Healthspan, Decoded.

Home
Notes
Archive
Leaderboard
About

Recent posts

View all
"Bench to Bedside" Needs an Update. Here's What Comes Next.
A new physician-scientist archetype is emerging at the intersection of data science, consumer technology, and real-world medicine.
 • Brooks Leitner, MD, PhD
The Germ Theory of Fitness
Why molecular benchmarks of functional capacity may be what medicine needs to truly improve healthspan
 • Brooks Leitner, MD, PhD
The Dataset Imperative to Guide AI-Driven Healthspan and Performance
With the launch of LLM-Health, carefully designed and curated datasets will determine how healthy we become. Physician and Performance Scientist-led…
 • Brooks Leitner, MD, PhD
The Metabolic Mechanisms of Exercise's Anti-Cancer Effects
New research out in PNAS elucidates how exercise shunts glucose and amino acids away from the tumor and towards muscle... and baseline fitness is a…
 • Brooks Leitner, MD, PhD
What is Your Maximal Sustainable Workload?
Physiology-inspired capacity principles for founders, athletes, physicians & operators
 • Brooks Leitner, MD, PhD
Biomarkers as a Resource Allocation Mechanism in Healthcare
Quantitative biomarkers of health and disease dictate who gets care and what types of healthcare is paid for. How to align innovations in biomarkers…
 • Brooks Leitner, MD, PhD
Metabolic Dysfunction Hidden in Plain Sight
By standard medical guidelines, young and lean study subjects from a 2004 NEJM trial are in peak health. Functional assessments reveal impaired…
 • Brooks Leitner, MD, PhD
Chronic Disease Screening: What are we Preventing?
"Disease Prevention" suggests an intervention occurs PRIOR to disease manifesting. If screening methods only prompt intervention when a disease…
 • Brooks Leitner, MD, PhD
© 2026 Brooks Leitner · Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture