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Such science gateways that enable access to distributed computing resources for large\u2010scale data management need to be made more programmable, extensible, and scalable. In this article, we propose a novel socio\u2010technical approach for developing a next\u2010generation healthcare science gateway, namely,<jats:italic>OnTimeEvidence<\/jats:italic>that addresses data consumer challenges surrounding the COVID\u201019 pandemic related data analytics. OnTimeEvidence implements an intelligent agent, namely,<jats:italic>Vidura Advisor<\/jats:italic>that integrates an evidence\u2010based filtering method to transform manual practices and improve scalability of data analytics. It also features a plug\u2010in management middleware that improves the programmability and extensibility of the science gateway capabilities using microservices. Lastly, we present a usability study that shows the important factors from data consumers' perspective to adopt OnTimeEvidence with chatbot\u2010assisted middleware support to increase their productivity and collaborations to access vast publication archives for rapid knowledge discovery tasks.<\/jats:p>","DOI":"10.1002\/cpe.7195","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T07:00:56Z","timestamp":1658214056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Science gateway adoption using plug\u2010in middleware for evidence\u2010based healthcare data management"],"prefix":"10.1002","volume":"35","author":[{"given":"Roland","family":"Oruche","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}]},{"given":"Eric","family":"Milman","sequence":"additional","affiliation":[{"name":"College of Media and Communication Texas Tech University Lubbock Texas USA"}]},{"given":"Mauro","family":"Lemus Alarcon","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}]},{"given":"Xiyao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}]},{"given":"Ashish","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}]},{"given":"Songjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-5389","authenticated-orcid":false,"given":"Prasad","family":"Calyam","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science University of Missouri Columbia Missouri USA"}]},{"given":"Kerk","family":"Kee","sequence":"additional","affiliation":[{"name":"College of Media and Communication Texas Tech University Lubbock Texas USA"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"480","article-title":"Evidence matters","volume":"94","author":"Timm D","year":"2006","journal-title":"J Med Libr Assoc"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmed-2016-110401"},{"key":"e_1_2_10_4_1","first-page":"210","volume-title":"Modern Analytical Ultracentrifugation: Techniques and Methods","author":"Demeler B","year":"2005"},{"key":"e_1_2_10_5_1","unstructured":"SivarathriSS CalyamP ZhangY et al.Chatbot guided domain\u2010science knowledge discovery in a science gateway application. 14th Gateway Computing Environments Conference;2019:1\u20104."},{"volume-title":"Diffusion of Innovations","year":"2010","author":"Rogers EM","key":"e_1_2_10_6_1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"De ConinckQ MichelF PirauxM et al.Pluginizing quic. 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