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  <title>bafonavy</title>
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  <lastBuildDate>Tue, 01 Nov 2011 10:12:59 GMT</lastBuildDate>
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  <pubDate>Tue, 01 Nov 2011 10:12:59 GMT</pubDate>
  <title>Tweet By Hospital Employee: What information is considered PHI?</title>
  <author>bafonavy</author>
  <link>https://bafonavy.livejournal.com/1837.html</link>
  <description>Tweet By &lt;a href=&quot;http://medicsmed.com/buy-viagra-usa.html&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;viagra &lt;a href=&quot;http://medicsmed.com/buy-viagra-usa.html&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;cialis online pharmacy&lt;/a&gt; pharmacy&lt;/a&gt; Employee: What information is considered PHI?&lt;br /&gt;&lt;br /&gt;Interesting Tweet HIPAA Breach story coming out of Mississippi involving Governor Haley Barbour. The incident involved a response to Governor Barbour&apos;s tweet by a University Medical Center employee.&lt;br /&gt;&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Ves Dimov, M.D.&lt;/a&gt; at &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Clinical Cases and Images Blog&lt;/a&gt; posts about the story - &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Single tweet by hospital employee to Mississippi Governor allegedly violates HIPAA, forces her to resign&lt;/a&gt;.&lt;br /&gt;&lt;br /&gt;The incident will provide a good case study for health privacy lawyers who regularly consider the question of what information is and is not &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;protected health information (PHI) under 45 CFR 160.103&lt;/a&gt;.  PHI is defined under HIPAA as:&lt;br /&gt;&lt;p&gt;The Privacy Rule protects all &lt;i&gt;&quot;individually identifiable health information&quot;&lt;/i&gt; held or transmitted by a covered entity or its business associate, in any form or media, whether electronic, paper, or oral. The Privacy Rule calls this information &quot;protected health information (PHI).&quot;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;blockquote&gt;&lt;p&gt;&amp;#8220;Individually identifiable health information&amp;#8221; is information, including demographic data, that relates to:&lt;/p&gt;&lt;ul&gt;&lt;li&gt;the individual&amp;#8217;s past, present or future physical or mental health or condition,&lt;/li&gt;&lt;li&gt;the provision of health care to the individual, or&lt;/li&gt;&lt;li&gt;the past, present, or future payment for the provision of health care to the individual,&lt;/li&gt;&lt;/ul&gt;&lt;p&gt;and that identifies the individual or for which there is a reasonable basis to believe it can be used to identify the individual.  Individually identifiable health information includes many common identifiers (e.g., name, address, birth date, Social Security Number). &lt;/p&gt;&lt;/blockquote&gt;&lt;p&gt;&lt;/p&gt;Thanks for the tip &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;@RLBates&lt;/a&gt; and &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;@EdBennett&lt;/a&gt;.</description>
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  <pubDate>Sat, 29 Oct 2011 09:02:49 GMT</pubDate>
  <title>Watermelon Body Fluid Replacement</title>
  <author>bafonavy</author>
  <link>https://bafonavy.livejournal.com/1633.html</link>
  <description>&lt;div dir=&quot;ltr&quot; style=&quot;text-align:left&quot; trbidi=&quot;on&quot;&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:center&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;300&quot; src=&quot;https://imgprx.livejournal.net/b168fbee0f9095c7d9275e8ab3d1ce01627bf2eb7bed65139e805bfb8f42691b/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0jACAV_xRg9_U4AjbgY-mB0dpP1Z2T0BOo1tixDDvLDdxF1oFrSdvyUwmxFbuGcigzHtxhTNIZT71Os6Tl5FLg1xf8QEhMztW50mo83FIKcR_BnlELBfZog:bxE_4xgYgLtNw00qSYe7nQ&quot; width=&quot;300&quot; fetchpriority=&quot;high&quot; /&gt;&lt;/a&gt;&lt;/div&gt;&lt;div style=&quot;text-align:justify&quot;&gt;&lt;span class=&quot;&quot; lang=&quot;en&quot;&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;Watermelon&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;is a fruit&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;that&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;is very&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;often&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;encountered&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;in&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;the market&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;,&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;supermarket&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;,&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;mini market&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;,&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;and&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;stalls&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;.&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;Lots of&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;watermelon&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;spread&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;throughout the&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;world&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;with&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;many-&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;different types&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;and&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;colors.&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;There are&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;colored&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;yellow&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;and&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;red&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;watermelon&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;.&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;There are so many&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;benefits&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;you can&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;get&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;when&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;eating&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;watermelon&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;.&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;text-align:justify&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/div&gt;&lt;div style=&quot;text-align:justify&quot;&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Semangka paling sering dihidangkan sebagai buah dan makanan penutup di berbagai acara, karena mudah diperoleh dan mengandung banyak vitamin serta antioksidan yang baik untuk kesehatan.&quot;&gt;Watermelon  most often served as a fruit and desserts in a variety of events,  because of easily available and contain many vitamins and antioxidants  that are good for health. &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain itu, juga mengandung nutrisi penting yang sangat bermanfaat untuk kehidupan seks pria.&quot;&gt;It also contains important nutrients that are beneficial to man&apos;s sex life. &lt;/span&gt;&lt;span title=&quot;Apa itu?&quot;&gt;What is it? &lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain banyak mengandung vitamin C, kalium dan vitamin B6, semangka juga mengandung senyawa antioksidan yang membantu melawan radikal bebas penyebab kerusakan sel.&quot;&gt;In  addition to many contain vitamin C, potassium and vitamin B6,  watermelon also contains antioxidant compounds that help fight free  radicals cause cellular damage. &lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Tak hanya itu, semangka juga kaya asam amino citrulline and arginin, yang keduanya memiliki dampak positif pada tubuh.&quot;&gt;Not only that, watermelon is also rich in amino acids citrulline and arginine, which both have a positive impact on the body. &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Penelitian menunjukkan bahwa nutrisi pada semangka ini dapat memberikan kelimpahan manfaat, terutama bagi kemampuan seks pria.&quot;&gt;Research shows that nutrients in watermelon is to provide an abundance of benefits, especially for male sexual capability. &lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Beberapa manfaat semangka untuk kehidupan seks pria seperti dilansir Livestrong, Kamis (19/1/2011):&quot;&gt;Some of the benefits of watermelon for the sex life of men as reported by LIVESTRONG on Thursday (01/19/2011):&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Beberapa manfaat semangka untuk kehidupan seks pria seperti dilansir Livestrong, Kamis (19/1/2011):&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;span title=&quot;1.&quot;&gt;&lt;b&gt;1. &lt;/b&gt;&lt;/span&gt;&lt;span title=&quot;Mencegah kanker prostat&quot;&gt;&lt;b&gt;Preventing prostate cancer.&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span title=&quot;Mencegah kanker prostat&quot;&gt;&lt;b&gt;&lt;br /&gt;&lt;br /&gt;&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;According  to research from Curtin University of Technology in Australia,  watermelon contains many antioxidant lycopene that may protect men  against prostate cancer.&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Kanker prostat merupakan kanker kedua yang paling mematikan.&quot;&gt;Prostate cancer is the second most deadly cancer. &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain itu, pria yang menderita kanker prostat bisa mengalami penurunan fungsi seksual dan kesuburan karena teknik pengobatan radiasi.&quot;&gt;In  addition, men with prostate cancer may experience decreased sexual  function and fertility because of radiation treatment techniques.&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain itu, pria yang menderita kanker prostat bisa mengalami penurunan fungsi seksual dan kesuburan karena teknik pengobatan radiasi.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;table cellpadding=&quot;0&quot; cellspacing=&quot;0&quot; class=&quot;&quot; style=&quot;float: left; margin-right: 1em; text-align: left;&quot;&gt;&lt;tbody&gt;
&lt;tr&gt;&lt;td style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;200&quot; src=&quot;https://lh4.googleusercontent.com/-CbSdBWn8pVo/TXO8lFj8jpI/AAAAAAAAAIU/uxED8w2Cqik/s200/diabetes.jpg&quot; width=&quot;193&quot; loading=&quot;lazy&quot; /&gt;&lt;/a&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;&quot; style=&quot;text-align: center;&quot;&gt;Diabetes&lt;/td&gt;&lt;/tr&gt;
&lt;/tbody&gt;&lt;/table&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain itu, pria yang menderita kanker prostat bisa mengalami penurunan fungsi seksual dan kesuburan karena teknik pengobatan radiasi.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;span title=&quot;2.&quot;&gt;&lt;b&gt;&lt;br /&gt;&lt;br /&gt;&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain itu, pria yang menderita kanker prostat bisa mengalami penurunan fungsi seksual dan kesuburan karena teknik pengobatan radiasi.&quot;&gt;&lt;span title=&quot;2.&quot;&gt;&lt;b&gt;2. &lt;/b&gt;&lt;/span&gt;&lt;span title=&quot;Mengobati diabetes tipe 2&quot;&gt;&lt;b&gt;Treating type 2 diabetes.&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Selain itu, pria yang menderita kanker prostat bisa mengalami penurunan fungsi seksual dan kesuburan karena teknik pengobatan radiasi.&quot;&gt;&lt;span title=&quot;Mengobati diabetes tipe 2&quot;&gt;&lt;b&gt;&lt;br /&gt;&lt;br /&gt;&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Kandungan arginin yang tinggi pada semangka dapat membantu mengobati diabetes tipe 2 (karena gaya hidup).&quot;&gt;High content of arginine in watermelon can help treat diabetes type 2 (due to lifestyle). &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Penelitian menemukan arginin dapat meningkatkan metabolisme glukosa dan sensitifitas insulin, keduanya membantu menurunkan kadar glukosa yang tinggi dan berhubungan dengan diabetes.&quot;&gt;Studies  have found arginine can improve glucose metabolism and insulin  sensitivity, both of which help lower the high glucose levels and is  associated with diabetes.&amp;nbsp;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Pria yang mengalami diabetes dikaitkan dengan kehilangan kemampuan seksual karena mengalami disfungsi ereksi.&quot;&gt;Men who have diabetes is associated with loss of sexual performance due to erectile &lt;a href=&quot;http://alpharxonline.com/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;online pharmacy&lt;/a&gt;.&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Pria yang mengalami diabetes dikaitkan dengan kehilangan kemampuan seksual karena mengalami disfungsi ereksi.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Pria yang mengalami diabetes dikaitkan dengan kehilangan kemampuan seksual karena mengalami disfungsi ereksi.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Pria yang mengalami diabetes dikaitkan dengan kehilangan kemampuan seksual karena mengalami disfungsi ereksi.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;span title=&quot;3.&quot;&gt;&lt;b&gt;3. &lt;/b&gt;&lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Meningkatkan fungsi pembuluh darah&quot;&gt;&lt;b&gt;Improve blood vessel function.&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Meningkatkan fungsi pembuluh darah&quot;&gt;&lt;b&gt;&lt;br /&gt;&lt;br /&gt;&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Meningkatkan fungsi pembuluh darah&quot;&gt;&lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Menurut penelitian dari Texas A&amp;amp;M University, citrulline yang ditemukan pada semangka dapat membantu meningkatkan fungsi pembuluh darah.&quot;&gt;According  to research from Texas A &amp;amp; M University, citrulline is found in  watermelon can help improve blood vessel function. &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Peneliti menemukan bahwa citrulline dapat meningkatkan produksi oksida nitrat, yaitu molekul gas yang membantu memperluas dan melebarkan pembuluh darah.&quot;&gt;Researchers  found that citrulline can increase nitric oxide production, namely the  gas molecules that help expand and dilate blood vessels. &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Oleh karena itu, semangka sering disebut memiliki efek Viagra karena dapat memperlancar aliran darah menuju penis.&quot;&gt;Therefore, the watermelon is often referred to has the effect of Viagra because it can facilitate blood flow to the penis.&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Oleh karena itu, semangka sering disebut memiliki efek Viagra karena dapat memperlancar aliran darah menuju penis.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;span title=&quot;4.&quot;&gt;&lt;b&gt;4. &lt;/b&gt;&lt;/span&gt;&lt;span title=&quot;Menurunkan tekanan darah&quot;&gt;&lt;b&gt;Lowering blood pressure.&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span title=&quot;Menurunkan tekanan darah&quot;&gt;&lt;b&gt;&lt;br /&gt;&lt;br /&gt;&lt;/b&gt;&lt;/span&gt;&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span title=&quot;Menurunkan tekanan darah&quot;&gt;&lt;/span&gt;&lt;span title=&quot;Semangka juga telah lama dikenal sebagai buah yang dapat menurunkan tekanan darah.&quot;&gt;Watermelon also has long been known as a fruit that can lower blood pressure. &lt;/span&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Dengan tekanan darah yang normal, pria semakin dijauhkan dengan segala penyakit berbahaya seperti jantung dan stroke.&quot;&gt;With normal blood pressure, men increasingly turned away with all the dangerous diseases such as heart disease and stroke.&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;text-align:justify&quot;&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;background-color: white;&quot; title=&quot;Dengan tekanan darah yang normal, pria semakin dijauhkan dengan segala penyakit berbahaya seperti jantung dan stroke.&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;text-align:justify&quot;&gt;&lt;span class=&quot;&quot; lang=&quot;en&quot;&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;There are so many&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;benefits of&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;watermelon&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;for&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;your&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;body&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;.&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;From now on&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;get used to&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;eating&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;watermelon&lt;/span&gt; &lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;for dessert&lt;/span&gt;&lt;span class=&quot;&quot; title=&quot;Klik untuk terjemahan alternatif&quot;&gt;.&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;</description>
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  <pubDate>Tue, 24 May 2011 07:16:41 GMT</pubDate>
  <title>Back to your male might</title>
  <author>bafonavy</author>
  <link>https://bafonavy.livejournal.com/1455.html</link>
  <description>&amp;gt;&amp;gt;&amp;gt;   &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;www.b8y-rxming.ru&lt;/a&gt;&lt;br&gt;                                &lt;br&gt;-   Today the problem of male erectile dysfunction stands out ery acutely &amp;#65533; if you like so many others have experienced its devastating blow then you know what we are talking about. But in any case you should not panic if this sad news has one day striken you &amp;#65533; nowadays that you have the opportunity of using any erectile dysfunction pill that there is on the offer you will not be left all alone with your health issues. &lt;br&gt;                                     &lt;br&gt;-   First of all there should be mentioned the fact that it shouldn&amp;#65533;t matter how old you are &amp;#65533; the &lt;a href=&quot;http://sigmarxonline.com/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;viagra&lt;/a&gt; for male impotence therapy work excellent in patients of any age group. Besides, even if your problem has been pestering you for quite some time you still have all the chances of going into sex orbit as early as this weekend after you order a ack of quality erectile dysfunction &lt;a href=&quot;http://consultantmediconline.com&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;cialis&lt;/a&gt; online. &lt;br&gt;                            &lt;br&gt;-   Among the benefits you get from rectile dysfunction pills there are listed some important bonuses. For example, you do not only manage to achieve and maintain rock hard erection, but you also enjoy magnificently sensitized penile tissues that will bring you closer to unbelievably powerful orgasms. The patient from all around the globe claim to have felt previeously unexperienced intensity of desire and the most complete satisfaction after taking those magic diamond shaped pills. &lt;br&gt;                                                                                         &lt;br&gt;-   Women who have the experience of having sexual interourse with men who take this or that erectile dysfunction pills before the contact state that their own sensations during the love act differ greatly from their usual sex routines. All of this goes to show that getting erectile dysfunction drugs online you win the reputation of a skillful and tireless lover that women are so crazy about. &lt;br&gt;                                                &lt;br&gt;-   It all comes down to one simple solution &amp;#65533; you are going to profit from getting those magical blue pills in more than just one sense. There is no need for celibacy forced by your health condition any longer, as today you can get erectile dysfunction drugs at an affordable price from a reliable and licenced resource. &lt;br&gt;                 &lt;p&gt;--- &amp;gt;   &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;www.b8y-rxming.ru&lt;/a&gt;   &amp;lt; ---&lt;p&gt; _V______C________L&lt;br&gt; ___I_______I_______E&lt;br&gt; _____A_______A_______V&lt;br&gt; _______G_______L_______I&lt;br&gt; _________R_______I_______T&lt;br&gt; ___________A_______S_______R&lt;br&gt; _____________________________A&lt;br&gt;                                                                                        &lt;br&gt;   There should be always time for love in our crazy world! Our pilules work like aphrodisiacs, ready to refill your source of desire anytime. Give her love on the table and in cinema! Order and get powers to be crazy again.&lt;br&gt;-&lt;br&gt; - - -&lt;br&gt;---------     &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;www.b8y-rxming.ru&lt;/a&gt;&lt;br&gt; - - -&lt;br&gt;-</description>
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  <pubDate>Tue, 17 May 2011 12:07:38 GMT</pubDate>
  <title>ADHD Drugs Can Cause Sudden Cardiac Deaths</title>
  <author>bafonavy</author>
  <link>https://bafonavy.livejournal.com/1218.html</link>
  <description>&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;img style=&quot;margin: 0pt 10px 10px 0pt; float: left; cursor: pointer; width: 142px; height: 200px;&quot; src=&quot;https://imgprx.livejournal.net/13b6d6decd7cd794cc52eb80e609e79be8b9ca7ab3ba7a9069f07fd113785db7/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0jgCAV_xRg9_U4AjbgY-mB0dpP3ImSkhf7310pALJLDBPE0MauTYrwHQmxFbuGcigzHtxhRY1ZSC7GOq6rNdHmVJX8QEgMTtW80C1-mcOKM1xDHlELBfZog:jxHa1kXEjTlPChl2Wf8BSg&quot; alt=&quot;&quot; border=&quot;0&quot; fetchpriority=&quot;high&quot; /&gt;&lt;/a&gt;&lt;span style=&quot;font-style: italic;&quot;&gt;The death of a beloved child means that the future is a thing of the past.&lt;/span&gt;&lt;br /&gt;&lt;span&gt;  -- Peter De Vries (1910-1993), from &lt;/span&gt;&lt;span&gt;The Blood of the Lamb (1961)&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;So... not only are ADHD drugs &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;ineffective&lt;/a&gt;, they can also &lt;span style=&quot;font-style: italic;&quot;&gt;kill&lt;/span&gt; your child. And yet the doctors and authorities who undoubtedly have many fingers in the pie urge you to keep your child drugged up in spite of the horrendous risks. Hypocritical much?&lt;br /&gt;&lt;br /&gt;Seriously, isn&apos;t it time you considered &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;safer&lt;/a&gt; and &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;more effective alternatives&lt;/a&gt;? Or, perhaps you might want to move to Canada, where the government has enough morals to keep Big Pharma from pushing potentially fatal drugs to children.&lt;br /&gt;&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Continue reading &amp;#187;&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;span class=&quot;&quot;&gt;&lt;span style=&quot;font-weight: bold;&quot;&gt;Study Shows Possible Link Between Deaths and ADHD Drugs&lt;/span&gt;&lt;br /&gt;By Shankar Vedantam&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Washington Post&lt;/a&gt;&lt;br /&gt;June 16, 2009&lt;br /&gt;&lt;br /&gt;Children taking stimulant drugs such as Ritalin to treat attention-deficit hyperactivity disorder are several times as likely to suffer sudden, unexplained death as children who are not taking such drugs, according to a study published yesterday that was funded by the Food and Drug Administration (FDA) and the National Institute of Mental Health (NIMH).&lt;br /&gt;&lt;br /&gt;While the numbers involved in the study were very small and researchers stopped short of suggesting a cause and effect, the study is the first to rigorously demonstrate a rare but worrisome connection between ADHD drugs and sudden death among children. In doing so, the research adds to the evolving puzzle parents and doctors face in deciding whether to treat children with &lt;a href=&quot;http://softdj.net/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;cheap cialis&lt;/a&gt;.&lt;br /&gt;&lt;br /&gt;Doctors have speculated about such a connection in the past because &lt;span style=&quot;font-weight: bold;&quot;&gt;stimulants increase heart rate&lt;/span&gt; and have other &lt;span style=&quot;font-weight: bold;&quot;&gt;cardiovascular effects&lt;/span&gt;.&lt;br /&gt;&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Read the full article at the Washington Post&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;font-weight: bold;&quot;&gt;FDA urges caution in weighing risks of ADHD drugs&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;By Matthew Perrone&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;The Associated Press&lt;/a&gt;&lt;br /&gt;June 15, 2009&lt;br /&gt;&lt;br /&gt;WASHINGTON -- Federal health regulators are &lt;span&gt;urging&lt;/span&gt; parents to keep their children on attention deficit drugs like Ritalin and Adderall, &lt;span style=&quot;font-weight: bold;&quot;&gt;despite new evidence&lt;/span&gt; from a government-backed study that the stimulants can increase the risk of sudden death.&lt;br /&gt;&lt;br /&gt;Published Monday in the American Journal of Psychiatry, the study suggests a link between use of the stimulant drugs and sudden death in children and adolescents. The drugs, used to treat attention deficit and hyperactivity disorder, already carry warnings about &lt;span style=&quot;font-weight: bold;&quot;&gt;risks of heart attack and stroke in children with underlying heart conditions&lt;/span&gt;.&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;font-weight: bold;&quot;&gt;Healthy children&lt;/span&gt; taking the medications were &lt;span style=&quot;font-weight: bold;&quot;&gt;six to seven times more likely to die suddenly&lt;/span&gt; for unexplained reasons than those not taking the drugs, according to the study from the National Institute of Mental Health.&lt;br /&gt;&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Read the full article at AP&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;font-weight: bold;&quot;&gt;Cardiac Screening Recommended for Kids Taking Stimulants for ADHD&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;By Alan Mozes&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;HealthDay Reporter&lt;/a&gt;&lt;br /&gt;April 21, 2008&lt;br /&gt;&lt;br /&gt;Children with underlying heart disease who take stimulants for ADHD appear to face an increased risk for sudden cardiac arrest, the American Heart Association (AHA) noted. This risk association is particularly troublesome for young ADHD patients, because &lt;span style=&quot;font-weight: bold;&quot;&gt;heart disease often goes undiagnosed in children and may be present without noticeable symptoms&lt;/span&gt;.&lt;br /&gt;&lt;br /&gt;The AHA also pointed to a number of studies that suggest that between 33 percent and 42 percent of pediatric heart patients also have ADHD.&lt;br /&gt;&lt;br /&gt;FDA data collected for the period 1999 through 2004 revealed that 19 children following an ADHD prescription regimen had died suddenly, while 26 experienced heart complications such as stroke, heart attack, and/or heart palpitations.&lt;br /&gt;&lt;br /&gt;Vetter noted that, in 2005, the Canadian equivalent of the FDA -- Health Canada -- decided to &lt;span&gt;place a &lt;/span&gt;&lt;span style=&quot;font-weight: bold;&quot;&gt;ban on Adderall&lt;/span&gt;, an amphetamine-based ADHD medication designed for kids over the age of 3. The Canadian decision was actually based on a review of FDA records concerning 12 reported deaths among American children taking ADHD drugs.&lt;br /&gt;&lt;br /&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Read the full article at HealthDay&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;font-weight: bold;&quot;&gt;See also:&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&amp;#8226; &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Does your child really have ADHD?&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&amp;#8226; &lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;Biomedical Treatment for ADHD&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;br /&gt;&lt;div&gt;&lt;lj-embed id=&quot;1&quot; /&gt;&lt;/div&gt;&lt;br /&gt;&lt;span class=&quot;&quot; displaytext=&quot;Facebook&quot;&gt;&lt;/span&gt;&lt;span class=&quot;&quot; displaytext=&quot;Tweet&quot;&gt;&lt;/span&gt;&lt;span class=&quot;&quot; displaytext=&quot;Email&quot;&gt;&lt;/span&gt;</description>
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  <pubDate>Tue, 03 May 2011 16:08:01 GMT</pubDate>
  <title>Nitrate use in Heart Failure</title>
  <author>bafonavy</author>
  <link>https://bafonavy.livejournal.com/962.html</link>
  <description>See also: &lt;a href=&quot;http://nbwhp.org/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;cheap cialis&lt;/a&gt;&amp;nbsp;|&amp;nbsp;&lt;a href=&quot;http://bestpharmshop.net/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;cialis&lt;/a&gt;&amp;nbsp;|&amp;nbsp;&lt;br&gt;&lt;br /&gt;&lt;br /&gt;&lt;div dir=&quot;ltr&quot; style=&quot;text-align:left&quot; trbidi=&quot;on&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:left&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;320&quot; src=&quot;https://imgprx.livejournal.net/28208449dd9ea29cf323fe9a6c7cef68b2c13d0f96b9efea2a819aca2ec7aaea/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0jACAV_xRg9_U4AjbgY-mB0dpTXhvGx9VjEx2rWvJLDd_KGFBtwwasn8mxFbuGcigzHtxhTxUZT64Otq7pcIcpl1h8QEhMztW2WWbyTUSfZ4-AidJfg0:TJmzt-hfEudnms4ZgX-LfQ&quot; width=&quot;213&quot; fetchpriority=&quot;high&quot; /&gt;&lt;/a&gt;&lt;span class=&quot;&quot; style=&quot;font-size: 12px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;Isosorbide dinitrate can be used with hydralazine in heart failure as an alternative to ACE-inhibitors or ARBs.&amp;nbsp; The medications act complementary to dilate the blood vessels.&amp;nbsp; Hydralazine reduces afterload by decreasing both pulmonary and systemic vascular resistance.&amp;nbsp; Its effects on vasodilation are not completely understood.&amp;nbsp; It also has some moderate inotropic effects.&amp;nbsp; It reduces renal vascular resistance, though not by as much as ACE-inhibitors.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;1&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;Nitrates like isosorbide dinitrate relax blood vessels by releasing NO.&amp;nbsp; Isosorbide dinitrate improves exercise capacity in patients with heart failure&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;1,2&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;.&amp;nbsp; Nitrates can inhibit vascular and myocardial remodeling&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;.&amp;nbsp; Nitrates must be dosed so that there is a six to eight hour period of negligible drug levels or tolerance may develop.&amp;nbsp; Hydralazine may decrease nitrate tolerance. &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;1,3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;The V-HeFT trial in 1986 showed decreased mortality with the use of hydralazine and isosorbide dinitrate compared to prazosin&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; 2&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;.&amp;nbsp; The V-HeFT II trial compared isosorbide dinitrate to enalapril in patients with moderate heart failure and found decreased survival due to a higher incidence of sudden death in the isosorbide dinitrate-hydralazine arm.&amp;nbsp; There was no difference in mortality rate in African Americans taking isosorbide dinitrate-hydralazine compared to enalapril. &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;2&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&amp;nbsp; &amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:center&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;320&quot; src=&quot;https://imgprx.livejournal.net/c0701dfbd4b5db68aeb911376d5d46acf94e6fb4811619dda0188f4e7b193ef6/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0iwCAV_xRg9_U4AjbgY-mB0dpTR9QLFR8ghJCthnnLDd_KGEkzUoR-2EmxFbuGcigzHtxhTxIZTXmA_XKu5lZmUAA8QEhMztW2WWbyTUSfZ0-AidJfg0:ZO31h1HavMm8OaObcWZyKw&quot; width=&quot;213&quot; loading=&quot;lazy&quot; /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/a&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;The A-HeFT trail in 2004 compared the addition of isosorbide dinitrate with hydralazine or placebo to standard heart failure treatment in patients of African descent in NYHA stage III or IV heart failure.&amp;nbsp; The trial was terminated early due to increased survival in patients taking hydralazine with isosorbide dinitrate.&amp;nbsp; The target dosing used in this trial was 75mg hydralazine and 40mg isosorbide dinitrate three times daily for a total daily dose of 225mg hydralazine and 120mg isosorbide dinitrate.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;4&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;Compliance is more difficult with a regimen containing isosorbide dinitrate and hydralazine because these medications are dosed three to four times a day.&amp;nbsp; The new product, BiDil, contains both medications but is about twice as expensive and must also be taken multiple times per day.&amp;nbsp; There is also a high discontinuation rate due to incidence of headache and GI upset.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;There is a lack of trials evaluating the use of isosorbide dinitrate without hydralazine in heart failure; these medications should be used together&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;. &amp;nbsp; The ACC/AHA guidelines recommend to consider the addition of hydralazine with isosorbide dinitrate in African Americans.&amp;nbsp; However, hydralazine with isosorbide should not be considered before an ACE-inhibitor if the patient has no history or ACE-inhibitor intolerance or if they are tolerating ACE-inhibitor therapy.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&amp;nbsp; The HFSA guidelines recommend to consider the use of hydralazine and isosorbide dinitrate in African Americans in standard therapy, as they do not respond as well to ACE-inhibitors as white patients.&amp;nbsp; The HFSA also recommends to consider the addition of hydralazine with isosorbide dinitrate in African Americans with stage II or III heart failure and LV dysfunction even if their regimen includes an ACE-inhibitor or beta-blocker.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;5&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:center&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;266&quot; src=&quot;https://imgprx.livejournal.net/cf279d5243295ad578c25813f89ec06a1708d4a3a02368f1771aa44bd9d182e7/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0jACAV_xRg9_U4AjbgY-mB0dpTVUhH2dmpRptqD_NLDd_KGEYsCkR0WkmxFbuGcigzHtxhTxQZUq4CtStsNMc0HR98QEmMTtW2WWbyTUSfZw-Igdpfg0:ULs1LJXNH5ldf4YI_FVC3Q&quot; width=&quot;400&quot; loading=&quot;lazy&quot; /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/a&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt; &lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;*Note: images are not of heart failure but are of the beach&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt; &lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;References:&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;ol style=&quot;list-style-type: decimal;&quot;&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Brunton LL, Lazo JS, Parker KL, editors.&amp;nbsp; Goodman &amp;amp; Gilman&amp;#8217;s: the pharmacological basis of therapeutics.&amp;nbsp; 11th ed.&amp;nbsp; New York: McGraw-Hill Companies, Inc.; 2006.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Elkayam U, Bitar F.&amp;nbsp; Effects of nitrates and hydralazine in heart failure: clinical evidence before the African American heart failure trial.&amp;nbsp; American Journal of Cardiology 2005;96(suppl):37i-43i.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al.&amp;nbsp; ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult.&amp;nbsp; Circulation 2005;112:e154-e235.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Taylor AL, Ziesche S, Yancy C, Carson P,&amp;nbsp; D&amp;#8217;Agostino R, Ferdinand K et al.&amp;nbsp; Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.&amp;nbsp; The New England Journal of Medicine 2004;351(20):2049-2057.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Adams KF, Lindenfeld J, Arnold JMO, Baker DW, Barnard DH, Baughman KL et al.&amp;nbsp; Executive summary: HFSA 2006 comprehensive heart failure practice guideline.&amp;nbsp; Journal of Cardiac Failure 2006; 12(1):10-38.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;/ol&gt;&lt;/div&gt;</description>
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  <pubDate>Tue, 03 May 2011 13:31:04 GMT</pubDate>
  <title>Nitrate use in Heart Failure</title>
  <author>bafonavy</author>
  <link>https://bafonavy.livejournal.com/634.html</link>
  <description>See also: &lt;a href=&quot;http://nbwhp.org/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;purchase cialis&lt;/a&gt;&amp;nbsp;|&amp;nbsp;&lt;a href=&quot;http://bestpharmshop.net/&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;cialis&lt;/a&gt;&amp;nbsp;|&amp;nbsp;&lt;br&gt;&lt;br /&gt;&lt;br /&gt;&lt;div dir=&quot;ltr&quot; style=&quot;text-align:left&quot; trbidi=&quot;on&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:left&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;320&quot; src=&quot;https://imgprx.livejournal.net/28208449dd9ea29cf323fe9a6c7cef68b2c13d0f96b9efea2a819aca2ec7aaea/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0jACAV_xRg9_U4AjbgY-mB0dpTXhvGx9VjEx2rWvJLDd_KGFBtwwasn8mxFbuGcigzHtxhTxUZT64Otq7pcIcpl1h8QEhMztW2WWbyTUSfZ4-AidJfg0:TJmzt-hfEudnms4ZgX-LfQ&quot; width=&quot;213&quot; fetchpriority=&quot;high&quot; /&gt;&lt;/a&gt;&lt;span class=&quot;&quot; style=&quot;font-size: 12px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;Isosorbide dinitrate can be used with hydralazine in heart failure as an alternative to ACE-inhibitors or ARBs.&amp;nbsp; The medications act complementary to dilate the blood vessels.&amp;nbsp; Hydralazine reduces afterload by decreasing both pulmonary and systemic vascular resistance.&amp;nbsp; Its effects on vasodilation are not completely understood.&amp;nbsp; It also has some moderate inotropic effects.&amp;nbsp; It reduces renal vascular resistance, though not by as much as ACE-inhibitors.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;1&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;Nitrates like isosorbide dinitrate relax blood vessels by releasing NO.&amp;nbsp; Isosorbide dinitrate improves exercise capacity in patients with heart failure&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;1,2&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;.&amp;nbsp; Nitrates can inhibit vascular and myocardial remodeling&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;.&amp;nbsp; Nitrates must be dosed so that there is a six to eight hour period of negligible drug levels or tolerance may develop.&amp;nbsp; Hydralazine may decrease nitrate tolerance. &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;1,3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;The V-HeFT trial in 1986 showed decreased mortality with the use of hydralazine and isosorbide dinitrate compared to prazosin&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; 2&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;.&amp;nbsp; The V-HeFT II trial compared isosorbide dinitrate to enalapril in patients with moderate heart failure and found decreased survival due to a higher incidence of sudden death in the isosorbide dinitrate-hydralazine arm.&amp;nbsp; There was no difference in mortality rate in African Americans taking isosorbide dinitrate-hydralazine compared to enalapril. &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;2&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&amp;nbsp; &amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:center&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;320&quot; src=&quot;https://imgprx.livejournal.net/c0701dfbd4b5db68aeb911376d5d46acf94e6fb4811619dda0188f4e7b193ef6/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0iwCAV_xRg9_U4AjbgY-mB0dpTR9QLFR8ghJCthnnLDd_KGEkzUoR-2EmxFbuGcigzHtxhTxIZTXmA_XKu5lZmUAA8QEhMztW2WWbyTUSfZ0-AidJfg0:ZO31h1HavMm8OaObcWZyKw&quot; width=&quot;213&quot; loading=&quot;lazy&quot; /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/a&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;The A-HeFT trail in 2004 compared the addition of isosorbide dinitrate with hydralazine or placebo to standard heart failure treatment in patients of African descent in NYHA stage III or IV heart failure.&amp;nbsp; The trial was terminated early due to increased survival in patients taking hydralazine with isosorbide dinitrate.&amp;nbsp; The target dosing used in this trial was 75mg hydralazine and 40mg isosorbide dinitrate three times daily for a total daily dose of 225mg hydralazine and 120mg isosorbide dinitrate.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;4&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;Compliance is more difficult with a regimen containing isosorbide dinitrate and hydralazine because these medications are dosed three to four times a day.&amp;nbsp; The new product, BiDil, contains both medications but is about twice as expensive and must also be taken multiple times per day.&amp;nbsp; There is also a high discontinuation rate due to incidence of headache and GI upset.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;white-space: pre;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;There is a lack of trials evaluating the use of isosorbide dinitrate without hydralazine in heart failure; these medications should be used together&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;. &amp;nbsp; The ACC/AHA guidelines recommend to consider the addition of hydralazine with isosorbide dinitrate in African Americans.&amp;nbsp; However, hydralazine with isosorbide should not be considered before an ACE-inhibitor if the patient has no history or ACE-inhibitor intolerance or if they are tolerating ACE-inhibitor therapy.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;3&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&amp;nbsp; The HFSA guidelines recommend to consider the use of hydralazine and isosorbide dinitrate in African Americans in standard therapy, as they do not respond as well to ACE-inhibitors as white patients.&amp;nbsp; The HFSA also recommends to consider the addition of hydralazine with isosorbide dinitrate in African Americans with stage II or III heart failure and LV dysfunction even if their regimen includes an ACE-inhibitor or beta-blocker.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;font: normal normal normal 8px/normal &amp;apos;Gill Sans Light&amp;apos;; letter-spacing: 0px;&quot;&gt;&lt;sup&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;5&lt;/span&gt;&lt;/span&gt;&lt;/sup&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div class=&quot;&quot; style=&quot;clear:both;text-align:center&quot;&gt;&lt;a href=&quot;#&quot; target=&quot;_blank&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;img border=&quot;0&quot; height=&quot;266&quot; src=&quot;https://imgprx.livejournal.net/cf279d5243295ad578c25813f89ec06a1708d4a3a02368f1771aa44bd9d182e7/P2WlxyVijxKvg21n8sheUUMdsf-ah7h0jACAV_xRg9_U4AjbgY-mB0dpTVUhH2dmpRptqD_NLDd_KGEYsCkR0WkmxFbuGcigzHtxhTxQZUq4CtStsNMc0HR98QEmMTtW2WWbyTUSfZw-Igdpfg0:ULs1LJXNH5ldf4YI_FVC3Q&quot; width=&quot;400&quot; loading=&quot;lazy&quot; /&gt;&lt;/span&gt;&lt;/span&gt;&lt;/a&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt; &lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;*Note: images are not of heart failure but are of the beach&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px;min-height:14.0px&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;&lt;br /&gt;&lt;br /&gt;&lt;/span&gt; &lt;/span&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; &lt;/span&gt;&lt;/div&gt;&lt;div style=&quot;font:12.0px &amp;apos;margin:0.0px 0.0px 0.0px 0.0px&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt;References:&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;ol style=&quot;list-style-type: decimal;&quot;&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Brunton LL, Lazo JS, Parker KL, editors.&amp;nbsp; Goodman &amp;amp; Gilman&amp;#8217;s: the pharmacological basis of therapeutics.&amp;nbsp; 11th ed.&amp;nbsp; New York: McGraw-Hill Companies, Inc.; 2006.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Elkayam U, Bitar F.&amp;nbsp; Effects of nitrates and hydralazine in heart failure: clinical evidence before the African American heart failure trial.&amp;nbsp; American Journal of Cardiology 2005;96(suppl):37i-43i.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al.&amp;nbsp; ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult.&amp;nbsp; Circulation 2005;112:e154-e235.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Taylor AL, Ziesche S, Yancy C, Carson P,&amp;nbsp; D&amp;#8217;Agostino R, Ferdinand K et al.&amp;nbsp; Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.&amp;nbsp; The New England Journal of Medicine 2004;351(20):2049-2057.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;li style=&quot;font: 12.0px &amp;apos;Gill Sans Light&amp;apos;; margin: 0.0px 0.0px 0.0px 0.0px;&quot;&gt;&lt;span style=&quot;letter-spacing: 0px;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;font-family: inherit;&quot;&gt;&lt;span class=&quot;&quot; style=&quot;color: #444444;&quot;&gt; Adams KF, Lindenfeld J, Arnold JMO, Baker DW, Barnard DH, Baughman KL et al.&amp;nbsp; Executive summary: HFSA 2006 comprehensive heart failure practice guideline.&amp;nbsp; Journal of Cardiac Failure 2006; 12(1):10-38.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/li&gt;&lt;br /&gt;&lt;/ol&gt;&lt;/div&gt;</description>
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