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To fully harness the power of data-driven research, it is imperative to have well-organized machine-readable facts into a knowledge base (KB). Motivated by this urgent need, we introduce the Collaborative Oriented Relation Extraction (CORE) system for building KBs with limited manual annotations. CORE is based on the combination of distant supervision and active learning paradigms and offers a seamless, transparent, modular architecture equipped for large-scale processing. We focus on precision medicine and build the largest KB on \u2018fine-grained\u2019 gene expression\u2013cancer associations\u2014a key to complement and validate experimental data for cancer research. We show the robustness of CORE and discuss the usefulness of the provided KB.<\/jats:p>\n               <jats:p>Database URL https:\/\/zenodo.org\/record\/7577127<\/jats:p>","DOI":"10.1093\/database\/baad061","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T23:35:11Z","timestamp":1695857711000},"source":"Crossref","is-referenced-by-count":3,"title":["Building a large gene expression-cancer knowledge base with limited human annotations"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-5893","authenticated-orcid":false,"given":"Stefano","family":"Marchesin","sequence":"first","affiliation":[{"name":"Department of Information Engineering, University of Padova , Via G. Gradenigo 6b, Padova 35131, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-682X","authenticated-orcid":false,"given":"Laura","family":"Menotti","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova , Via G. Gradenigo 6b, Padova 35131, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-5498","authenticated-orcid":false,"given":"Fabio","family":"Giachelle","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova , Via G. Gradenigo 6b, Padova 35131, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-4554","authenticated-orcid":false,"given":"Gianmaria","family":"Silvello","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova , Via G. 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