{"id":9911,"date":"2021-12-31T00:19:26","date_gmt":"2021-12-31T08:19:26","guid":{"rendered":"https:\/\/cholesterolcode.com\/?p=9911"},"modified":"2021-12-31T00:19:31","modified_gmt":"2021-12-31T08:19:31","slug":"blasting-off-into-2022","status":"publish","type":"post","link":"https:\/\/cholesterolcode.com\/blasting-off-into-2022\/","title":{"rendered":"Blasting Off Into 2022"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"420\" src=\"https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-1024x420.jpeg\" alt=\"\" class=\"wp-image-9902\" srcset=\"https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-1024x420.jpeg 1024w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-300x123.jpeg 300w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-768x315.jpeg 768w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-796x326.jpeg 796w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off.jpeg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Make no mistake, 2021 has been a watershed year for us. There have been many substantial developments both in what has been completed and what has just begun.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">New Research Spotlight for Siobhan Huggins <\/h2>\n\n\n\n<p>Early in the year my colleague, <a rel=\"noreferrer noopener\" href=\"https:\/\/cholesterolcode.com\/author\/siobhanh\/\" target=\"_blank\">Siobhan Huggins<\/a> was diagnosed with Lipedema and quickly shifted focus to this and related conditions. In a very short time, she has developed a number of hypotheses that she has since presented on, with more presentations planned (including Low Carb Boca this upcoming January). She is also now communicating closely with leadership at the <a rel=\"noreferrer noopener\" href=\"https:\/\/lipedemaproject.org\/\" target=\"_blank\">Lipedema Project<\/a> to see where future collaboration on this important topic may be useful to the community and for seeking to increase the knowledge on Lipedema where possible. As a result, just last last week Siobhan was selected as <a rel=\"noreferrer noopener\" href=\"https:\/\/twitter.com\/siobhan_huggins\/status\/1474168501203922948\" target=\"_blank\">Program Co-Director for the upcoming April Symposium<\/a>, which will focus on ketogenic diets for Lymphatic and Fat Disorders.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/twitter.com\/siobhan_huggins\/status\/1474168501203922948\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Lean Mass Hyper-responder Study Launched<\/h2>\n\n\n\n<p>After an extensive process for the protocol, we received official IRB approval and <a rel=\"noreferrer noopener\" href=\"https:\/\/citizensciencefoundation.org\/the-lean-mass-hyper-responder-study-launches-today\/\" target=\"_blank\">announced the study on August 27th<\/a>. This study will be focusing on LMHRs and borderline LMHRs, <em>and note it is still recruiting<\/em>.<\/p>\n\n\n\n<p>For more details and to see if you&#8217;re eligible, <a href=\"https:\/\/citizensciencefoundation.org\/study\/\" target=\"_blank\" rel=\"noreferrer noopener\">visit our official recruitment page<\/a> to learn more.<\/p>\n\n\n\n<p>Feel free to watch the announcement video here:<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"796\" height=\"448\" src=\"https:\/\/www.youtube.com\/embed\/xdOlY_qP7uY?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Lean Mass Hyper-responder Paper Published<\/h2>\n\n\n\n<p>Our new paper for low carb impacts on lipids and the Lean Mass Hyper-responder phenotype was published in Current Developments in Nutrition. Here&#8217;s the direct link:<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/doi.org\/10.1093\/cdn\/nzab144\">https:\/\/doi.org\/10.1093\/cdn\/nzab144<\/a><\/h2>\n\n\n\n<p>You can watch this interview from <a href=\"https:\/\/www.dietdoctor.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Diet Doctor<\/a> where my coauthors and I discuss this paper in depth:<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"796\" height=\"448\" src=\"https:\/\/www.youtube.com\/embed\/DDkonntw3vk?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Lipid Energy Model Paper in Development<\/h2>\n\n\n\n<p>I know it&#8217;s been a long time coming, and you can see much of its progress through this time in our <a href=\"https:\/\/cholesterolcode.com\/model\/\" data-type=\"page\" data-id=\"3530\">poster<\/a>, my <a href=\"https:\/\/cholesterolcode.com\/presenting-the-lipid-energy-model-to-stanford-university\/\" data-type=\"post\" data-id=\"8909\">Stanford presentation<\/a>, or even the super simplified, <a rel=\"noreferrer noopener\" href=\"https:\/\/www.youtube.com\/watch?v=C1T-7-6bpz8\" target=\"_blank\">Lipid Energy Model in a nutshell<\/a> (just 5 minutes). But there have still be plenty of updates to expand the model since then.<\/p>\n\n\n\n<p>The new collaboration of <a rel=\"noreferrer noopener\" href=\"https:\/\/twitter.com\/nicknorwitz\" target=\"_blank\">Nick Norwitz<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/twitter.com\/Ad_SotoMota\" target=\"_blank\">Adrian Soto-Mota<\/a>, and myself have helped shaped the model for its coming submission for publication. I&#8217;m incredibly honored to be working with such extensive talent and can&#8217;t wait until we finally have our 1.0 up in the literature.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Debut of the Triad and All Cause Mortality<\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/checklist.png\" alt=\"\" class=\"wp-image-9909\" width=\"247\" height=\"312\" srcset=\"https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/checklist.png 399w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/checklist-238x300.png 238w\" sizes=\"auto, (max-width: 247px) 100vw, 247px\" \/><\/figure><\/div>\n\n\n\n<p><meta charset=\"utf-8\">A <a rel=\"noreferrer noopener\" href=\"https:\/\/twitter.com\/deirdre_tobias\/status\/1473635692626513921\" target=\"_blank\">recent analysis<\/a> was performed with the Women&#8217;s Health Study data that concluded <meta charset=\"utf-8\">the highest LDLc levels correlate to the highest All Cause Mortality (ACM) where compared to low and mid ranges of likewise HDLc \u2265&nbsp;50 and TG \u2264 100 levels. The process in how it came to this finding is very interesting and worth a coming post of its own which I&#8217;ll be doing in collaboration with a biostatistician.<\/p>\n\n\n\n<p><meta charset=\"utf-8\">Of special interest, the event actually helped to solve one of the largest problems in this space I&#8217;ve long struggled to tackle. For some time I&#8217;ve wanted to fashion a criteria for analyses that would be &#8220;pre-approved&#8221; as much as possible by all major voices in this debate. This would be the ideal given it would be in place <em>before<\/em> approaching the datasets we&#8217;d apply it to. But in reality, this was also likely near impossible given the wide variety of opinions across the spectrum on what the right methodology might be. <\/p>\n\n\n\n<p><meta charset=\"utf-8\">Fortunately, this current analysis and its originating criteria were widely accepted and shared by prominent voices for low LDLc (including many I&#8217;ve long discussed this with online). Its final iteration excluding <a rel=\"noreferrer noopener\" href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/metabolic-syndrome\/diagnosis-treatment\/drc-20351921\" target=\"_blank\">standard attributes of metabolic syndrome<\/a> is of special significance, and exactly what I was hoping given this helps better stratify toward metabolic health. In other words, over a short time we not only have mutual interest in looking to the triad vs ACM, but a lot of agreement on the specific parameters to use for the approach. This helps provide an important roadmap for <a href=\"https:\/\/cholesterolcode.com\/announcement-20000-donation-for-lipid-triad-analysis\/\">our coming analyses<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-2-1024x683.jpg\" alt=\"\" class=\"wp-image-9934\" srcset=\"https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-2-1024x683.jpg 1024w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-2-300x200.jpg 300w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-2-768x512.jpg 768w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-2-796x531.jpg 796w, https:\/\/cholesterolcode.com\/wp-content\/uploads\/2021\/12\/blast-off-2.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Make no mistake, 2021 has been a watershed year for us. There have been many substantial developments both in what has been completed and what has just begun. New Research Spotlight for Siobhan Huggins Early in the year my colleague, Siobhan Huggins was diagnosed with Lipedema and quickly shifted focus to this and related conditions. &hellip; <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/cholesterolcode.com\/blasting-off-into-2022\/\">Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8,56,7,9,32,10,31,12,11],"tags":[],"class_list":["post-9911","post","type-post","status-publish","format-standard","hentry","category-cholesterol","category-citizen-science-foundation","category-experiments","category-interview","category-lean-mass-hyper-responder","category-presentation","category-study","category-twitter","category-video","item-wrap"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p9EmAp-2zR","_links":{"self":[{"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/posts\/9911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/comments?post=9911"}],"version-history":[{"count":19,"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/posts\/9911\/revisions"}],"predecessor-version":[{"id":9935,"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/posts\/9911\/revisions\/9935"}],"wp:attachment":[{"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/media?parent=9911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/categories?post=9911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cholesterolcode.com\/wp-json\/wp\/v2\/tags?post=9911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}