{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:50:43Z","timestamp":1768294243157,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":353,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Small angle X-ray scattering (SAXS) is an established method for studying biological macromolecules in solution, whereby the experimental scattering patterns relate to the quaternary and tertiary structure of the macromolecule. Here we present DARA, a web-server, that queries over 150\u2009000 scattering profiles pre-computed from the high resolution models of macromolecules and biological assemblies in the Protein Data Bank, to rapidly find nearest neighbours of a given experimental or theoretical SAXS pattern. Identification of the best scattering equivalents provides a straightforward and automated way of structural assessment of macromolecules based on a SAXS profile. DARA results are useful e.g. for fold recognition and finding of biologically active oligomers.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/dara.embl-hamburg.de\/<\/jats:p>\n               <jats:p>Contact: \u00a0svergun@embl-hamburg.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv611","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:20:03Z","timestamp":1445905203000},"page":"616-618","source":"Crossref","is-referenced-by-count":20,"title":["DARA: a web server for rapid search of structural neighbours using solution small angle X-ray scattering data"],"prefix":"10.1093","volume":"32","author":[{"given":"Alexey G.","family":"Kikhney","sequence":"first","affiliation":[{"name":"1 European Molecular Biology Laboratory, Hamburg Outstation, EMBL c\/o DESY, 22607 Hamburg, Germany and"}]},{"given":"Alejandro","family":"Panjkovich","sequence":"additional","affiliation":[{"name":"1 European Molecular Biology Laboratory, Hamburg Outstation, EMBL c\/o DESY, 22607 Hamburg, Germany and"}]},{"given":"Anna V.","family":"Sokolova","sequence":"additional","affiliation":[{"name":"2 Bragg Institute, ANSTO, Lucas Heights, 2234 NSW Australia"}]},{"given":"Dmitri I.","family":"Svergun","sequence":"additional","affiliation":[{"name":"1 European Molecular Biology Laboratory, Hamburg Outstation, EMBL c\/o DESY, 22607 Hamburg, Germany and"}]}],"member":"286","published-online":{"date-parts":[[2015,10,25]]},"reference":[{"key":"2023020110343268600_btv611-B1","doi-asserted-by":"crossref","first-page":"D301","DOI":"10.1093\/nar\/gkl971","article-title":"The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data","volume":"35","author":"Berman","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023020110343268600_btv611-B2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2008"},{"key":"2023020110343268600_btv611-B3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1107\/S0021889803000220","article-title":"Prototype of a database for rapid protein classification based on solution scattering data","volume":"36","author":"Sokolova","year":"2003","journal-title":"J. Appl. Cryst."},{"key":"2023020110343268600_btv611-B4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1107\/S0021889892001663","article-title":"Determination of the regularization parameter in indirect-transform methods using perceptual criteria","volume":"25","author":"Svergun","year":"1992","journal-title":"J. Appl. Cryst."},{"key":"2023020110343268600_btv611-B5","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1107\/S0021889895007047","article-title":"CRYSOL \u2013 a program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates","volume":"28","author":"Svergun","year":"1995","journal-title":"J. Appl. Cryst."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/32\/4\/616\/49017415\/bioinformatics_32_4_616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/32\/4\/616\/49017415\/bioinformatics_32_4_616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T19:55:27Z","timestamp":1675281327000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/32\/4\/616\/1743953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,25]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btv611","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,2,15]]},"published":{"date-parts":[[2015,10,25]]}}}