{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:45:26Z","timestamp":1774075526731,"version":"3.50.1"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFB0202600"],"award-info":[{"award-number":["2017YFB0202600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703416"],"award-info":[{"award-number":["81703416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21773313"],"award-info":[{"award-number":["21773313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Natural Science Founds for Distinguished Young Scholars","award":["2016A030306038"],"award-info":[{"award-number":["2016A030306038"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province of China","award":["A2017071"],"award-info":[{"award-number":["A2017071"]}]},{"name":"GDAS' Project of Science and Technology Development","award":["2019GDASYL-0103009"],"award-info":[{"award-number":["2019GDASYL-0103009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2019,9,23]]},"DOI":"10.1021\/acs.jcim.9b00443","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T14:42:41Z","timestamp":1565620961000},"page":"3667-3678","source":"Crossref","is-referenced-by-count":37,"title":["Exploring Chemical and Biological Space of Terpenoids"],"prefix":"10.1021","volume":"59","author":[{"given":"Tao","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, P.R. China"}]},{"given":"Huawei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China"}]},{"given":"Wengan","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China"}]},{"given":"Xiaowen","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China"}]},{"given":"Liwei","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, P.R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-046X","authenticated-orcid":true,"given":"Ruibo","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China"}]}],"member":"316","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00287"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2006.03.014"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0084"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.11.008"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/432823a"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/jm401309q"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/ar500432k"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614680114"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2479"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14178"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155165"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ja00738a045"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00015-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.05.017"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.03.017"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00302"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00747"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00504"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00125"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00619"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b01022"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201603224"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.076"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00862"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00560"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005053"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006025"},{"key":"ref29\/cit29","unstructured":"Dictionary of\nNatural Products (Dnp), Version 27.2. http:\/\/dnp.chemnetbase.com (accessed 5 May 2019)."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"ref31\/cit31","unstructured":"Pipeline Pilot,\nVersion 8.0; Accelrys: San Diego, 2008."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"ref33\/cit33","unstructured":"Drugbank, Version 5.1.1. https:\/\/www.drugbank.ca (Accessed 2019, Apr 2)."},{"key":"ref34\/cit34","unstructured":"Molecular\nOperating Environment (Moe), 2014.09; Chemical\nComputing Group Inc., 1010 Sherbooke St. West, Suite\n#910, Montreal, QC, Canada, H3a 2r7. 2014."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21707"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1515\/psr-2018-0103"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ci300535x"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ci500588j"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw055"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm9602928"},{"key":"ref41\/cit41","unstructured":"Landrum, G. Rdkit: Open-Source Cheminformatics Software. http:\/\/www.rdkit.org (accessed 29 November 2018)."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1074"},{"key":"ref43\/cit43","unstructured":"Chembl, Version\n24. https:\/\/www.ebi.ac.uk\/chembl (accessed 27\nNovember 2018)."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jm060217p"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jm901241e"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012741107"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1186102"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053202214"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2003.11.014"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ja0499593"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00154"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/C8CP02262C"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b01462"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2017.03.037"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3390\/md11062042"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.16"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.050"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.051"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.24.17159"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/nature02732"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-351"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1080\/10915810701464641"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1768-322X.1987.tb00513.x"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.11.3296"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5175"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.1.8566551"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610202104"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003302"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1346608"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5361.292"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2012.02.007"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.03.013"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.9b00443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T05:32:11Z","timestamp":1681536731000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.9b00443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":76,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,23]]}},"alternative-id":["10.1021\/acs.jcim.9b00443"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.9b00443","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]}}}