{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:23:58Z","timestamp":1776871438447,"version":"3.51.2"},"reference-count":37,"publisher":"Elsevier BV","issue":"10-12","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computers &amp; Chemical Engineering"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.compchemeng.2006.05.036","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T01:27:50Z","timestamp":1153186070000},"page":"1482-1496","source":"Crossref","is-referenced-by-count":103,"title":["Ontological informatics infrastructure for pharmaceutical product development and manufacturing"],"prefix":"10.1016","volume":"30","author":[{"given":"Venkat","family":"Venkatasubramanian","sequence":"first","affiliation":[]},{"given":"Chunhua","family":"Zhao","sequence":"additional","affiliation":[]},{"given":"Girish","family":"Joglekar","sequence":"additional","affiliation":[]},{"given":"Ankur","family":"Jain","sequence":"additional","affiliation":[]},{"given":"Leaelaf","family":"Hailemariam","sequence":"additional","affiliation":[]},{"given":"Pradeep","family":"Suresh","sequence":"additional","affiliation":[]},{"given":"Pavankumar","family":"Akkisetty","sequence":"additional","affiliation":[]},{"given":"Ken","family":"Morris","sequence":"additional","affiliation":[]},{"given":"G.V.","family":"Reklaitis","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.compchemeng.2006.05.036_bib1","unstructured":"Aspen Tech (2005). Aspen Custom Modeler. http:\/\/www.aspentech.com\/product.cfm?ProductID=54."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib2","series-title":"A Semantic Web primer","author":"Antoniou","year":"2004"},{"issue":"3","key":"10.1016\/j.compchemeng.2006.05.036_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0098-1354(94)00051-O","article-title":"Design support systems for process engineering\u2014II: KBDS: An experimental prototype","volume":"19","author":"Ba\u00f1ares-Alc\u00e1ntara","year":"1995","journal-title":"Computers and Chemical Engineering"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib4","unstructured":"Batch Process Technologies Inc. (2005). Batches reference manual. W. Lafayette, IN."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib5","first-page":"2","article-title":"An MDA manifesto","volume":"5","author":"Booch","year":"2004","journal-title":"MDA Journal"},{"issue":"2","key":"10.1016\/j.compchemeng.2006.05.036_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1207\/s15516709cog0902_1","article-title":"An overview of the KL-ONE knowledge representation system","volume":"9","author":"Branchman","year":"1985","journal-title":"Cognitive Science"},{"issue":"10","key":"10.1016\/j.compchemeng.2006.05.036_bib7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0098-1354(96)00321-3","article-title":"A formal representation of process model equations","volume":"21","author":"Bogusch","year":"1997","journal-title":"Computers & Chemical Engineering"},{"issue":"7\u20138","key":"10.1016\/j.compchemeng.2006.05.036_bib8","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0098-1354(01)00626-3","article-title":"Computer-aided process modeling with ModKit","volume":"25","author":"Bogusch","year":"2001","journal-title":"Computers & Chemical Engineering"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF01271279","article-title":"The STEP integration information architecture","volume":"11","author":"Burkett","year":"1995","journal-title":"Engineering with Computers"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib10","series-title":"Proceedings of MKM 2004","article-title":"Mathematical service matching using description logic and OWL","author":"Caprotti","year":"2004"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib11","unstructured":"Chaudhri, V. K., Farquhar, A., Fikes, R., Karp, P. D., & Rice J. P. (1998). Open knowledge base connectivity 2.0.3. Technical report."},{"issue":"2","key":"10.1016\/j.compchemeng.2006.05.036_bib12","doi-asserted-by":"crossref","DOI":"10.1145\/1041791.1041795","article-title":"MKM: A new interdisciplinary field of research","volume":"38","author":"Farmer","year":"2004","journal-title":"ACM SIGSAM Bulletin"},{"issue":"6","key":"10.1016\/j.compchemeng.2006.05.036_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1006\/ijhc.1996.0121","article-title":"The ontolingua server: A tool for collaborative ontology construction","volume":"46","author":"Farquhar","year":"1997","journal-title":"International Journal of Human Computer Studies"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib14","unstructured":"FDA (2005). Process analytical technology initiative. http:\/\/www.fda.gov\/cder\/OPS\/PAT.htm."},{"issue":"2","key":"10.1016\/j.compchemeng.2006.05.036_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/knac.1993.1008","article-title":"A translation approach to portable ontology specification","volume":"5","author":"Gruber","year":"1993","journal-title":"Knowledge Acquisition"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib16","unstructured":"Jarke, M., & Marquardt, W. (1996). Design and evaluation of computer-aided process modeling tools. In J. F. Davis, G. Stephanopoulos, & V. Venkatasubramanian (Eds.), Intelligent systems in process engineering, AIChE symposium series no. 312, 92s, 97\u2013109."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/014492999118913","article-title":"Task modeling for cooperative work","volume":"18","author":"Killich","year":"1999","journal-title":"Behavior and Information Technology"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib18","series-title":"International workshop on the model-driven Semantic Web","article-title":"Ontology-driven software development in the context of the Semantic Web: An example scenario with Prot\u00e9g\u00e9\/OWL","author":"Knublauch","year":"2004"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib19","series-title":"Fluidization Engineering","author":"Kunii","year":"1969"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib20","series-title":"Building large knowledge-based systems: Representation and interface in the Cyc project","author":"Lenat","year":"1990"},{"issue":"3","key":"10.1016\/j.compchemeng.2006.05.036_bib21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1145\/122296.122309","article-title":"Inside the LOOM classifier","volume":"2","author":"MacGregor","year":"1991","journal-title":"SIGART Bulletin"},{"issue":"8","key":"10.1016\/j.compchemeng.2006.05.036_bib22","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1021\/ie0496434","article-title":"Computer-aided modeling of chemical and biological systems: Methods, tools, and applications","volume":"44","author":"Mangold","year":"2005","journal-title":"Industrial & Engineering Chemistry Research"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib23","series-title":"Proceedings of the international conference on mathematical knowledge management","article-title":"The mathematical Semantic Web","author":"Marchiori","year":"2003"},{"issue":"4","key":"10.1016\/j.compchemeng.2006.05.036_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/1063293X9500300404","article-title":"A concurrent engineering environment for chemical engineering","volume":"3","author":"McGreavy","year":"1995","journal-title":"Concurrent Engineering: Research and Applications"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib25","unstructured":"Noy, N. F., & McGuinness, D. L. (2001). Ontology development 101: A guide to creating your first ontology. Stanford Knowledge Systems Laboratory Technical Report KSL-01-05."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib26","unstructured":"OWL (2004). Web ontology language overview. W3C Recommendation. http:\/\/www.w3.org\/TR\/owl-features\/."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib27","first-page":"38","article-title":"Considerations in selecting a Laboratory Information Management System (LIMS)","volume":"9","author":"Paszko","year":"2000","journal-title":"American Laboratory"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib28","unstructured":"Peleg, M., Boxwala, A., Tu, S., Wang, D., Ogunyemi, O., & Zeng, Q. (2004). Guideline Interchange Format 3.5 Technical Specification. http:\/\/smi-web.stanford.edu\/projects\/intermed-web\/guidelines\/."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib29","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0009-2509(02)00075-1","article-title":"Information technology support in the chemical process life cycle","volume":"57","author":"Schneider","year":"2002","journal-title":"Chemical Engineering Science"},{"issue":"3","key":"10.1016\/j.compchemeng.2006.05.036_bib30","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1021\/op0402127","article-title":"Process analytical technology: An investment in process knowledge","volume":"9","author":"Sistare","year":"2005","journal-title":"Organic Process Research and Development"},{"issue":"1\u20132","key":"10.1016\/j.compchemeng.2006.05.036_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0169-023X(97)00056-6","article-title":"Knowledge engineering: Principles and methods","volume":"25","author":"Studer","year":"1998","journal-title":"IEEE Transactions on Data and Knowledge Engineering"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib32","unstructured":"TopQuadrant (2003). Semantic integration: Strategies and tools. TopQuadrant technology briefing."},{"issue":"5","key":"10.1016\/j.compchemeng.2006.05.036_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jbi.2004.06.002","article-title":"Design and implementation of the GLIF3 guideline execution engine","volume":"37","author":"Wang","year":"2004","journal-title":"Journal of Biomedical Information"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib34","first-page":"2","article-title":"The Nascent Paperless Laboratory","volume":"31","author":"Zall","year":"2001","journal-title":"Chemical Innovation"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib35","unstructured":"Zhao, C. (2002). Knowledge engineering framework for automated HAZOP analysis. Ph.D. Thesis. Purdue University."},{"key":"10.1016\/j.compchemeng.2006.05.036_bib36","series-title":"Proceedings of ESCAPE 13","article-title":"Roles of ontology in automated process safety analysis","author":"Zhao","year":"2003"},{"key":"10.1016\/j.compchemeng.2006.05.036_bib37","series-title":"Proceedings of ESCAPE15","article-title":"Pharmaceutical informatics: A novel paradigm for pharmaceutical product development and manufacture","author":"Zhao","year":"2005"}],"container-title":["Computers &amp; Chemical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098135406001578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098135406001578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T02:28:20Z","timestamp":1547519300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098135406001578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":37,"journal-issue":{"issue":"10-12","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0098135406001578"],"URL":"https:\/\/doi.org\/10.1016\/j.compchemeng.2006.05.036","relation":{},"ISSN":["0098-1354"],"issn-type":[{"value":"0098-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}