@charset "UTF-8";
#top_under {
  margin-bottom: 0;
}

/* リセット */
body {
  letter-spacing: 0;
}
h2,
h3,
h4 {
  padding: 0;
  margin: 0;
  border: unset;
  display: block;
  background: transparent;
  color: #000;
}
p {
  letter-spacing: 0;
  margin: 0;
  color: #000;
  font-family: 游明朝, Yu Mincho, YuMincho, Hiragino Mincho Pro, serif;
  text-align: left;
}
a {
  text-decoration: none;
}
/* 共通 */
.l-inner {
  width: min(1100px, 100%);
  margin: 0 auto;
}
.c-red {
  color: #d10000;
}
.c-txt {
  font-size: clamp(13px, 1.6vw, 16px);
  font-family: '游明朝', YuMincho, 'ヒラギノ明朝 ProN W3', 'Hiragino Mincho ProN', 'HG明朝B', serif;
  font-weight: normal;
}
.c-txt + .c-txt {
  margin-top: 20px;
}
.c-txt--center {
  text-align: center;
}
.c-txt--center-sp-left {
  text-align: center;
}
.c-notes {
  text-align: center;
  color: #707070;
  font-size: 12px;
}
.c-notes--left {
  text-align: left;
}
.c-yugothic {
  font-family: 游ゴシック medium, yu gothic medium, 游ゴシック, yu gothic, メイリオ, meiryo, ヒラギノ角ゴ pro,
    hiragino kaku gothic pro, sans-serif;
}
.c-ttl {
  color: #fff;
  font-family: '游明朝', YuMincho, 'ヒラギノ明朝 ProN W3', 'Hiragino Mincho ProN', 'HG明朝B', serif;
  padding: 4px 20px;
  background: linear-gradient(90deg, #0d0d0d, #4d4d4d);
  position: relative;
  padding-left: 35px;
  font-size: 25px;
  line-height: 1.3em;
  margin: 80px 0 40px;
  box-shadow: 0 1px 10px 1px rgb(0 0 0 / 20%);
  padding: 15px;
  padding-left: 35px;
}
.c-ttl::before {
  background: #999999;
  display: block;
  content: '';
  position: absolute;
  left: 10px;
  top: 50%;
  transform: translateY(-50%);
  width: 5px;
  height: 59%;
}
.p-btn-outer {
  text-align: left;
}
.p-btn-outer--small {
  text-align: right;
  max-width: 330px;
  background: linear-gradient(90deg, #eed6ff, #dbefff);
  margin-left: auto;
}
.p-btn-outer--max {
  width: 100%;
  background: linear-gradient(90deg, #eed6ff, #dbefff);
}
.p-btn-outer--big {
  max-width: 600px;
  margin: 0 auto;
  background: linear-gradient(90deg, #eed6ff, #dbefff);
}
.p-btn {
  display: inline-block;
  position: relative;
  padding: 20px 0;
  border: 1px solid #cccccc;
  background: #fff;
  text-align: center;
  font-size: 16px;
  font-family: '游明朝', YuMincho, 'ヒラギノ明朝 ProN W3', 'Hiragino Mincho ProN', 'HG明朝B', serif;
  width: 100%;
  max-width: 328px;
  text-decoration: none;
  transition: ease all 0.3s;
  color: #000;
  box-sizing: border-box;
}
.p-btn:hover {
  text-decoration: none;
}
.p-btn--small:hover {
  background: rgba(255, 255, 255, 0);
}
.p-btn--br {
  padding: 9px 0;
  line-height: 1.5;
}
.p-btn-outer .p-btn:last-child {
  margin-right: 0;
}
.p-btn-outer .p-btn:hover {
  background: rgba(255, 255, 255, 0);
  text-decoration: none;
}
.p-btn__arrow {
  content: '';
  display: block;
  width: 12px;
  height: 12px;
  position: absolute;
  right: 15px;
  top: 50%;
  transform: translateY(-50%);
}
.p-btn__arrow::before {
  content: '';
  display: block;
  width: 12px;
  height: 12px;
  border-top: 1px solid #000;
  border-right: 1px solid #000;
  transform: rotate(45deg);
}
.p-btn--big {
  max-width: 600px;
  background: #fff;
}
.p-btn--max {
  max-width: 100%;
}
.p-btn__bg {
  display: inline-block;
  vertical-align: bottom;
  margin-right: 5px;
  width: 100%;
  max-width: 330px;
  background: linear-gradient(90deg, #eed6ff, #dbefff);
}
@media screen and (max-width: 1100px) {
  .l-inner {
    padding: 0 20px;
    box-sizing: border-box;
  }
  .c-txt {
    line-height: 1.8;
  }
  .c-txt--center {
    text-align: left;
  }
  .c-ttl {
    padding-left: 30px;
    font-size: 20px;
    margin: 40px 0 20px;
    line-height: 1.5;
  }
}
@media screen and (max-width: 640px) {
  .c-txt--center-sp-left {
    text-align: left;
  }
}

/* FV */
.p-prs {
  position: relative;
}
.p-prs__inner {
  position: absolute;
  top: 50%;
  left: 50%;
  transform: translateY(-50%) translateX(-50%);
  -webkit-transform: translateY(-50%) translateX(-50%);
}
.p-prs__cont {
  background-color: rgba(255, 255, 255, 0.8);
  display: flex;
  align-items: center;
  justify-content: center;
  padding: 20px;
  box-sizing: border-box;
  min-height: 250px;
}
.p-prs__ttl {
  margin: 0;
  padding: 0;
  background: transparent;
  position: relative;
  color: #000;
  text-align: center;
  font-size: 42px;
  font-weight: 600;
  line-height: 1.5;
  height: 100%;
}
.p-prs__ttl-lead {
  font-size: 14px;
  display: flex;
  flex-direction: column;
  justify-content: center;
  align-items: center;
  margin-top: 10px;
}
.p-prs__ttl-lead::before {
  content: '';
  width: calc(100% + 116px);
  display: block;
  border-top: 2px solid #707070;
  margin-bottom: 17px;
}
.p-prs__img {
}
.p-prs__img-cover {
  width: 2000px;
  height: 400px;
  object-fit: cover;
  object-position: center;
}
@media screen and (max-width: 640px) {
  .p-prs__ttl {
    font-size: clamp(24px, 4.2vw, 42px);
  }
  .p-prs__ttl-lead {
    font-size: 12px;
    margin-top: 10px;
  }
  .p-prs__cont {
    padding: 10px;
  }
  .p-prs__ttl-lead::before {
    width: calc(100% + min(116px, calc(calc(40 / 375) * 100vw)));
    margin-bottom: 14px;
  }
  .p-prs__cont {
    min-height: 180px;
  }
  .p-prs__img-cover {
    height: 300px;
  }
}
.p-prs-about {
  padding-top: 110px;
  background: url('../images/prs/prs_bg.jpg') no-repeat;
  margin-bottom: 180px;
}
/* .p-prs-about__link {
  display: block;
  transition: 0.3s;
  margin: 0 -10px;
} */
.p-prs-about__link:hover {
  opacity: 0.8;
}
.p-prs-about__ttl {
  text-align: center;
  font-size: clamp(20px, 5vw, 50px);
  letter-spacing: 0;
  font-weight: normal;
  line-height: 1.5;
  margin-bottom: 40px;
}

.p-prs-flow {
  counter-reset: prs-flow-num 0;
}

.p-prs-flow__flex {
  display: flex;
  align-items: flex-end;
  gap: 40px;
  counter-increment: prs-flow-num 1;
}

.p-prs-flow__flex + .p-prs-flow__flex {
  margin-top: 80px;
}

.p-prs-flow__flex--reverse {
  flex-direction: row-reverse;
}
.p-prs-flow__flex-item {
}
.p-prs-flow__flex-item--txt {
  width: min(calc(calc(100% - 400px) - 40px), 100%);
  padding-bottom: 15px;
}
.p-prs-flow__flex-item--right {
  text-align: right;
}
.p-prs-flow__flex-item--txt::before {
  content: counter(prs-flow-num, decimal-leading-zero);
  color: #e3e3e3;
  font-family: '游明朝', YuMincho, 'ヒラギノ明朝 ProN W3', 'Hiragino Mincho ProN', 'HG明朝B', serif;
  font-size: clamp(50px, 14vw, 139px);
  letter-spacing: 0;
  font-weight: normal;
  line-height: 1;
  margin-bottom: -15px;
  display: block;
}
.p-prs-flow__flex-item--img {
  width: min(400px, 100%);
}
.p-prs-flow__ttl {
  font-size: clamp(20px, 3.6vw, 36px);
  color: #000;
  margin-bottom: 10px;
  letter-spacing: 0;
  line-height: 1.5;
}
@media screen and (max-width: 640px) {
  .p-prs-about {
    background-size: 800px auto;
    padding-top: 50px;
    margin-bottom: 80px;
  }
  .p-prs-about__ttl {
    margin-bottom: 20px;
  }
  .p-prs-flow__flex {
    display: block;
  }
  .p-prs-flow__flex + .p-prs-flow__flex {
    margin-top: 40px;
  }
  .p-prs-flow__flex-item--txt {
    width: 100%;
  }
  .p-prs-flow__flex-item--sp-center {
    text-align: center;
  }
  .p-prs-flow__flex-item--img {
    margin: 0 auto;
  }
  .p-prs-flow__flex-item--txt::before {
    margin-bottom: 0;
  }
  .p-prs-flow__flex-item--right {
    text-align: left;
  }
}
.p-prs-standard {
  background: url('../images/prs/standard_bg.jpg') no-repeat;
  background-position: 0 90px;
  position: relative;
  margin-bottom: 130px;
}
/* .p-prs-standard::after {
  content: '';
  background: url('../images/prs/standard_bottom_bg.jpg') no-repeat;
  background-position: bottom;
  display: block;
  width: 100%;
  height: 100%;
  position: absolute;
  bottom: 0;
  z-index: -1;
} */
.p-prs-standard__ttl {
  background: url('../images/prs/standard_ttl_bg.png') no-repeat;
  background-size: 100% auto;
  font-size: clamp(17px, 3vw, 30px);
  font-weight: 700;
  color: #fff;
  text-align: center;
  padding: 64px 20px;
  line-height: 1.8;
  margin-bottom: 70px;
  line-height: 1.6;
  display: flex;
  align-items: center;
  justify-content: center;
  box-sizing: border-box;
}

.p-prs-standard__flex {
  display: flex;
  justify-content: center;
  gap: clamp(10px, 2vw, 20px);
  margin-bottom: 20px;
}

.p-prs-standard__flex-img {
  width: min(350px, calc(calc(100% - clamp(10px, 2vw, 20px)) / 2));
  box-shadow: 0 10px 10px rgba(0, 0, 0, 0.16);
}

.p-prs-standard__box {
  padding: clamp(10px, 2.5vw, 25px);
  background-color: #fff;
  box-shadow: 0 3px 6px rgba(0, 0, 0, 0.16);
  margin-bottom: 100px;
}

.p-prs-standard__box--border {
  content: '';
  width: 100%;
  height: 100%;
  border: clamp(3px, 0.5vw, 5px) solid;
  border-image: linear-gradient(135deg, #989898 0%, #ececec 65%, #b8b8b8 100%);
  border-image-slice: 1;
  padding: clamp(10px, 4.5vw, 45px) clamp(10px, 3vw, 30px);
  box-sizing: border-box;
}
.p-prs-standard__infoBox {
  position: relative;
  background-color: #f3f3f3;
  border-radius: 10px;
  padding: clamp(15px, 2vw, 20px);
}
.p-prs-standard__infoBox::before {
  content: '';
  width: 29px;
  height: 29px;
  background: url('../images/prs/icon_info.png') no-repeat;
  background-size: 100%;
  display: block;
  position: absolute;
  top: -15px;
  left: 15px;
}
.p-prs-standard__infoBox-txt {
  font-size: clamp(12px, 1.5vw, 15px);
  font-weight: bold;
  font-family: 游ゴシック medium, yu gothic medium, 游ゴシック, yu gothic, メイリオ, meiryo, ヒラギノ角ゴ pro,
    hiragino kaku gothic pro, sans-serif;
  line-height: 1.8;
}
/* .p-prs-standard__infoBox-txt--notes {
  position: relative;
  padding-left: 16px;
  display: block;
}
.p-prs-standard__infoBox-txt--notes::before {
  content: '※';
  position: absolute;
  top: 0;
  left: 0;
} */
.p-prs-standard__flow-ttl {
  background: #fff;
  position: relative;
  font-size: 25px;
  border-bottom: 1px solid #333333;
  line-height: 1.3em;
  padding: 15px;
  padding-left: 35px;
  letter-spacing: 0;
}
.p-prs-standard__flow-ttl::before {
  background: #999999;
  display: block;
  content: '';
  position: absolute;
  left: 10px;
  top: 50%;
  transform: translateY(-50%);
  width: 5px;
  height: 59%;
}
.p-prs-standard__flow-ttl ~ .p-prs-standard__flow-ttl {
  margin-top: 150px;
}
.p-prs-standard__flow-txt {
  margin-bottom: 30px;
  font-size: clamp(13px, 1.6vw, 16px);
  line-height: 1.8;
}
.p-prs-standard__mediumTtl {
  font-size: clamp(20px, 3.6vw, 36px);
  line-height: 1.5;
}
.p-prs-standard__lead-txt {
  font-size: 12px;
  line-height: 1.5;
}
.p-prs-standard__lead-link {
  font-size: 12px;
  text-decoration: underline;
  transition: all 0.3s;
  color: #000;
}
.p-prs-standard__lead-link:hover {
  text-decoration: none;
}
.p-prs-standard__list {
  display: flex;
  flex-wrap: wrap;
  gap: 20px 25px;
}
.p-prs-standard__list-item {
  width: calc(calc(100% - 50px) / 3);
  margin-bottom: 0;
}
@media screen and (max-width: 640px) {
  .p-prs-standard {
    background-position: 0 45px;
    margin-bottom: 80px;
  }
  .p-prs-standard__ttl {
    background-size: contain;
    background-image: url(../images/prs/standard_ttl_bg-sp.png);
    padding: calc(calc(24 / 375) * 100vw) 20px;
    margin-bottom: 30px;
    font-size: calc(calc(17 / 375) * 100vw);
    height: min(204px, calc(calc(102 / 375) * 100vw));
  }
  .p-prs-standard__box {
    margin-bottom: 50px;
  }
  .p-prs-standard__infoBox::before {
    width: 22px;
    height: 22px;
    top: -10px;
    left: 10px;
  }
  .p-prs-standard__infoBox-txt--notes {
    padding-left: 14px;
  }
  .p-prs-standard__flow-txt {
    margin-bottom: 20px;
  }
  .p-prs-standard__flow-ttl {
    padding-left: 30px;
    font-size: 20px;
    margin: 40px 0 20px;
    line-height: 1.5;
  }
  .p-prs-standard__flow-ttl::before {
    height: 78%;
  }
  .p-prs-standard__flow-ttl ~ .p-prs-standard__flow-ttl {
    margin-top: 45px;
  }
  .p-prs-standard__list {
    gap: 10px;
  }
  .p-prs-standard__list-item {
    width: calc(calc(100% - 20px) / 3);
  }
  .p-prs-standard__flex {
    margin-bottom: 10px;
  }
}

/* 顧問医師論文情報 */
.p-prs-doctor__ttl {
  font-size: clamp(20px, 3.6vw, 36px);
  font-weight: 600;
  font-family: '游明朝', YuMincho, 'ヒラギノ明朝 ProN W3', 'Hiragino Mincho ProN', 'HG明朝B', serif;
  text-align: center;
}
.p-general__desc {
  margin-bottom: 30px;
}
.p-general__desc-ttl {
  border-bottom: 1px solid #b2984e;
  color: #333;
  font-family: 游明朝, Yu Mincho, YuMincho, Hiragino Mincho Pro, serif;
  font-size: clamp(16px, 2vw, 20px);
  line-height: 1;
  margin-bottom: 15px;
  padding-bottom: 9px;
}
.p-general__desc-data--paper {
  border: 1px solid #ececec;
  font-size: clamp(11px, 1.3vw, 13px);
  height: 200px;
  line-height: 1.5;
  overflow-y: auto;
  padding: 10px 20px;
}
.p-general__paper-txt {
  font-family: 游ゴシック medium, yu gothic medium, 游ゴシック, yu gothic, メイリオ, meiryo, ヒラギノ角ゴ pro,
    hiragino kaku gothic pro, sans-serif;
}
.p-general__paper-txt--gd {
  color: #b2984e;
  font-weight: bold;
  font-family: 游ゴシック medium, yu gothic medium, 游ゴシック, yu gothic, メイリオ, meiryo, ヒラギノ角ゴ pro,
    hiragino kaku gothic pro, sans-serif;
    margin-top: 15px;
}
.p-general__magazine {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  line-height: 1.5;
}
.p-general__magazine-item {
  width: calc((100% - 10px * 2) / 3);
  background-color: #f5f5f5;
}
.p-general__itemFlex-item--img {
  width: 60px;
}
.p-general__magazine-txt {
  flex: 1;
  color: #000;
  line-height: 1.6;
  letter-spacing: 0;
  display: flex;
  flex-direction: column;
  justify-content: space-between;
  font-family: 游明朝, Yu Mincho, YuMincho, Hiragino Mincho Pro, serif;
}
.p-doctor-magazine__quote {
  color: #707070;
  font-size: 10px;
  width: 100%;
  text-decoration: underline;
  line-height: 1.5;
}
.p-general__itemFlex {
  display: flex;
  gap: 20px;
  padding: 10px;
  transition: all 0.3s;
  height: 100%;
  box-sizing: border-box;
}
.p-general__itemFlex:hover {
  opacity: 0.6;
}
.p-doctor-magazine-txt {
  font-family: 游ゴシック medium, yu gothic medium, 游ゴシック, yu gothic, メイリオ, meiryo, ヒラギノ角ゴ pro,
    hiragino kaku gothic pro, sans-serif;
  flex: 1;
  font-size: clamp(10px, 1.2vw, 12px);
  display: flex;
  flex-direction: column;
  justify-content: space-between;
}
/* .p-general__magazine-txtItem {
  margin-bottom: 10px;
}
.p-general__magazine-txtCont {
  display: flex;
  font-size: clamp(10px, 1.1vw, 11px);
  line-height: 1.8;
  font-weight: 600;
}
.p-general__magazine-txtCont-ttl {
  width: 55px;
}

.p-general__magazine-txtCont-lead {
  width: calc(100% - 55px);
  font-feature-settings: 'palt';
  letter-spacing: 0.5px;
} */

@media screen and (max-width: 640px) {
  .p-general__magazine-item {
    width: 100%;
  }
  .p-general__itemFlex {
    gap: 10px;
  }
  /* .p-general__magazine-txtCont-ttl {
    width: auto;
  }
  .p-general__magazine-txtCont {
    font-size: 10px;
  } */
  .p-doctor-magazine__quote {
    font-size: 10px;
  }
}

/* 20240322 学術論文箇所に追記 */

.marker-yellow {
  background-color: #faf2dd;
}