial, and the community.

Repo OpenClaw Stars Forks Skills
ClawBio✓78716163
OpenClaw-Medical-Skills✓1,037123869
bioSkills✓33152425
LabClaw✓31754211
claude-scientific-skills~14.5k1,585250
Biomni—2,826508314

View all 9 repos in the full marketplace →

Recent Updates
Latest from the community
🔧
Skill execution refactor: routing now reads from per-skill intent.json descriptors. Separates descriptor discovery (symlink-following) from execution root (registry-anchored), so externally-symlinked skills like GENtle resolve to the correct ClawBio checkout. Adds path-traversal hardening, descriptor-validation gates (status="needs_registration"), demo-mode guard fixes, and ~960 lines of new regression tests. Contributed by Steffen Möller (@smoe).
PR #208 · 9 May 2026
🧬
New skill: dnasp — Python reimplementation of DnaSP 6 for population genetics. 16 analyses: nucleotide diversity (Pi, Theta-W, Theta-L), Tajima's D, Fu & Li D*/F*, Ka/Ks, McDonald-Kreitman, Fst, site frequency spectrum, codon usage bias, and more. Accepts FASTA or NEXUS input; 355 tests. Contributed by Dr David de Lorenzo (@drdaviddelorenzo). Total: 63 skills, 22 production-ready.
PR #238 · 8 May 2026
🧬
Four new skills: analyze-fasta (MVP, single-FASTA nucleotide/protein analyser: GC%, ORFs, MW, pI, GRAVY), rare-disease-rnaseq (blood RNA-seq expression-outlier detection for rare-disease diagnosis), wgs-prs (end-to-end WGS to polygenic risk score pipeline), and clawpathy-autoresearch (eval-driven iterative skill-tuning loop).
PRs #233, #234, #212, #192 · 8 May 2026
🤖
CI benchmark automation: the public leaderboard now self-updates. A GitHub Actions workflow runs clawbio_bench --smoke weekly and opens a PR with the updated scores. Fine-mapping is now included at 19/20 (95.0%). Total: 168 / 182 passing (92.3%).
PRs #217, #218 · 3 May 2026
📊
Public benchmark leaderboard: ClawBio publishes per-skill scientific-correctness scores at clawbio.ai/benchmarks. Latest run via clawbio_bench v0.1.5: 168 / 182 (92.3%), up from 80 / 140 (57.1%) at the original audit baseline. Equity-scorer 20 to 100, pharmgx 42 to 98, bio-orchestrator 76 to 98.
PRs #213, #215 · 3 May 2026
🔁
Portable reproducibility bundles: every skill now writes a commands.sh with portable paths, anchor-relative replay, and non-deterministic output exclusions. Anyone can rerun an analysis without the agent and verify the result.
PR #146 · 3 May 2026
📦
Importable package API: ClawBio is now usable as a Python library via from clawbio import run_skill, list_skills, in addition to the CLI. Clean public API surface for programmatic use.
PR #210 · 28 April 2026

View all merged pull requests on GitHub →

Get started in 30 seconds

Install as a Claude Code plugin or clone from source — every skill includes demo data.

# Option 1: Claude Code plugin (fastest)
/plugin marketplace add ClawBio/ClawBio
/plugin install clawbio

# Option 2: Clone and install
git clone https://github.com/ClawBio/ClawBio.git && cd ClawBio
pip install -r requirements.txt
python clawbio.py run pharmgx --demo
⭐ Star on GitHub 🤖 Try RoboTerri 📄 Documentation