![\"\u6740\u6b7b\u516b\u79cd\u764c\u75c7\uff01\u4e2d\u56fd\u8981\u6709\u81ea\u5df1\u7684\u6297\u764c\u201c\u795e\u836f\u201d\u4e86\uff1f\"](\"https:\/\/aqzt.com\/wp-content\/uploads\/20220210093201-9.jpg\")
<\/p>\nKeytruda\uff0c\u5e15\u535a\u4e3d\u73e0\u5355\u6297\u7684\u5546\u54c1\u540d\uff0c\u5728\u764c\u75c7\u6cbb\u7597\u533b\u751f\u548c\u60a3\u8005\u53e3\u4e2d\uff0c\u5b83\u5e38\u88ab\u7b80\u79f0\u4e3a\u201cK\u836f\u201d\u3002\u5b83\u8fd8\u6709\u53e6\u4e00\u4e2a\u79f0\u547c\uff0c\u764c\u75c7\u201c\u795e\u836f\u201d\u3002<\/p>\n<\/p>\n
\u795e\u5728\u54ea\uff1f<\/p>\n
\u8d85\u51fa\u4eba\u4eec\u56fa\u6709\u7684\u201c\u5bf9\u75c7\u4e0b\u836f\u201d\u7684\u4f20\u7edf\u8ba4\u77e5\uff0cK\u836f\u7684\u795e\u5c31\u795e\u5728\u4ed6\u662f\u5168\u7403\u9996\u4e2a\u88ab\u6279\u51c6\u7684\uff0c\u4e0d\u4ee5\u80bf\u7624\u90e8\u4f4d\u4e3a\u53c2\u8003\uff0c\u4ec5\u4f9d\u9760\u751f\u7269\u6807\u5fd7\u7269\u8fdb\u884c\u6cbb\u7597\u9009\u62e9\u7684\u836f\u7269\uff0c\u6210\u4eba\u548c\u513f\u7ae5\u5747\u53ef\u670d\u7528\u3002<\/p>\n
\u7b80\u5355\u6765\u8bf4\uff0c\u65e0\u8bba\u60a3\u8005\u6240\u7f79\u60a3\u7684\u764c\u75c7\u79cd\u7c7b\u5982\u4f55\uff0c\u53ea\u8981\u7b26\u5408K\u836f\u7684\u9002\u7528\u6761\u4ef6\uff0cK\u836f\u5c31\u80fd\u627e\u5230\u81ea\u5df1\u7684\u7528\u6b66\u4e4b\u5730\uff0c\u7ae5\u53df\u65e0\u6b3a\u3002<\/p>\n
\u4f46\u5bf9\u4e8e\u6211\u56fd\u800c\u8a00\uff0c\u59cb\u7ec8\u6ca1\u6709\u53ef\u4e0e\u795e\u836f\u5339\u654c\u7684\u7c7b\u4f3c\u836f\u4e0a\u5e02\u3002\u8fd1\u65e5\uff084 \u6708 22 \u65e5\uff09\uff0c\u8fd9\u4e00\u683c\u5c40\u53d1\u751f\u4e86\u4e9b\u8bb8\u6539\u53d8\u3002<\/p>\n
\u6211\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8\u590d\u5b8f\u6c49\u9716\u516c\u5e03\u6d88\u606f\u3002\u5176\u81ea\u4e3b\u7814\u5236\u7684\u521b\u65b0\u578b PD-1 \u6291\u5236\u5242\u65af\u9c81\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08HLX10\uff09\u9488\u5bf9\u7ecf\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08Microsatellite Instability-High, MSI-H\uff09\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u6ce8\u518c\u7533\u8bf7\uff08NDA\uff09\u6b63\u5f0f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\uff0c\u5e76\u62df\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\uff0c\u6709\u671b\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u6cbb\u7597 MSI-H \u5b9e\u4f53\u7624\u7684\u6297 PD-1 \u5355\u6297\u3002<\/p>\n
\u4e13\u6709\u540d\u8bcd\u8fc7\u591a\uff0c\u6211\u6765\u4e3a\u8bf8\u541b\u7b54\u7591\u89e3\u60d1\u3002<\/p>\n
**\u6355\u6349\u9003\u9038\u7684\u80bf\u7624\u00a0**<\/p>\n
\u4f60\u4e86\u89e3\u81ea\u5df1\u8eab\u4f53\u5185\u90e8\u7684\u8fd0\u8f6c\u89c4\u5f8b\u5417\uff1f\u5b83\u81ea\u6210\u4e00\u6d3e\u3002<\/p>\n
\u6211\u4eec\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u662f\u4eba\u4f53\u62b5\u6297\u5404\u79cd\u611f\u67d3\u7684\u5929\u7136\u9632\u7ebf\uff0c\u5f53\u75c5\u6bd2\u5165\u4fb5\uff0c\u514d\u75ab\u7cfb\u7edf\u5c31\u4f1a\u8c03\u96c6\u7cbe\u5175\u608d\u5c06\uff08T\u7ec6\u80de\uff09\u4e0e\u654c\u4eba\u5c55\u5f00\u53ae\u6740\u3002<\/p>\n
\u8fd9\u9690\u85cf\u6280\u80fd\u7ed9\u79d1\u5b66\u5bb6\u63d0\u4e86\u4e2a\u9192\uff0c\u6211\u4eec\u662f\u5426\u53ef\u4ee5\u8c03\u52a8\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u7684\u529b\u91cf\uff0c\u5305\u6284\u56f4\u527f\u764c\u7ec6\u80de\uff1f\u5f53\u8bbe\u60f3\u8d70\u8fdb\u73b0\u5b9e\uff0c\u5b83\u88ab\u79f0\u4e3a\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n
\u60f3\u8981\u4e86\u89e3\u5b83\uff0c\u6211\u4eec\u8981\u5148\u660e\u786e\u4e00\u4e2a\u95ee\u9898\uff0c\u4eba\u4e3a\u4ec0\u4e48\u4f1a\u5f97\u764c\u75c7\uff1f<\/p>\n
\u4eba\u4f53\u5c31\u50cf\u7531\u4e00\u4e2a\u4e2a\u7ec6\u80de\u7ec4\u6210\u7684\u793e\u533a\u3002\u6bcf\u4e2a\u7ec6\u80de\u7167\u7ae0\u884c\u4e8b\uff0c\u77e5\u9053\u4f55\u65f6\u8be5\u751f\u957f\u5206\u88c2\uff0c\u4e5f\u77e5\u9053\u600e\u6837\u548c\u522b\u7684\u7ec6\u80de\u7ed3\u5408\uff0c\u5f62\u6210\u7ec4\u7ec7\u548c\u5668\u5b98\u3002\u800c\u6784\u5efa\u4e0d\u540c\u7ec4\u7ec7\u7684\u201c\u56fe\u7eb8\u201d\uff0c\u5c31\u662f\u57fa\u56e0\u3002<\/p>\n
\u4e00\u65e6\u793e\u533a\u7ec6\u80de\u201c\u8c0b\u53cd\u201d\u4e86\uff0c\u4e0d\u9075\u7167\u89c4\u7ae0\u5236\u5ea6\u5f00\u59cb\u75af\u72c2\u751f\u957f\uff0c\u5c31\u4f1a\u5f62\u6210\u80bf\u7624\u3002<\/p>\n
\u6076\u6027\u80bf\u7624\u5c31\u662f\u764c\u75c7\uff0c\u4e0e\u4e4b\u76f8\u5bf9\u7684\u662f\u826f\u6027\u80bf\u7624\u3002\u80bf\u7624\u662f\u6307\u673a\u4f53\u5728\u5404\u79cd\u81f4\u7624\u56e0\u7d20\u4f5c\u7528\u4e0b\uff0c\u5c40\u90e8\u4e3b\u6cbb\u7684\u7ec6\u80de\u5f02\u5e38\u589e\u751f\u800c\u5f62\u6210\u7684\u5c40\u90e8\u80bf\u5757\u3002\u53ef\u4ee5\u628a\u5b83\u7406\u89e3\u6210\u7ec6\u80de\u7684\u751f\u957f\u504f\u79bb\u4e86\u6b63\u5e38\u7684\u8f68\u9053\uff0c\u8df3\u51fa\u4e86\u56fa\u6709\u89c4\u5f8b\u3002<\/p>\n
\u826f\u6027\u80bf\u7624\u5bb9\u6613\u6e05\u9664\u5e72\u51c0\uff0c\u4e00\u822c\u4e0d\u8f6c\u79fb\u3001\u4e0d\u590d\u53d1\uff0c\u5bf9\u5668\u5b98\u3001\u7ec4\u7ec7\u53ea\u6709\u6324\u538b\u548c\u963b\u585e\u4f5c\u7528\u3002\u4f46\u6076\u6027\u80bf\u7624\u8fd8\u53ef\u4ee5\u7834\u574f\u7ec4\u7ec7\u3001\u5668\u5b98\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u5f15\u8d77\u574f\u6b7b\u51fa\u8840\u5408\u5e76\u611f\u67d3\uff0c\u60a3\u8005\u6700\u7ec8\u53ef\u80fd\u7531\u4e8e\u5668\u5b98\u529f\u80fd\u8870\u7aed\u800c\u6b7b\u4ea1\u3002<\/p>\n
<\/p>\n
\u764c\u75c7\u5f62\u6210\u8fc7\u7a0b<\/p>\n
\u4eba\u4f53\u51e0\u4e4e\u6bcf\u4e2a\u90e8\u4f4d\u90fd\u53ef\u80fd\u906d\u53d7\u764c\u75c7\u4fb5\u5bb3\u3002\u672c\u6765\uff0c\u4eba\u4f53\u8fd9\u4e2a\u751f\u7269\u673a\u5668\u8fd0\u884c\u5f97\u5929\u8863\u65e0\u7f1d\uff0c\u7136\u800c\u764c\u75c7\u6539\u53d8\u4e86\u8fd9\u79cd\u60c5\u5f62\uff0c\u5b83\u7684\u4efb\u52a1\u5c31\u662f\u7834\u574f\u3002\u5982\u679c\u7ee7\u7eed\u4e0b\u53bb\uff0c\u5c31\u4f1a\u5c06\u4eba\u4f53\u62d6\u57ae\u3002<\/p>\n
\u4f46\u662f\uff0c\u80bf\u7624\u4e0d\u50cf\u75c5\u6bd2\uff0c\u4e0d\u662f\u4f53\u5916\u5165\u4fb5\u8005\uff0c\u5b83\u7684\u6210\u5206\u548c\u6b63\u5e38\u7ec4\u7ec7\u4e00\u6837\uff0c\u56e0\u6b64\u673a\u4f53\u65e0\u6cd5\u5bf9\u5b83\u8fdb\u884c\u8bc6\u522b\u514d\u75ab\u3002\u4e00\u65e6\u764c\u53d8\u7ec6\u80de\u901a\u8fc7\u5404\u79cd\u9003\u907f\u624b\u6bb5\u9003\u8fc7\u514d\u75ab\u7cfb\u7edf\u7684\u201c\u76d1\u89c6\u201d\u3001\u80bf\u7624\u624d\u4f1a\u7ee7\u7eed\u751f\u957f\u3002<\/p>\n
\u80bf\u7624\u4e3a\u4ec0\u4e48\u4f1a\u9003\u9038\uff1f<\/strong><\/p>\n \u4eba\u4f53\u7684T\u7ec6\u80de\u8868\u9762\u5b58\u5728 PD-1 \u53d7\u4f53\uff0c\u4e00\u65e6\u5b83\u4e0e\u5176\u4ed6\u7ec6\u80de\u4e0a\u7684 PD-1 \u86cb\u767d\u7ed3\u5408\uff0c\u4fbf\u4f1a\u4ea7\u751f\u6291\u5236\u8baf\u53f7\uff0cT\u7ec6\u80de\u4fbf\u4f1a\u505c\u6b62\u653b\u51fb\u3002<\/p>\n \u4e0d\u4ec5\u5982\u6b64\uff0c\u72e1\u733e\u7684\u764c\u7ec6\u80de\u4f1a\u5728\u8868\u9762\u8868\u8fbe PD-L1 \u86cb\u767d\uff0cPD-1 \u548c PD-L1 \u4e4b\u95f4\u5c31\u50cf\u94a5\u5319\u548c\u9501\uff0c\u4e00\u65e6\u76f8\u9047\u4fbf\u4f1a\u7d27\u5bc6\u7ed3\u5408\u3002<\/p>\n \u5f53T\u7ec6\u80de\u4e0a\u7684 PD-1 \u53d7\u4f53\u4e0e\u4e4b\u7ed3\u5408\u540e\u7ed3\u5408\u540e\uff0cT\u7ec6\u80de\u5982\u6b7b\u6c34\u4e00\u822c\uff0c\u5931\u53bb\u4e86\u81ea\u8eab\u529f\u80fd\uff0c\u4e0d\u4f1a\u5bf9\u764c\u7ec6\u80de\u5c55\u5f00\u653b\u51fb\u3002<\/p>\n \u80bf\u7624\u7ec6\u80de\u5982\u4f55\u9003\u907f\u514d\u75ab\u7cfb\u7edf<\/p>\n \u90a3\u4e48\uff0c\u5982\u679c\u628a\u4e0a\u8ff0\u8fc7\u7a0b\u4e00\u5200\u963b\u9694\uff0c\u6211\u4eec\u5c06\u8986\u76d6\u5728\u80bf\u7624\u8eab\u4e0a\u201c\u9690\u5f62\u6597\u7bf7\u201d\u62ff\u6389\uff0c\u518d\u7ed9\u514d\u75ab\u7cfb\u7edf\u914d\u5907\u4e00\u4e2a\u671b\u8fdc\u955c\uff0c\u8ba9\u5b83\u80fd\u51c6\u786e\u201c\u76d1\u89c6\u201d\u80bf\u7624\u7ec6\u80de\u7684\u4e00\u4e3e\u4e00\u52a8\uff0c\u968f\u540e\u518d\u4e3e\u5175\u5bf9\u5176\u5c55\u5f00\u201c\u6b7c\u706d\u8ba1\u5212\u201d\uff0c\u764c\u75c7\u662f\u5426\u5c31\u4e0d\u518d\u90a3\u4e48\u4ee4\u4eba\u751f\u754f\uff1f<\/p>\n \u6297 PD1 \u836f\u7269\u4f5c\u7528\u539f\u7406<\/p>\n \u8fd9\u5c31\u662f\u590d\u5b8f\u6c49\u9716\u5019\u9009\u836f\u7269\u7684\u4e3b\u8981\u539f\u7406\uff0c\u4e5f\u662f\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u4f5c\u7528\u8def\u5f84\uff0c\u76ee\u524d\uff0c\u6b63\u5728\u5f00\u5c55 2 \u9879\u5355\u836f\u53ca 8 \u9879\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n 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