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This enhances the understanding of biological nervous systems and the applicability of the model in various fields. However, the existing DNM suffers from high complexity and limited generalisation capability. To address these issues, a DNM pruning method with dendrite layer significance constraints is proposed. This method not only evaluates the significance of dendrite layers but also allocates the significance of a few dendrite layers in the trained model to a few dendrite layers, allowing the removal of low\u2010significance dendrite layers. 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