Drug safety: phenacetin.

@article{Macklin1979DrugSP,
  title={Drug safety: phenacetin.},
  author={A. W. Macklin and Robert Welch and Pedro Cuatrecasas},
  journal={Science},
  year={1979},
  volume={205 4402},
  pages={
          144, 146, 148
        },
  url={https://api.semanticscholar.org/CorpusID:32053336}
}
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8 Citations
Background Citations
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8 Citations

On Participatory Realism

In the Philosophical Investigations, Ludwig Wittgenstein wrote, “‘I’ is not the name of a person, nor ‘here’ of a place, .... But they are connected with names. ... [And] it is characteristic of…

Changes in micropore system of roots of wheat and triticale seedlings under aluminum stress as determined using water vapor adsorption—desorption

Plant root structure including the pore system is severely injured in Al-toxic environments. Experimental water vapor desorption isotherms estimated using vacuum chamber method were used to…

Aluminium-induced changes in the surface and micropore properties of wheat roots: a study using the water vapor adsorption-desorption technique

The geometric and energetic characteristics of root surfaces of two wheat (Triticum L.) varieties, Al tolerant (Inia 66/16) and Al sensitive (Henika), were estimated from experimental water vapor…

Phenacetin abuse and malignant tumors

It is proved that not only tumors of the renal pelvis, but also of the ureter and the urinary bladder, are significantly more frequent in PA than in nonabusers and even after stopping any analgesic abuse, UTT will further increase due to the longer induction time.

Species-specific activation of phenacetin into bacterial mutagens by hamster liver enzymes and identification of N-hydroxyphenacetin O-glucuronide as a promutagen in the urine.

The data support the conclusions that N-hydroxyphenacetin is a proximate mutagenic metabolite of phenacetin which, after N-deacylation, is responsible for the mutagenicity observed in vitro and in the urine of hamsters.

Analgesic Nephropathy: A Reassessment of the Role of Phenacetin and Other Analgesics

Phenacetin is thus not the only drug which can cause renal papillary necrosis, and in comparison with these other drugs it appears to be relatively safe as far as the kidney is concerned.

Carcinogenesis in Urogenital Tissues

This chapter will present a brief overview of what is known or suspected about carcinogenesis in general and, more specifically, deal with neoplasia in the urinary tract of both sexes and in the genital tissues of the male.

Use of rat/hamster S-9 mixture in the Ames mutagenicity assay.

The Ames test was performed with a mixture of rat/hamster S-9, and except for an increased mutagenic activation by the mixture with nitrosopiperidine the mixture was comparable to the rat S- 9 alone, indicating that replacing ratS-9 with a rat/Hamster S9 mixture in the standard Ames test could increase the results of the test without interfering with rat S -9 activity.

9 References

Mutagenicities of phenacetin and its metabolites.

Chromosome tests with 134 compounds on Chinese hamster cells in vitro--a screening for chemical carcinogens.

Tumor induction in rats by feeding aminopyrine or oxytetracycline with nitrite

It is not certain whether the result of feeding oxytetracycline and sodium nitrite indicates significant carcinogenicity of this combination, but it is possible that many people have been exposed to a potent carcinogen (dimethylnitrosamine) by its formation in vivo.

Comparative Nephrotoxicity of Aspirin and Phenacetin Derivatives

Both aspirin and phenacetin derivatives were shown to be nephrotoxic when administered to rats as a single intravenous injection, and with the exception of a single derivative, the renal lesions were confined to the proximal convoluted tubule, even after administration of compounds which under other conditions have induced renal papillary necrosis.

The binding of radioactive label from labelled phenacetin and related compounds to rat tissues in vivo and to nucleic acids and bovine plasma albumin in vitro.

Radioactive label from the ethyl-(14)C-labelled derivatives of 4-nitrophenetole, 4-phenetidine and phenacetin binds in vitro to various extents to bovine plasma albumin, salmon sperm DNA and yeast RNA; the extent of binding is increased in the presence of a rat liver microsomal hydroxylating system.

Chromatographic methods for analysis of the metabolites of acetophenetidin (phenacetin).

A simple, specific means has been developed for routine analysis of N -acetyl- p -aminophenol and the other possible metabolites of acetophenetidin in the urine of animals given the drug. The…

CARCINOGENICITY OF PHENACETIN?

Mutagenicity studies with x-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems.

Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates.