Infectious diseases remain one of human health's greatest challenges. Our lab is committed to making impact in our understanding of the basic mechanisms of infection pathogenesis in an effort to leverage these basic principles in service of new vaccines and therapeutics.

We are especially interested in the role of the human innate immune system in controlling infection dynamics. We draw from our combined expertise in immune engineering, molecular microbiology, synthetic and systems biology, and computational modeling to accelerate the generation of novel insights about infection.

Presently, our research group is especially focused on Mycobacterium tuberculosis (Mtb) which causes tuberculosis (TB). TB is the leading cause of infectious disease death and one of human history's top ten causes of mortality. More than one million people die every year due to TB, and estimates suggest that 1/4 to 1/3 of the global population has been infected with Mtb.