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The characteristics of these TICs provide important information about a lesion's composition, but their analysis is time\u2010consuming due to their large number. Subsequently, these TICs are used to classify a lesion as benign or malignant. This lesion scoring is commonly done manually by physicians and may therefore be subject to bias. We propose an approach that addresses both of these problems by combining an automated lesion classification with a visual confirmatory analysis, especially for uncertain cases. Firstly, we cluster the TICs of a lesion using ordering points to identify the clustering structure (OPTICS) and then visualize these clusters. Together with their relative size, they are added to a library. We then model fuzzy inference rules by using the lesion's TIC clusters as antecedents and its score as consequent. Using a fuzzy scoring system, we can suggest a score for a new lesion. Secondly, to allow physicians to confirm the suggestion in uncertain cases, we display the TIC clusters together with their spatial distribution and allow them to compare two lesions side by side. With our knowledge\u2010assisted comparative visual analysis, physicians can explore and classify breast lesions. The true positive prediction accuracy of our scoring system achieved 71.4 % in one\u2010fold cross\u2010validation using 14 lesions.<\/jats:p>","DOI":"10.1111\/cgf.13959","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T12:57:39Z","timestamp":1595077059000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Knowledge\u2010Assisted Comparative Assessment of Breast Cancer using Dynamic Contrast\u2010Enhanced Magnetic Resonance Imaging"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9640-279X","authenticated-orcid":false,"given":"K.","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Simulation and Graphics Otto\u2010von\u2010Guericke University Magdeburg  Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-5398","authenticated-orcid":false,"given":"P.","family":"Baltzer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-9478","authenticated-orcid":false,"given":"B.","family":"Preim","sequence":"additional","affiliation":[{"name":"Department of Simulation and Graphics Otto\u2010von\u2010Guericke University Magdeburg  Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2333-5404","authenticated-orcid":false,"given":"G.","family":"Mistelbauer","sequence":"additional","affiliation":[{"name":"Department of Simulation and Graphics Otto\u2010von\u2010Guericke University Magdeburg  Germany"}]}],"member":"311","published-online":{"date-parts":[[2020,7,18]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","unstructured":"AhadiF. 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