{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:37:03Z","timestamp":1766428623006,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1059775","1083450"],"award-info":[{"award-number":["1059775","1083450"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1611261","61772566"],"award-info":[{"award-number":["U1611261","61772566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Comput Chem"],"published-print":{"date-parts":[[2018,8,15]]},"abstract":"<jats:p>Malonylation is a recently discovered post\u2010translational modification (PTM) in which a malonyl group attaches to a lysine (K) amino acid residue of a protein. In this work, a novel machine learning model, SPRINT\u2010Mal, is developed to predict malonylation sites by employing sequence and predicted structural features. Evolutionary information and physicochemical properties are found to be the two most discriminative features whereas a structural feature called half\u2010sphere exposure provides additional improvement to the prediction performance. SPRINT\u2010Mal trained on mouse data yields robust performance for 10\u2010fold cross validation and independent test set with Area Under the Curve (AUC) values of 0.74 and 0.76 and Matthews\u2019 Correlation Coefficient (MCC) of 0.213 and 0.20, respectively. Moreover, SPRINT\u2010Mal achieved comparable performance when testing on <jats:italic>H. sapiens<\/jats:italic> proteins without species\u2010specific training but not in bacterium <jats:italic>S. erythraea<\/jats:italic>. This suggests similar underlying physicochemical mechanisms between mouse and human but not between mouse and bacterium. SPRINT\u2010Mal is freely available as an online server at: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/sparks-lab.org\/server\/SPRINT-Mal\/\">http:\/\/sparks-lab.org\/server\/SPRINT-Mal\/<\/jats:ext-link>. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcc.25353","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T06:44:49Z","timestamp":1526366689000},"page":"1757-1763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Predicting lysine\u2010malonylation sites of proteins using sequence and predicted structural features"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-3967","authenticated-orcid":false,"given":"Ghazaleh","family":"Taherzadeh","sequence":"first","affiliation":[{"name":"School of Information and Communication Technology Griffith University, Parklands Drive Southport 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